{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:34:47Z","timestamp":1788305687557,"version":"build-2803163510"},"reference-count":26,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T00:00:00Z","timestamp":1591833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21592060"],"award-info":[{"award-number":["21592060"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Asian Journal of Urology"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.ajur.2020.06.004","type":"journal-article","created":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T12:04:30Z","timestamp":1592309070000},"page":"280-288","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Cytopathic effects and local immune responses in repeated neoadjuvant HSV-tk + ganciclovir gene therapy for prostate cancer"],"prefix":"10.1016","volume":"8","author":[{"given":"Nobuyuki","family":"Yanagisawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takefumi","family":"Satoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken-ichi","family":"Tabata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyasu","family":"Tsumura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasutomo","family":"Nasu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masami","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy C.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isao","family":"Okayasu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Murakumo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiro","family":"Baba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatsugu","family":"Iwamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ajur.2020.06.004_bib1","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1001\/jamaoncol.2016.5688","article-title":"Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 32 cancer groups, 1990 to 2015: a systematic analysis for the global burden of disease study","volume":"3","author":"Fitzmaurice","year":"2017","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.ajur.2020.06.004_bib2","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.eururo.2012.02.054","article-title":"International variation in prostate cancer incidence and mortality rates","volume":"61","author":"Center","year":"2012","journal-title":"Eur Urol"},{"key":"10.1016\/j.ajur.2020.06.004_bib3","first-page":"1269","article-title":"Treatment options for localized prostate cancer","volume":"59","author":"Keyes","year":"2013","journal-title":"Can Fam Physician"},{"key":"10.1016\/j.ajur.2020.06.004_bib4","first-page":"A9250","article-title":"Hormone therapy in prostate cancer; a pharmacotherapeutic challenge","volume":"159","author":"Westdorp","year":"2015","journal-title":"Ned Tijdschr Geneeskd"},{"key":"10.1016\/j.ajur.2020.06.004_bib5","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1007\/s003450050185","article-title":"Prospects for herpes-simplex-virus thymidine-kinase and cytokine gene transduction as immunomodulatory gene therapy for prostate cancer","volume":"18","author":"Hassan","year":"2000","journal-title":"World J Urol"},{"key":"10.1016\/j.ajur.2020.06.004_bib6","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1093\/jnci\/82.4.297","article-title":"Curability of tumors bearing herpes thymidine kinase genes transferred by retroviral vectors","volume":"82","author":"Moolten","year":"1990","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ajur.2020.06.004_bib7","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.ymthe.2005.11.022","article-title":"Biological response determinants in HSV-tk + ganciclovir gene therapy for prostate cancer","volume":"13","author":"Ayala","year":"2006","journal-title":"Mol Ther"},{"key":"10.1016\/j.ajur.2020.06.004_bib8","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1053\/hupa.2000.8453","article-title":"Cytopathic effect of in situ gene therapy in prostate cancer","volume":"31","author":"Ayala","year":"2000","journal-title":"Hum Pathol"},{"key":"10.1016\/j.ajur.2020.06.004_bib9","doi-asserted-by":"crossref","first-page":"515","DOI":"10.3892\/mco.2015.519","article-title":"Enhanced central memory cluster of differentiation 8+ and tumor antigen-specific T cells in prostate cancer patients receiving repeated in situ adenovirus-mediated suicide gene therapy","volume":"3","author":"Kubo","year":"2015","journal-title":"Mol Clin Oncol"},{"key":"10.1016\/j.ajur.2020.06.004_bib10","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1089\/104303401753204535","article-title":"Prostate-specific antigen response and systemic T cell activation after in situ gene therapy in prostate cancer patients failing radiotherapy","volume":"12","author":"Miles","year":"2001","journal-title":"Hum Gene Ther"},{"key":"10.1016\/j.ajur.2020.06.004_bib11","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/sj.mt.6300096","article-title":"Suicide gene therapy with adenoviral delivery of HSV-tK gene for patients with local recurrence of prostate cancer after hormonal therapy","volume":"15","author":"Nasu","year":"2007","journal-title":"Mol Ther"},{"key":"10.1016\/j.ajur.2020.06.004_bib12","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.ijrobp.2004.01.020","article-title":"Enhanced systemic T-cell activation after in situ gene therapy with radiotherapy in prostate cancer patients","volume":"59","author":"Satoh","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ajur.2020.06.004_bib13","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.eururo.2005.02.013","article-title":"Virus specific immune responses after human neoadjuvant adenovirus-mediated suicide gene therapy for prostate cancer","volume":"48","author":"van der Linden","year":"2005","journal-title":"Eur Urol"},{"key":"10.1016\/j.ajur.2020.06.004_bib14","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1093\/jnci\/90.10.766","article-title":"A preoperative nomogram for disease recurrence following radical prostatectomy for prostate cancer","volume":"90","author":"Kattan","year":"1998","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ajur.2020.06.004_bib15","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.urology.2005.01.051","article-title":"Cancer core distribution in patients diagnosed by extended transperineal prostate biopsy","volume":"66","author":"Satoh","year":"2005","journal-title":"Urology"},{"key":"10.1016\/j.ajur.2020.06.004_bib16","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1126\/science.1129139","article-title":"Type, density, and location of immune cells within human colorectal tumors predict clinical outcome","volume":"313","author":"Galon","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.ajur.2020.06.004_bib17","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1200\/JCO.2010.30.5037","article-title":"Tumor-infiltrating CD8+ lymphocytes predict clinical outcome in breast cancer","volume":"29","author":"Mahmoud","year":"2011","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ajur.2020.06.004_bib18","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.ejca.2006.01.003","article-title":"Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: potential targets of anti-cancer therapy","volume":"42","author":"Sica","year":"2006","journal-title":"Eur J Canc"},{"key":"10.1016\/j.ajur.2020.06.004_bib19","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/cmi.2009.3","article-title":"Cell death mechanisms induced by cytotoxic lymphocytes","volume":"6","author":"Chavez-Galan","year":"2009","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.ajur.2020.06.004_bib20","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.immuni.2011.03.024","article-title":"Germinal center B cell and T follicular helper cell development initiates in the interfollicular zone","volume":"34","author":"Kerfoot","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.ajur.2020.06.004_bib21","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jim.2009.06.004","article-title":"Characterization of the intra-prostatic immune cell infiltration in androgen-deprived prostate cancer patients","volume":"348","author":"Gannon","year":"2009","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.ajur.2020.06.004_bib22","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1200\/JCO.2009.23.7370","article-title":"Tumor-associated lymphocytes as an independent predictor of response to neoadjuvant chemotherapy in breast cancer","volume":"28","author":"Denkert","year":"2010","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ajur.2020.06.004_bib23","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1016\/j.humpath.2011.12.013","article-title":"Tumor-infiltrating lymphocytes are important pathologic predictors for neoadjuvant chemotherapy in patients with breast cancer","volume":"43","author":"Yamaguchi","year":"2012","journal-title":"Hum Pathol"},{"key":"10.1016\/j.ajur.2020.06.004_bib24","first-page":"608","article-title":"Selective killing of glioma cells in culture and in\u00a0vivo by retrovirus transfer of the herpes simplex virus thymidine kinase gene","volume":"3","author":"Ezzeddine","year":"1991","journal-title":"N Biol"},{"key":"10.1016\/j.ajur.2020.06.004_bib25","first-page":"5274","article-title":"The \"bystander effect\": tumor regression when a fraction of the tumor mass is genetically modified","volume":"53","author":"Freeman","year":"1993","journal-title":"Canc Res"},{"key":"10.1016\/j.ajur.2020.06.004_bib26","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.ymthe.2004.08.002","article-title":"AdvHSV-tk gene therapy with intravenous ganciclovir improves survival in human malignant glioma: a randomised, controlled study","volume":"10","author":"Immonen","year":"2004","journal-title":"Mol Ther"}],"container-title":["Asian Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214388220300436?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2214388220300436?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T12:33:29Z","timestamp":1762000409000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2214388220300436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["S2214388220300436"],"URL":"https:\/\/doi.org\/10.1016\/j.ajur.2020.06.004","relation":{},"ISSN":["2214-3882"],"issn-type":[{"value":"2214-3882","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cytopathic effects and local immune responses in repeated neoadjuvant HSV-tk + ganciclovir gene therapy for prostate cancer","name":"articletitle","label":"Article Title"},{"value":"Asian Journal of Urology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ajur.2020.06.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Editorial Office of Asian Journal of Urology. Production and hosting by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}