{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:51:38Z","timestamp":1792083098472,"version":"4.4.0"},"reference-count":57,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alcohol"],"published-print":{"date-parts":[[2008,2]]},"DOI":"10.1016\/j.alcohol.2007.10.003","type":"journal-article","created":{"date-parts":[[2008,2,6]],"date-time":"2008-02-06T13:58:07Z","timestamp":1202306287000},"page":"29-36","source":"Crossref","is-referenced-by-count":20,"title":["Ethanol exposure of neonatal rats does not increase biomarkers of oxidative stress in isolated cerebellar granule neurons"],"prefix":"10.1016","volume":"42","author":[{"given":"Cynthia J.M.","family":"Kane","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason Y.","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula K.","family":"Roberson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarun K.","family":"Garg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihong","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.alcohol.2007.10.003_bib1","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1111\/j.1742-4658.2006.05213.x","article-title":"The mitochondrial permeability transition from in vitro artifact to disease target","volume":"273","author":"Bernardi","year":"2006","journal-title":"FEBS J."},{"key":"10.1016\/j.alcohol.2007.10.003_bib2","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/tera.1420440203","article-title":"Permanent neuronal deficits in rats exposed to alcohol during the brain growth spurt","volume":"44","author":"Bonthius","year":"1991","journal-title":"Teratology"},{"key":"10.1016\/j.alcohol.2007.10.003_bib3","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0304-3940(96)12468-X","article-title":"Cyclic AMP and pituitary adenylate cyclase-activating polypeptide (PACAP) prevent programmed cell death of cultured rat cerebellar granule cells","volume":"206","author":"Chang","year":"1996","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.alcohol.2007.10.003_bib4","first-page":"129","article-title":"Neurotoxicity of tunicamycin on cultured cerebellar granule cells","volume":"18","author":"Chang","year":"1997","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.alcohol.2007.10.003_bib5","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0197-0186(97)00020-X","article-title":"25-Hydroxycholesterol causes death but does not prevent nerve growth factor-induced neurite outgrowth in PC12 cells","volume":"31","author":"Chang","year":"1997","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.alcohol.2007.10.003_bib6","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0197-0186(97)00103-4","article-title":"Neurotoxicity of cholesterol oxides on cultured cerebellar granule cells","volume":"32","author":"Chang","year":"1998","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.alcohol.2007.10.003_bib7","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1471-2210-1-10","article-title":"Peroxisome proliferator-activated receptor agonists prevent 25-OH-cholesterol induced c-jun activation and cell death","volume":"1","author":"Chang","year":"2001","journal-title":"BMC Pharmacol."},{"key":"10.1016\/j.alcohol.2007.10.003_bib37","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1007\/s00018-005-4571-z","article-title":"Ethanol inhibits insulin expression and actions in the developing brain","volume":"62","author":"de la Monte","year":"2005","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.alcohol.2007.10.003_bib8","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0892-0362(90)90094-S","article-title":"Prenatal alcohol exposure: Comparability of effects in humans and animal models","volume":"12","author":"Driscoll","year":"1990","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.alcohol.2007.10.003_bib9","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1111\/j.1530-0277.2002.tb02634.x","article-title":"Melatonin (an antioxidant) does not ameliorate alcohol-induced Purkinje cell loss in the developing cerebellum","volume":"26","author":"Edwards","year":"2002","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.alcohol.2007.10.003_bib10","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1471-2415-3-5","article-title":"Oxidative stress causes ERK phosphorylation and cell death in cultured retinal pigment epithelium: Prevention of cell death by AG126 and 15-deoxy-delta 12, 14-PGJ2","volume":"3","author":"Garg","year":"2003","journal-title":"BMC Ophthalmol."},{"key":"10.1016\/j.alcohol.2007.10.003_bib11","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1471-2210-4-6","article-title":"15-Deoxy-delta 12, 14-prostaglandin J2 prevents reactive oxygen species generation and mitochondrial membrane depolarization induced by oxidative stress","volume":"4","author":"Garg","year":"2004","journal-title":"BMC Pharmacol."},{"key":"10.1016\/j.alcohol.2007.10.003_bib12","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jneuroim.2005.09.007","article-title":"Methylmercury causes oxidative stress and cytotoxicity in microglia: Attenuation by 15-deoxy-delta 12, 14-prostaglandin J2","volume":"171","author":"Garg","year":"2006","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.alcohol.2007.10.003_bib13","first-page":"738","article-title":"Alcohol-induced Purkinje cell loss with a single binge exposure in neonatal rats: A stereological study of temporal windows of vulnerability","volume":"21","author":"Goodlett","year":"1997","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.alcohol.2007.10.003_bib14","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0741-8329(90)90070-S","article-title":"A single day of alcohol exposure during the brain growth spurt induces brain weight restriction and cerebellar Purkinje cell loss","volume":"7","author":"Goodlett","year":"1990","journal-title":"Alcohol"},{"key":"10.1016\/j.alcohol.2007.10.003_bib15","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0006-8993(02)03561-8","article-title":"Neonatal ethanol produces cerebellar deep nuclear cell loss and correlated disruption of eyeblink conditioning in adult rats","volume":"956","author":"Green","year":"2002","journal-title":"Brain Res."},{"key":"10.1016\/j.alcohol.2007.10.003_bib16","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1097\/01.ALC.0000171932.13148.CF","article-title":"Antioxidant pretreatment does not ameliorate alcohol-induced Purkinje cell loss in the developing rat cerebellum","volume":"29","author":"Grisel","year":"2005","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.alcohol.2007.10.003_bib17","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1111\/j.1530-0277.1993.tb00808.x","article-title":"The effects of the timing of ethanol exposure during the brain growth spurt on the number of cerebellar Purkinje and granule cell nuclear profiles","volume":"17","author":"Hamre","year":"1993","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.alcohol.2007.10.003_bib18","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/j.1530-0277.2000.tb02019.x","article-title":"Amelioration of ethanol-induced neurotoxicity in the neonatal rat central nervous system by antioxidant therapy","volume":"24","author":"Heaton","year":"2000","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.alcohol.2007.10.003_bib19","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/1097-4695(20001105)45:2<95::AID-NEU4>3.0.CO;2-Y","article-title":"Overexpression of NGF ameliorates ethanol neurotoxicity in the developing cerebellum","volume":"45","author":"Heaton","year":"2000","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.alcohol.2007.10.003_bib20","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/j.1530-0277.2003.tb04402.x","article-title":"The role of neurotrophic factors, apoptosis-related proteins, and endogenous antioxidants in the differential temporal vulnerability of neonatal cerebellum to ethanol","volume":"27","author":"Heaton","year":"2003","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.alcohol.2007.10.003_bib21","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/neu.20208","article-title":"Effect of bax deletion on ethanol sensitivity in the neonatal rat cerebellum","volume":"66","author":"Heaton","year":"2006","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.alcohol.2007.10.003_bib22","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0304-3940(02)01123-0","article-title":"Ethanol-mediated generation of reactive oxygen species in developing rat cerebellum","volume":"334","author":"Heaton","year":"2002","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.alcohol.2007.10.003_bib23","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1111\/j.1530-0277.1995.tb01572.x","article-title":"In utero ethanol exposure elicits oxidative stress in the rat fetus","volume":"19","author":"Henderson","year":"1995","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.alcohol.2007.10.003_bib24","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1126\/science.287.5455.1056","article-title":"Ethanol-induced apoptotic neurodegeneration and fetal alcohol syndrome","volume":"287","author":"Ikonomidou","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.alcohol.2007.10.003_bib25","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0304-3940(96)12332-6","article-title":"Transforming growth factor-beta2 increases NMDA receptor-mediated excitotoxicity in rat cerebral cortical neurons independently of glia","volume":"204","author":"Kane","year":"1996","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.alcohol.2007.10.003_bib26","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/0165-3806(96)00092-2","article-title":"Transforming growth factor-beta 2 both stimulates and inhibits neurogenesis of rat cerebellar granule cells in culture","volume":"96","author":"Kane","year":"1996","journal-title":"Brain Res. Dev. Brain Res."},{"key":"10.1016\/j.alcohol.2007.10.003_bib27","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0091-3057(96)00239-0","article-title":"Nutritional factors modify the inhibition of CNS development by combined exposure to methadone and ethanol in neonatal rats","volume":"56","author":"Kane","year":"1997","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.alcohol.2007.10.003_bib28","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0006-8993(02)02492-7","article-title":"Therapeutic effects of complex motor training on motor performance deficits induced by neonatal binge-like alcohol exposure in rats: II. A quantitative stereological study of synaptic plasticity in female rat cerebellum","volume":"937","author":"Klintsova","year":"2002","journal-title":"Brain Res."},{"key":"10.1016\/j.alcohol.2007.10.003_bib29","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0165-3806(02)00573-4","article-title":"Effects of prenatal exposure to ethanol on the cyclin-dependent kinase system in the developing rat cerebellum","volume":"139","author":"Li","year":"2002","journal-title":"Brain Res. Dev. Brain Res."},{"key":"10.1016\/j.alcohol.2007.10.003_bib30","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0306-4522(02)00344-5","article-title":"Time course and manner of Purkinje neuron death following a single ethanol exposure on postnatal day 4 in the developing rat","volume":"114","author":"Light","year":"2002","journal-title":"Neuroscience"},{"key":"10.1016\/j.alcohol.2007.10.003_bib31","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0006-8993(01)03224-3","article-title":"Ethanol-induced alterations of neurotrophin receptor expression on Purkinje cells in the neonatal rat cerebellum","volume":"924","author":"Light","year":"2002","journal-title":"Brain Res."},{"key":"10.1016\/j.alcohol.2007.10.003_bib32","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/S0169-328X(01)00182-6","article-title":"Early postnatal ethanol exposure selectively decreases BDNF and truncated TrkB-T2 receptor mRNA expression in the rat cerebellum","volume":"93","author":"Light","year":"2001","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.alcohol.2007.10.003_bib33","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1111\/j.1530-0277.1998.tb03954.x","article-title":"Intragastric intubation: Important aspects of the model for administration of ethanol to rat pups during the postnatal period","volume":"22","author":"Light","year":"1998","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.alcohol.2007.10.003_bib34","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1046\/j.1471-4159.1997.69020581.x","article-title":"Mechanism of cellular 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction","volume":"69","author":"Liu","year":"1997","journal-title":"J. Neurochem."},{"key":"10.1016\/j.alcohol.2007.10.003_bib35","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1111\/j.1530-0277.1999.tb04176.x","article-title":"Fetal alcohol exposure and temporal vulnerability: Regional differences in cell loss as a function of the timing of binge-like alcohol exposure during brain development","volume":"23","author":"Maier","year":"1999","journal-title":"Alcohol. Clin. Exp. Res."},{"issue":"Pt 3","key":"10.1016\/j.alcohol.2007.10.003_bib36","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1046\/j.1469-7580.1999.19430423.x","article-title":"The effect of the timing of ethanol exposure during early postnatal life on total number of Purkinje cells in rat cerebellum","volume":"194","author":"Miki","year":"1999","journal-title":"J. Anat."},{"key":"10.1016\/j.alcohol.2007.10.003_bib38","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1152\/physiol.00020.2005","article-title":"Mitochondrial ion channels: Gatekeepers of life and death","volume":"20","author":"O'Rourke","year":"2005","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.alcohol.2007.10.003_bib39","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.neulet.2006.02.025","article-title":"Are oxidative mechanisms primary in ethanol induced Purkinje neuron death of the neonatal rat?","volume":"400","author":"Pierce","year":"2006","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.alcohol.2007.10.003_bib40","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/tera.1420400205","article-title":"Differential neuronal loss following early postnatal alcohol exposure","volume":"40","author":"Pierce","year":"1989","journal-title":"Teratology"},{"key":"10.1016\/j.alcohol.2007.10.003_bib41","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1159\/000111241","article-title":"Microencephaly and selective decreases in cerebellar Purkinje cell numbers following combined exposure to ethanol and methadone during rat brain development","volume":"19","author":"Pierce","year":"1997","journal-title":"Dev. Neurosci."},{"key":"10.1016\/j.alcohol.2007.10.003_bib42","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1111\/j.1530-0277.1993.tb05241.x","article-title":"Intragastric intubation of alcohol during postnatal development of rats results in selective cell loss in the cerebellum","volume":"17","author":"Pierce","year":"1993","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.alcohol.2007.10.003_bib43","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0892-0362(87)90089-4","article-title":"Differential deficits in regional brain growth induced by postnatal alcohol","volume":"9","author":"Pierce","year":"1987","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.alcohol.2007.10.003_bib44","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1111\/j.1530-0277.1999.tb04057.x","article-title":"Purkinje cell vulnerability to developmental ethanol exposure in the rat cerebellum","volume":"23","author":"Pierce","year":"1999","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.alcohol.2007.10.003_bib45","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1002\/jnr.10767","article-title":"Ethanol-induced oxidative stress precedes mitochondrially mediated apoptotic death of cultured fetal cortical neurons","volume":"74","author":"Ramachandran","year":"2003","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.alcohol.2007.10.003_bib46","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1111\/j.1530-0277.1993.tb00857.x","article-title":"Effects of in utero administration of alcohol on glutathione levels in brain and liver","volume":"17","author":"Reyes","year":"1993","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.alcohol.2007.10.003_bib47","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0022-1759(92)90008-H","article-title":"A microplate assay for the detection of oxidative products using 2\u2032,7\u2032-dichlorofluorescin-diacetate","volume":"156","author":"Rosenkranz","year":"1992","journal-title":"J.\u00a0Immunol. Methods"},{"key":"10.1016\/j.alcohol.2007.10.003_bib48","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1002\/jnr.20591","article-title":"Functional mechanisms of apoptosis-related proteins in neonatal rat cerebellum are differentially influenced by ethanol at postnatal days 4 and 7","volume":"81","author":"Siler-Marsiglio","year":"2005","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.alcohol.2007.10.003_bib49","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/neu.20057","article-title":"Protective mechanisms of pycnogenol in ethanol-insulted cerebellar granule cells","volume":"61","author":"Siler-Marsiglio","year":"2004","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.alcohol.2007.10.003_bib50","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.brainres.2005.06.030","article-title":"Mitochondrially targeted vitamin E and vitamin E mitigate ethanol-mediated effects on cerebellar granule cell antioxidant defense systems","volume":"1052","author":"Siler-Marsiglio","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.alcohol.2007.10.003_bib51","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.devbrainres.2005.09.004","article-title":"Neonatal alcohol exposure increases malondialdehyde (MDA) and glutathione (GSH) levels in the developing cerebellum","volume":"160","author":"Smith","year":"2005","journal-title":"Brain Res. Dev. Brain Res."},{"key":"10.1016\/j.alcohol.2007.10.003_bib52","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1093\/cercor\/12.8.856","article-title":"Regional brain shape abnormalities persist into adolescence after heavy prenatal alcohol exposure","volume":"12","author":"Sowell","year":"2002","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.alcohol.2007.10.003_bib53","series-title":"Fetal alcohol syndrome: Diagnosis, epidemiology, prevention and treatment","author":"Stratton","year":"1996"},{"key":"10.1016\/j.alcohol.2007.10.003_bib54","doi-asserted-by":"crossref","first-page":"237S","DOI":"10.1111\/j.1530-0277.2001.tb02402.x","article-title":"Ethanol and oxidative stress","volume":"25","author":"Sun","year":"2001","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.alcohol.2007.10.003_bib55","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/01.ALC.0000150004.53870.E1","article-title":"Vitamin E does not protect against neonatal ethanol-induced cerebellar damage or deficits in eyeblink classical conditioning in rats","volume":"29","author":"Tran","year":"2005","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.alcohol.2007.10.003_bib56","first-page":"638","article-title":"Alcohol-related birth defects: An update","volume":"103","author":"Warren","year":"1988","journal-title":"Public Health Rep."},{"key":"10.1016\/j.alcohol.2007.10.003_bib57","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/BF02098878","article-title":"Fetal alcohol syndrome: The vulnerability of the developing brain and possible mechanisms of damage","volume":"9","author":"West","year":"1994","journal-title":"Metab. Brain Dis."}],"container-title":["Alcohol"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741832907002017?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741832907002017?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,31]],"date-time":"2018-12-31T22:56:44Z","timestamp":1546297004000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0741832907002017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2]]},"references-count":57,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,2]]}},"alternative-id":["S0741832907002017"],"URL":"https:\/\/doi.org\/10.1016\/j.alcohol.2007.10.003","relation":{},"ISSN":["0741-8329"],"issn-type":[{"value":"0741-8329","type":"print"}],"subject":[],"published":{"date-parts":[[2008,2]]}}}