{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T16:56:37Z","timestamp":1773939397263,"version":"3.50.1"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Alcohol"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.alcohol.2018.11.005","type":"journal-article","created":{"date-parts":[[2018,11,23]],"date-time":"2018-11-23T00:53:59Z","timestamp":1542934439000},"page":"33-42","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["The impact of low to moderate chronic intermittent ethanol exposure on behavioral endpoints in aged, adult, and adolescent rats"],"prefix":"10.1016","volume":"78","author":[{"given":"Douglas B.","family":"Matthews","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meredith R.","family":"Watson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly","family":"James","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abigail","family":"Kastner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2405-2318","authenticated-orcid":false,"given":"Amelia","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy","family":"Mittleman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.alcohol.2018.11.005_bib1","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00213-013-3163-0","article-title":"Age-dependent effects of stress on ethanol-induced motor activity in rats","volume":"230","author":"Acevedo","year":"2013","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.alcohol.2018.11.005_bib2","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0741-8329(01)00127-6","article-title":"Age-independent and dose-response effects of ethanol on spatial memory in rats","volume":"23","author":"Acheson","year":"2001","journal-title":"Alcohol"},{"key":"10.1016\/j.alcohol.2018.11.005_bib3","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1097\/JGP.0b013e318190b8ef","article-title":"The epidemiology of substance use and disorders among middle aged and elderly community adults: National survey on drug use and health","volume":"17","author":"Blazer","year":"2009","journal-title":"American Journal of Geriatric Psychiatry"},{"key":"10.1016\/j.alcohol.2018.11.005_bib4","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1037\/0735-7044.116.2.305","article-title":"Physiological and behavioral effects of acute ethanol hangover in juvenile, adolescent, and adult rats","volume":"116","author":"Brasser","year":"2002","journal-title":"Behavioral Neuroscience"},{"key":"10.1016\/j.alcohol.2018.11.005_bib5","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1111\/acer.13365","article-title":"Trends in alcohol consumption among older Americans: National Health Interview Surveys, 1997 to 2014","volume":"41","author":"Breslow","year":"2017","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1016\/j.alcohol.2018.11.005_bib6","doi-asserted-by":"crossref","first-page":"884","DOI":"10.15288\/jsa.2003.64.884","article-title":"Alcohol consumption by elderly Americans","volume":"64","author":"Breslow","year":"2003","journal-title":"Journal of Studies on Alcohol"},{"key":"10.1016\/j.alcohol.2018.11.005_bib7","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/j.1530-0277.1994.tb00903.x","article-title":"Severity and treatment of alcohol withdrawal in elderly versus younger patients","volume":"18","author":"Brower","year":"1994","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1016\/j.alcohol.2018.11.005_bib8","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1300\/J069v16n02_02","article-title":"Efficacy of outpatient intensive treatment for drug abuse","volume":"16","author":"Campbell","year":"1997","journal-title":"Journal of Addictive Diseases"},{"key":"10.1016\/j.alcohol.2018.11.005_bib9","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.exger.2012.03.019","article-title":"Alcohol use disorders in the elderly: A brief overview from epidemiology to treatment options","volume":"47","author":"Caputo","year":"2012","journal-title":"Experimental Gerontology"},{"key":"10.1016\/j.alcohol.2018.11.005_bib10","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1196\/annals.1308.057","article-title":"Age-related differences in elevated plus maze behavior between adolescent and adult rats","volume":"1021","author":"Doremus","year":"2004","journal-title":"Annals of the New York Academy of Sciences"},{"key":"10.1016\/j.alcohol.2018.11.005_bib11","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.pbb.2006.03.019","article-title":"Factor analysis of elevated plus-maze behavior in adolescent and adult rats","volume":"83","author":"Doremus","year":"2006","journal-title":"Pharmacology, Biochemistry, and Behavior"},{"key":"10.1016\/j.alcohol.2018.11.005_bib12","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.neuroscience.2011.10.011","article-title":"Periadolescent ethanol exposure reduces adult forebrain ChAT+IR neurons: Correlation with behavioral pathology","volume":"199","author":"Ehlers","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.alcohol.2018.11.005_bib13","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.neurobiolaging.2017.01.025","article-title":"A\u00a0cross-sectional comparison of ethanol-related cytokine expression in the hippocampus of young and aged Fischer 344 rats","volume":"54","author":"Gano","year":"2017","journal-title":"Neurobiology of Aging"},{"key":"10.1016\/j.alcohol.2018.11.005_bib14","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1111\/j.1530-0277.2011.01528.x","article-title":"Adolescent C57BL\/6J mice show elevated alcohol intake, but reduced taste aversion, as compared to adult mice: A potential behavioral mechanism for binge drinking","volume":"35","author":"Holstein","year":"2011","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1016\/j.alcohol.2018.11.005_bib15","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.neubiorev.2004.11.001","article-title":"Anxiety-like behaviors following chronic ethanol exposure","volume":"28","author":"Kliethermes","year":"2005","journal-title":"Neuroscience & Biobehavioral Reviews"},{"key":"10.1016\/j.alcohol.2018.11.005_bib16","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1001\/archinte.1997.00440400084010","article-title":"Impact of age on the severity, course, and complications of alcohol withdrawal","volume":"157","author":"Kraemer","year":"1997","journal-title":"Archives of Internal Medicine"},{"key":"10.1016\/j.alcohol.2018.11.005_bib17","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0376-8716(89)90014-8","article-title":"The effect of repeated withdrawal episodes on subsequent withdrawal severity in ethanol-treated rats","volume":"23","author":"Maier","year":"1989","journal-title":"Drug and Alcohol Dependence"},{"key":"10.1016\/j.alcohol.2018.11.005_bib18","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1006\/nlme.1998.3900","article-title":"Acute ethanol administration impairs spatial performance while facilitating nonspatial performance in rats","volume":"72","author":"Matthews","year":"1999","journal-title":"Neurobiology of Learning and Memory"},{"key":"10.1016\/j.alcohol.2018.11.005_bib19","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.neulet.2017.08.012","article-title":"Age-dependent effects of chronic intermittent ethanol treatment: Gross motor behavior and body weight in aged, adult and adolescent rats","volume":"657","author":"Matthews","year":"2017","journal-title":"Neuroscience Letters"},{"key":"10.1016\/j.alcohol.2018.11.005_bib20","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.alcohol.2017.01.012","article-title":"Impact of adolescent alcohol use across the lifespan: Long-lasting tolerance to high-dose alcohol coupled with potentiated spatial memory impairments to moderate-dose alcohol","volume":"61","author":"Matthews","year":"2017","journal-title":"Alcohol"},{"key":"10.1016\/j.alcohol.2018.11.005_bib21","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1111\/j.1530-0277.1995.tb00965.x","article-title":"Acute ethanol impairs spatial memory but not stimulus\/response memory in the rat","volume":"19","author":"Matthews","year":"1995","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1016\/j.alcohol.2018.11.005_bib22","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.alcohol.2008.09.001","article-title":"Chronic intermittent exposure to ethanol during adolescence produces tolerance to the hypnotic effects of ethanol in male rats: A dose-dependent analysis","volume":"42","author":"Matthews","year":"2008","journal-title":"Alcohol"},{"key":"10.1016\/j.alcohol.2018.11.005_bib23","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1521\/bumc.66.2.166.23364","article-title":"Assessment and treatment of alcoholism and substance-related disorders in the elderly","volume":"66","author":"Menninger","year":"2002","journal-title":"Bulletin of the Menninger Clinic"},{"key":"10.1016\/j.alcohol.2018.11.005_bib24","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/BF02982710","article-title":"The danger of weight loss in the elderly","volume":"12","author":"Miller","year":"2008","journal-title":"The Journal of Nutrition, Health & Aging"},{"key":"10.1016\/j.alcohol.2018.11.005_bib25","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/297681a0","article-title":"Place navigation impaired in rats with hippocampal lesions","volume":"297","author":"Morris","year":"1982","journal-title":"Nature"},{"key":"10.1016\/j.alcohol.2018.11.005_bib26","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.pbb.2015.03.015","article-title":"Alcohol use across the lifespan: An analysis of adolescent and aged rodents and humans","volume":"133","author":"Novier","year":"2015","journal-title":"Pharmacology, Biochemistry, and Behavior"},{"key":"10.1016\/j.alcohol.2018.11.005_bib27","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1111\/acer.13098","article-title":"Differences in behavioral Responding in adult and aged rats following chronic ethanol exposure","volume":"40","author":"Novier","year":"2016","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1016\/j.alcohol.2018.11.005_bib28","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1111\/acer.12110","article-title":"Acute alcohol produces ataxia and cognitive impairments in aged animals: A comparison between young adult and aged rats","volume":"37","author":"Novier","year":"2013","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1016\/j.alcohol.2018.11.005_bib29","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0091-3057(02)00715-3","article-title":"Cognitive deficits and CNS damage after a 4-day binge ethanol exposure in rats","volume":"72","author":"Obernier","year":"2002","journal-title":"Pharmacology, Biochemistry, and Behavior"},{"key":"10.1016\/j.alcohol.2018.11.005_bib30","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.alcohol.2014.12.002","article-title":"The effects of acute alcohol on motor impairments in adolescent, adult, and aged rats","volume":"49","author":"Ornelas","year":"2015","journal-title":"Alcohol"},{"key":"10.1016\/j.alcohol.2018.11.005_bib31","series-title":"An aging nation: The older population in the United States","author":"Ortman","year":"2014"},{"key":"10.1016\/j.alcohol.2018.11.005_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pbb.2018.07.012","article-title":"Late aging alters behavioral sensitivity to ethanol in a sex-specific manner in Fischer 344 rats","volume":"175","author":"Perkins","year":"2018","journal-title":"Pharmacology, Biochemistry, and Behavior"},{"key":"10.1016\/j.alcohol.2018.11.005_bib33","author":"Population Reference Bureau"},{"key":"10.1016\/j.alcohol.2018.11.005_bib34","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1016\/S0140-6736(09)60746-7","article-title":"Global burden of disease and injury and economic cost attributable to alcohol use and alcohol-use disorders","volume":"373","author":"Rehm","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.alcohol.2018.11.005_bib35","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1097\/01.ALC.0000090141.66526.22","article-title":"Chronic intermittent injections of high-dose ethanol during adolescence produce metabolic, hypnotic, and cognitive tolerance in rats","volume":"27","author":"Silvers","year":"2003","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1016\/j.alcohol.2018.11.005_bib36","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.alcohol.2006.09.001","article-title":"Chronic intermittent ethanol exposure during adolescence reduces the effect of ethanol challenge on hippocampal allopregnanolone levels and Morris water maze task performance","volume":"39","author":"Silvers","year":"2006","journal-title":"Alcohol"},{"key":"10.1016\/j.alcohol.2018.11.005_bib37","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/nprot.2012.044","article-title":"Using the rat forced swim test to assess antidepressant-like activity in rodents","volume":"7","author":"Slattery","year":"2012","journal-title":"Nature Protocols"},{"key":"10.1016\/j.alcohol.2018.11.005_bib38","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1097\/01.ALC.0000122767.69206.1B","article-title":"Comparison of the onset of hypoactivity and anxiety-like behavior during alcohol withdrawal in adolescent and adult rats","volume":"28","author":"Slawecki","year":"2004","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1016\/j.alcohol.2018.11.005_bib39","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1111\/acer.12531","article-title":"Age-related effects of alcohol from adolescent, adult, and aged populations using human and animal models","volume":"38","author":"Squeglia","year":"2014","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1016\/j.alcohol.2018.11.005_bib40","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1891\/0739-6686.23.1.245","article-title":"Alcohol use, misuse, abuse, and dependence in later adulthood","volume":"23","author":"Stevenson","year":"2005","journal-title":"Annual Review of Nursing Research"},{"key":"10.1016\/j.alcohol.2018.11.005_bib41","article-title":"Substance use disorders in late life: A review of current evidence","volume":"4","author":"Tampi","year":"2015","journal-title":"Healthy Aging Research"},{"key":"10.1016\/j.alcohol.2018.11.005_bib52","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1046\/j.1532-5415.2001.49085.x","article-title":"Alcohol abuse, cognitive impairment, and mortality among older people","volume":"49","author":"Thomas","year":"2001","journal-title":"Journal of the American Geriatrics Society"},{"key":"10.1016\/j.alcohol.2018.11.005_bib42","doi-asserted-by":"crossref","first-page":"629","DOI":"10.3171\/2012.5.JNS112224","article-title":"Effects of aging on behavioral assessment performance: Implications for clinically relevant models of neurological disease","volume":"117","author":"Turner","year":"2012","journal-title":"Journal of Neurosurgery"},{"key":"10.1016\/j.alcohol.2018.11.005_bib43","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1111\/j.1530-0277.2010.01303.x","article-title":"Behavioral effects of ethanol in cerebellum are age dependent: Potential system and molecular mechanisms","volume":"34","author":"Van Skike","year":"2010","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1016\/j.alcohol.2018.11.005_bib44","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/acer.12617","article-title":"Chronic intermittent ethanol exposure produces persistent anxiety in adolescent and adult rats","volume":"39","author":"Van Skike","year":"2015","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1016\/j.alcohol.2018.11.005_bib45","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1097\/01.ALC.0000108655.51087.DF","article-title":"Acute ethanol withdrawal (hangover) and social behavior in adolescent and adult male and female Sprague-Dawley rats","volume":"28","author":"Varlinskaya","year":"2004","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1016\/j.alcohol.2018.11.005_bib46","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1016\/j.neubiorev.2012.08.004","article-title":"Conditioned taste aversion and drugs of abuse: History and interpretation","volume":"36","author":"Verendeev","year":"2012","journal-title":"Neuroscience & Biobehavioral Reviews"},{"key":"10.1016\/j.alcohol.2018.11.005_bib47","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/nprot.2007.44","article-title":"The use of the elevated plus maze as an assay of anxiety-related behavior in rodents","volume":"2","author":"Walf","year":"2007","journal-title":"Nature Protocols"},{"key":"10.1016\/j.alcohol.2018.11.005_bib48","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.alcohol.2010.06.006","article-title":"Effects of prolonged ethanol vapor exposure on forced swim behavior, and neuropeptide Y and corticotropin-releasing factor levels in rat brains","volume":"44","author":"Walker","year":"2010","journal-title":"Alcohol"},{"key":"10.1016\/j.alcohol.2018.11.005_bib49","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0197-4580(82)90046-X","article-title":"Age differences in ethanol-induced hypothermia and impairment in mice","volume":"3","author":"Wood","year":"1982","journal-title":"Neurobiology of Aging"},{"key":"10.1016\/j.alcohol.2018.11.005_bib50","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/0091-3057(82)90490-7","article-title":"Ethanol intoxication and withdrawal among three age groups of C57BL\/6NNIA mice","volume":"17","author":"Wood","year":"1982","journal-title":"Pharmacology, Biochemistry, and Behavior"},{"issue":"97","key":"10.1016\/j.alcohol.2018.11.005_bib51","doi-asserted-by":"crossref","DOI":"10.3791\/52587","article-title":"The forced swim test as a model of depressive-like behavior","author":"Yankelevitch-Yahav","year":"2015","journal-title":"Journal of Visualized Experiments"}],"container-title":["Alcohol"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741832918302179?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741832918302179?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T10:13:39Z","timestamp":1562062419000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0741832918302179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":52,"alternative-id":["S0741832918302179"],"URL":"https:\/\/doi.org\/10.1016\/j.alcohol.2018.11.005","relation":{},"ISSN":["0741-8329"],"issn-type":[{"value":"0741-8329","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The impact of low to moderate chronic intermittent ethanol exposure on behavioral endpoints in aged, adult, and adolescent rats","name":"articletitle","label":"Article Title"},{"value":"Alcohol","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.alcohol.2018.11.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}