{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T14:40:40Z","timestamp":1785163240041,"version":"3.55.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alcohol"],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1016\/j.alcohol.2011.09.024","type":"journal-article","created":{"date-parts":[[2012,3,24]],"date-time":"2012-03-24T02:17:35Z","timestamp":1332555455000},"page":"235-243","source":"Crossref","is-referenced-by-count":34,"title":["Protective effect of Opuntia ficus indica f. inermis prickly pear juice upon ethanol-induced damages in rat erythrocytes"],"prefix":"10.1016","volume":"46","author":[{"given":"Hichem","family":"Alimi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najla","family":"Hfaeidh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zouhour","family":"Bouoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsen","family":"Sakly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kh\u00e9mais","family":"Ben Rhouma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.alcohol.2011.09.024_bib1","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1111\/j.1530-0277.1989.tb00408.x","article-title":"Hematological complications of alcoholism","volume":"13","author":"Ballard","year":"1989","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1016\/j.alcohol.2011.09.024_bib2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0023-6438(95)80008-5","article-title":"Use of a free radical method to evaluate antioxidant activity","volume":"28","author":"Brand-Williams","year":"1995","journal-title":"Lebensmittel-Wissenschaft und -Technologie"},{"key":"10.1016\/j.alcohol.2011.09.024_bib3","doi-asserted-by":"crossref","first-page":"6895","DOI":"10.1021\/jf025696p","article-title":"Antioxidant activities of Sicilian prickly pear (Opuntia ficus indica) fruit extracts and reducing properties of its betalains: betanin and indicaxanthin","volume":"50","author":"Butera","year":"2002","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"10.1016\/j.alcohol.2011.09.024_bib4","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0040-6031(99)00217-8","article-title":"Interactions of aminoacids in concentrated aqueous solutions of urea or ethanol. Implications for the mechanism of protein denaturation","volume":"339","author":"Castronuovo","year":"1999","journal-title":"Thermochimca Acta"},{"key":"10.1016\/j.alcohol.2011.09.024_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.chemphyslip.2008.09.004","article-title":"Lipid peroxidation of membrane phospholipids generates hydroxyalkenals and oxidized phospholipids active in physiological and\/or pathological conditions","volume":"157","author":"Catala","year":"2009","journal-title":"Chemistry and Physics of Lipids"},{"key":"10.1016\/j.alcohol.2011.09.024_bib6","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.foodchem.2007.06.017","article-title":"The protective effect of Opuntia dillenii Haw fruit against low-density lipoprotein peroxidation and its active compounds","volume":"106","author":"Chang","year":"2008","journal-title":"Food Chemistry"},{"key":"10.1016\/j.alcohol.2011.09.024_bib7","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.ijbiomac.2006.12.003","article-title":"Interaction of flavonoids with red blood cell membrane lipids and proteins: antioxidant and antihemolytic effects","volume":"41","author":"Chaudhuri","year":"2007","journal-title":"International Journal of Biological Macromolecules"},{"key":"10.1016\/j.alcohol.2011.09.024_bib8","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1007\/s11130-009-0117-0","article-title":"Phenolic\u00a0composition, antioxidant capacity and in\u00a0vitro cancer cell cytotoxicity of nine prickly pear (Opuntia spp.) juices","volume":"64","author":"Chavez-Santoscoy","year":"2009","journal-title":"Plant Foods for Human Nutrition"},{"key":"10.1016\/j.alcohol.2011.09.024_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cca.2007.12.025","article-title":"Free radical metabolism in human erythrocytes","volume":"390","author":"\u00c7imen","year":"2008","journal-title":"Clinica Chimica Acta"},{"key":"10.1016\/j.alcohol.2011.09.024_bib10","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1258\/000456303322326407","article-title":"Herbal remedies and clinical biochemistry","volume":"40","author":"Corns","year":"2003","journal-title":"Annals of Clinical Biochemistry"},{"key":"10.1016\/j.alcohol.2011.09.024_bib11","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.foodchem.2005.04.028","article-title":"Antioxidant activity of some Algerian medicinal plants extracts containing phenols compounds","volume":"97","author":"Djeridane","year":"2006","journal-title":"Food Chemistry"},{"key":"10.1016\/j.alcohol.2011.09.024_bib12","first-page":"259","article-title":"Erythrocyte susceptibility to lipid peroxidation in patients with coronary atherosclerosis","volume":"53","author":"Dincer","year":"1999","journal-title":"Acta Medica Okayama"},{"key":"10.1016\/j.alcohol.2011.09.024_bib13","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.cbi.2005.07.002","article-title":"Protective effect of green tea on erythrocyte membrane of different age rats intoxicated with ethanol","volume":"156","author":"Dobrzynska","year":"2005","journal-title":"Chemico-Biological Interactions"},{"key":"10.1016\/j.alcohol.2011.09.024_bib14","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0003-9861(63)90042-0","article-title":"The preparation and chemical characterization of haemoglobin-free ghosts of human erythrocytes","volume":"100","author":"Dodge","year":"1963","journal-title":"Archives of Biochemistry and Biophysics"},{"key":"10.1016\/j.alcohol.2011.09.024_bib15","first-page":"272","article-title":"Shapes and shape changes in\u00a0vitro in normal red blood cell","volume":"1071","author":"Elgsaeter","year":"1991","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/j.alcohol.2011.09.024_bib16","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1023\/A:1008000232406","article-title":"Composition of pulp, skin and seeds of prickly pears fruit (Opuntia ficus indica sp.)","volume":"52","author":"El Kossori","year":"1998","journal-title":"Plant Foods for Human Nutrition"},{"key":"10.1016\/j.alcohol.2011.09.024_bib17","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0006-2952(77)90310-0","article-title":"The distribution and metabolism of acetaldehyde in rats during ethanol oxidation-I. The distribution of acetaldehyde in liver, brain, blood and breath","volume":"26","author":"Eriksson","year":"1977","journal-title":"Biochemical Pharmacology"},{"key":"10.1016\/j.alcohol.2011.09.024_bib18","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2337\/diacare.11.1.63","article-title":"Hypoglycemic effect of Opuntia streptacantha lemaire in NIDDM","volume":"11","author":"Frati","year":"1988","journal-title":"Diabetes Care"},{"key":"10.1016\/j.alcohol.2011.09.024_bib19","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0021-9258(18)84277-6","article-title":"Tyrosine and tryptophane determination in proteins","volume":"27","author":"Folin","year":"1927","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.alcohol.2011.09.024_bib20","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.cbi.2007.06.001","article-title":"Oxidative damage in rat erythrocyte membranes following ethanol intake: effect of ethyl pyruvate","volume":"169","author":"Gabbianelli","year":"2007","journal-title":"Chemico-Biological Interactions"},{"key":"10.1016\/j.alcohol.2011.09.024_bib21","doi-asserted-by":"crossref","first-page":"4903","DOI":"10.1021\/jf030123d","article-title":"Chemical characterization and biological effects of Sicilian Opuntia ficus indica (L.) Mill. fruit juice: antioxidant and antiulcerogenic activity","volume":"51","author":"Galati","year":"2003","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"10.1016\/j.alcohol.2011.09.024_bib22","first-page":"571","article-title":"Erythrocyte membrane fluidity, lipid peroxidation and lysis in alcoholic liver disease","volume":"40","author":"Goebel","year":"1981","journal-title":"Acta Biologica et Medica Germanica"},{"key":"10.1016\/j.alcohol.2011.09.024_bib23","first-page":"42","article-title":"The hematological complications of alcoholism","volume":"21","author":"Harold","year":"1997","journal-title":"Alcohol Health & Research World"},{"key":"10.1016\/j.alcohol.2011.09.024_bib24","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/cbf.1273","article-title":"Betaine prevents loss of sialic acid residues and peroxidative injury of erythrocyte membrane in ethanol-given rats","volume":"25","author":"Kanbak","year":"2007","journal-title":"Cell Biochemistry and Function"},{"key":"10.1016\/j.alcohol.2011.09.024_bib25","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1093\/alcalc\/agh093","article-title":"Combined therapy: what does acamprosate and naltrexone combination tell us?","volume":"39","author":"Kiefer","year":"2004","journal-title":"Alcohol and Alcoholism"},{"key":"10.1016\/j.alcohol.2011.09.024_bib26","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0308-8146(03)00184-5","article-title":"Antioxidant compounds from four Opuntia cactus pear fruit varieties","volume":"85","author":"Kuti","year":"2004","journal-title":"Food Chemistry"},{"key":"10.1016\/j.alcohol.2011.09.024_bib27","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/0005-2736(95)80033-C","article-title":"Ethanol and acetonitrile-induced inhibition of water diffusional permeability across bovine red blood cell membrane","volume":"1235","author":"Lahajnar","year":"1995","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/j.alcohol.2011.09.024_bib28","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/BF03402186","article-title":"Acetaldehyde adducts in blood and bone marrow of patients with ethanol-induced erythrocyte abnormalities","volume":"7","author":"Latvala","year":"2001","journal-title":"Molecular Medicine"},{"key":"10.1016\/j.alcohol.2011.09.024_bib29","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0741-8329(98)00020-2","article-title":"Rat erythrocyte susceptibility to lipid peroxidation after chronic ethanol intake","volume":"16","author":"Lindi","year":"1998","journal-title":"Alcohol"},{"key":"10.1016\/j.alcohol.2011.09.024_bib30","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.alcohol.2011.09.024_bib31","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1021\/jf00087a017","article-title":"Carotenoids in finish foods: vegetables, fruit, and berries","volume":"37","author":"Marina","year":"1989","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"10.1016\/j.alcohol.2011.09.024_bib32","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0309-1740(03)00135-9","article-title":"Lipid and protein oxidation in\u00a0vitro, and antioxidant potential in meat from Charolais cows finished on pasture or mixed diet","volume":"66","author":"Mercier","year":"2004","journal-title":"Meat Science"},{"key":"10.1016\/j.alcohol.2011.09.024_bib33","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0304-4165(79)90289-7","article-title":"Levels of glutathione, glutathione reductase and glutathione-S-transferase activities in rat liver","volume":"582","author":"Moron","year":"1979","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/j.alcohol.2011.09.024_bib34","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxide in animal tissues by thiobarbutiric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Analytical Biochemistry"},{"key":"10.1016\/j.alcohol.2011.09.024_bib35","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1093\/ajcn\/44.2.257","article-title":"Plasma ascorbic acid in adult males: effects of depletion and supplementation","volume":"44","author":"Omaye","year":"1986","journal-title":"American Journal of Clinical Nutrition"},{"key":"10.1016\/j.alcohol.2011.09.024_bib36","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3164\/jcbn.2008003","article-title":"Erythrocyte glutathione depletion impairs resistance to haemolysis in women consuming alcohol","volume":"42","author":"Padmini","year":"2008","journal-title":"Journal of Clinical Biochemistry and Nutrition"},{"key":"10.1016\/j.alcohol.2011.09.024_bib37","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1093\/alcalc\/agh034","article-title":"Changes in composition and properties of erythrocyte membrane in chronic alcoholics","volume":"39","author":"Parmahamsa","year":"2004","journal-title":"Alcohol and Alcoholism"},{"key":"10.1016\/j.alcohol.2011.09.024_bib38","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.bioelechem.2008.04.002","article-title":"Effects of glycerol and sorbitol on the thermal dependence of the lysis of human erythrocytes by ethanol","volume":"73","author":"Penha-Silva","year":"2008","journal-title":"Bioelectrochemistry"},{"key":"10.1016\/j.alcohol.2011.09.024_bib40","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/S0005-2736(98)00057-1","article-title":"Red blood cell shape as a function of medium's ionic strength and pH","volume":"1372","author":"Rasia","year":"1998","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/j.alcohol.2011.09.024_bib41","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1016\/j.fct.2009.05.014","article-title":"Modulatory role of Emblica officinalis against alcohol induced biochemical and biophysical changes in rat erythrocyte membranes","volume":"47","author":"Reddy","year":"2009","journal-title":"Food and Chemical Toxicology"},{"key":"10.1016\/j.alcohol.2011.09.024_bib42","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1007\/s002170000219","article-title":"Phytochemical and nutritional significance of cactus pear","volume":"212","author":"Stintzing","year":"2001","journal-title":"European Food Research and Technology"},{"key":"10.1016\/j.alcohol.2011.09.024_bib43","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1021\/jf048751y","article-title":"Color, betalain pattern, and antioxidant properties of cactus pear (Opuntia spp.) clones","volume":"53","author":"Stintzing","year":"2005","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"10.1016\/j.alcohol.2011.09.024_bib44","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1093\/ajcn\/80.4.941","article-title":"Absorption, excretion, and distribution of dietary antioxidant in LDLs: potential health effects of betalains in humans","volume":"80","author":"Tesoriere","year":"2004","journal-title":"American Journal of Clinical Nutrition"},{"key":"10.1016\/j.alcohol.2011.09.024_bib45","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0005-2736(99)00092-9","article-title":"Association of ethanol with lipid membranes containing cholesterol, sphingomyelin and ganglioside: a titration calorimetry study","volume":"1420","author":"Trandum","year":"1999","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/j.alcohol.2011.09.024_bib46","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0925-4439(00)00086-7","article-title":"Does ethanol metabolism affect erythrocyte hemolysis?","volume":"1535","author":"Tyulina","year":"2000","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/j.alcohol.2011.09.024_bib47","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.bbadis.2006.03.003","article-title":"Erythrocyte and plasma protein modification in alcoholism: a possible role of acetaldehyde","volume":"1762","author":"Tyulina","year":"2006","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/j.alcohol.2011.09.024_bib48","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S1383-5718(01)00317-5","article-title":"Some new methodological aspects of the hen's egg test for micronucleus induction (HET-MN)","volume":"514","author":"Wolf","year":"2002","journal-title":"Mutation Research"},{"key":"10.1016\/j.alcohol.2011.09.024_bib49","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1093\/jn\/129.4.814","article-title":"Decreased plasma membrane thiol concentration is associated with increased osmotic fragility of erythrocytes in zinc-deficient rats","volume":"129","author":"Xia","year":"1999","journal-title":"Journal of Nutrition"},{"key":"10.1016\/j.alcohol.2011.09.024_bib50","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1080\/09595230500293795","article-title":"Natural medicines for alcoholism treatment: a review","volume":"24","author":"Xu","year":"2005","journal-title":"Drug and Alcohol Review"},{"key":"10.1016\/j.alcohol.2011.09.024_bib51","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0928-4680(99)00011-5","article-title":"Prevention of ethanol-induced erythrocyte transformations by fructose and natural honey in low alcohol tolerance mice","volume":"6","author":"Yamada","year":"1999","journal-title":"Pathophysiology"},{"key":"10.1016\/j.alcohol.2011.09.024_bib52","first-page":"1","article-title":"Cactus pear: a natural product in cancer chemoprevention","volume":"25","author":"Zou","year":"2005","journal-title":"Nutrition Journal"}],"container-title":["Alcohol"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741832911005209?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741832911005209?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T01:26:38Z","timestamp":1641518798000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0741832911005209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["S0741832911005209"],"URL":"https:\/\/doi.org\/10.1016\/j.alcohol.2011.09.024","relation":{},"ISSN":["0741-8329"],"issn-type":[{"value":"0741-8329","type":"print"}],"subject":[],"published":{"date-parts":[[2012,5]]}}}