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A., Latasa, M. U., Rubio, A., Mart\u00edn-Duce, A., Lu, S. C., Mato, J. M., & Corrales, F. J. (Epub 11 March 2003). Functional proteomics of nonalcoholic steatohepatitis: mitochondrial proteins as targets of S-adenosylmethionine. Proceedings of the National Academy of Sciences of the United States of America. 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