{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T20:46:52Z","timestamp":1789937212324,"version":"4.0.1"},"reference-count":33,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Alcohol"],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1016\/j.alcohol.2013.05.004","type":"journal-article","created":{"date-parts":[[2013,7,18]],"date-time":"2013-07-18T21:30:14Z","timestamp":1374183014000},"page":"459-465","source":"Crossref","is-referenced-by-count":39,"title":["Toll-like receptor 4 increases intestinal permeability through up-regulation of membrane PKC activity in alcoholic steatohepatitis"],"prefix":"10.1016","volume":"47","author":[{"given":"Xin","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youqing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.alcohol.2013.05.004_bib1","doi-asserted-by":"crossref","first-page":"38480","DOI":"10.1074\/jbc.M104923200","article-title":"Protein kinase C regulates the phosphorylation and cellular localization of occludin","volume":"276","author":"Andreeva","year":"2001","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.alcohol.2013.05.004_bib2","first-page":"1075","article-title":"Ethanol-induced barrier dysfunction and its prevention by growth factors in human intestinal monolayers: evidence for oxidative and cytoskeletal mechanisms","volume":"291","author":"Banan","year":"1999","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.alcohol.2013.05.004_bib3","doi-asserted-by":"crossref","first-page":"e43","DOI":"10.1111\/j.1440-1746.2007.05080.x","article-title":"Functional and morphological alterations in small intestine mucosa of chronic alcoholics","volume":"23","author":"Bhonchal","year":"2008","journal-title":"Journal of Gastroenterology and Hepatology"},{"key":"10.1016\/j.alcohol.2013.05.004_bib4","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1111\/j.1365-2982.2009.01361.x","article-title":"Understanding measurements of intestinal permeability in healthy humans with urine lactulose and mannitol excretion","volume":"22","author":"Camilleri","year":"2010","journal-title":"Neurogastroenterology and Motility"},{"issue":"Pt 18","key":"10.1016\/j.alcohol.2013.05.004_bib5","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.1242\/jcs.113.18.3187","article-title":"Protein kinase C activation leads to dephosphorylation of occludin and tight junction permeability increase in LLC-PK1 epithelial cell sheets","volume":"113","author":"Clarke","year":"2000","journal-title":"Journal of Cell Science"},{"key":"10.1016\/j.alcohol.2013.05.004_bib6","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1189\/jlb.0106053","article-title":"Endotoxin tolerance attenuates LPS-induced TLR4 mobilization to lipid rafts: a condition reversed by PKC activation","volume":"80","author":"Cuschieri","year":"2006","journal-title":"Journal of Leukocyte Biology"},{"key":"10.1016\/j.alcohol.2013.05.004_bib7","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/s10620-006-3193-0","article-title":"Attenuation of colonic inflammation by PPAR\u03b3 in intestinal epithelial cells: effect on toll-like receptor pathway","volume":"51","author":"Eun","year":"2006","journal-title":"Digestive Diseases and Sciences"},{"key":"10.1016\/j.alcohol.2013.05.004_bib8","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1046\/j.1440-1746.2003.03032.x","article-title":"Intestinal barrier: an interface between health and disease","volume":"18","author":"Farhadi","year":"2003","journal-title":"Journal of Gastroenterology and Hepatology"},{"key":"10.1016\/j.alcohol.2013.05.004_bib9","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1042\/BST0351473","article-title":"TLR4 signalling in the intestine in health and disease","volume":"35","author":"Fukata","year":"2007","journal-title":"Biochemical Society Transactions"},{"key":"10.1016\/j.alcohol.2013.05.004_bib10","first-page":"941","article-title":"Chromogenic endotoxin assay in plasma. Selection of plasma pretreatment and production of standard curves","volume":"27","author":"Fukui","year":"1989","journal-title":"Journal of Clinical Chemistry & Clinical Biochemistry"},{"key":"10.1016\/j.alcohol.2013.05.004_bib11","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jaci.2009.05.038","article-title":"Intestinal barrier function: molecular regulation and disease pathogenesis","volume":"124","author":"Groschwitz","year":"2009","journal-title":"Journal of Allergy and Clinical Immunology"},{"key":"10.1016\/j.alcohol.2013.05.004_bib12","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1097\/MPG.0b013e3181eb3128","article-title":"Intestinal mucosal permeability of severely underweight and nonmalnourished Bangladeshi children and effects of nutritional rehabilitation","volume":"51","author":"Hossain","year":"2010","journal-title":"Journal of Pediatric Gastroenterology and Nutrition"},{"key":"10.1016\/j.alcohol.2013.05.004_bib13","first-page":"1509","article-title":"Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice","volume":"35","author":"Inokuchi","year":"2011","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1016\/j.alcohol.2013.05.004_bib14","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.jhep.2008.10.028","article-title":"Evidence that chronic alcohol exposure promotes intestinal oxidative stress, intestinal hyperpermeability and endotoxemia prior to development of alcoholic steatohepatitis in rats","volume":"50","author":"Keshavarzian","year":"2009","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.alcohol.2013.05.004_bib15","first-page":"186","article-title":"Clottable protein in Limulus; its localization and kinetics of its coagulation by endotoxin","volume":"19","author":"Levin","year":"1968","journal-title":"Thrombosis et Diathesis Haemorrhagica"},{"key":"10.1016\/j.alcohol.2013.05.004_bib16","first-page":"197","article-title":"Liquid diet technique of ethanol administration: 1989 update","volume":"24","author":"Lieber","year":"1989","journal-title":"Alcohol and Alcoholism"},{"key":"10.1016\/j.alcohol.2013.05.004_bib17","doi-asserted-by":"crossref","first-page":"G250","DOI":"10.1152\/ajpgi.2000.279.2.G250","article-title":"Molecular physiology and pathophysiology of tight junctions I. Tight junction structure and function: lessons from mutant animals and proteins","volume":"279","author":"Mitic","year":"2000","journal-title":"American Journal of Physiology \u2013 Gastrointestinal and Liver Physiology"},{"key":"10.1016\/j.alcohol.2013.05.004_bib18","first-page":"3254","article-title":"Intestinal alkaline phosphatase in the colonic mucosa of children with inflammatory bowel disease","volume":"18","author":"Moln\u00e1r","year":"2012","journal-title":"World Journal of Gastroenterology"},{"key":"10.1016\/j.alcohol.2013.05.004_bib19","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1006\/excr.1996.0244","article-title":"Chronic exposure of LLC-PK1 epithelia to the phorbol ester TPA produces polyp-like foci with leaky tight junctions and altered protein kinase C-alpha expression and localization","volume":"227","author":"Mullin","year":"1996","journal-title":"Experimental Cell Research"},{"key":"10.1016\/j.alcohol.2013.05.004_bib20","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1111\/j.1530-0277.2009.01022.x","article-title":"Intestinal dysbiosis: a possible mechanism of alcohol-induced endotoxemia and alcoholic steatohepatitis in rats","volume":"33","author":"Mutlu","year":"2009","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1016\/j.alcohol.2013.05.004_bib21","doi-asserted-by":"crossref","first-page":"453","DOI":"10.2131\/jts.32.453","article-title":"Common pathogenic mechanism in development progression of liver injury caused by non-alcoholic or alcoholic steatohepatitis","volume":"32","author":"Nagata","year":"2007","journal-title":"Journal of Toxicological Sciences"},{"key":"10.1016\/j.alcohol.2013.05.004_bib22","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.4049\/jimmunol.164.4.2151","article-title":"Role of p38 mitogen-activated protein kinase in a murine model of pulmonary inflammation","volume":"164","author":"Nick","year":"2000","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.alcohol.2013.05.004_bib23","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/1471-230X-11-109","article-title":"Increased intestinal permeability and tight junction disruption by altered expression and localization of occludin in a murine graft versus host disease model","volume":"11","author":"Noth","year":"2011","journal-title":"BMC Gastroenterology"},{"key":"10.1016\/j.alcohol.2013.05.004_bib24","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.surg.2008.01.005","article-title":"Deletion of toll-like receptor-4 downregulates protein kinase C-zeta and attenuates liver injury in experimental pancreatitis","volume":"143","author":"Peng","year":"2008","journal-title":"Surgery"},{"key":"10.1016\/j.alcohol.2013.05.004_bib25","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.alcohol.2008.03.131","article-title":"Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: summary of a symposium","volume":"42","author":"Purohit","year":"2008","journal-title":"Alcohol"},{"key":"10.1016\/j.alcohol.2013.05.004_bib26","doi-asserted-by":"crossref","first-page":"30","DOI":"10.2133\/dmpk.DMPK-10-RV-087","article-title":"Progression of alcoholic and non-alcoholic steatohepatitis: common metabolic aspects of innate immune system and oxidative stress","volume":"26","author":"Sakaguchi","year":"2011","journal-title":"Drug Metabolism and Pharmacokinetics"},{"key":"10.1016\/j.alcohol.2013.05.004_bib27","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1084\/jem.20071990","article-title":"TLR4-induced IFN-\u03b3 production increases TLR2 sensitivity and drives Gram-negative sepsis in mice","volume":"205","author":"Spiller","year":"2008","journal-title":"Journal of Experimental Medicine"},{"key":"10.1016\/j.alcohol.2013.05.004_bib28","doi-asserted-by":"crossref","first-page":"3574","DOI":"10.1074\/jbc.M709141200","article-title":"Role of phospholipase Cgamma-induced activation of protein kinase Cepsilon (PKCepsilon) and PKCbetaI in epidermal growth factor-mediated protection of tight junctions from acetaldehyde in Caco-2 cell monolayers","volume":"283","author":"Suzuki","year":"2008","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.alcohol.2013.05.004_bib29","first-page":"4855","article-title":"Mechanism for maintaining homeostasis in the immune system of the intestine","volume":"29","author":"Taniguchi","year":"2009","journal-title":"Anticancer Research"},{"key":"10.1016\/j.alcohol.2013.05.004_bib30","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1053\/jhep.2001.29400","article-title":"Delivery of IkappaB superrepressor gene with adenovirus reduces early alcohol-induced liver injury in rats","volume":"34","author":"Uesugi","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.alcohol.2013.05.004_bib31","doi-asserted-by":"crossref","first-page":"G32","DOI":"10.1152\/ajpgi.00024.2012","article-title":"Lactobacillus rhamnosus GG culture supernatant ameliorates acute alcohol-induced intestinal permeability and liver injury","volume":"303","author":"Wang","year":"2012","journal-title":"American Journal of Physiology \u2013 Gastrointestinal and Liver Physiology"},{"key":"10.1016\/j.alcohol.2013.05.004_bib32","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.dld.2009.10.007","article-title":"Toll-like receptor 4 participates in gastric mucosal protection through Cox-2 and PGE2","volume":"42","author":"Zhang","year":"2010","journal-title":"Digestive and Liver Disease"},{"key":"10.1016\/j.alcohol.2013.05.004_bib33","doi-asserted-by":"crossref","first-page":"G625","DOI":"10.1152\/ajpgi.00350.2009","article-title":"The role of zinc deficiency in alcohol-induced intestinal barrier dysfunction","volume":"298","author":"Zhong","year":"2010","journal-title":"American Journal of Physiology \u2013 Gastrointestinal and Liver Physiology"}],"container-title":["Alcohol"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741832913000748?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741832913000748?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T00:25:43Z","timestamp":1715732743000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0741832913000748"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["S0741832913000748"],"URL":"https:\/\/doi.org\/10.1016\/j.alcohol.2013.05.004","relation":{},"ISSN":["0741-8329"],"issn-type":[{"value":"0741-8329","type":"print"}],"subject":[],"published":{"date-parts":[[2013,9]]}}}