{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T10:42:03Z","timestamp":1792233723725,"version":"4.4.0"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["amjtransplant.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["American Journal of Transplantation"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.ajt.2026.09.018","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T06:49:10Z","timestamp":1789800550000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Progression to insulin requirement at 1 year after kidney-alone transplantation in insulin-independent type 2 diabetes: Implications for simultaneous pancreas-kidney candidate selection"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7516-2782","authenticated-orcid":false,"given":"Mohamed","family":"Ibraheem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7061-9739","authenticated-orcid":false,"given":"Vugar","family":"Isazade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0985-4227","authenticated-orcid":false,"given":"Nan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6706-666X","authenticated-orcid":false,"given":"Nitin K.","family":"Katariya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9841-6285","authenticated-orcid":false,"given":"Aditi","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0367-2008","authenticated-orcid":false,"given":"Raymond L.","family":"Heilman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9688-8216","authenticated-orcid":false,"given":"Sumi S.","family":"Nair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3764-0047","authenticated-orcid":false,"given":"Girish K.","family":"Mour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4141-7243","authenticated-orcid":false,"given":"Lavanya","family":"Kodali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajt.2026.09.018_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2021.109119","article-title":"IDF Diabetes Atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045","volume":"183","author":"Sun","year":"2022","journal-title":"Diabetes Res Clin Pract"},{"issue":"1","key":"10.1016\/j.ajt.2026.09.018_bib2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3949\/ccjm.88a.20088","article-title":"The role of SGLT-2 inhibitors in managing type 2 diabetes","volume":"88","author":"Tsushima","year":"2021","journal-title":"Cleve Clin J Med"},{"issue":"3","key":"10.1016\/j.ajt.2026.09.018_bib3","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1002\/kjm2.12800","article-title":"Recent advances in the treatment of type 2 diabetes mellitus using new drug therapies","volume":"40","author":"Chong","year":"2024","journal-title":"Kaohsiung J Med Sci"},{"issue":"1","key":"10.1016\/j.ajt.2026.09.018_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s41745-023-00357-w","article-title":"The evolution of diabetes treatment through the ages: from starvation diets to insulin, incretins, SGLT2-inhibitors and beyond","volume":"103","author":"Mudaliar","year":"2023","journal-title":"J Indian Inst Sci"},{"issue":"4","key":"10.1016\/j.ajt.2026.09.018_bib5","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1080\/14728214.2016.1257608","article-title":"An update on DPP-4 inhibitors in the management of type 2 diabetes","volume":"21","author":"Cahn","year":"2016","journal-title":"Expert Opin Emerg Drugs"},{"issue":"6","key":"10.1016\/j.ajt.2026.09.018_bib6","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1056\/NEJMoa2107519","article-title":"Tirzepatide versus semaglutide once weekly in patients with type 2 diabetes","volume":"385","author":"Fr\u00edas","year":"2021","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ajt.2026.09.018_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/ti.2025.14772","article-title":"Simultaneous pancreas and kidney transplantation in patients with type 2 diabetes mellitus","volume":"38","author":"Owen","year":"2025","journal-title":"Transpl Int"},{"issue":"5","key":"10.1016\/j.ajt.2026.09.018_bib8","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.2215\/CJN.06860810","article-title":"Outcomes of simultaneous pancreas-kidney transplantation in type 2 diabetic recipients","volume":"6","author":"Sampaio","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"issue":"22","key":"10.1016\/j.ajt.2026.09.018_bib9","doi-asserted-by":"crossref","first-page":"631","DOI":"10.21037\/atm.2019.10.106","article-title":"Effect of simultaneous pancreas-kidney transplantation on blood glucose level for patients with end-stage renal disease with type 1 and type 2 diabetes","volume":"7","author":"Liu","year":"2019","journal-title":"Ann Transl Med"},{"key":"10.1016\/j.ajt.2026.09.018_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/ti.2023.11792","article-title":"Multi-centre UK analysis of simultaneous pancreas and kidney (SPK) transplant in recipients with type 2 diabetes mellitus","volume":"36","author":"Owen","year":"2024","journal-title":"Transpl Int"},{"issue":"7","key":"10.1016\/j.ajt.2026.09.018_bib11","doi-asserted-by":"crossref","first-page":"132","DOI":"10.4239\/wjd.v9.i7.132","article-title":"New-onset diabetes after kidney transplantation: incidence and associated factors","volume":"9","author":"Gomes","year":"2018","journal-title":"World J Diabetes"},{"issue":"3","key":"10.1016\/j.ajt.2026.09.018_bib12","doi-asserted-by":"crossref","first-page":"273","DOI":"10.4103\/ijem.IJEM_178_19","article-title":"Prevalence and predictors of \u201cnew-onset diabetes after transplantation\u201d (NODAT) in renal transplant recipients: an observational study","volume":"23","author":"Choudhury","year":"2019","journal-title":"Indian J Endocrinol Metab"},{"issue":"1","key":"10.1016\/j.ajt.2026.09.018_bib13","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.trim.2013.10.006","article-title":"New onset of diabetes after transplantation\u2014an overview of epidemiology, mechanism of development and diagnosis","volume":"30","author":"Kesiraju","year":"2014","journal-title":"Transpl Immunol"},{"issue":"6","key":"10.1016\/j.ajt.2026.09.018_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0268044","article-title":"Weight gain after renal transplant: incidence, risk factors, and outcomes","volume":"17","author":"Altheaby","year":"2022","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.ajt.2026.09.018_bib15","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1210\/er.2015-1084","article-title":"Post-transplant diabetes mellitus: causes, treatment, and impact on outcomes","volume":"37","author":"Shivaswamy","year":"2015","journal-title":"Endocr Rev"},{"issue":"4","key":"10.1016\/j.ajt.2026.09.018_bib16","doi-asserted-by":"crossref","first-page":"820","DOI":"10.3803\/EnM.2020.743","article-title":"Insulin secretion and insulin resistance trajectories over 1 year after kidney transplantation: a multicenter prospective cohort study","volume":"35","author":"Bang","year":"2020","journal-title":"Endocrinol Metab (Seoul)"},{"issue":"3","key":"10.1016\/j.ajt.2026.09.018_bib17","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1111\/ajt.15106","article-title":"The survival advantage of pancreas after kidney transplant","volume":"19","author":"Fridell","year":"2019","journal-title":"Am J Transplant"},{"issue":"6","key":"10.1016\/j.ajt.2026.09.018_bib18","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s11892-017-0864-5","article-title":"Simultaneous pancreas and kidney transplantation\u2014is it a treatment option for patients with type 2 diabetes mellitus? An analysis of the International Pancreas Transplant Registry","volume":"17","author":"Gruessner","year":"2017","journal-title":"Curr Diab Rep"},{"issue":"6","key":"10.1016\/j.ajt.2026.09.018_bib19","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1177\/096368970000900617","article-title":"Beneficial effect of pancreas and kidney transplantation on advanced diabetic retinopathy","volume":"9","author":"Ko\u017eNarov\u00e1","year":"2000","journal-title":"Cell Transplant"},{"issue":"1","key":"10.1016\/j.ajt.2026.09.018_bib20","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1186\/s12882-021-02522-8","article-title":"Cardiovascular outcomes after simultaneous pancreas kidney transplantation compared to kidney transplantation alone: a propensity score matching analysis","volume":"22","author":"Lange","year":"2021","journal-title":"BMC Nephrol"},{"issue":"5","key":"10.1016\/j.ajt.2026.09.018_bib21","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1089\/dia.2009.0157","article-title":"Continuous glucose monitoring in subjects after simultaneous pancreas-kidney and kidney-alone transplantation","volume":"12","author":"Rodr\u00edguez","year":"2010","journal-title":"Diabetes Technol Ther"},{"key":"10.1016\/j.ajt.2026.09.018_bib22","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/7574628","article-title":"Simultaneous pancreas kidney transplantation improves cardiovascular autonomic neuropathy with improved Valsalva ratio as the most precocious test","volume":"2020","author":"Argente-Pla","year":"2020","journal-title":"J Diabetes Res"},{"key":"10.1016\/j.ajt.2026.09.018_bib23","unstructured":"OPTN\/SRTR 2024 Annual Data Report. U.S. Department of Health and Human Services, Health Resources and Services Administration; 2026. Accessed October 13, 2026. https:\/\/srtr.transplant.hrsa.gov\/annualdatareports."}],"container-title":["American Journal of Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613526027619?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1600613526027619?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T09:51:18Z","timestamp":1792230678000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1600613526027619"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":23,"alternative-id":["S1600613526027619"],"URL":"https:\/\/doi.org\/10.1016\/j.ajt.2026.09.018","relation":{},"ISSN":["1600-6135"],"issn-type":[{"value":"1600-6135","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Progression to insulin requirement at 1 year after kidney-alone transplantation in insulin-independent type 2 diabetes: Implications for simultaneous pancreas-kidney candidate selection","name":"articletitle","label":"Article Title"},{"value":"American Journal of Transplantation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajt.2026.09.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of American Society of Transplantation & American Society of Transplant Surgeons.","name":"copyright","label":"Copyright"}]}}