{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:49:23Z","timestamp":1792010963520,"version":"4.4.0"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["NV26-06-00299"],"award-info":[{"award-number":["NV26-06-00299"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["NW26A-CARDIA"],"award-info":[{"award-number":["NW26A-CARDIA"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["amjtransplant.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Transplantation"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.ajt.2026.09.015","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T09:51:50Z","timestamp":1789120310000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Molecular rejection signatures in pancreas transplant biopsies"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3115-2221","authenticated-orcid":false,"given":"Eva","family":"Girmanova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8663-413X","authenticated-orcid":false,"given":"Petra","family":"Hruba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5147-3009","authenticated-orcid":false,"given":"Marek","family":"Kollar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6692-8421","authenticated-orcid":false,"given":"Martina","family":"Mackova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4883-0471","authenticated-orcid":false,"given":"Petra","family":"Mrazova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6516-345X","authenticated-orcid":false,"given":"Mariia","family":"Bibik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7785-2880","authenticated-orcid":false,"given":"Jiri","family":"Veleba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6281-8973","authenticated-orcid":false,"given":"Ludek","family":"Voska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7976-4377","authenticated-orcid":false,"given":"Martin","family":"Kment","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1049-2195","authenticated-orcid":false,"given":"Ondrej","family":"Viklicky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1371-1947","authenticated-orcid":false,"given":"Philip F.","family":"Halloran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0944-8189","authenticated-orcid":false,"given":"Peter","family":"Girman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.ajt.2026.09.015_bib1","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1097\/TP.0000000000002694","article-title":"How should pancreas transplant rejection be treated?","volume":"103","author":"Aziz","year":"2019","journal-title":"Transplantation"},{"issue":"2S1","key":"10.1016\/j.ajt.2026.09.015_bib2","doi-asserted-by":"crossref","first-page":"S119","DOI":"10.1016\/j.ajt.2024.01.013","article-title":"OPTN\/SRTR 2022 annual data report: pancreas","volume":"24","author":"Kandaswamy","year":"2024","journal-title":"Am J Transplant"},{"issue":"2","key":"10.1016\/j.ajt.2026.09.015_bib3","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s40472-015-0061-x","article-title":"Diagnosis and treatment of pancreas rejection","volume":"2","author":"Redfield","year":"2015","journal-title":"Curr Transplant Rep"},{"issue":"suppl 3","key":"10.1016\/j.ajt.2026.09.015_bib4","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/ajt.16750","article-title":"First world consensus conference on pancreas transplantation: part II \u2013 recommendations","volume":"21","author":"Boggi","year":"2021","journal-title":"Am J Transplant"},{"issue":"1","key":"10.1016\/j.ajt.2026.09.015_bib5","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/TP.0b013e3181dda17e","article-title":"Pancreas allograft rejection: analysis of concurrent renal allograft biopsies and posttherapy follow-up biopsies","volume":"90","author":"Troxell","year":"2010","journal-title":"Transplantation"},{"issue":"3","key":"10.1016\/j.ajt.2026.09.015_bib6","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.ajt.2023.10.011","article-title":"Banff 2022 pancreas transplantation multidisciplinary report: refinement of guidelines for T cell-mediated rejection, antibody-mediated rejection and islet pathology. Assessment of duodenal cuff biopsies and noninvasive diagnostic methods","volume":"24","author":"Drachenberg","year":"2024","journal-title":"Am J Transplant"},{"key":"10.1016\/j.ajt.2026.09.015_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/ti.2024.13087","article-title":"Analysis of rejection, infection and surgical outcomes in type I versus type II diabetic recipients after simultaneous pancreas-kidney transplantation","volume":"37","author":"Martinez","year":"2024","journal-title":"Transpl Int"},{"issue":"8","key":"10.1016\/j.ajt.2026.09.015_bib8","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1016\/j.ajt.2026.04.006","article-title":"Banff 2024 pancreas transplantation report: diagnosis and impact of chronic active T-cell mediated allograft rejection and re-evaluation of the indeterminate category with utilization of CD3\/CD68 immunostains in biopsies with ambiguous findings","volume":"26","author":"B\u00fcttner-Herold","year":"2026","journal-title":"Am J Transplant"},{"issue":"2","key":"10.1016\/j.ajt.2026.09.015_bib9","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.ajt.2024.09.032","article-title":"Gene expression-based molecular scoring of pancreas transplant rejection for a quantitative assessment of rejection severity and resistance to treatment","volume":"25","author":"Brown","year":"2025","journal-title":"Am J Transplant"},{"issue":"11","key":"10.1016\/j.ajt.2026.09.015_bib10","doi-asserted-by":"crossref","DOI":"10.1111\/ctr.14065","article-title":"Molecular assessment of antibody-mediated rejection in human pancreas allograft biopsies","volume":"34","author":"Roufosse","year":"2020","journal-title":"Clin Transplant"},{"issue":"2","key":"10.1016\/j.ajt.2026.09.015_bib11","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1097\/TP.0b013e31818c8fbf","article-title":"A pilot study of gene expression-based categorization of pancreas transplant biopsies","volume":"87","author":"Luan","year":"2009","journal-title":"Transplantation"},{"issue":"6","key":"10.1016\/j.ajt.2026.09.015_bib12","doi-asserted-by":"crossref","first-page":"E214","DOI":"10.1111\/j.1399-0012.2010.01285.x","article-title":"Serial analysis of biomarkers of acute pancreas allograft rejection","volume":"24","author":"Cashion","year":"2010","journal-title":"Clin Transplant"},{"issue":"11","key":"10.1016\/j.ajt.2026.09.015_bib13","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.1111\/ajt.14329","article-title":"Real time central assessment of kidney transplant indication biopsies by microarrays: the INTERCOMEX study","volume":"17","author":"Halloran","year":"2017","journal-title":"Am J Transplant"},{"issue":"11","key":"10.1016\/j.ajt.2026.09.015_bib14","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.healun.2017.05.029","article-title":"Building a tissue-based molecular diagnostic system in heart transplant rejection: the heart molecular microscope diagnostic (MMDx) system","volume":"36","author":"Halloran","year":"2017","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.ajt.2026.09.015_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/ti.2024.12847","article-title":"Treatment responses in histologic versus molecular diagnoses of lung rejection","volume":"37","author":"Zajacova","year":"2024","journal-title":"Transpl Int"},{"issue":"1","key":"10.1016\/j.ajt.2026.09.015_bib16","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/TP.0000000000004624","article-title":"The molecular phenotype of kidney transplants: insights from the MMDx project","volume":"108","author":"Halloran","year":"2024","journal-title":"Transplantation"},{"issue":"8","key":"10.1016\/j.ajt.2026.09.015_bib17","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1097\/TP.0000000000004058","article-title":"International survey of clinical monitoring practices in pancreas and islet transplantation","volume":"106","author":"Ward","year":"2022","journal-title":"Transplantation"},{"issue":"10","key":"10.1016\/j.ajt.2026.09.015_bib18","doi-asserted-by":"crossref","DOI":"10.1097\/TXD.0000000000001848","article-title":"Intercenter variability in the application of biopsy-based transcriptomics in kidney transplantation","volume":"11","author":"Hruba","year":"2025","journal-title":"Transplant Direct"},{"issue":"10","key":"10.1016\/j.ajt.2026.09.015_bib19","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1111\/ajt.15351","article-title":"Generating automated kidney transplant biopsy reports combining molecular measurements with ensembles of machine learning classifiers","volume":"19","author":"Reeve","year":"2019","journal-title":"Am J Transplant"},{"issue":"12","key":"10.1016\/j.ajt.2026.09.015_bib20","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.94197","article-title":"Assessing rejection-related disease in kidney transplant biopsies based on archetypal analysis of molecular phenotypes","volume":"2","author":"Reeve","year":"2017","journal-title":"JCI Insight"},{"issue":"1","key":"10.1016\/j.ajt.2026.09.015_bib21","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.ajt.2024.07.034","article-title":"Subthreshold rejection activity in many kidney transplants currently classified as having no rejection","volume":"25","author":"Halloran","year":"2025","journal-title":"Am J Transplant"},{"key":"10.1016\/j.ajt.2026.09.015_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2026.1825364","article-title":"Molecular diagnostics in pancreas transplantation: past, present, and future","volume":"13","author":"Swaab","year":"2026","journal-title":"Front Mol Biosci"},{"issue":"5","key":"10.1016\/j.ajt.2026.09.015_bib23","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1111\/ajt.15752","article-title":"Discrepancy analysis comparing molecular and histology diagnoses in kidney transplant biopsies","volume":"20","author":"Madill-Thomsen","year":"2020","journal-title":"Am J Transplant"},{"issue":"18","key":"10.1016\/j.ajt.2026.09.015_bib24","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241813817","article-title":"Discrepancy analysis between histology and molecular diagnoses in kidney allograft biopsies: a single-center experience","volume":"24","author":"Suo","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"11","key":"10.1016\/j.ajt.2026.09.015_bib25","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.1111\/ajt.12443","article-title":"Acute cellular and antibody-mediated rejection of the pancreas allograft: incidence, risk factors and outcomes","volume":"13","author":"Niederhaus","year":"2013","journal-title":"Am J Transplant"}],"container-title":["American Journal of Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613526027589?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613526027589?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:22:43Z","timestamp":1792009363000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1600613526027589"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":25,"alternative-id":["S1600613526027589"],"URL":"https:\/\/doi.org\/10.1016\/j.ajt.2026.09.015","relation":{},"ISSN":["1600-6135"],"issn-type":[{"value":"1600-6135","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular rejection signatures in pancreas transplant biopsies","name":"articletitle","label":"Article Title"},{"value":"American Journal of Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajt.2026.09.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of American Society of Transplantation & American Society of Transplant Surgeons.","name":"copyright","label":"Copyright"}]}}