{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:44:45Z","timestamp":1791398685143,"version":"4.3.3"},"reference-count":48,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Alcohol"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1016\/j.alcohol.2012.01.003","type":"journal-article","created":{"date-parts":[[2012,5,7]],"date-time":"2012-05-07T11:00:34Z","timestamp":1336388434000},"page":"603-612","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":58,"title":["Postnatal day 7 ethanol treatment causes persistent reductions in adult mouse brain volume and cortical neurons with sex specific effects on neurogenesis"],"prefix":"10.1016","volume":"46","author":[{"suffix":"Jr.","given":"Leon G.","family":"Coleman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ipek","family":"Oguz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joohwi","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Styner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulton T.","family":"Crews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.alcohol.2012.01.003_bib1","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/j.1469-8749.2002.tb00294.x","article-title":"MRI findings in children with school problems who had been exposed prenatally to alcohol","volume":"44","author":"Autti-Ramo","year":"2002","journal-title":"Developmental Medicine & Child Neurology"},{"key":"10.1016\/j.alcohol.2012.01.003_bib2","first-page":"283","article-title":"Identifying maternal self-reported alcohol use associated with fetal alcohol spectrum disorders","volume":"25","author":"Barr","year":"2001","journal-title":"Alcoholism: Clinical & Experimental Research"},{"key":"10.1016\/j.alcohol.2012.01.003_bib3","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1111\/j.1530-0277.2010.01184.x","article-title":"The remarkably high prevalence of epilepsy and seizure history in fetal alcohol spectrum disorders","volume":"34","author":"Bell","year":"2010","journal-title":"Alcoholism: Clinical & Experimental Research"},{"key":"10.1016\/j.alcohol.2012.01.003_bib4","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1177\/1087054705283880","article-title":"Association of attention deficit hyperactivity disorder and gestational alcohol exposure: an exploratory study","volume":"9","author":"Bhatara","year":"2006","journal-title":"Journal of Attention Disorders"},{"key":"10.1016\/j.alcohol.2012.01.003_bib5","first-page":"59","article-title":"Brain function in fetal alcohol syndrome assessed by single photon emission computed tomography","volume":"55","author":"Bhatara","year":"2002","journal-title":"South Dakota Journal of Medicine"},{"key":"10.1016\/j.alcohol.2012.01.003_bib6","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1530-0277.1990.tb00455.x","article-title":"Alcohol-induced neuronal loss in developing rats: increased brain damage with binge exposure","volume":"14","author":"Bonthius","year":"1990","journal-title":"Alcoholism: Clinical & Experimental Research"},{"key":"10.1016\/j.alcohol.2012.01.003_bib7","doi-asserted-by":"crossref","DOI":"10.1111\/j.1530-0277.2010.01269.x","article-title":"The impact of maternal age on the effects of prenatal alcohol exposure on attention","author":"Chiodo","year":"2010","journal-title":"Alcoholism: Clinical & Experimental Research"},{"key":"10.1016\/j.alcohol.2012.01.003_bib8","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1111\/j.1530-0277.2010.01385.x","article-title":"Adolescent binge drinking alters adult brain neurotransmitter gene expression, behavior, brain regional volumes, and neurochemistry in mice","volume":"35","author":"Coleman","year":"2011","journal-title":"Alcoholism: Clinical & Experimental Research"},{"key":"10.1016\/j.alcohol.2012.01.003_bib9","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.pbb.2009.04.017","article-title":"Deficits in adult prefrontal cortex neurons and behavior following early post-natal NMDA antagonist treatment","volume":"93","author":"Coleman","year":"2009","journal-title":"Pharmacology Biochemistry & Behavior"},{"key":"10.1016\/j.alcohol.2012.01.003_bib10","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0741-8329(04)00081-3","article-title":"Exercise reverses ethanol inhibition of neural stem cell proliferation","volume":"33","author":"Crews","year":"2004","journal-title":"Alcohol"},{"key":"10.1016\/j.alcohol.2012.01.003_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.devbrainres.2004.11.005","article-title":"Ethanol-induced neuroapoptosis in the developing rodent cerebellum and related brain stem structures","volume":"155","author":"Dikranian","year":"2005","journal-title":"Brain Research. Developmental Brain Research"},{"key":"10.1016\/j.alcohol.2012.01.003_bib12","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0378-3782(79)90022-7","article-title":"Comparative aspects of the brain growth spurt","volume":"3","author":"Dobbing","year":"1979","journal-title":"Early Human Development"},{"key":"10.1016\/j.alcohol.2012.01.003_bib13","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1523\/JNEUROSCI.23-05-01742.2003","article-title":"Hippocampal neurogenesis follows kainic acid-induced apoptosis in neonatal rats","volume":"23","author":"Dong","year":"2003","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.alcohol.2012.01.003_bib14","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.bbr.2008.02.008","article-title":"Inactivation of the medial prefrontal cortex of the rat impairs strategy set-shifting, but not reversal learning, using a novel, automated procedure","volume":"190","author":"Floresco","year":"2008","journal-title":"Behavioral Brain Research"},{"key":"10.1016\/j.alcohol.2012.01.003_bib15","series-title":"The mouse brain in stereotaxic coordinates","author":"Franklin","year":"2001"},{"key":"10.1016\/j.alcohol.2012.01.003_bib16","doi-asserted-by":"crossref","first-page":"e733","DOI":"10.1542\/peds.2006-1606","article-title":"Evaluation of psychopathological conditions in children with heavy prenatal alcohol exposure","volume":"119","author":"Fryer","year":"2007","journal-title":"Pediatrics"},{"key":"10.1016\/j.alcohol.2012.01.003_bib17","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/j.1530-0277.2009.01071.x","article-title":"Magnetic resonance microscopy defines ethanol-induced brain abnormalities in prenatal mice: effects of acute insult on gestational day 7","volume":"34","author":"Godin","year":"2010","journal-title":"Alcoholism: Clinical & Experimental Research"},{"key":"10.1016\/j.alcohol.2012.01.003_bib18","first-page":"738","article-title":"Alcohol-induced Purkinje cell loss with a single binge exposure in neonatal rats: a stereological study of temporal windows of vulnerability","volume":"21","author":"Goodlett","year":"1997","journal-title":"Alcoholism: Clinical & Experimental Research"},{"key":"10.1016\/j.alcohol.2012.01.003_bib19","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1523\/JNEUROSCI.23-05-01832.2003","article-title":"Perinatal neurosteroid levels influence GABAergic interneuron localization in adult rat prefrontal cortex","volume":"23","author":"Grobin","year":"2003","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.alcohol.2012.01.003_bib20","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.pbb.2006.11.003","article-title":"Neurogenesis decreases during brain maturation from adolescence to adulthood","volume":"86","author":"He","year":"2007","journal-title":"Pharmacology Biochemistry & Behavior"},{"key":"10.1016\/j.alcohol.2012.01.003_bib21","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1111\/j.1460-9568.2005.04120.x","article-title":"Chronic alcohol exposure reduces hippocampal neurogenesis and dendritic growth of newborn neurons","volume":"21","author":"He","year":"2005","journal-title":"European Journal of Neuroscience"},{"key":"10.1016\/j.alcohol.2012.01.003_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2009.07.090","article-title":"The effects of exercise on adolescent hippocampal neurogenesis in a rat model of binge alcohol exposure during the brain growth spurt","volume":"1294","author":"Helfer","year":"2009","journal-title":"Brain Research"},{"key":"10.1016\/j.alcohol.2012.01.003_bib23","doi-asserted-by":"crossref","first-page":"e101","DOI":"10.1371\/journal.pmed.0030101","article-title":"Nicotinamide protects against ethanol-induced apoptotic neurodegeneration in the developing mouse brain","volume":"3","author":"Ieraci","year":"2006","journal-title":"PLoS Med"},{"key":"10.1016\/j.alcohol.2012.01.003_bib24","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.nbd.2007.02.011","article-title":"Single alcohol exposure in early life damages hippocampal stem\/progenitor cells and reduces adult neurogenesis","volume":"26","author":"Ieraci","year":"2007","journal-title":"Neurobiology of Disease"},{"key":"10.1016\/j.alcohol.2012.01.003_bib25","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1126\/science.287.5455.1056","article-title":"Ethanol-induced apoptotic neurodegeneration and fetal alcohol syndrome","volume":"287","author":"Ikonomidou","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.alcohol.2012.01.003_bib26","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1126\/science.283.5398.70","article-title":"Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain","volume":"283","author":"Ikonomidou","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.alcohol.2012.01.003_bib27","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1111\/j.1530-0277.2007.00528.x","article-title":"Persistent impairment of hippocampal neurogenesis in young adult rats following early postnatal alcohol exposure","volume":"31","author":"Klintsova","year":"2007","journal-title":"Alcoholism: Clinical & Experimental Research"},{"key":"10.1016\/j.alcohol.2012.01.003_bib28","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.neubiorev.2006.06.020","article-title":"Defining the behavioral phenotype in children with fetal alcohol spectrum disorders: a review","volume":"31","author":"Kodituwakku","year":"2007","journal-title":"Neuroscience and Biobehavioral Reviews"},{"key":"10.1016\/j.alcohol.2012.01.003_bib29","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1111\/j.1530-0277.2006.00187.x","article-title":"Neurobehavioral characteristics of children with fetal alcohol spectrum disorders in communities from Italy: preliminary results","volume":"30","author":"Kodituwakku","year":"2006","journal-title":"Alcoholism: Clinical & Experimental Research"},{"key":"10.1016\/j.alcohol.2012.01.003_bib30","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1176\/ajp.2007.164.2.205","article-title":"Hippocampal neurogenesis: a matter of survival","volume":"164","author":"Lagace","year":"2007","journal-title":"American Journal of Psychiatry"},{"key":"10.1016\/j.alcohol.2012.01.003_bib31","volume":"7259","author":"Lee","year":"2009"},{"key":"10.1016\/j.alcohol.2012.01.003_bib32","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/j.1530-0277.1998.tb03651.x","article-title":"A\u00a0review of the neurobehavioral deficits in children with fetal alcohol syndrome or prenatal exposure to alcohol","volume":"22","author":"Mattson","year":"1998","journal-title":"Alcoholism: Clinical & Experimental Research"},{"key":"10.1016\/j.alcohol.2012.01.003_bib33","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/S0022-3476(97)70099-4","article-title":"Heavy prenatal alcohol exposure with or without physical features of fetal alcohol syndrome leads to IQ deficits","volume":"131","author":"Mattson","year":"1997","journal-title":"Journal of Pediatrics"},{"key":"10.1016\/j.alcohol.2012.01.003_bib34","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/ddrr.68","article-title":"Prevalence and epidemiologic characteristics of FASD from various research methods with an emphasis on recent in-school studies","volume":"15","author":"May","year":"2009","journal-title":"Developmental Disabilities Research Reviews"},{"key":"10.1016\/j.alcohol.2012.01.003_bib35","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1111\/j.1530-0277.1995.tb01014.x","article-title":"Generation of neurons in the rat dentate gyrus and hippocampus: effects of prenatal and postnatal treatment with ethanol","volume":"19","author":"Miller","year":"1995","journal-title":"Alcoholism: Clinical & Experimental Research"},{"key":"10.1016\/j.alcohol.2012.01.003_bib36","doi-asserted-by":"crossref","first-page":"12343","DOI":"10.1523\/JNEUROSCI.6108-08.2009","article-title":"Novel subtype-specific genes identify distinct subpopulations of callosal projection neurons","volume":"29","author":"Molyneaux","year":"2009","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.alcohol.2012.01.003_bib37","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1046\/j.1471-4159.2002.01214.x","article-title":"Binge ethanol exposure decreases neurogenesis in adult rat hippocampus","volume":"83","author":"Nixon","year":"2002","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/j.alcohol.2012.01.003_bib38","doi-asserted-by":"crossref","first-page":"9714","DOI":"10.1523\/JNEUROSCI.3063-04.2004","article-title":"Temporally specific burst in cell proliferation increases hippocampal neurogenesis in protracted abstinence from alcohol","volume":"24","author":"Nixon","year":"2004","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.alcohol.2012.01.003_bib39","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/ddrr.72","article-title":"Neuroimaging and fetal alcohol spectrum disorders","volume":"15","author":"Norman","year":"2009","journal-title":"Developmental Disabilities Research Reviews"},{"key":"10.1016\/j.alcohol.2012.01.003_bib40","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1002\/bdra.20719","article-title":"Magnetic resonance microscopy-based analyses of the brains of normal and ethanol-exposed fetal mice","volume":"88","author":"O'Leary-Moore","year":"2010","journal-title":"Birth Defects Research. Part A, Clinical and Molecular Teratology"},{"key":"10.1016\/j.alcohol.2012.01.003_bib41","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s11065-011-9164-z","article-title":"Magnetic resonance-based imaging in animal models of fetal alcohol spectrum disorder","volume":"21","author":"O'Leary-Moore","year":"2011","journal-title":"Neuropsychology Review"},{"key":"10.1016\/j.alcohol.2012.01.003_bib42","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1006\/nbdi.2001.0475","article-title":"Ethanol-induced caspase-3 activation in the in\u00a0vivo developing mouse brain","volume":"9","author":"Olney","year":"2002","journal-title":"Neurobiology of Disease"},{"key":"10.1016\/j.alcohol.2012.01.003_bib43","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0165-3806(02)00279-1","article-title":"Ethanol-induced apoptotic neurodegeneration in the developing C57BL\/6 mouse brain","volume":"133","author":"Olney","year":"2005","journal-title":"Brain Research. Developmental Brain Research"},{"key":"10.1016\/j.alcohol.2012.01.003_bib44","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1111\/j.1530-0277.2009.00921.x","article-title":"Magnetic resonance microscopy defines ethanol-induced brain abnormalities in prenatal mice: effects of acute insult on gestational day 8","volume":"33","author":"Parnell","year":"2009","journal-title":"Alcoholism: Clinical & Experimental Research"},{"key":"10.1016\/j.alcohol.2012.01.003_bib45","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/glia.20467","article-title":"Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration","volume":"55","author":"Qin","year":"2007","journal-title":"Glia"},{"key":"10.1016\/j.alcohol.2012.01.003_bib46","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1212\/WNL.57.2.235","article-title":"Mapping callosal morphology and cognitive correlates: effects of heavy prenatal alcohol exposure","volume":"57","author":"Sowell","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.alcohol.2012.01.003_bib47","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1037\/0735-7044.119.2.420","article-title":"Systemic and prefrontal cortical NMDA receptor blockade differentially affect discrimination learning and set-shift ability in rats","volume":"119","author":"Stefani","year":"2005","journal-title":"Behavioral Neuroscience"},{"key":"10.1016\/j.alcohol.2012.01.003_bib48","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1002\/ar.1092310411","article-title":"Unbiased stereological estimation of the total number of neurons in thesubdivisions of the rat hippocampus using the optical fractionator","volume":"231","author":"West","year":"1991","journal-title":"Anatomical Record"}],"container-title":["Alcohol"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741832912000602?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741832912000602?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T20:45:07Z","timestamp":1760042707000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0741832912000602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":48,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["S0741832912000602"],"URL":"https:\/\/doi.org\/10.1016\/j.alcohol.2012.01.003","relation":{},"ISSN":["0741-8329"],"issn-type":[{"value":"0741-8329","type":"print"}],"subject":[],"published":{"date-parts":[[2012,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Postnatal day 7 ethanol treatment causes persistent reductions in adult mouse brain volume and cortical neurons with sex specific effects on neurogenesis","name":"articletitle","label":"Article Title"},{"value":"Alcohol","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.alcohol.2012.01.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}