{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:00:33Z","timestamp":1791846033479,"version":"4.3.4"},"reference-count":44,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alcohol"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1016\/j.alcohol.2012.12.014","type":"journal-article","created":{"date-parts":[[2013,1,26]],"date-time":"2013-01-26T11:47:57Z","timestamp":1359200877000},"page":"215-221","source":"Crossref","is-referenced-by-count":11,"title":["Are brain and heart tissue prone to the development of thiamine deficiency?"],"prefix":"10.1016","volume":"47","author":[{"given":"Astrid","family":"Klooster","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Larkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janneke","family":"Wiersema-Buist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinold O.B.","family":"Gans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Thornalley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerjan","family":"Navis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"van Goor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henri G.D.","family":"Leuvenink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan J.L.","family":"Bakker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.alcohol.2012.12.014_bib1","first-page":"951","article-title":"Blood thiamine and derivatives as measured by high-performance liquid chromatography: levels and associations in DM patients with varying degrees of microalbuminuria","volume":"35","author":"Al-Attas","year":"2012","journal-title":"Journal of Endocrinological Investigation"},{"key":"10.1016\/j.alcohol.2012.12.014_bib2","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s10741-006-9195-3","article-title":"The management of conditioned nutritional requirements in heart failure","volume":"11","author":"Allard","year":"2006","journal-title":"Heart Failure Reviews"},{"key":"10.1016\/j.alcohol.2012.12.014_bib3","doi-asserted-by":"crossref","first-page":"F796","DOI":"10.1152\/ajprenal.00078.2006","article-title":"Thiamine uptake by the human-derived renal epithelial (HEK-293) cells: cellular and molecular mechanisms","volume":"291","author":"Ashokkumar","year":"2006","journal-title":"American Journal of Physiology \u2013 Renal Physiology"},{"key":"10.1016\/j.alcohol.2012.12.014_bib4","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1093\/ajcn\/28.12.1377","article-title":"Inability of chronic alcoholics with liver disease to use food as a source of folates, thiamin and vitamin B6","volume":"28","author":"Baker","year":"1975","journal-title":"The American Journal of Clinical Nutrition"},{"key":"10.1016\/j.alcohol.2012.12.014_bib5","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1007\/s001250051047","article-title":"The association of dietary fibres with glucose tolerance is partly explained by concomitant intake of thiamine: the Hoorn Study","volume":"41","author":"Bakker","year":"1998","journal-title":"Diabetologia"},{"key":"10.1016\/j.alcohol.2012.12.014_bib6","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0306-9877(95)90115-9","article-title":"Hypothesis on cellular ATP depletion and adenosine release as causes of heart failure and vasodilatation in cardiovascular beriberi","volume":"45","author":"Bakker","year":"1995","journal-title":"Medical Hypotheses"},{"key":"10.1016\/j.alcohol.2012.12.014_bib7","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jchromb.2004.11.004","article-title":"Determination of thiamine and its phosphate esters in rat tissues analyzed as thiochromes on a RP-amide C16 column","volume":"816","author":"Batifoulier","year":"2005","journal-title":"Journal of Chromatography B"},{"key":"10.1016\/j.alcohol.2012.12.014_bib8","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/00075197-200303000-00008","article-title":"Metabolic and nutritional support in acute cardiac failure","volume":"6","author":"Berger","year":"2003","journal-title":"Current Opinion in Clinical Nutrition and Metabolic Care"},{"key":"10.1016\/j.alcohol.2012.12.014_bib9","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0303-8467(92)90089-L","article-title":"Similar brain lesions in alcoholics and Korsakoff patients: MRI, psychometric and clinical findings","volume":"94","author":"Blansjaar","year":"1992","journal-title":"Clinical Neurology and Neurosurgery"},{"key":"10.1016\/j.alcohol.2012.12.014_bib10","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1046\/j.1471-4159.1995.64031034.x","article-title":"Heterogenous expression of transketolase in rat brain","volume":"64","author":"Calingasan","year":"1995","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/j.alcohol.2012.12.014_bib11","doi-asserted-by":"crossref","unstructured":"Cardiovascular beriberi. (1982). Lancet 1,\u00a01287.","DOI":"10.1016\/S0140-6736(82)92850-1"},{"key":"10.1016\/j.alcohol.2012.12.014_bib12","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1177\/000456329603300413","article-title":"A\u00a0stable reagent mixture for the whole blood transketolase assay","volume":"33","author":"Chamberlain","year":"1996","journal-title":"Annals of Clinical Biochemistry"},{"key":"10.1016\/j.alcohol.2012.12.014_bib13","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1093\/oxfordjournals.alcalc.a008400","article-title":"B\u00a0vitamin deficiency and neuropsychiatric syndromes in alcohol misuse","volume":"33","author":"Cook","year":"1998","journal-title":"Alcohol and Alcoholism"},{"key":"10.1016\/j.alcohol.2012.12.014_bib14","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1097\/00004728-200303000-00022","article-title":"Wernicke encephalopathy: unusual findings in nonalcoholic patients","volume":"27","author":"Doss","year":"2003","journal-title":"Journal of Computer Assisted Tomography"},{"key":"10.1016\/j.alcohol.2012.12.014_bib15","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/s00424-003-1068-1","article-title":"SLC19: the folate\/thiamine transporter family","volume":"447","author":"Ganapathy","year":"2004","journal-title":"European Journal of Physiology"},{"key":"10.1016\/j.alcohol.2012.12.014_bib16","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/BF00972141","article-title":"Activities of thiamine-dependent enzymes in two experimental models of thiamine deficiency encephalopahty: 3. Transketolase","volume":"12","author":"Gigu\u00e8re","year":"1987","journal-title":"Neurochemical Research"},{"key":"10.1016\/j.alcohol.2012.12.014_bib17","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1038\/nm834","article-title":"Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy","volume":"9","author":"Hammes","year":"2003","journal-title":"Nature Medicine"},{"key":"10.1016\/j.alcohol.2012.12.014_bib18","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1111\/j.1468-1331.2006.01530.x","article-title":"Thiamine (vitamin B1) deficiency and associated brain damage is still common throughout the world and prevention is simple and safe!","volume":"13","author":"Harper","year":"2006","journal-title":"European Journal of Neurology"},{"key":"10.1016\/j.alcohol.2012.12.014_bib19","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/BF01991779","article-title":"An international perspective on the prevalence of the Wernicke-Korsakoff syndrome","volume":"10","author":"Harper","year":"1995","journal-title":"Metabolic Brain Disease"},{"key":"10.1016\/j.alcohol.2012.12.014_bib20","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1136\/jnnp.49.4.341","article-title":"Clinical signs in the Wernicke-Korsakoff complex: a retrospective analysis of 131 cases diagnosed at necropsy","volume":"49","author":"Harper","year":"1986","journal-title":"Journal of Neurology, Neurosurgery, and Psychiatry"},{"key":"10.1016\/j.alcohol.2012.12.014_bib21","doi-asserted-by":"crossref","first-page":"542","DOI":"10.5694\/j.1326-5377.1998.tb139081.x","article-title":"Prevalence of Wernicke-Korsakoff syndrome in Australia: has thiamine fortification made a difference?","volume":"168","author":"Harper","year":"1998","journal-title":"Medical Journal of Australia"},{"key":"10.1016\/j.alcohol.2012.12.014_bib22","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1111\/j.1530-0277.1986.tb05147.x","article-title":"Mechanisms of vitamin deficiencies in alcoholism","volume":"10","author":"Hoyumpa","year":"1986","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1016\/j.alcohol.2012.12.014_bib23","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s10072-008-0859-8","article-title":"Severe dysphagia as the presenting symptom of Wernicke\u2013Korsakoff syndrome in a non-alcoholic man","volume":"29","author":"Karaiskos","year":"2008","journal-title":"Neurological Sciences"},{"key":"10.1016\/j.alcohol.2012.12.014_bib24","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1681\/ASN.2010070750","article-title":"Benfotiamine protects against peritoneal and kidney damage in peritoneal dialysis","volume":"22","author":"Kihm","year":"2011","journal-title":"Journal of the American Society of Nephrology"},{"key":"10.1016\/j.alcohol.2012.12.014_bib25","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1093\/ndtplus\/sfn194","article-title":"Severe thiamine deficiency complicated by weight loss protects against renal ischaemia-reperfusion injury in rats","volume":"2","author":"Klooster","year":"2008","journal-title":"NDT Plus"},{"key":"10.1016\/j.alcohol.2012.12.014_bib26","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1097\/TP.0b013e31817ba53a","article-title":"Brain death induces inflammation in the donor intestine","volume":"86","author":"Koudstaal","year":"2008","journal-title":"Transplantation"},{"key":"10.1016\/j.alcohol.2012.12.014_bib27","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1111\/j.1749-6632.1982.tb31206.x","article-title":"Thiamin deficiency and alcoholism","volume":"378","author":"Leevy","year":"1982","journal-title":"Annals of the New York Academy of Sciences"},{"key":"10.1016\/j.alcohol.2012.12.014_bib28","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1177\/026988110401800321","article-title":"Evidence-based guidelines for the pharmacological management of substance misuse, addiction and comorbidity: recommendations from the British Association for Psychopharmacology","volume":"18","author":"Lingford-Hughes","year":"2004","journal-title":"Journal of Psychopharmacology"},{"key":"10.1016\/j.alcohol.2012.12.014_bib29","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1177\/1533317511432736","article-title":"Role of thiamine in Alheimer's disease","volume":"26","author":"Lu'o'ng","year":"2011","journal-title":"American Journal of Alzheimer's Disease and Other Dementias"},{"key":"10.1016\/j.alcohol.2012.12.014_bib30","doi-asserted-by":"crossref","first-page":"385","DOI":"10.3177\/jnsv.23.385","article-title":"Effect of thiamine deficiency pyrithiamine and oxythiamine on pyruvate metabolism in rat liver and brain in\u00a0vivo","volume":"23","author":"Meghal","year":"1977","journal-title":"Journal of Nutritional Science and Vitaminology"},{"key":"10.1016\/j.alcohol.2012.12.014_bib31","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1177\/0148607194018002104","article-title":"Nutritional and metabolic characterization of a thiamine deficient rat model","volume":"18","author":"Molina","year":"1994","journal-title":"Journal of Parenteral and Enteral Nutrition"},{"key":"10.1016\/j.alcohol.2012.12.014_bib32","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1080\/07315724.1994.10718372","article-title":"Thiamin status of the elderly: dietary intake and thiamin pyrophosphate response","volume":"13","author":"Nichols","year":"1994","journal-title":"Journal of the American College of Nutrition"},{"key":"10.1016\/j.alcohol.2012.12.014_bib33","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1056\/NEJM198504183121606","article-title":"Current concepts. Wernicke's encephalopathy","volume":"312","author":"Reuler","year":"1985","journal-title":"The New England Journal of Medicine"},{"key":"10.1016\/j.alcohol.2012.12.014_bib34","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s00392-011-0376-2","article-title":"Thiamine supplementation in symptomatic chronic heart failure: a randomized, double-blind, placebo-controlled, cross-over pilot study","volume":"101","author":"Schoenenberger","year":"2012","journal-title":"Clinical Research in Cardiology"},{"key":"10.1016\/j.alcohol.2012.12.014_bib35","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/S1474-4422(07)70104-7","article-title":"Wernicke's encephalopathy: new clinical settings and recent advances in diagnosis and management","volume":"6","author":"Sechi","year":"2007","journal-title":"The Lancet Neurology"},{"key":"10.1016\/j.alcohol.2012.12.014_bib36","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1046\/j.1471-4159.1996.67020684.x","article-title":"Regional reductions of transketolase in thiamine deficient rat brain","volume":"67","author":"Sheu","year":"1996","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/j.alcohol.2012.12.014_bib37","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0002-9343(99)80349-0","article-title":"Improved left ventricular function after thiamine supplementation in patients with congestive heart failure receiving long-term furosemide therapy","volume":"98","author":"Shimon","year":"1995","journal-title":"American Journal of Medicine"},{"key":"10.1016\/j.alcohol.2012.12.014_bib38","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1177\/0884533611426149","article-title":"Thiamine in nutrition therapy","volume":"27","author":"Sriram","year":"2012","journal-title":"Nutrition in Clinical Practice"},{"key":"10.1016\/j.alcohol.2012.12.014_bib39","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1055\/s-2001-17399","article-title":"Efficacy of benfotiamine versus thiamine of function and glycation products of peripheral nerves in diabetic rats","volume":"109","author":"Stracke","year":"2001","journal-title":"Experimental and Clinical Endocrinology and Diabetes"},{"key":"10.1016\/j.alcohol.2012.12.014_bib40","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1093\/alcalc\/35.Supplement_1.2","article-title":"Mechanisms of vitamin deficiency in chronic alcohol misusers and the development of the Wernicke-Korsakoff syndrome","volume":"35","author":"Thomson","year":"2000","journal-title":"Alcohol and Alcoholism \u2013 Supplements"},{"key":"10.1016\/j.alcohol.2012.12.014_bib41","first-page":"1866","article-title":"Putting thiamine in beer: comments on Truswell's editorial","volume":"95","author":"Thomson","year":"2000","journal-title":"Addiction"},{"key":"10.1016\/j.alcohol.2012.12.014_bib42","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1093\/alcalc\/37.6.513","article-title":"The Royal College of Physicians report on alcohol: guidelines for managing Wernicke's encephalopathy in the accident and Emergency Department","volume":"37","author":"Thomson","year":"2002","journal-title":"Alcohol and Alcoholism"},{"key":"10.1016\/j.alcohol.2012.12.014_bib43","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1007\/s00125-007-0771-4","article-title":"High prevalence of low plasma thiamine concentration in diabetes linked to a marker of vascular disease","volume":"50","author":"Thornalley","year":"2007","journal-title":"Diabetologia"},{"key":"10.1016\/j.alcohol.2012.12.014_bib44","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0022-510X(82)90145-9","article-title":"Brain lesions in alcoholics. A neuropathological study with clinical correlations","volume":"56","author":"Torvik","year":"1982","journal-title":"Journal of the Neurological Sciences"}],"container-title":["Alcohol"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S074183291200211X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S074183291200211X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T22:55:09Z","timestamp":1562626509000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S074183291200211X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["S074183291200211X"],"URL":"https:\/\/doi.org\/10.1016\/j.alcohol.2012.12.014","relation":{},"ISSN":["0741-8329"],"issn-type":[{"value":"0741-8329","type":"print"}],"subject":[],"published":{"date-parts":[[2013,5]]}}}