{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T02:46:25Z","timestamp":1770518785070,"version":"3.49.0"},"reference-count":21,"publisher":"Elsevier BV","issue":"2-3","license":[{"start":{"date-parts":[[2004,10,1]],"date-time":"2004-10-01T00:00:00Z","timestamp":1096588800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alcohol"],"published-print":{"date-parts":[[2004,10]]},"DOI":"10.1016\/j.alcohol.2004.06.011","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T19:44:46Z","timestamp":1109447086000},"page":"273-277","source":"Crossref","is-referenced-by-count":12,"title":["Relation of tumor necrosis factor (TNF) gene polymorphisms with serum concentrations and in vitro production of TNF-alpha and interleukin-8 in heavy drinkers"],"prefix":"10.1016","volume":"34","author":[{"given":"Arturo","family":"Gonz\u00e1lez-Quintela","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria-Jesus","family":"Dominguez-Santalla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lourdes","family":"Loidi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celsa","family":"Quinteiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis F.","family":"Perez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.alcohol.2004.06.011_bib1","doi-asserted-by":"crossref","first-page":"917","DOI":"10.7326\/0003-4819-112-12-917","article-title":"Increased plasma tumor necrosis factor in severe alcoholic hepatitis","volume":"112","author":"Bird","year":"1990","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.alcohol.2004.06.011_bib2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S0168-8278(87)80003-X","article-title":"Endotoxemia in patients with alcoholic and non-alcoholic cirrhosis and in subjects with no evidence of chronic liver disease following acute alcohol excess","volume":"4","author":"Bode","year":"1987","journal-title":"J Hepatol"},{"key":"10.1016\/j.alcohol.2004.06.011_bib3","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1111\/j.1530-0277.2001.tb02336.x","article-title":"Increased serum IgE in alcoholics: relationship with Th1\/Th2 cytokine production by stimulated blood mononuclear cells","volume":"25","author":"Dominguez-Santalla","year":"2001","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.alcohol.2004.06.011_bib4","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1530-0277.1990.tb00482.x","article-title":"Plasma tumor necrosis factor alpha predicts decreased long-term survival in severe alcoholic hepatitis","volume":"14","author":"Felver","year":"1990","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.alcohol.2004.06.011_bib5","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1006\/cyto.2000.0715","article-title":"Influence of acute alcohol intake and alcohol withdrawal on circulating levels of IL-6, IL-8, IL-10 and IL-12","volume":"12","author":"Gonz\u00e1lez-Quintela","year":"2000","journal-title":"Cytokine"},{"key":"10.1016\/j.alcohol.2004.06.011_bib6","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/hep.510260119","article-title":"Association of a tumor necrosis factor promoter polymorphism with susceptibility to alcoholic steatohepatitis","volume":"26","author":"Grove","year":"1997","journal-title":"Hepatology"},{"key":"10.1016\/j.alcohol.2004.06.011_bib7","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1164\/ajrccm.165.8.200110-0320","article-title":"Increased frequency of the uncommon tumor necrosis factor \u2212857T allele in British and Dutch patients with sarcoidosis","volume":"165","author":"Grutters","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.alcohol.2004.06.011_bib8","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1111\/j.1399-0039.1998.tb03002.x","article-title":"Polymorphism of the 5\u2032-flanking region of the human tumor necrosis factor (TNF)-alpha gene in Japanese","volume":"51","author":"Higuchi","year":"1998","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.alcohol.2004.06.011_bib9","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0022-1759(99)00208-2","article-title":"A critical comparison of frequently used methods for the analysis of tumor necrosis factor-\u03b1 expression by human immune cells","volume":"235","author":"Mayringer","year":"2000","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.alcohol.2004.06.011_bib10","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1055\/s-2007-1007110","article-title":"Cytokines in alcoholic liver disease","volume":"19","author":"McClain","year":"1999","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.alcohol.2004.06.011_bib11","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/hep.1840090302","article-title":"Increased tumor necrosis factor production by monocytes in alcoholic hepatitis","volume":"9","author":"McClain","year":"1989","journal-title":"Hepatology"},{"key":"10.1016\/j.alcohol.2004.06.011_bib12","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1001\/jama.282.6.561","article-title":"Association of TNF2, a TNF-\u03b1 promoter polymorphism, with septic shock susceptibility and mortality","volume":"282","author":"Mira","year":"1999","journal-title":"JAMA"},{"key":"10.1016\/j.alcohol.2004.06.011_bib13","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/S0016-5085(99)70390-2","article-title":"Crohn's disease is associated with novel polymorphisms in the 5\u2032-flanking region of the tumor necrosis factor gene","volume":"117","author":"Negoro","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1016\/j.alcohol.2004.06.011_bib14","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1080\/00365520310002508","article-title":"Association of TNF-alpha-857C with inflammatory bowel disease in the Australian population","volume":"38","author":"O'Callaghan","year":"2003","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.alcohol.2004.06.011_bib15","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/j.1365-3083.1995.tb03686.x","article-title":"Functional analysis of a new polymorphism in the human TNF alpha gene promoter","volume":"42","author":"Pociot","year":"1995","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.alcohol.2004.06.011_bib16","first-page":"41","article-title":"Circulating and tissue levels of the neutrophil chemotaxin interleukin-8 are elevated in severe acute alcoholic hepatitis, and tissue levels correlate with neutrophil infiltration","volume":"18","author":"Sheron","year":"1993","journal-title":"Hepatology"},{"key":"10.1016\/j.alcohol.2004.06.011_bib17","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1093\/hmg\/8.8.1443","article-title":"A common functional polymorphism (C\u2192A substitution at position \u2013863) in the promoter region of the tumour necrosis factor-\u03b1 (TNF-\u03b1) gene associated with reduced circulating levels of TNF-\u03b1","volume":"8","author":"Skoog","year":"1999","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.alcohol.2004.06.011_bib18","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1097\/00003246-199603000-00004","article-title":"A genomic polymorphism within the tumor necrosis factor locus influences plasma tumor necrosis factor-alpha concentrations and outcome of patients with severe sepsis","volume":"24","author":"St\u00fcber","year":"1996","journal-title":"Crit Care Med"},{"key":"10.1016\/j.alcohol.2004.06.011_bib19","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1079\/PNS2002178","article-title":"Gene\u2013environment interaction: a central concept in multifactorial diseases","volume":"61","author":"Tiret","year":"2002","journal-title":"Proc Nutr Soc"},{"key":"10.1016\/j.alcohol.2004.06.011_bib20","doi-asserted-by":"crossref","DOI":"10.1093\/infdis\/167.2.461","article-title":"Endotoxin and tumor necrosis factor-alpha\u2013induced interleukin-8 release in humans","volume":"167","author":"van Deventer","year":"1993","journal-title":"J Infect Dis"},{"key":"10.1016\/j.alcohol.2004.06.011_bib21","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1073\/pnas.94.7.3195","article-title":"Effects of a polymorphism in the human tumor necrosis factor \u03b1 promoter on transcriptional activation","volume":"94","author":"Wilson","year":"1997","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Alcohol"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741832904001648?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741832904001648?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T06:57:58Z","timestamp":1548658678000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0741832904001648"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,10]]},"references-count":21,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[2004,10]]}},"alternative-id":["S0741832904001648"],"URL":"https:\/\/doi.org\/10.1016\/j.alcohol.2004.06.011","relation":{},"ISSN":["0741-8329"],"issn-type":[{"value":"0741-8329","type":"print"}],"subject":[],"published":{"date-parts":[[2004,10]]}}}