{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T08:12:32Z","timestamp":1769501552558,"version":"3.49.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alcohol"],"published-print":{"date-parts":[[2008,6]]},"DOI":"10.1016\/j.alcohol.2008.01.010","type":"journal-article","created":{"date-parts":[[2008,4,9]],"date-time":"2008-04-09T14:00:48Z","timestamp":1207749648000},"page":"295-302","source":"Crossref","is-referenced-by-count":20,"title":["Alcohol exposure on postnatal day 5 induces Purkinje cell loss and evidence of Purkinje cell degradation in lobule I of rat cerebellum"],"prefix":"10.1016","volume":"42","author":[{"given":"Youngki","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Rowe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyle","family":"Eskue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James R.","family":"West","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan E.","family":"Maier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.alcohol.2008.01.010_bib2","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1139\/o00-071","article-title":"Pattern formation in the cerebellar cortex","volume":"78","author":"Armstrong","year":"2000","journal-title":"Biochem. Cell. Biol."},{"key":"10.1016\/j.alcohol.2008.01.010_bib3","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0006-8993(77)90310-9","article-title":"The effect of ethanol chronically administered to preweanling rats on cerebellar development: a morphological study","volume":"119","author":"Bauer-Moffet","year":"1977","journal-title":"Brain Res."},{"key":"10.1016\/j.alcohol.2008.01.010_bib4","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1530-0277.1990.tb00455.x","article-title":"Alcohol-induced neuronal loss in developing rats: increased brain damage with binge exposure","volume":"14","author":"Bonthius","year":"1990","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.alcohol.2008.01.010_bib5","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1096\/fj.00-0862fje","article-title":"Octanol antagonism of ethanol teratogenesis","volume":"15","author":"Chen","year":"2001","journal-title":"FASEB J"},{"key":"10.1016\/j.alcohol.2008.01.010_bib6","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.molbrainres.2004.06.034","article-title":"Altered expression of Bcl2, Bad and Bax mRNA occurs in the rat cerebellum within hours after ethanol exposure on postnatal day 4 but not on postnatal day 9","volume":"129","author":"Ge","year":"2004","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.alcohol.2008.01.010_bib7","first-page":"738","article-title":"Alcohol-induced Purkinje cell loss with a single binge exposure in neonatal rats: A stereological study of temporal windows of vulnerability","volume":"21","author":"Goodlett","year":"1997","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.alcohol.2008.01.010_bib8","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0091-3057(96)00248-1","article-title":"Temporal determinants of neonatal alcohol-induced cerebellar damage and motor performance deficits","volume":"55","author":"Goodlett","year":"1996","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.alcohol.2008.01.010_bib9","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0741-8329(90)90070-S","article-title":"A single day of alcohol exposure during the brain growth spurt induces brain weight restriction and cerebellar Purkinje cell loss","volume":"7","author":"Goodlett","year":"1990","journal-title":"Alcohol"},{"key":"10.1016\/j.alcohol.2008.01.010_bib10","first-page":"379","article-title":"Some new, simple and efficient stereological tools and their use in pathological research and diagnosis","volume":"96","author":"Gundersen","year":"1988","journal-title":"AMPIS"},{"key":"10.1016\/j.alcohol.2008.01.010_bib11","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1111\/j.1530-0277.1993.tb00808.x","article-title":"The effects of the timing of ethanol exposure during the brain growth spurt on the number of cerebellar Purkinje and granule cell nuclear profiles","volume":"17","author":"Hamre","year":"1993","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.alcohol.2008.01.010_bib12","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/j.1530-0277.2000.tb02019.x","article-title":"Amelioration of ethanol-induced neurotoxicity in the neonatal rat central nervous system by antioxidant therapy","volume":"24","author":"Heaton","year":"2000","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.alcohol.2008.01.010_bib46","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/j.1530-0277.2003.tb04402.x","article-title":"The role of neurotrophic factors, apoptosis-related proteins, and endogenous antioxidants in the differential vulnerability of neonatal cerebellum to ethanol. Alcohol Clin","volume":"27","author":"Heaton","year":"2003","journal-title":"Exp. Res."},{"key":"10.1016\/j.alcohol.2008.01.010_bib13","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0006-8993(98)01173-1","article-title":"Bcl-2 overexpression protects the neonatal cerebellum from ethanol toxicity","volume":"817","author":"Heaton","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.alcohol.2008.01.010_bib14","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/neu.20208","article-title":"Effect of bax deletion on ethanol sensitivity in the neonatal rat cerebellum","volume":"66","author":"Heaton","year":"2006","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.alcohol.2008.01.010_bib15","series-title":"Statistical Methods for Psychology","author":"Howell","year":"1997"},{"key":"10.1016\/j.alcohol.2008.01.010_bib16","doi-asserted-by":"crossref","first-page":"e101","DOI":"10.1371\/journal.pmed.0030101","article-title":"Nicotinamide protects against ethanol-induced apoptotic neurodegeneration in the developing mouse brain","volume":"3","author":"Ieraci","year":"2006","journal-title":"PLoS. Medicine"},{"key":"10.1016\/j.alcohol.2008.01.010_bib17","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.ntt.2006.01.011","article-title":"Spatial learning deficits induced by chronic prenatal ethanol exposure can be overcome by non-spatial pre-training","volume":"28","author":"Iqbal","year":"2006","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.alcohol.2008.01.010_bib18","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/S0140-6736(73)91092-1","article-title":"Recognition of the fetal alcohol syndrome in early infancy","volume":"2","author":"Jones","year":"1973","journal-title":"Lancet"},{"key":"10.1016\/j.alcohol.2008.01.010_bib19","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1023\/A:1021003600900","article-title":"Motor coordination, exploration, and spatial learning in a natural mouse mutation (nervous) with Purkinje cell degeneration","volume":"33","author":"Lalonde","year":"2003","journal-title":"Behav. Genet."},{"key":"10.1016\/j.alcohol.2008.01.010_bib20","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1080\/14734220310017456","article-title":"The effects of cerebellar damage on maze learning in animals","volume":"2","author":"Lalonde","year":"2003","journal-title":"Cerebellum"},{"key":"10.1016\/j.alcohol.2008.01.010_bib21","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0306-4522(02)00344-5","article-title":"Time course and manner of Purkinje neuron death following a single ethanol exposure on postnatal day 4 in the developing rat","volume":"114","author":"Light","year":"2002","journal-title":"Neurosci."},{"key":"10.1016\/j.alcohol.2008.01.010_bib22","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0892-0362(03)00030-8","article-title":"Fetal alcohol exposure and temporal vulnerability: effects of binge-like alcohol exposure on the developing rat hippocampus","volume":"25","author":"Livy","year":"2003","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.alcohol.2008.01.010_bib23","series-title":"Fetal Alcohol Syndrome, From Mechanism to Prevention","first-page":"27","article-title":"The effects of timing and duration of alcohol exposure on development of the fetal brain","author":"Maier","year":"1996"},{"key":"10.1016\/j.alcohol.2008.01.010_bib24","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1111\/j.1530-0277.1999.tb04176.x","article-title":"Fetal alcohol exposure and temporal vulnerability: regional differences in cell loss as a function of the timing of binge-like alcohol exposure during brain development","volume":"23","author":"Maier","year":"1999","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.alcohol.2008.01.010_bib25","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0741-8329(00)00133-6","article-title":"Regional differences in cell loss associated with binge-like alcohol exposure during the first two trimesters equivalent in the rat","volume":"23","author":"Maier","year":"2001","journal-title":"Alcohol"},{"key":"10.1016\/j.alcohol.2008.01.010_bib26","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1002\/(SICI)1097-4695(19971120)33:6<835::AID-NEU10>3.0.CO;2-3","article-title":"Glial-derived neurotrophic factor rescues calbindin-D28k-immunoreactive neurons in alcohol-treated cerebellar explant cultures","volume":"33","author":"McAlhany","year":"1997","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.alcohol.2008.01.010_bib27","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.alcohol.2006.05.005","article-title":"Reversal learning after prenatal or early postnatal alcohol exposure in juvenile and adults rats","volume":"38","author":"O'Leary-Moore","year":"2006","journal-title":"Alcohol"},{"key":"10.1016\/j.alcohol.2008.01.010_bib28","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0165-3806(91)90067-S","article-title":"Expression of proenkephalin mRNA in developing cerebellar cortex of the rat: expression levels coincide with maturational gradients in Purkinje cells","volume":"63","author":"Osborne","year":"1991","journal-title":"Brain Res. Dev. Brain Res."},{"key":"10.1016\/j.alcohol.2008.01.010_bib29","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1111\/j.1530-0277.1999.tb04057.x","article-title":"Purkinje cell vulnerability to developmental ethanol exposure in the rat cerebellum","volume":"23","author":"Pierce","year":"1999","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.alcohol.2008.01.010_bib30","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.bbr.2006.07.012","article-title":"Adult rat's offspring of alcoholic mothers are impaired on spatial learning and object recognition in the CAN test","volume":"174","author":"Popovic","year":"2006","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.alcohol.2008.01.010_bib31","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1093\/toxsci\/kfh224","article-title":"Developmental neurotoxicity of ketamine: morphometric confirmation, exposure parameters, and multiple fluorescent labeling of apoptotic neurons","volume":"81","author":"Scallet","year":"2004","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.alcohol.2008.01.010_bib32","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0006-8993(00)02513-0","article-title":"Fluoro-Jade B: a high affinity fluorescent marker for the localization of neuronal degeneration","volume":"874","author":"Schmued","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.alcohol.2008.01.010_bib33","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/neu.10311","article-title":"Pycnogenol and vitamin E inhibit ethanol-induced apoptosis in rat cerebellar granule cells","volume":"59","author":"Siler-Marsiglio","year":"2004","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.alcohol.2008.01.010_bib34","first-page":"774","article-title":"Prevention of fetal demise and growth restriction in a mouse model of fetal alcohol syndrome","volume":"297","author":"Spong","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.alcohol.2008.01.010_bib36","series-title":"Fetal Alcohol Syndrome Diagnosis, Epidemiology, Prevention and Treatment","author":"Stratton","year":"1996"},{"key":"10.1016\/j.alcohol.2008.01.010_bib37","doi-asserted-by":"crossref","first-page":"345","DOI":"10.3758\/BF03208008","article-title":"Higher reliability and closer relationship between open field test measures on aggregation data","volume":"13","author":"Tachibana","year":"1985","journal-title":"Anim. Learn. Behav."},{"key":"10.1016\/j.alcohol.2008.01.010_bib38","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0165-3806(97)00164-8","article-title":"Alcohol-induced Purkinje cell loss depends on developmental timing of alcohol exposure and correlates with motor performance","volume":"10","author":"Thomas","year":"1998","journal-title":"Brain Res. Dev. Brain Res."},{"key":"10.1016\/j.alcohol.2008.01.010_bib39","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.ntt.2003.10.005","article-title":"Perinatal choline supplementation does not mitigate motor coordination deficits associated with neonatal alcohol exposure in rats","volume":"26","author":"Thomas","year":"2004","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.alcohol.2008.01.010_bib40","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/sj.cdd.4401217","article-title":"Realizing the promise of apoptosis-based therapies: separating the living from the clinically undead","volume":"10","author":"Tilly","year":"2003","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.alcohol.2008.01.010_bib41","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/01.ALC.0000150004.53870.E1","article-title":"Vitamin E does not protect against neonatal ethanol-induced cerebellar damage or deficits in eyeblink classical conditioning in rats","volume":"29","author":"Tran","year":"2005","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.alcohol.2008.01.010_bib42","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0892-0362(03)00074-6","article-title":"Critical periods for ethanol-induced cell loss in the hippocampal formation","volume":"25","author":"Tran","year":"2003","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.alcohol.2008.01.010_bib43","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0741-8329(84)90101-0","article-title":"Delay in brain growth induced by alcohol in artificially reared rat pups","volume":"1","author":"West","year":"1984","journal-title":"Alcohol"},{"key":"10.1016\/j.alcohol.2008.01.010_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.902960102","article-title":"Unbiased stereological estimation of the number of neurons in the human hippocampus","volume":"296","author":"West","year":"1990","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.alcohol.2008.01.010_bib45","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/S1385-299X(01)00086-1","article-title":"Fluoro-jade and silver methods: application to the neuropathology of scrapie, a transmissible spongiform encephalopathy","volume":"8","author":"Ye","year":"2001","journal-title":"Brain Res. Protoc."}],"container-title":["Alcohol"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741832908000372?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741832908000372?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T01:47:41Z","timestamp":1557452861000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0741832908000372"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["S0741832908000372"],"URL":"https:\/\/doi.org\/10.1016\/j.alcohol.2008.01.010","relation":{},"ISSN":["0741-8329"],"issn-type":[{"value":"0741-8329","type":"print"}],"subject":[],"published":{"date-parts":[[2008,6]]}}}