{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:01:12Z","timestamp":1790395272942,"version":"4.1.0"},"reference-count":19,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000291","name":"Kidney Research UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000291","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["amjtransplant.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Transplantation"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.ajt.2026.09.003","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T23:30:24Z","timestamp":1788823824000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Characterising prognostic complement biomarkers during clinical normothermic machine perfusion for renal transplantation"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8644-9380","authenticated-orcid":false,"given":"John","family":"Fallon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1907-4758","authenticated-orcid":false,"given":"Richard","family":"Dumbill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4837-9446","authenticated-orcid":false,"given":"Simon","family":"Knight","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7801-665X","authenticated-orcid":false,"given":"Rutger","family":"Ploeg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0841-9685","authenticated-orcid":false,"given":"Peter","family":"Friend","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6257-0899","authenticated-orcid":false,"given":"Cees","family":"van Kooten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4972-6879","authenticated-orcid":false,"given":"James","family":"Hunter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.ajt.2026.09.003_bib1","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1038\/s41591-023-02376-7","article-title":"Normothermic machine perfusion versus static cold storage in donation after circulatory death kidney transplantation: a randomized controlled trial","volume":"29","author":"Hosgood","year":"2023","journal-title":"Nat Med"},{"issue":"4","key":"10.1016\/j.ajt.2026.09.003_bib2","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1111\/ajt.14059","article-title":"Continuous normothermic ex vivo kidney perfusion is superior to brief normothermic perfusion following static cold storage in donation after circulatory death pig kidney transplantation","volume":"17","author":"Kaths","year":"2017","journal-title":"Am J Transplant"},{"issue":"1","key":"10.1016\/j.ajt.2026.09.003_bib3","doi-asserted-by":"crossref","first-page":"4584","DOI":"10.1038\/s41467-025-59829-5","article-title":"Prolonged normothermic perfusion of the kidney prior to transplantation: a historically controlled, phase 1 cohort study","volume":"16","author":"Dumbill","year":"2025","journal-title":"Nat Commun"},{"issue":"5","key":"10.1016\/j.ajt.2026.09.003_bib4","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/j.ajt.2025.12.021","article-title":"Normothermic versus hypothermic machine perfusion in kidney transplantation: a randomized controlled trial","volume":"26","author":"Slagter","year":"2026","journal-title":"Am J Transplant"},{"issue":"7","key":"10.1016\/j.ajt.2026.09.003_bib5","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1016\/j.ajt.2026.03.001","article-title":"The use of a centralized normothermic preservation and assessment center to rescue kidneys declined after standard allocation","volume":"26","author":"Holzner","year":"2026","journal-title":"Am J Transplant"},{"issue":"4","key":"10.1016\/j.ajt.2026.09.003_bib6","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1002\/eji.1830250434","article-title":"Expression and tissue localization of donor-specific complement C3 synthesized in human renal allografts","volume":"25","author":"Andrews","year":"1995","journal-title":"Eur J Immunol"},{"issue":"4","key":"10.1016\/j.ajt.2026.09.003_bib7","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1006\/cyto.1996.0164","article-title":"Interferon-gamma induces biosynthesis of complement components C2, C4 and factor H by human proximal tubular epithelial cells","volume":"9","author":"Gerritsma","year":"1997","journal-title":"Cytokine"},{"issue":"10","key":"10.1016\/j.ajt.2026.09.003_bib8","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/0161-5890(96)84610-4","article-title":"Interleukin-1 alpha enhances the biosynthesis of complement C3 and factor B by human kidney proximal tubular epithelial cells in vitro","volume":"33","author":"Gerritsma","year":"1996","journal-title":"Mol Immunol"},{"issue":"12","key":"10.1016\/j.ajt.2026.09.003_bib9","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/s41581-018-0071-x","article-title":"The multifaceted role of complement in kidney transplantation","volume":"14","author":"Biglarnia","year":"2018","journal-title":"Nat Rev Nephrol"},{"issue":"11","key":"10.1016\/j.ajt.2026.09.003_bib10","doi-asserted-by":"crossref","first-page":"2428","DOI":"10.1681\/ASN.V7112428","article-title":"Intraglomerular C3 synthesis in human kidney detected by in situ hybridization","volume":"7","author":"Miyazaki","year":"1996","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.ajt.2026.09.003_bib11","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.3389\/fimmu.2020.01833","article-title":"Podocytes produce and secrete functional complement C3 and complement factor H","volume":"11","author":"M\u00fchlig","year":"2020","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.ajt.2026.09.003_bib12","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1159\/000044876","article-title":"Compartmental localization of complement component transcripts in the normal human kidney","volume":"78","author":"Song","year":"1998","journal-title":"Nephron"},{"issue":"5","key":"10.1016\/j.ajt.2026.09.003_bib13","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1172\/JCI83000","article-title":"Collectin-11 detects stress-induced L-fucose pattern to trigger renal epithelial injury","volume":"126","author":"Farrar","year":"2016","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ajt.2026.09.003_bib14","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.3389\/fimmu.2018.01757","article-title":"CL-L1 and CL-K1 exhibit widespread tissue distribution with high and co-localized expression in secretory epithelia and mucosa","volume":"9","author":"Hansen","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.ajt.2026.09.003_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.831371","article-title":"Complement is activated during normothermic machine perfusion of porcine and human discarded kidneys","volume":"13","author":"Jager","year":"2022","journal-title":"Front Immunol"},{"issue":"4","key":"10.1016\/j.ajt.2026.09.003_bib16","doi-asserted-by":"crossref","first-page":"319","DOI":"10.3109\/00365513.2016.1161233","article-title":"A new method of modelling early plasma creatinine changes predicts 1-year graft function after kidney transplantation","volume":"76","author":"Krogstrup","year":"2016","journal-title":"Scand J Clin Lab Invest"},{"issue":"1","key":"10.1016\/j.ajt.2026.09.003_bib17","doi-asserted-by":"crossref","DOI":"10.1111\/xen.12262","article-title":"Complement C3 inhibitor Cp40 attenuates xenoreactions in pig hearts perfused with human blood","volume":"24","author":"Abicht","year":"2017","journal-title":"Xenotransplantation"},{"issue":"4","key":"10.1016\/j.ajt.2026.09.003_bib18","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1111\/ajt.14075","article-title":"Remote ischemic conditioning on recipients of deceased renal transplants does not improve early graft function: a multicenter randomized, controlled clinical trial","volume":"17","author":"Krogstrup","year":"2017","journal-title":"Am J Transplant"},{"issue":"9","key":"10.1016\/j.ajt.2026.09.003_bib19","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1016\/j.ajt.2025.05.003","article-title":"Back-table intra-arterial administration of C1 esterase inhibitor to deceased donor kidney allografts improves posttransplant allograft function: Results of a randomized double-blind placebo-controlled clinical trial","volume":"25","author":"Huang","year":"2025","journal-title":"Am J Transplant"}],"container-title":["American Journal of Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613526027462?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613526027462?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:27:38Z","timestamp":1790393258000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1600613526027462"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":19,"alternative-id":["S1600613526027462"],"URL":"https:\/\/doi.org\/10.1016\/j.ajt.2026.09.003","relation":{},"ISSN":["1600-6135"],"issn-type":[{"value":"1600-6135","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterising prognostic complement biomarkers during clinical normothermic machine perfusion for renal transplantation","name":"articletitle","label":"Article Title"},{"value":"American Journal of Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajt.2026.09.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of American Society of Transplantation & American Society of Transplant Surgeons.","name":"copyright","label":"Copyright"}]}}