{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T12:43:11Z","timestamp":1792759391054,"version":"4.5.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100010261","name":"Thoracic Surgery Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010261","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"National Institute of Allergy and Infectious Diseases Division of Intramural Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008868","name":"International Society for Heart and Lung Transplantation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008868","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015691","name":"National Institute of Allergy and Infectious Diseases Division of Microbiology and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["amjtransplant.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Transplantation"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.ajt.2026.06.011","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T15:23:52Z","timestamp":1782314632000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Intraorgan and targeted nanodelivery in organ transplantation of nonhuman primates"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8012-190X","authenticated-orcid":false,"given":"Sungwook","family":"Jung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1833-7501","authenticated-orcid":false,"given":"Youngrong","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6260-238X","authenticated-orcid":false,"given":"Jane M.","family":"O","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0189-3691","authenticated-orcid":false,"given":"Nicole","family":"Hays","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3198-1916","authenticated-orcid":false,"given":"Parth M.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3108-3690","authenticated-orcid":false,"given":"JangHyuk","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1483-2380","authenticated-orcid":false,"given":"Junsang","family":"Doh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6499-1443","authenticated-orcid":false,"given":"James S.","family":"Allan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2724-1333","authenticated-orcid":false,"given":"Joren C.","family":"Madsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4789-5422","authenticated-orcid":false,"given":"Reza","family":"Abdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.ajt.2026.06.011_bib1","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.pulmoe.2022.04.010","article-title":"Infections in lung transplanted patients: a review","volume":"30","author":"Dettori","year":"2024","journal-title":"Pulmonology"},{"issue":"1","key":"10.1016\/j.ajt.2026.06.011_bib2","first-page":"5","article-title":"Individualizing immunosuppression in lung transplantation","volume":"2018","author":"McDermott","year":"2018","journal-title":"Glob Cardiol Sci Pract"},{"issue":"1","key":"10.1016\/j.ajt.2026.06.011_bib3","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1007\/s13665-025-00378-z","article-title":"Immunosuppression in lung transplantation: current and emerging therapies","volume":"14","author":"Barnes","year":"2025","journal-title":"Curr Pulmonol Rep"},{"issue":"8","key":"10.1016\/j.ajt.2026.06.011_bib4","doi-asserted-by":"crossref","first-page":"647","DOI":"10.4155\/tde-2017-0037","article-title":"Drug delivery to the lungs: challenges and opportunities","volume":"8","author":"Newman","year":"2017","journal-title":"Ther Deliv"},{"issue":"8","key":"10.1016\/j.ajt.2026.06.011_bib5","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1097\/TP.0000000000004913","article-title":"Nanotechnology-based strategies for molecular imaging, diagnosis, and therapy of organ transplantation","volume":"108","author":"Sun","year":"2024","journal-title":"Transplantation"},{"issue":"2","key":"10.1016\/j.ajt.2026.06.011_bib6","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s40472-017-0146-9","article-title":"Nanotechnological approaches to immunosuppression and tolerance induction","volume":"4","author":"Patel","year":"2017","journal-title":"Curr Transplant Rep"},{"issue":"6","key":"10.1016\/j.ajt.2026.06.011_bib7","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.celrep.2016.04.007","article-title":"Targeted delivery of immunomodulators to lymph nodes","volume":"15","author":"Azzi","year":"2016","journal-title":"Cell Rep."},{"issue":"40","key":"10.1016\/j.ajt.2026.06.011_bib8","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202300812","article-title":"Nanotargeted delivery of immune therapeutics in type 1 diabetes","volume":"35","author":"Jung","year":"2023","journal-title":"Adv Mater"},{"issue":"11","key":"10.1016\/j.ajt.2026.06.011_bib9","doi-asserted-by":"crossref","first-page":"4770","DOI":"10.1172\/JCI120923","article-title":"Targeted delivery of immune therapeutics to lymph nodes prolongs cardiac allograft survival","volume":"128","author":"Bahmani","year":"2018","journal-title":"J Clin Invest"},{"issue":"24","key":"10.1016\/j.ajt.2026.06.011_bib10","doi-asserted-by":"crossref","DOI":"10.1172\/JCI159672","article-title":"Delivery of costimulatory blockade to lymph nodes promotes transplant acceptance in mice","volume":"132","author":"Zhao","year":"2022","journal-title":"J Clin Invest"},{"issue":"1","key":"10.1016\/j.ajt.2026.06.011_bib11","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.kint.2025.03.017","article-title":"Targeted delivery of IL-21 neutralizing nanotherapeutics to lymph nodes and kidney allografts attenuates B cell alloimmunity","volume":"108","author":"Zhang","year":"2025","journal-title":"Kidney Int"},{"issue":"11","key":"10.1016\/j.ajt.2026.06.011_bib12","doi-asserted-by":"crossref","first-page":"12393","DOI":"10.1021\/acsnano.9b05115","article-title":"Nanodelivery of mycophenolate mofetil to the organ improves transplant vasculopathy","volume":"13","author":"Uehara","year":"2019","journal-title":"ACS Nano"},{"issue":"9","key":"10.1016\/j.ajt.2026.06.011_bib13","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1111\/ajt.14266","article-title":"Novel application of localized nanodelivery of anti-interleukin-6 protects organ transplant from ischemia-reperfusion injuries","volume":"17","author":"Solhjou","year":"2017","journal-title":"Am J Transplant"},{"key":"10.1016\/j.ajt.2026.06.011_bib14","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.coche.2014.11.003","article-title":"Overcoming transport barriers for interstitial-, lymphatic-, and lymph node-targeted drug delivery","volume":"7","author":"Thomas","year":"2015","journal-title":"Curr Opin Chem Eng"},{"issue":"6","key":"10.1016\/j.ajt.2026.06.011_bib15","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/s41578-019-0110-7","article-title":"Material design for lymph node drug delivery","volume":"4","author":"Schudel","year":"2019","journal-title":"Nat Rev Mater"},{"issue":"1","key":"10.1016\/j.ajt.2026.06.011_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nano.2012.05.013","article-title":"The big picture on nanomedicine: the state of investigational and approved nanomedicine products","volume":"9","author":"Etheridge","year":"2013","journal-title":"Nanomedicine"},{"key":"10.1016\/j.ajt.2026.06.011_bib17","doi-asserted-by":"crossref","first-page":"4357","DOI":"10.2147\/IJN.S46900","article-title":"Nanopharmaceuticals (part 1): products on the market","volume":"9","author":"Weissig","year":"2014","journal-title":"Int J Nanomedicine"},{"issue":"30","key":"10.1016\/j.ajt.2026.06.011_bib18","doi-asserted-by":"crossref","first-page":"6068","DOI":"10.1016\/j.biomaterials.2005.03.021","article-title":"Poly(d,l-lactide-co-glycolide)\/montmorillonite nanoparticles for oral delivery of anticancer drugs","volume":"26","author":"Dong","year":"2005","journal-title":"Biomaterials"},{"issue":"15","key":"10.1016\/j.ajt.2026.06.011_bib19","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.1016\/j.biomaterials.2005.12.021","article-title":"Sustained release of dexamethasone from hydrophilic matrices using PLGA nanoparticles for neural drug delivery","volume":"27","author":"Kim","year":"2006","journal-title":"Biomaterials"},{"issue":"2-3","key":"10.1016\/j.ajt.2026.06.011_bib20","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0171-2985(11)80470-5","article-title":"Controlled-release vaccines\u2014biodegradable polylactide\/polyglycolide (PL\/PG) microspheres as antigen vehicles","volume":"184","author":"Aguado","year":"1992","journal-title":"Immunobiology"},{"issue":"9","key":"10.1016\/j.ajt.2026.06.011_bib21","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/nbt.3330","article-title":"Principles of nanoparticle design for overcoming biological barriers to drug delivery","volume":"33","author":"Blanco","year":"2015","journal-title":"Nat Biotechnol"},{"issue":"4","key":"10.1016\/j.ajt.2026.06.011_bib22","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1586\/erm.09.15","article-title":"Current advances in research and clinical applications of PLGA-based nanotechnology","volume":"9","author":"L\u00fc","year":"2009","journal-title":"Expert Rev Mol Diagn"},{"key":"10.1016\/j.ajt.2026.06.011_bib23","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.3389\/fphar.2018.01260","article-title":"PLGA-based nanoparticles in cancer treatment","volume":"9","author":"Rezvantalab","year":"2018","journal-title":"Front Pharmacol"},{"issue":"1","key":"10.1016\/j.ajt.2026.06.011_bib24","doi-asserted-by":"crossref","first-page":"6675","DOI":"10.1038\/s41598-020-63767-1","article-title":"Mitigation of tacrolimus-associated nephrotoxicity by PLGA nanoparticulate delivery following multiple dosing to mice while maintaining its immunosuppressive activity","volume":"10","author":"Alshamsan","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.ajt.2026.06.011_bib25","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/896141","article-title":"Immunosuppressive activity of size-controlled PEG-PLGA nanoparticles containing encapsulated cyclosporine A","volume":"2012","author":"Tang","year":"2012","journal-title":"J Transplant"},{"issue":"4","key":"10.1016\/j.ajt.2026.06.011_bib26","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1111\/j.1399-0012.1996.tb00458.x","article-title":"Microemulsion technology in the reformulation of cyclosporine: the reason behind the pharmacokinetic properties of Neoral","volume":"10","author":"Ritschel","year":"1996","journal-title":"Clin Transplant"},{"key":"10.1016\/j.ajt.2026.06.011_bib27","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/5194780","article-title":"Physical properties of nanoparticles that result in improved cancer targeting","volume":"2020","author":"Zein","year":"2020","journal-title":"J Oncol"},{"issue":"2","key":"10.1016\/j.ajt.2026.06.011_bib28","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1021\/acscentsci.9b01139","article-title":"Size-tunable strategies for a tumor targeted drug delivery system","volume":"6","author":"Yu","year":"2020","journal-title":"ACS Cent Sci"},{"issue":"9","key":"10.1016\/j.ajt.2026.06.011_bib29","doi-asserted-by":"crossref","first-page":"E1142","DOI":"10.1073\/pnas.1521265113","article-title":"Tailoring nanoparticle designs to target cancer based on tumor pathophysiology","volume":"113","author":"Sykes","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"10.1016\/j.ajt.2026.06.011_bib30","first-page":"297","article-title":"Stealth liposomes: review of the basic science, rationale, and clinical applications, existing and potential","volume":"1","author":"Immordino","year":"2006","journal-title":"Int J Nanomedicine"},{"issue":"2","key":"10.1016\/j.ajt.2026.06.011_bib31","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nrd1632","article-title":"Recent advances with liposomes as pharmaceutical carriers","volume":"4","author":"Torchilin","year":"2005","journal-title":"Nat Rev Drug Discov"},{"issue":"14","key":"10.1016\/j.ajt.2026.06.011_bib32","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.2174\/1389450115666141015113914","article-title":"Multistage nanovectors enhance the delivery of free and encapsulated drugs","volume":"16","author":"Martinez","year":"2015","journal-title":"Curr Drug Targets"},{"issue":"36","key":"10.1016\/j.ajt.2026.06.011_bib33","doi-asserted-by":"crossref","first-page":"4669","DOI":"10.2174\/138161206779026245","article-title":"Polymeric micelles for drug delivery","volume":"12","author":"Croy","year":"2006","journal-title":"Curr Pharm Des"},{"issue":"8","key":"10.1016\/j.ajt.2026.06.011_bib34","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1021\/acs.bioconjchem.1c00213","article-title":"Cysteine-based coupling: challenges and solutions","volume":"32","author":"You","year":"2021","journal-title":"Bioconjug Chem"},{"issue":"1","key":"10.1016\/j.ajt.2026.06.011_bib35","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1158\/1541-7786.MCR-19-0582","article-title":"Antibody-drug conjugates: a comprehensive review","volume":"18","author":"Khongorzul","year":"2020","journal-title":"Mol Cancer Res"},{"issue":"11","key":"10.1016\/j.ajt.2026.06.011_bib36","doi-asserted-by":"crossref","first-page":"7307","DOI":"10.4049\/jimmunol.0803606","article-title":"The role of intrapulmonary de novo lymphoid tissue in obliterative bronchiolitis after lung transplantation","volume":"182","author":"Sato","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.ajt.2026.06.011_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2023.101943","article-title":"Spleen-targeted nanosystems for immunomodulation","volume":"52","author":"Wang","year":"2023","journal-title":"Nano Today"},{"issue":"26","key":"10.1016\/j.ajt.2026.06.011_bib38","doi-asserted-by":"crossref","first-page":"23491","DOI":"10.1021\/acsnano.5c04836","article-title":"Nanomedicine and spleen-targeting strategies for precision immunomodulation: advances, challenges, and future perspectives","volume":"19","author":"Oh","year":"2025","journal-title":"ACS Nano"},{"issue":"1","key":"10.1016\/j.ajt.2026.06.011_bib39","first-page":"17","article-title":"The impact of delayed graft function on the long-term outcome of renal transplantation","volume":"15","author":"Geddes","year":"2002","journal-title":"J Nephrol"},{"issue":"11","key":"10.1016\/j.ajt.2026.06.011_bib40","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1111\/j.1600-6143.2011.03754.x","article-title":"Delayed graft function in the kidney transplant","volume":"11","author":"Siedlecki","year":"2011","journal-title":"Am J Transplant"},{"issue":"1","key":"10.1016\/j.ajt.2026.06.011_bib41","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1186\/s12882-020-02181-1","article-title":"Predictors and one-year outcomes of patients with delayed graft function after deceased donor kidney transplantation","volume":"21","author":"Chen","year":"2020","journal-title":"BMC Nephrol"},{"issue":"11","key":"10.1016\/j.ajt.2026.06.011_bib42","doi-asserted-by":"crossref","first-page":"2682","DOI":"10.1172\/JCI119457","article-title":"The cytokine-adhesion molecule cascade in ischemia\/reperfusion injury of the rat kidney. Inhibition by a soluble P-selectin ligand","volume":"99","author":"Takada","year":"1997","journal-title":"J Clin Invest"},{"issue":"4","key":"10.1016\/j.ajt.2026.06.011_bib43","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/0003-4975(95)00544-U","article-title":"Effect of ischemic injury on subsequent rat lung allograft rejection","volume":"60","author":"Shiraishi","year":"1995","journal-title":"Ann Thorac Surg"},{"issue":"7","key":"10.1016\/j.ajt.2026.06.011_bib44","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1097\/00007890-199710150-00001","article-title":"Effects of initial ischemia\/reperfusion injury on the transplanted kidney","volume":"64","author":"Tilney","year":"1997","journal-title":"Transplantation"},{"issue":"11","key":"10.1016\/j.ajt.2026.06.011_bib45","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1016\/j.healun.2004.06.007","article-title":"Prolonged cold ischemia in rat cardiac allografts promotes ischemia-reperfusion injury and the development of graft coronary artery disease in a linear fashion","volume":"24","author":"Tanaka","year":"2005","journal-title":"J Heart Lung Transplant"},{"issue":"4","key":"10.1016\/j.ajt.2026.06.011_bib46","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1097\/MOT.0b013e3283069d87","article-title":"Tolerance induction","volume":"13","author":"Kupiec-Weglinski","year":"2008","journal-title":"Curr Opin Organ Transplant"},{"issue":"1","key":"10.1016\/j.ajt.2026.06.011_bib47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/TP.0b013e31817c11e6","article-title":"The multiple facets of toll-like receptors in transplantation biology","volume":"86","author":"Alegre","year":"2008","journal-title":"Transplantation"},{"issue":"1","key":"10.1016\/j.ajt.2026.06.011_bib48","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1600-065X.2011.01009.x","article-title":"Innate immunity in transplant tolerance and rejection","volume":"241","author":"Murphy","year":"2011","journal-title":"Immunol Rev"}],"container-title":["American Journal of Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613526026201?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613526026201?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T11:56:52Z","timestamp":1792756612000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1600613526026201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":48,"alternative-id":["S1600613526026201"],"URL":"https:\/\/doi.org\/10.1016\/j.ajt.2026.06.011","relation":{},"ISSN":["1600-6135"],"issn-type":[{"value":"1600-6135","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intraorgan and targeted nanodelivery in organ transplantation of nonhuman primates","name":"articletitle","label":"Article Title"},{"value":"American Journal of Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajt.2026.06.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}