{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T12:15:32Z","timestamp":1762604132801,"version":"3.37.3"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,17]],"date-time":"2018-08-17T00:00:00Z","timestamp":1534464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AA023610"],"award-info":[{"award-number":["AA023610"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008294","name":"Louisiana State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008294","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008294","name":"Louisiana State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008294","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Alcohol"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.alcohol.2018.08.005","type":"journal-article","created":{"date-parts":[[2018,8,21]],"date-time":"2018-08-21T02:53:36Z","timestamp":1534820016000},"page":"81-89","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Influence of low-dose alcohol consumption on post-ischemic inflammation: Role of cystathionine \u03b3-lyase"],"prefix":"10.1016","volume":"76","author":[{"given":"Kimberly D.","family":"McCarter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guodong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.alcohol.2018.08.005_bib1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3109\/10408363.2011.580567","article-title":"Molecular and behavioral aspects of the actions of alcohol on the adult and developing brain","volume":"48","author":"Alfonso-Loeches","year":"2011","journal-title":"Critical Reviews in Clinical Laboratory Sciences"},{"key":"10.1016\/j.alcohol.2018.08.005_bib2","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1111\/bph.12171","article-title":"Selectivity of commonly used pharmacological inhibitors for cystathionine \u03b2 synthase (CBS) and cystathionine \u03b3 lyase (CSE)","volume":"169","author":"Asimakopoulou","year":"2013","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.alcohol.2018.08.005_bib3","doi-asserted-by":"crossref","first-page":"e146","DOI":"10.1161\/CIR.0000000000000485","article-title":"Heart disease and stroke statistics - 2017 update: A report from the American heart association","volume":"135","author":"Benjamin","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.alcohol.2018.08.005_bib4","doi-asserted-by":"crossref","first-page":"5528","DOI":"10.1523\/JNEUROSCI.21-15-05528.2001","article-title":"Role of IL-1alpha and IL-1beta in ischemic brain damage","volume":"21","author":"Boutin","year":"2001","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.alcohol.2018.08.005_bib5","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.eururo.2008.05.014","article-title":"Hydrogen sulphide is involved in testosterone vascular effect","volume":"56","author":"Bucci","year":"2009","journal-title":"European Urology"},{"key":"10.1016\/j.alcohol.2018.08.005_bib6","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1074\/jbc.M117.806869","article-title":"Hydrogen sulfide inhibits the NLRP3 inflammasome activation and reduces cytokine production both in\u00a0vitro and in a mouse model of inflammation","volume":"293","author":"Castelblanco","year":"2017","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.alcohol.2018.08.005_bib7","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/1742-2094-7-74","article-title":"The dual role of the neuroinflammatory response after ischemic stroke: Modulatory effects of hypothermia","volume":"7","author":"Ceulemans","year":"2010","journal-title":"Journal of Neuroinflammation"},{"key":"10.1016\/j.alcohol.2018.08.005_bib8","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.4103\/1673-5374.135329","article-title":"Autophagy: A double-edged sword for neuronal survival after cerebral ischemia","volume":"9","author":"Chen","year":"2014","journal-title":"Neural Regeneration Research"},{"key":"10.1016\/j.alcohol.2018.08.005_bib9","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.neuint.2006.09.014","article-title":"Inhibition of cystathionine-gamma-lyase leads to loss of glutathione and aggravation of mitochondrial dysfunction mediated by excitatory amino acid in the CNS","volume":"50","author":"Diwakar","year":"2007","journal-title":"Neurochemistry International"},{"key":"10.1016\/j.alcohol.2018.08.005_bib10","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/1742-2094-10-105","article-title":"The growth factor progranulin attenuates neuronal injury induced by cerebral ischemia-reperfusion through the suppression of neutrophil recruitment","volume":"10","author":"Egashira","year":"2013","journal-title":"Journal of Neuroinflammation"},{"key":"10.1016\/j.alcohol.2018.08.005_bib11","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.ncl.2016.06.013","article-title":"Epidemiology of ischemic stroke","volume":"34","author":"Favate","year":"2016","journal-title":"Neurologic Clinics"},{"key":"10.1016\/j.alcohol.2018.08.005_bib12","doi-asserted-by":"crossref","first-page":"42871","DOI":"10.1038\/srep42871","article-title":"Silver nanoparticles reduce brain inflammation and related neurotoxicity through induction of H2S-synthesizing enzymes","volume":"7","author":"Gonzalez-Carter","year":"2017","journal-title":"Scientific Reports"},{"key":"10.1016\/j.alcohol.2018.08.005_bib13","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/1742-2094-10-115","article-title":"Leukocyte infiltration in experimental stroke","volume":"10","author":"Gronberg","year":"2013","journal-title":"Journal of Neuroinflammation"},{"key":"10.1016\/j.alcohol.2018.08.005_bib14","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1161\/01.STR.26.10.1768","article-title":"Alcohol consumption and stroke mortality. 20-year follow-up of 15,077 men and women","volume":"26","author":"Hansagi","year":"1995","journal-title":"Stroke"},{"key":"10.1016\/j.alcohol.2018.08.005_bib15","doi-asserted-by":"crossref","first-page":"2916","DOI":"10.1161\/STROKEAHA.115.010620","article-title":"Role of neutrophils in exacerbation of brain injury after focal cerebral ischemia in hyperlipidemic mice","volume":"46","author":"Herz","year":"2015","journal-title":"Stroke"},{"key":"10.1016\/j.alcohol.2018.08.005_bib16","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1161\/01.STR.31.12.3047","article-title":"Postischemic cerebrovascular E-selectin expression mediates tissue injury in murine stroke","volume":"31","author":"Huang","year":"2000","journal-title":"Stroke"},{"key":"10.1016\/j.alcohol.2018.08.005_bib17","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1111\/j.1471-4159.2006.04283.x","article-title":"Hydrogen sulfide attenuates lipopolysaccharide-induced inflammation by inhibition of p38 mitogen-activated protein kinase in microglia","volume":"100","author":"Hu","year":"2007","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/j.alcohol.2018.08.005_bib18","doi-asserted-by":"crossref","first-page":"2936","DOI":"10.1161\/STROKEAHA.108.520288","article-title":"Alcohol consumption and mortality from stroke and coronary heart disease among Japanese men and women: The Japan collaborative cohort study","volume":"39","author":"Ikehara","year":"2008","journal-title":"Stroke"},{"key":"10.1016\/j.alcohol.2018.08.005_bib19","first-page":"1382","article-title":"Reperfusion injury after focal cerebral ischemia: The role of inflammation and the therapeutic horizon","volume":"43","author":"Jean","year":"1998","journal-title":"Neurosurgery"},{"key":"10.1016\/j.alcohol.2018.08.005_bib20","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/B978-0-12-394309-5.00006-7","article-title":"Cell biology of ischemia\/reperfusion injury","volume":"298","author":"Kalogeris","year":"2012","journal-title":"International Review of Cell and Molecular Biology"},{"key":"10.1016\/j.alcohol.2018.08.005_bib21","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1002\/lt.21810","article-title":"Role of hydrogen sulfide in hepatic ischemia-reperfusion-induced injury in rats","volume":"15","author":"Kang","year":"2009","journal-title":"Liver Transplantation"},{"key":"10.1016\/j.alcohol.2018.08.005_bib22","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.2174\/0929867321666131228205146","article-title":"Innate inflammatory responses in stroke: Mechanisms and potential therapeutic targets","volume":"21","author":"Kim","year":"2014","journal-title":"Current Medicinal Chemistry"},{"key":"10.1016\/j.alcohol.2018.08.005_bib23","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1097\/00004647-199812000-00008","article-title":"Deficiency of intercellular adhesion molecule 1 attenuates microcirculatory disturbance and infarction size in focal cerebral ischemia","volume":"18","author":"Kitagawa","year":"1998","journal-title":"Journal of Cerebral Blood Flow and Metabolism"},{"key":"10.1016\/j.alcohol.2018.08.005_bib24","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/glia.20362","article-title":"Hydrogen sulphide regulates calcium homeostasis in microglial cells","volume":"54","author":"Lee","year":"2006","journal-title":"Glia"},{"key":"10.1016\/j.alcohol.2018.08.005_bib25","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1161\/CIRCULATIONAHA.113.002208","article-title":"Decreased endogenous production of hydrogen sulfide accelerates atherosclerosis","volume":"127","author":"Mani","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.alcohol.2018.08.005_bib26","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nri3024","article-title":"Neutrophils in the activation and regulation of innate and adaptive immunity","volume":"11","author":"Mantovani","year":"2011","journal-title":"Nature Reviews Immunology"},{"key":"10.1016\/j.alcohol.2018.08.005_bib27","doi-asserted-by":"crossref","first-page":"12547","DOI":"10.1038\/s41598-017-12720-w","article-title":"Effect of low-dose alcohol consumption on inflammation following transient focal cerebral ischemia in rats","volume":"7","author":"McCarter","year":"2017","journal-title":"Scientific Report"},{"key":"10.1016\/j.alcohol.2018.08.005_bib28","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1590\/S0004-28032013000200027","article-title":"Immunohistochemical approach reveals localization of cystathionine-\u03b3-lyase and cystathionine-\u03b2-synthetase in ethanol-induced gastric mucosa damage in mice","volume":"50","author":"Medeiros","year":"2013","journal-title":"Arquivos de Gastroenterologia"},{"key":"10.1016\/j.alcohol.2018.08.005_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0019766","article-title":"Hydrogen sulfide attenuated tumor necrosis factor-\u03b1-induced inflammatory signaling and dysfunction in vascular endothelial cells","volume":"6","author":"Pan","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.alcohol.2018.08.005_bib30","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1089\/ars.2011.4349","article-title":"Role of cystathionine \u03b3-lyase\/hydrogen sulfide pathway in cardiovascular disease: A novel therapeutic strategy?","volume":"17","author":"Pan","year":"2012","journal-title":"Antioxidants and Redox Signaling"},{"key":"10.1016\/j.alcohol.2018.08.005_bib31","first-page":"73","article-title":"Microglia and ischemic stroke: A double-edged sword","volume":"5","author":"Patel","year":"2013","journal-title":"International Journal of Physiology, Pathophysiology and Pharmacology"},{"key":"10.1016\/j.alcohol.2018.08.005_bib32","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1186\/1471-2458-10-258","article-title":"Alcohol consumption and the risk of morbidity and mortality for different stroke types--a systematic review and meta-analysis","volume":"10","author":"Patra","year":"2010","journal-title":"BMC Public Health"},{"key":"10.1016\/j.alcohol.2018.08.005_bib33","doi-asserted-by":"crossref","first-page":"d671","DOI":"10.1136\/bmj.d671","article-title":"Association of alcohol consumption with selected cardiovascular disease outcomes: A systematic review and meta-analysis","volume":"342","author":"Ronksley","year":"2011","journal-title":"BMJ"},{"key":"10.1016\/j.alcohol.2018.08.005_bib34","article-title":"Low-dose alcohol consumption protects against transient focal cerebral ischemia in mice: Possible role of PPAR\u03b3","volume":"7","author":"Sun","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.alcohol.2018.08.005_bib35","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1523\/JNEUROSCI.22-01-00038.2002","article-title":"Interleukin-1 influences ischemic brain damage in the mouse independently of the interleukin-1 type I receptor","volume":"22","author":"Touzani","year":"2002","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.alcohol.2018.08.005_bib36","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1038\/labinvest.2008.73","article-title":"Generation of endogenous hydrogen sulfide by cystathionine gamma-lyase limits renal ischemia\/reperfusion injury and dysfunction","volume":"88","author":"Tripatara","year":"2008","journal-title":"Laboratory Investigation"},{"key":"10.1016\/j.alcohol.2018.08.005_bib37","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1161\/01.STR.0000057976.53301.69","article-title":"Levels of anti-inflammatory cytokines and neurological worsening in acute ischemic stroke","volume":"34","author":"Vila","year":"2003","journal-title":"Stroke"},{"key":"10.1016\/j.alcohol.2018.08.005_bib38","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1111\/jnc.12695","article-title":"Hydrogen sulfide protects blood-brain barrier integrity following cerebral ischemia","volume":"129","author":"Wang","year":"2014","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/j.alcohol.2018.08.005_bib39","doi-asserted-by":"crossref","first-page":"186908","DOI":"10.1155\/2015\/186908","article-title":"Role of hydrogen sulfide in ischemia-reperfusion injury","volume":"2015","author":"Wu","year":"2015","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"10.1016\/j.alcohol.2018.08.005_bib40","doi-asserted-by":"crossref","first-page":"e25","DOI":"10.1016\/j.jss.2012.09.028","article-title":"Inhibition of hydrogen sulfide generation contributes to lung injury after experimental orthotopic lung transplantation","volume":"182","author":"Wu","year":"2013","journal-title":"Journal of Surgical Research"},{"key":"10.1016\/j.alcohol.2018.08.005_bib41","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.brainres.2012.10.046","article-title":"Exogenous hydrogen sulfide protects against global cerebral ischemia\/reperfusion injury via its anti-oxidative, anti-inflammatory and anti-apoptotic effects in rats","volume":"1491","author":"Yin","year":"2013","journal-title":"Brain Research"},{"key":"10.1016\/j.alcohol.2018.08.005_bib42","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1096\/fj.06-6270fje","article-title":"Hydrogen sulfide is an endogenous modulator of leukocyte-mediated inflammation","volume":"20","author":"Zanardo","year":"2006","journal-title":"Federation of American Societies for Experimental Biology Journal"},{"key":"10.1016\/j.alcohol.2018.08.005_bib43","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.bbi.2017.07.156","article-title":"The cystathionine \u03b2-synthase\/hydrogen sulfide pathway contributes to microglia-mediated neuroinflammation following cerebral ischemia","volume":"66","author":"Zhang","year":"2017","journal-title":"Brain, Behavior, and Immunity"},{"key":"10.1016\/j.alcohol.2018.08.005_bib44","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1111\/j.1530-0277.2011.01461.x","article-title":"Dose-related influence of chronic alcohol consumption on cerebral ischemia\/reperfusion injury","volume":"35","author":"Zhao","year":"2011","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1016\/j.alcohol.2018.08.005_bib45","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/s11011-014-9539-y","article-title":"Microglia: Dismantling and rebuilding circuits after acute neurological injury","volume":"30","author":"Ziebell","year":"2015","journal-title":"Metabolic Brain Disease"}],"container-title":["Alcohol"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741832918301447?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741832918301447?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T15:44:58Z","timestamp":1565279098000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0741832918301447"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":45,"alternative-id":["S0741832918301447"],"URL":"https:\/\/doi.org\/10.1016\/j.alcohol.2018.08.005","relation":{},"ISSN":["0741-8329"],"issn-type":[{"type":"print","value":"0741-8329"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Influence of low-dose alcohol consumption on post-ischemic inflammation: Role of cystathionine \u03b3-lyase","name":"articletitle","label":"Article Title"},{"value":"Alcohol","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.alcohol.2018.08.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}