{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:15:24Z","timestamp":1789085724613,"version":"build-2803163510"},"reference-count":127,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","alcoholjournal.org","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Alcohol"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1016\/j.alcohol.2014.07.021","type":"journal-article","created":{"date-parts":[[2014,11,17]],"date-time":"2014-11-17T03:35:03Z","timestamp":1416195303000},"page":"389-398","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":63,"title":["Circadian rhythms, alcohol and gut interactions"],"prefix":"10.1016","volume":"49","author":[{"given":"Christopher B.","family":"Forsyth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin M.","family":"Voigt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen J.","family":"Burgess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garth R.","family":"Swanson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Keshavarzian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.alcohol.2014.07.021_bib1","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.freeradbiomed.2013.09.009","article-title":"CYP2E1 potentiates binge alcohol-induced gut leakiness, steatohepatitis, and apoptosis","volume":"65","author":"Abdelmegeed","year":"2013","journal-title":"Free Radical Biology & Medicine"},{"key":"10.1016\/j.alcohol.2014.07.021_bib2","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/0016-5085(95)90027-6","article-title":"Antibiotics prevent liver injury in rats following long-term exposure to ethanol","volume":"108","author":"Adachi","year":"1995","journal-title":"Gastroenterology"},{"key":"10.1016\/j.alcohol.2014.07.021_bib3","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.beem.2010.08.003","article-title":"Circadian disruption and metabolic disease: findings from animal models","volume":"24","author":"Arble","year":"2010","journal-title":"Best Practice & Research. Clinical Endocrinology & Metabolism"},{"key":"10.1016\/j.alcohol.2014.07.021_bib4","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.alcohol.2007.07.003","article-title":"NF-kappaB activation as a key mechanism in ethanol-induced disruption of the F-actin cytoskeleton and monolayer barrier integrity in intestinal epithelium","volume":"41","author":"Banan","year":"2007","journal-title":"Alcohol"},{"key":"10.1016\/j.alcohol.2014.07.021_bib5","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1126\/science.1195027","article-title":"Circadian integration of metabolism and energetics","volume":"330","author":"Bass","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.alcohol.2014.07.021_bib6","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/nrg1633","article-title":"Circadian rhythms from multiple oscillators: lessons from diverse organisms","volume":"6","author":"Bell-Pedersen","year":"2005","journal-title":"Nature Reviews. Genetics"},{"key":"10.1016\/j.alcohol.2014.07.021_bib7","doi-asserted-by":"crossref","first-page":"9897","DOI":"10.1073\/pnas.1120636110","article-title":"Circadian clock regulates the host response to Salmonella","volume":"110","author":"Bellet","year":"2013","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.alcohol.2014.07.021_bib8","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1472-6904-5-4","article-title":"Distribution of cytochrome P450 2C, 2E1, 3A4, and 3A5 in human colon mucosa","volume":"5","author":"Bergheim","year":"2005","journal-title":"BMC Clinical Pharmacology"},{"key":"10.1016\/j.alcohol.2014.07.021_bib9","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0140-6736(84)92109-3","article-title":"The leaky gut of alcoholism: possible route of entry for toxic compounds","volume":"1","author":"Bjarnason","year":"1984","journal-title":"Lancet"},{"key":"10.1016\/j.alcohol.2014.07.021_bib10","doi-asserted-by":"crossref","first-page":"11174","DOI":"10.1158\/0008-5472.CAN-05-1945","article-title":"Melatonin-depleted blood from premenopausal women exposed to light at night stimulates growth of human breast cancer xenografts in nude rats","volume":"65","author":"Blask","year":"2005","journal-title":"Cancer Research"},{"issue":"11 Suppl.","key":"10.1016\/j.alcohol.2014.07.021_bib11","doi-asserted-by":"crossref","first-page":"166S","DOI":"10.1097\/01.alc.0000189280.19073.28","article-title":"Activation of the innate immune system and alcoholic liver disease: effects of ethanol per se or enhanced intestinal translocation of bacterial toxins induced by ethanol?","volume":"29","author":"Bode","year":"2005","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1016\/j.alcohol.2014.07.021_bib12","doi-asserted-by":"crossref","first-page":"e4882","DOI":"10.1371\/journal.pone.0004882","article-title":"Regulation of clock-controlled genes in mammals","volume":"4","author":"Bozek","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.alcohol.2014.07.021_bib13","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1046\/j.1471-4159.2003.02300.x","article-title":"Chronic ethanol consumption impairs the circadian rhythm of pro-opiomelanocortin and period genes mRNA expression in the hypothalamus of the male rat","volume":"88","author":"Chen","year":"2004","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/j.alcohol.2014.07.021_bib14","doi-asserted-by":"crossref","first-page":"237","DOI":"10.5009\/gnl.2014.8.3.237","article-title":"Host-microbiome interactions in alcoholic liver disease","volume":"8","author":"Chen","year":"2014","journal-title":"Gut and Liver"},{"issue":"Suppl. 1","key":"10.1016\/j.alcohol.2014.07.021_bib15","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3109\/15622975.2011.598389","article-title":"Chronotherapeutics and psychiatry: setting the clock to relieve the symptoms","volume":"12","author":"Coogan","year":"2011","journal-title":"The World Journal of Biological Psychiatry"},{"key":"10.1016\/j.alcohol.2014.07.021_bib16","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.immuni.2014.02.002","article-title":"Circadian clock proteins and immunity","volume":"40","author":"Curtis","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.alcohol.2014.07.021_bib17","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1093\/sleep\/27.8.1453","article-title":"Shift work sleep disorder: prevalence and consequences beyond that of symptomatic day workers","volume":"27","author":"Drake","year":"2004","journal-title":"Sleep"},{"key":"10.1016\/j.alcohol.2014.07.021_bib18","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/nure.12027","article-title":"Ethanol metabolism and its effects on the intestinal epithelial barrier","volume":"71","author":"Elamin","year":"2013","journal-title":"Nutrition Reviews"},{"issue":"15 Suppl.","key":"10.1016\/j.alcohol.2014.07.021_bib19","doi-asserted-by":"crossref","first-page":"D20","DOI":"10.1046\/j.1440-1746.2000.02179.x","article-title":"Role of Kupffer cells and gut-derived endotoxins in alcoholic liver injury","author":"Enomoto","year":"2000","journal-title":"Journal of Gastroenterology and Hepatology"},{"key":"10.1016\/j.alcohol.2014.07.021_bib20","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1046\/j.1440-1746.2003.03032.x","article-title":"Intestinal barrier: an interface between health and disease","volume":"18","author":"Farhadi","year":"2003","journal-title":"Journal of Gastroenterology and Hepatology"},{"key":"10.1016\/j.alcohol.2014.07.021_bib21","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jchromb.2006.03.046","article-title":"Resolution of common dietary sugars from probe sugars for test of intestinal permeability using capillary column gas chromatography","volume":"836","author":"Farhadi","year":"2006","journal-title":"Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences"},{"key":"10.1016\/j.alcohol.2014.07.021_bib22","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.alcohol.2008.12.009","article-title":"Lactobacillus GG treatment ameliorates alcohol-induced intestinal oxidative stress, gut leakiness, and liver injury in a rat model of alcoholic steatohepatitis","volume":"43","author":"Forsyth","year":"2009","journal-title":"Alcohol"},{"key":"10.1016\/j.alcohol.2014.07.021_bib23","first-page":"1635","article-title":"Role of snail activation in alcohol-induced iNOS-mediated disruption of intestinal epithelial cell permeability","volume":"35","author":"Forsyth","year":"2011","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1016\/j.alcohol.2014.07.021_bib24","doi-asserted-by":"crossref","first-page":"G185","DOI":"10.1152\/ajpgi.00354.2012","article-title":"Role for intestinal CYP2E1 in alcohol-induced circadian gene-mediated intestinal hyperpermeability","volume":"305","author":"Forsyth","year":"2013","journal-title":"American Journal of Physiology. Gastrointestinal and Liver Physiology"},{"issue":"5 Suppl.","key":"10.1016\/j.alcohol.2014.07.021_bib25","doi-asserted-by":"crossref","first-page":"14S","DOI":"10.1177\/0148607111413772","article-title":"Gut microbiota, intestinal permeability, obesity-induced inflammation, and liver injury. JPEN","volume":"35","author":"Frazier","year":"2011","journal-title":"Journal of Parenteral and Enteral Nutrition"},{"key":"10.1016\/j.alcohol.2014.07.021_bib26","doi-asserted-by":"crossref","first-page":"7","DOI":"10.18632\/aging.100116","article-title":"Effect of feeding regimens on circadian rhythms: implications for aging and longevity","volume":"2","author":"Froy","year":"2010","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.alcohol.2014.07.021_bib27","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1161\/01.HYP.0000217362.34748.e0","article-title":"Short sleep duration as a risk factor for hypertension: analyses of the first National Health and Nutrition Examination Survey","volume":"47","author":"Gangwisch","year":"2006","journal-title":"Hypertension"},{"key":"10.1016\/j.alcohol.2014.07.021_bib28","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1136\/gut.2006.117176","article-title":"Probiotic treatment of rat pups normalises corticosterone release and ameliorates colonic dysfunction induced by maternal separation","volume":"56","author":"Gareau","year":"2007","journal-title":"Gut"},{"key":"10.1016\/j.alcohol.2014.07.021_bib29","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.jphysparis.2013.03.007","article-title":"The times they're a-changing: effects of circadian desynchronization on physiology and disease","volume":"107","author":"Golombek","year":"2013","journal-title":"Journal of Physiology, Paris"},{"key":"10.1016\/j.alcohol.2014.07.021_bib30","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1055\/s-2008-1040525","article-title":"Epidemiology of alcoholic liver disease","volume":"8","author":"Grant","year":"1988","journal-title":"Seminars in Liver Disease"},{"key":"10.1016\/j.alcohol.2014.07.021_bib31","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1093\/ajcn\/26.8.831","article-title":"Distribution of ethanol in the human gastrointestinal tract","volume":"26","author":"Halsted","year":"1973","journal-title":"The American Journal of Clinical Nutrition"},{"key":"10.1016\/j.alcohol.2014.07.021_bib32","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/nrn1177","article-title":"A\u00a0clockwork web: circadian timing in brain and periphery, in health and disease","volume":"4","author":"Hastings","year":"2003","journal-title":"Nature Reviews. Neuroscience"},{"key":"10.1016\/j.alcohol.2014.07.021_bib33","doi-asserted-by":"crossref","first-page":"67","DOI":"10.2174\/1871530314666140207103335","article-title":"Abundance and diversity of GI microbiota rather than IgG4 levels correlate with abdominal inconvenience and gut permeability in consumers claiming food intolerances","volume":"14","author":"Hippe","year":"2014","journal-title":"Endocrine, Metabolic & Immune Disorder Drug Targets"},{"key":"10.1016\/j.alcohol.2014.07.021_bib34","doi-asserted-by":"crossref","first-page":"15747","DOI":"10.1073\/pnas.0705614104","article-title":"Circadian control by the reduction\/oxidation pathway: catalase represses light-dependent clock gene expression in the zebrafish","volume":"104","author":"Hirayama","year":"2007","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.alcohol.2014.07.021_bib35","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s11154-009-9119-3","article-title":"Role of biological rhythms in gastrointestinal health and disease","volume":"10","author":"Hoogerwerf","year":"2009","journal-title":"Reviews in Endocrine & Metabolic Disorders"},{"key":"10.1016\/j.alcohol.2014.07.021_bib36","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1053\/j.gastro.2007.07.009","article-title":"Clock gene expression in the murine gastrointestinal tract: endogenous rhythmicity and effects of a feeding regimen","volume":"133","author":"Hoogerwerf","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.alcohol.2014.07.021_bib37","doi-asserted-by":"crossref","first-page":"G143","DOI":"10.1152\/ajpgi.00402.2009","article-title":"Rhythmic changes in colonic motility are regulated by period genes","volume":"298","author":"Hoogerwerf","year":"2010","journal-title":"American Journal of Physiology. Gastrointestinal and Liver Physiology"},{"key":"10.1016\/j.alcohol.2014.07.021_bib38","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1053\/j.gastro.2008.08.048","article-title":"Transcriptional profiling of mRNA expression in the mouse distal colon","volume":"135","author":"Hoogerwerf","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.alcohol.2014.07.021_bib39","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.micinf.2013.07.004","article-title":"The role of diet in triggering human inflammatory disorders in the modern age","volume":"15","author":"Huang","year":"2013","journal-title":"Microbes and Infection"},{"key":"10.1016\/j.alcohol.2014.07.021_bib40","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.addr.2010.06.002","article-title":"Chronotherapy and the molecular clock: clinical implications in oncology","volume":"62","author":"Innominato","year":"2010","journal-title":"Advanced Drug Delivery Reviews"},{"key":"10.1016\/j.alcohol.2014.07.021_bib41","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1007\/s11096-013-9749-0","article-title":"Timing is important in medication administration: a timely review of chronotherapy research","volume":"35","author":"Kaur","year":"2013","journal-title":"International Journal of Clinical Pharmacology"},{"key":"10.1016\/j.alcohol.2014.07.021_bib42","article-title":"Early life events influence whole-of-life metabolic health via gut microflora and gut permeability","author":"Kerr","year":"2014","journal-title":"Critical Reviews in Microbiology"},{"key":"10.1016\/j.alcohol.2014.07.021_bib43","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/S0022-3565(24)29249-1","article-title":"Preventing gut leakiness by oats supplementation ameliorates alcohol-induced liver damage in rats","volume":"299","author":"Keshavarzian","year":"2001","journal-title":"The Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.alcohol.2014.07.021_bib44","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.jhep.2008.10.028","article-title":"Evidence that chronic alcohol exposure promotes intestinal oxidative stress, intestinal hyperpermeability and endotoxemia prior to development of alcoholic steatohepatitis in rats","volume":"50","author":"Keshavarzian","year":"2009","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.alcohol.2014.07.021_bib45","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/j.1572-0241.1999.00797.x","article-title":"Leaky gut in alcoholic cirrhosis: a possible mechanism for alcohol-induced liver damage","volume":"94","author":"Keshavarzian","year":"1999","journal-title":"The American Journal of Gastroenterology"},{"key":"10.1016\/j.alcohol.2014.07.021_bib46","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.alcohol.2008.08.006","article-title":"Probiotics restore bowel flora and improve liver enzymes in human alcohol-induced liver injury: a pilot study","volume":"42","author":"Kirpich","year":"2008","journal-title":"Alcohol"},{"key":"10.1016\/j.alcohol.2014.07.021_bib47","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1001\/archinte.166.16.1768","article-title":"Role of sleep duration and quality in the risk and severity of type 2 diabetes mellitus","volume":"166","author":"Knutson","year":"2006","journal-title":"Archives of Internal Medicine"},{"key":"10.1016\/j.alcohol.2014.07.021_bib48","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1093\/occmed\/kqg048","article-title":"Health disorders of shift workers","volume":"53","author":"Knutsson","year":"2003","journal-title":"Occupational Medicine (Oxford, England)"},{"key":"10.1016\/j.alcohol.2014.07.021_bib49","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1126\/science.1226339","article-title":"Transcriptional architecture and chromatin landscape of the core circadian clock in mammals","volume":"338","author":"Koike","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.alcohol.2014.07.021_bib50","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/iub.1160","article-title":"Circadian events in human diseases and in cytochrome P450-related drug metabolism and therapy","volume":"65","author":"Ko\u0161ir","year":"2013","journal-title":"IUBMB Life"},{"key":"10.1016\/j.alcohol.2014.07.021_bib51","doi-asserted-by":"crossref","first-page":"e98016","DOI":"10.1371\/journal.pone.0098016","article-title":"Expressions of tight junction proteins Occludin and Claudin-1 are under the circadian control in the mouse large intestine: implications in intestinal permeability and susceptibility to colitis","volume":"9","author":"Kyoko","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.alcohol.2014.07.021_bib52","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1081\/DMR-200033441","article-title":"The discovery of the microsomal ethanol oxidizing system and its physiologic and pathologic role","volume":"36","author":"Lieber","year":"2004","journal-title":"Drug Metabolism Reviews"},{"key":"10.1016\/j.alcohol.2014.07.021_bib53","doi-asserted-by":"crossref","first-page":"R570","DOI":"10.1016\/j.cub.2012.06.023","article-title":"Circadian biology: a 2.5 billion year old clock","volume":"22","author":"Loudon","year":"2012","journal-title":"Current Biology"},{"key":"10.1016\/j.alcohol.2014.07.021_bib54","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/B978-0-12-387690-4.00006-4","article-title":"Genetics of circadian rhythms in mammalian model organisms","volume":"74","author":"Lowrey","year":"2011","journal-title":"Advances in Genetics"},{"key":"10.1016\/j.alcohol.2014.07.021_bib55","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.freeradbiomed.2007.11.004","article-title":"CYP2E1 and oxidative liver injury by alcohol","volume":"44","author":"Lu","year":"2008","journal-title":"Free Radical Biology & Medicine"},{"key":"10.1016\/j.alcohol.2014.07.021_bib56","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s12263-009-0150-5","article-title":"CYP2E1 potentiation of LPS and TNF\u03b1-induced hepatotoxicity by mechanisms involving enhanced oxidative and nitrosative stress, activation of MAP kinases, and mitochondrial dysfunction","volume":"5","author":"Lu","year":"2010","journal-title":"Genes & Nutrition"},{"key":"10.1016\/j.alcohol.2014.07.021_bib57","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1016\/j.freeradbiomed.2010.07.026","article-title":"Chronic alcohol-induced liver injury and oxidant stress are decreased in cytochrome P4502E1 knockout mice and restored in humanized cytochrome P4502E1 knock-in mice","volume":"49","author":"Lu","year":"2010","journal-title":"Free Radical Biology & Medicine"},{"key":"10.1016\/j.alcohol.2014.07.021_bib58","doi-asserted-by":"crossref","first-page":"G461","DOI":"10.1152\/ajpgi.00369.2011","article-title":"Circadian rhythms of gastrointestinal function are regulated by both central and peripheral oscillators","volume":"303","author":"Malloy","year":"2012","journal-title":"American Journal of Physiology. Gastrointestinal and Liver Physiology"},{"key":"10.1016\/j.alcohol.2014.07.021_bib59","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1007\/s11882-013-0404-6","article-title":"Role of \u201cWestern diet\u201d in inflammatory autoimmune diseases","volume":"14","author":"Manzel","year":"2014","journal-title":"Current Allergy and Asthma Reports"},{"key":"10.1016\/j.alcohol.2014.07.021_bib60","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1161\/CIRCRESAHA.109.208355","article-title":"Circadian rhythms and metabolic syndrome: from experimental genetics to human disease","volume":"106","author":"Maury","year":"2010","journal-title":"Circulation Research"},{"key":"10.1016\/j.alcohol.2014.07.021_bib61","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1101\/sqb.2007.72.031","article-title":"Role for the clock gene in bipolar disorder","volume":"72","author":"McClung","year":"2007","journal-title":"Cold Spring Harbor Symposia on Quantitative Biology"},{"key":"10.1016\/j.alcohol.2014.07.021_bib62","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.neuroscience.2009.08.020","article-title":"Ethanol modulates mammalian circadian clock phase resetting through extrasynaptic GABA receptor activation","volume":"164","author":"McElroy","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.alcohol.2014.07.021_bib63","doi-asserted-by":"crossref","first-page":"154","DOI":"10.3389\/fgene.2014.00154","article-title":"Fetal alcohol spectrum disorders and their transmission through genetic and epigenetic mechanisms","volume":"5","author":"Mead","year":"2014","journal-title":"Frontiers in Genetics"},{"key":"10.1016\/j.alcohol.2014.07.021_bib64","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/j.ejca.2005.05.010","article-title":"Night work and breast cancer risk: a systematic review and meta-analysis","volume":"41","author":"Megdal","year":"2005","journal-title":"European Journal of Cancer"},{"key":"10.1016\/j.alcohol.2014.07.021_bib65","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/j.cub.2004.07.055","article-title":"Circadian clock mutation disrupts estrous cyclicity and maintenance of pregnancy","volume":"14","author":"Miller","year":"2004","journal-title":"Current Biology"},{"key":"10.1016\/j.alcohol.2014.07.021_bib66","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0091-3057(92)90652-V","article-title":"Ethanol and circadian rhythms in the Syrian hamster: effects on entrained phase, reentrainment rate, and period","volume":"43","author":"Mistlberger","year":"1992","journal-title":"Pharmacology, Biochemistry, and Behavior"},{"key":"10.1016\/j.alcohol.2014.07.021_bib67","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1146\/annurev-neuro-060909-153128","article-title":"Central and peripheral circadian clocks in mammals","volume":"35","author":"Mohawk","year":"2012","journal-title":"Annual Review of Neuroscience"},{"key":"10.1016\/j.alcohol.2014.07.021_bib68","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1177\/0748730413506557","article-title":"Exposure to shift work as a risk factor for diabetes","volume":"28","author":"Monk","year":"2013","journal-title":"Journal of Biological Rhythms"},{"key":"10.1016\/j.alcohol.2014.07.021_bib69","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.cell.2013.04.020","article-title":"Homeostasis in intestinal epithelium is orchestrated by the circadian clock and microbiota cues transduced by TLRs","volume":"153","author":"Mukherji","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.alcohol.2014.07.021_bib70","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1111\/j.1530-0277.2009.01022.x","article-title":"Intestinal dysbiosis: a possible mechanism of alcohol-induced endotoxemia and alcoholic steatohepatitis in rats","volume":"33","author":"Mutlu","year":"2009","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1016\/j.alcohol.2014.07.021_bib71","doi-asserted-by":"crossref","first-page":"G966","DOI":"10.1152\/ajpgi.00380.2011","article-title":"Colonic microbiome is altered in alcoholism","volume":"302","author":"Mutlu","year":"2012","journal-title":"American Journal of Physiology. Gastrointestinal and Liver Physiology"},{"key":"10.1016\/j.alcohol.2014.07.021_bib72","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1038\/ajg.2010.48","article-title":"The impact of rotating shift work on the prevalence of irritable bowel syndrome in nurses","volume":"105","author":"Nojkov","year":"2010","journal-title":"The American Journal of Gastroenterology"},{"key":"10.1016\/j.alcohol.2014.07.021_bib73","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.neuroscience.2014.01.043","article-title":"Epigenetic control and the circadian clock: linking metabolism to neuronal responses","volume":"264","author":"Orozco-Solis","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.alcohol.2014.07.021_bib74","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/hep.23258","article-title":"Alcoholic liver disease","volume":"51","author":"O'Shea","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.alcohol.2014.07.021_bib75","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1194\/jlr.M900085-JLR200","article-title":"Clock is important for food and circadian regulation of macronutrient absorption in mice","volume":"50","author":"Pan","year":"2009","journal-title":"Journal of Lipid Research"},{"key":"10.1016\/j.alcohol.2014.07.021_bib76","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0092-8674(02)00722-5","article-title":"Coordinated transcription of key pathways in the mouse by the circadian clock","volume":"109","author":"Panda","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.alcohol.2014.07.021_bib77","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/417329a","article-title":"Circadian rhythms from flies to human","volume":"417","author":"Panda","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.alcohol.2014.07.021_bib78","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/S0168-8278(00)80242-1","article-title":"Increased intestinal permeability to macromolecules and endotoxemia in patients with chronic alcohol abuse in different stages of alcohol-induced liver disease","volume":"32","author":"Parlesak","year":"2000","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.alcohol.2014.07.021_bib79","doi-asserted-by":"crossref","first-page":"204","DOI":"10.3109\/07420528.2010.548615","article-title":"Hepatic, duodenal, and colonic circadian clocks differ in their persistence under conditions of constant light and in their entrainment by restricted feeding","volume":"28","author":"Polidarov\u00e1","year":"2011","journal-title":"Chronobiology International"},{"key":"10.1016\/j.alcohol.2014.07.021_bib80","doi-asserted-by":"crossref","first-page":"R2034","DOI":"10.1152\/ajpregu.00118.2008","article-title":"Adverse effects of chronic circadian desynchronization in animals in a \u201cchallenging\u201d environment","volume":"295","author":"Preuss","year":"2008","journal-title":"American Journal of Physiology. Regulatory, Integrative and Comparative Physiology"},{"key":"10.1016\/j.alcohol.2014.07.021_bib81","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.alcohol.2008.03.131","article-title":"Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: summary of a symposium","volume":"42","author":"Purohit","year":"2008","journal-title":"Alcohol"},{"key":"10.1016\/j.alcohol.2014.07.021_bib82","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1002\/hep.23009","article-title":"Endotoxemia and gut barrier dysfunction in alcoholic liver disease","volume":"50","author":"Rao","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.alcohol.2014.07.021_bib83","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.tcb.2009.10.005","article-title":"Healthy clocks, healthy body, healthy mind","volume":"20","author":"Reddy","year":"2010","journal-title":"Trends in Cell Biology"},{"key":"10.1016\/j.alcohol.2014.07.021_bib84","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1006\/bbrc.1994.2774","article-title":"Induction of CYP2E1 in liver, kidney, brain and intestine during chronic ethanol administration and withdrawal: evidence that CYP2E1 possesses a rapid phase half-life of 6 hours or less","volume":"205","author":"Roberts","year":"1994","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.alcohol.2014.07.021_bib85","doi-asserted-by":"crossref","first-page":"29632","DOI":"10.1074\/jbc.270.50.29632","article-title":"Ethanol induces CYP2E1 by protein stabilization. Role of ubiquitin conjugation in the rapid degradation of CYP2E1","volume":"270","author":"Roberts","year":"1995","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.alcohol.2014.07.021_bib86","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.cub.2012.03.038","article-title":"Social jetlag and obesity","volume":"22","author":"Roenneberg","year":"2012","journal-title":"Current Biology"},{"key":"10.1016\/j.alcohol.2014.07.021_bib87","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.physbeh.2005.01.016","article-title":"Effects of ethanol intake and ethanol withdrawal on free-running circadian activity rhythms in rats","volume":"84","author":"Rosenwasser","year":"2005","journal-title":"Physiology & Behavior"},{"key":"10.1016\/j.alcohol.2014.07.021_bib88","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1081\/CBI-200053496","article-title":"Chronic ethanol intake alters circadian period-responses to brief light pulses in rats","volume":"22","author":"Rosenwasser","year":"2005","journal-title":"Chronobiology International"},{"key":"10.1016\/j.alcohol.2014.07.021_bib89","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1146\/annurev.biochem.71.090501.142857","article-title":"Metabolism and the control of circadian rhythms","volume":"71","author":"Rutter","year":"2002","journal-title":"Annual Review of Biochemistry"},{"key":"10.1016\/j.alcohol.2014.07.021_bib90","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1126\/science.1060698","article-title":"Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors","volume":"293","author":"Rutter","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.alcohol.2014.07.021_bib91","doi-asserted-by":"crossref","first-page":"4453","DOI":"10.1073\/pnas.0808180106","article-title":"Adverse metabolic and cardiovascular consequences of circadian misalignment","volume":"106","author":"Scheer","year":"2009","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.alcohol.2014.07.021_bib92","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1093\/jnci\/95.11.825","article-title":"Night-shift work and risk of colorectal cancer in the nurses' health study","volume":"95","author":"Schernhammer","year":"2003","journal-title":"Journal of the National Cancer Institute"},{"key":"10.1016\/j.alcohol.2014.07.021_bib93","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1053\/gast.2000.9305","article-title":"Biological clocks and the digestive system","volume":"119","author":"Scheving","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1016\/j.alcohol.2014.07.021_bib94","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1053\/j.gastro.2007.08.068","article-title":"It's about time: clock genes unveiled in the gut","volume":"133","author":"Scheving","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.alcohol.2014.07.021_bib95","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/BF01296025","article-title":"Peptic ulcer is prevalent among shift workers","volume":"32","author":"Segawa","year":"1987","journal-title":"Digestive Diseases and Sciences"},{"key":"10.1016\/j.alcohol.2014.07.021_bib96","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1177\/0748730409338449","article-title":"Chronic ethanol intake alters circadian phase shifting and free-running period in mice","volume":"24","author":"Seggio","year":"2009","journal-title":"Journal of Biological Rhythms"},{"key":"10.1016\/j.alcohol.2014.07.021_bib97","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1158\/1055-9965.EPI-12-1227-T","article-title":"Sleep disruption among older men and risk of prostate cancer","volume":"22","author":"Sigurdardottir","year":"2013","journal-title":"Cancer Epidemiology, Biomarkers & Prevention"},{"key":"10.1016\/j.alcohol.2014.07.021_bib98","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1053\/j.gastro.2007.05.053","article-title":"Insight into the circadian clock within rat colonic epithelial cells","volume":"133","author":"Sl\u00e1dek","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.alcohol.2014.07.021_bib99","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1136\/gut.31.9.1037","article-title":"Occupational distribution of inflammatory bowel disease among German employees","volume":"31","author":"Sonnenberg","year":"1990","journal-title":"Gut"},{"key":"10.1016\/j.alcohol.2014.07.021_bib100","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1152\/physrev.00013.2008","article-title":"Alcoholism: a systems approach from molecular physiology to addictive behavior","volume":"89","author":"Spanagel","year":"2009","journal-title":"Physiological Reviews"},{"key":"10.1016\/j.alcohol.2014.07.021_bib101","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/nm1163","article-title":"The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption","volume":"11","author":"Spanagel","year":"2005","journal-title":"Nature Medicine"},{"key":"10.1016\/j.alcohol.2014.07.021_bib102","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1097\/01.alc.0000175074.70807.fd","article-title":"Alcohol consumption and the body's biological clock","volume":"29","author":"Spanagel","year":"2005","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1016\/j.alcohol.2014.07.021_bib103","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1159\/000116774","article-title":"Role of the brain-gut axis in the pathophysiology of Crohn's disease","volume":"26","author":"Stasi","year":"2008","journal-title":"Digestive Diseases"},{"key":"10.1016\/j.alcohol.2014.07.021_bib104","doi-asserted-by":"crossref","first-page":"e67102","DOI":"10.1371\/journal.pone.0067102","article-title":"Disruption of the circadian clock in mice increases intestinal permeability and promotes alcohol-induced hepatic pathology and inflammation","volume":"8","author":"Summa","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.alcohol.2014.07.021_bib105","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1111\/j.1530-0277.2011.01466.x","article-title":"Role of intestinal circadian genes in alcohol-induced gut leakiness","volume":"35","author":"Swanson","year":"2011","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1016\/j.alcohol.2014.07.021_bib106","series-title":"Research Society on Alcoholism, 37th Annual Meeting, Bellevue, WA","article-title":"Area under the curve of plasma melatonin in alcoholics inversely related to increased intestinal permeability","author":"Swanson","year":"2014"},{"key":"10.1016\/j.alcohol.2014.07.021_bib107","doi-asserted-by":"crossref","first-page":"e82006","DOI":"10.1371\/journal.pone.0082006","article-title":"ROS stress resets circadian clocks to coordinate pro-survival signals","volume":"8","author":"Tamaru","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.alcohol.2014.07.021_bib108","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1111\/j.1530-0277.2009.00946.x","article-title":"Nitric oxide-mediated intestinal injury is required for alcohol-induced gut leakiness and liver damage","volume":"33","author":"Tang","year":"2009","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1016\/j.alcohol.2014.07.021_bib109","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.sleep.2008.12.009","article-title":"Sleep deprivation worsens inflammation and delays recovery in a mouse model of colitis","volume":"10","author":"Tang","year":"2009","journal-title":"Sleep Medicine"},{"key":"10.1016\/j.alcohol.2014.07.021_bib110","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1128\/MMBR.63.2.479-506.1999","article-title":"PAS domains: internal sensors of oxygen, redox potential, and light","volume":"63","author":"Taylor","year":"1999","journal-title":"Microbiology and Molecular Biology Reviews"},{"key":"10.1016\/j.alcohol.2014.07.021_bib111","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1111\/j.1530-0277.2008.00623.x","article-title":"A\u00a0voluntary oral ethanol-feeding rat model associated with necroinflammatory liver injury","volume":"32","author":"Tipoe","year":"2008","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1016\/j.alcohol.2014.07.021_bib112","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1126\/science.1108750","article-title":"Obesity and metabolic syndrome in circadian Clock mutant mice","volume":"308","author":"Turek","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.alcohol.2014.07.021_bib113","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/nri2653","article-title":"Intestinal mucosal barrier function in health and disease","volume":"9","author":"Turner","year":"2009","journal-title":"Nature Reviews. Immunology"},{"key":"10.1016\/j.alcohol.2014.07.021_bib114","first-page":"1","volume":"1","year":"2005"},{"key":"10.1016\/j.alcohol.2014.07.021_bib115","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1126\/science.8171325","article-title":"Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior","volume":"264","author":"Vitaterna","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.alcohol.2014.07.021_bib116","doi-asserted-by":"crossref","first-page":"e97500","DOI":"10.1371\/journal.pone.0097500","article-title":"Circadian disorganization alters intestinal microbiota","volume":"9","author":"Voigt","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.alcohol.2014.07.021_bib117","first-page":"87","article-title":"Circadian disruption: potential implications in inflammatory and metabolic diseases associated with alcohol","volume":"35","author":"Voigt","year":"2013","journal-title":"Alcohol Research"},{"key":"10.1016\/j.alcohol.2014.07.021_bib118","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1146\/annurev-nutr-072610-145138","article-title":"Inflammation in alcoholic liver disease","volume":"32","author":"Wang","year":"2012","journal-title":"Annual Review of Nutrition"},{"key":"10.1016\/j.alcohol.2014.07.021_bib119","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.3748\/wjg.v16.i11.1304","article-title":"Alcohol, inflammation, and gut-liver-brain interactions in tissue damage and disease development","volume":"16","author":"Wang","year":"2010","journal-title":"World Journal of Gastroenterology"},{"key":"10.1016\/j.alcohol.2014.07.021_bib120","doi-asserted-by":"crossref","first-page":"2866","DOI":"10.1016\/j.ajpath.2011.08.039","article-title":"Lactobacillus rhamnosus GG treatment potentiates intestinal hypoxia-inducible factor, promotes intestinal integrity and ameliorates alcohol-induced liver injury","volume":"179","author":"Wang","year":"2011","journal-title":"The American Journal of Pathology"},{"key":"10.1016\/j.alcohol.2014.07.021_bib121","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1089\/ars.2012.4889","article-title":"Circadian rhythm connections to oxidative stress: implications for human health","volume":"19","author":"Wilking","year":"2012","journal-title":"Antioxidants & Redox Signaling"},{"key":"10.1016\/j.alcohol.2014.07.021_bib122","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1080\/07420520500545979","article-title":"Social jetlag: misalignment of biological and social time","volume":"23","author":"Wittmann","year":"2006","journal-title":"Chronobiology International"},{"key":"10.1016\/j.alcohol.2014.07.021_bib123","first-page":"102","article-title":"E-cadherin and claudin-4 expression has circadian rhythm in adult rat kidney","volume":"23","author":"Yamato","year":"2010","journal-title":"Journal of Nephrology"},{"key":"10.1016\/j.alcohol.2014.07.021_bib124","doi-asserted-by":"crossref","first-page":"5339","DOI":"10.1073\/pnas.0308709101","article-title":"PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues","volume":"101","author":"Yoo","year":"2004","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.alcohol.2014.07.021_bib125","doi-asserted-by":"crossref","first-page":"N15","DOI":"10.1088\/0952-4746\/32\/1\/N15","article-title":"Epidemiological investigations of aircrew: an occupational group with low-level cosmic radiation exposure","volume":"32","author":"Zeeb","year":"2012","journal-title":"Journal of Radiological Protection"},{"key":"10.1016\/j.alcohol.2014.07.021_bib126","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.neubiorev.2014.01.007","article-title":"The trouble with circadian clock dysfunction: multiple deleterious effects on the brain and body","volume":"40","author":"Zelinski","year":"2014","journal-title":"Neuroscience and Biobehavioral Reviews"},{"key":"10.1016\/j.alcohol.2014.07.021_bib127","doi-asserted-by":"crossref","first-page":"962","DOI":"10.2337\/diabetes.55.04.06.db05-0873","article-title":"Characterization of peripheral circadian clocks in adipose tissues","volume":"55","author":"Zvonic","year":"2006","journal-title":"Diabetes"}],"container-title":["Alcohol"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741832914201212?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741832914201212?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T18:55:05Z","timestamp":1747162505000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0741832914201212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":127,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["S0741832914201212"],"URL":"https:\/\/doi.org\/10.1016\/j.alcohol.2014.07.021","relation":{},"ISSN":["0741-8329"],"issn-type":[{"value":"0741-8329","type":"print"}],"subject":[],"published":{"date-parts":[[2015,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Circadian rhythms, alcohol and gut interactions","name":"articletitle","label":"Article Title"},{"value":"Alcohol","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.alcohol.2014.07.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}