{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:48:04Z","timestamp":1792453684728,"version":"4.5.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["amjtransplant.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Transplantation"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.ajt.2026.02.008","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:31:06Z","timestamp":1771288266000},"page":"1472-1481","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Simultaneous islet-kidney transplantation as an alternative for patients ineligible for pancreas transplant: Initial experience at a North American transplant center"],"prefix":"10.1016","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5026-4344","authenticated-orcid":false,"given":"Catherine","family":"Parmentier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6285-0365","authenticated-orcid":false,"given":"Xin","family":"Di Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3881-0300","authenticated-orcid":false,"given":"Abdulmohsen","family":"Bakhsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2620-4928","authenticated-orcid":false,"given":"Justin","family":"Manuel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2936-4951","authenticated-orcid":false,"given":"Hongtao","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2733-585X","authenticated-orcid":false,"given":"Xue-Zhong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3865-5232","authenticated-orcid":false,"given":"Shagani","family":"Thisairajah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2038-0774","authenticated-orcid":false,"given":"Surina","family":"Arora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0514-8560","authenticated-orcid":false,"given":"Paraish","family":"Misra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2841-9834","authenticated-orcid":false,"given":"Chaya","family":"Shwaartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4649-546X","authenticated-orcid":false,"given":"Ian","family":"McGilvray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4326-0887","authenticated-orcid":false,"given":"Markus","family":"Selzner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2514-0128","authenticated-orcid":false,"given":"Andrea","family":"Norgate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2862-1065","authenticated-orcid":false,"given":"Zaneta","family":"Sawicka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4108-7192","authenticated-orcid":false,"given":"Elmar","family":"Jaeckel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7377-3659","authenticated-orcid":false,"given":"Sonia","family":"Rodr\u00edguez-Ram\u00edrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0493-0646","authenticated-orcid":false,"given":"Jeffrey","family":"Schiff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2303-1606","authenticated-orcid":false,"given":"Trevor W.","family":"Reichman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.ajt.2026.02.008_bib1","doi-asserted-by":"crossref","first-page":"208","DOI":"10.5500\/wjt.v13.i5.208","article-title":"Simultaneous pancreas-kidney transplantation for end-stage renal failure in type 1 diabetes mellitus: current perspectives","volume":"13","author":"Nagendra","year":"2023","journal-title":"World J Transplant"},{"issue":"3-4","key":"10.1016\/j.ajt.2026.02.008_bib2","doi-asserted-by":"crossref","first-page":"135","DOI":"10.5489\/cuaj.1597","article-title":"Simultaneous pancreas-kidney transplantation: the role in the treatment of type 1 diabetes and end-stage renal disease","volume":"8","author":"Jiang","year":"2014","journal-title":"Can Urol Assoc J"},{"issue":"2","key":"10.1016\/j.ajt.2026.02.008_bib3","doi-asserted-by":"crossref","first-page":"321","DOI":"10.2337\/dc19-1580","article-title":"Superior long-term survival for simultaneous pancreas-kidney transplantation as renal replacement therapy: 30-year follow-up of a nationwide cohort","volume":"43","author":"Esmeijer","year":"2020","journal-title":"Diabetes Care"},{"issue":"7","key":"10.1016\/j.ajt.2026.02.008_bib4","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1016\/j.transproceed.2022.03.059","article-title":"The 2022 International Pancreas Transplant Registry report-a review","volume":"54","author":"Gruessner","year":"2022","journal-title":"Transplant Proc"},{"issue":"suppl 7","key":"10.1016\/j.ajt.2026.02.008_bib5","article-title":"Complications after pancreas transplantation","volume":"102","author":"Berger","year":"2018","journal-title":"Transplantation"},{"issue":"11","key":"10.1016\/j.ajt.2026.02.008_bib6","doi-asserted-by":"crossref","DOI":"10.1111\/ctr.14792","article-title":"Improved surgical outcomes following simultaneous pancreas-kidney transplantation in the contemporary era","volume":"36","author":"Sharda","year":"2022","journal-title":"Clin Transplant"},{"issue":"7","key":"10.1016\/j.ajt.2026.02.008_bib7","first-page":"E357","article-title":"Simultaneous pancreas-kidney transplantation: early complications and long-term outcomes - a single-center experience","volume":"16","author":"Vidal","year":"2022","journal-title":"Can Urol Assoc J"},{"issue":"5","key":"10.1016\/j.ajt.2026.02.008_bib8","doi-asserted-by":"crossref","first-page":"752","DOI":"10.2337\/dc14-1686","article-title":"Glycemic control in simultaneous islet-kidney versus pancreas-kidney transplantation in type 1 diabetes: a prospective 13-year follow-up","volume":"38","author":"Lehmann","year":"2015","journal-title":"Diabetes Care"},{"issue":"1","key":"10.1016\/j.ajt.2026.02.008_bib9","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1007\/s00125-007-0860-4","article-title":"Simultaneous islet-kidney vs pancreas-kidney transplantation in type 1 diabetes mellitus: a 5 year single centre follow-up","volume":"51","author":"Gerber","year":"2008","journal-title":"Diabetologia"},{"issue":"11","key":"10.1016\/j.ajt.2026.02.008_bib10","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.4103\/1735-1995.172845","article-title":"Diabetes mellitus and renal failure: prevention and management","volume":"20","author":"Nasri","year":"2015","journal-title":"J Res Med Sci"},{"issue":"9","key":"10.1016\/j.ajt.2026.02.008_bib11","doi-asserted-by":"crossref","first-page":"2704","DOI":"10.1111\/ajt.13807","article-title":"Validation of the BETA-2 score: an improved tool to estimate beta cell function after clinical islet transplantation using a single fasting blood sample","volume":"16","author":"Forbes","year":"2016","journal-title":"Am J Transplant"},{"issue":"9","key":"10.1016\/j.ajt.2026.02.008_bib12","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1097\/TP.0000000000002158","article-title":"Defining outcomes for \u03b2-cell replacement therapy in the treatment of diabetes: a consensus report on the Igls criteria from the IPITA\/EPITA Opinion Leaders Workshop","volume":"102","author":"Rickels","year":"2018","journal-title":"Transplantation"},{"issue":"10","key":"10.1016\/j.ajt.2026.02.008_bib13","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.1210\/clinem\/dgab386","article-title":"Examination of the Igls criteria for defining functional outcomes of \u03b2-cell replacement therapy: IPITA symposium report","volume":"106","author":"Landstra","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.ajt.2026.02.008_bib14","series-title":"Atlas of Organ Transplantation","first-page":"1","article-title":"Standard multiorgan procurement from the deceased donor","author":"Lopez-Solis","year":"2015"},{"issue":"27","key":"10.1016\/j.ajt.2026.02.008_bib15","first-page":"1343","article-title":"Human pancreatic islet isolation: part II: purification and culture of human islets","author":"Qi","year":"2009","journal-title":"J Vis Exp"},{"issue":"27","key":"10.1016\/j.ajt.2026.02.008_bib16","first-page":"1125","article-title":"Human pancreatic islet isolation: part I: digestion and collection of pancreatic tissue","author":"Qi","year":"2009","journal-title":"J Vis Exp"},{"issue":"suppl 1","key":"10.1016\/j.ajt.2026.02.008_bib17","doi-asserted-by":"crossref","first-page":"140","DOI":"10.2337\/diab.38.1.S140","article-title":"Automated islet isolation from human pancreas","volume":"38","author":"Ricordi","year":"1989","journal-title":"Diabetes"},{"key":"10.1016\/j.ajt.2026.02.008_bib18","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/978-3-319-39824-2_7","article-title":"Clinical islet isolation","volume":"938","author":"Hawthorne","year":"2016","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.ajt.2026.02.008_bib19","series-title":"Atlas of Organ Transplantation","first-page":"25","article-title":"Donation after cardiac death organ procurement and transplantation","author":"Reich","year":"2015"},{"issue":"6","key":"10.1016\/j.ajt.2026.02.008_bib20","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1097\/MOT.0b013e328332a489","article-title":"Islet assessment for transplantation","volume":"14","author":"Papas","year":"2009","journal-title":"Curr Opin Organ Transplant"},{"key":"10.1016\/j.ajt.2026.02.008_bib21","series-title":"Atlas of Organ Transplantation","first-page":"109","article-title":"Kidney transplantation","author":"Gunabushanam","year":"2015"},{"issue":"3","key":"10.1016\/j.ajt.2026.02.008_bib22","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1080\/19382014.2019.1601543","article-title":"Use of anti-inflammatory agents in clinical islet cell transplants: a qualitative systematic analysis","volume":"11","author":"Szempruch","year":"2019","journal-title":"Islets"},{"issue":"12","key":"10.1016\/j.ajt.2026.02.008_bib23","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1024\/0040-5930\/a000233","volume":"68","author":"Lehman","year":"2011","journal-title":"Ther Umsch"},{"issue":"12","key":"10.1016\/j.ajt.2026.02.008_bib24","doi-asserted-by":"crossref","first-page":"372","DOI":"10.5500\/wjt.v10.i12.372","article-title":"Donor risk factors in pancreas transplantation","volume":"10","author":"Mu\u00f1oz-Bellv\u00eds","year":"2020","journal-title":"World J Transplant"},{"issue":"7","key":"10.1016\/j.ajt.2026.02.008_bib25","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/j.pan.2019.08.010","article-title":"Risk analysis of extended pancreas donor selection criteria","volume":"19","author":"Mensink","year":"2019","journal-title":"Pancreatology"},{"key":"10.1016\/j.ajt.2026.02.008_bib26","doi-asserted-by":"crossref","DOI":"10.12659\/AOT.930787","article-title":"Results from an international survey of donor and recipient eligibility for solid organ pancreas transplantation","volume":"26","author":"Ling","year":"2021","journal-title":"Ann Transplant"},{"issue":"8","key":"10.1016\/j.ajt.2026.02.008_bib27","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.3727\/096368916X691141","article-title":"A multicenter study: North American Islet Donor Score in donor pancreas selection for human islet isolation for transplantation","volume":"25","author":"Wang","year":"2016","journal-title":"Cell Transplant"},{"issue":"2","key":"10.1016\/j.ajt.2026.02.008_bib28","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1177\/0963689718816989","article-title":"Validation of a new North American Islet Donor Score for donor pancreas selection and successful islet isolation in a medium-volume islet transplant center","volume":"28","author":"Go\u0142\u0119biewska","year":"2018","journal-title":"Cell Transplant"},{"issue":"6","key":"10.1016\/j.ajt.2026.02.008_bib29","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.2337\/diacare.28.6.1358","article-title":"Islet transplantation is associated with an improvement of cardiovascular function in type 1 diabetic kidney transplant patients","volume":"28","author":"Fiorina","year":"2005","journal-title":"Diabetes Care"},{"issue":"10","key":"10.1016\/j.ajt.2026.02.008_bib30","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/S2213-8587(24)00241-9","article-title":"Islet-after-kidney transplantation versus kidney alone in kidney transplant recipients with type 1 diabetes (KAIAK): a population-based target trial emulation in France","volume":"12","author":"Maanaoui","year":"2024","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"1","key":"10.1016\/j.ajt.2026.02.008_bib31","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41598-022-27203-w","article-title":"Comparison of long-term outcomes in simultaneous pancreas-kidney transplant versus simultaneous deceased donor pancreas and living donor kidney transplant","volume":"13","author":"Kim","year":"2023","journal-title":"Sci Rep"},{"issue":"11","key":"10.1016\/j.ajt.2026.02.008_bib32","doi-asserted-by":"crossref","DOI":"10.1111\/ctr.14462","article-title":"Survival benefit of the homologous kidney allograft in simultaneous pancreas-kidney transplants and its potential protective role","volume":"35","author":"Serrano","year":"2021","journal-title":"Clin Transplant"},{"issue":"12","key":"10.1016\/j.ajt.2026.02.008_bib33","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.2337\/dc21-2688","article-title":"Long-term outcomes with islet-alone and islet-after-kidney transplantation for type 1 diabetes in the Clinical Islet Transplantation Consortium: the CIT-08 study","volume":"45","author":"Rickels","year":"2022","journal-title":"Diabetes Care"},{"issue":"6","key":"10.1016\/j.ajt.2026.02.008_bib34","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S2213-8587(23)00082-7","article-title":"Association between primary graft function and 5-year outcomes of islet allogeneic transplantation in type 1 diabetes: a retrospective, multicentre, observational cohort study in 1210 patients from the Collaborative Islet Transplant Registry","volume":"11","author":"Chetboun","year":"2023","journal-title":"Lancet Diabetes Endocrinol"}],"container-title":["American Journal of Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613526000924?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613526000924?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T22:47:16Z","timestamp":1782427636000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1600613526000924"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S1600613526000924"],"URL":"https:\/\/doi.org\/10.1016\/j.ajt.2026.02.008","relation":{},"ISSN":["1600-6135"],"issn-type":[{"value":"1600-6135","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Simultaneous islet-kidney transplantation as an alternative for patients ineligible for pancreas transplant: Initial experience at a North American transplant center","name":"articletitle","label":"Article Title"},{"value":"American Journal of Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajt.2026.02.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}