{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:52:20Z","timestamp":1760061140203,"version":"build-2065373602"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Alcohol"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.alcohol.2020.04.004","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T11:16:28Z","timestamp":1592219788000},"page":"51-61","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Effects of low ethanol consumption on nonalcoholic steatohepatitis in mice"],"prefix":"10.1016","volume":"87","author":[{"given":"Yoshihisa","family":"Takahashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiori","family":"Watabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arisa","family":"Togashi-Kumagai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erdenetsogt","family":"Dungubat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Kusano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyuki","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Harada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoichi","family":"Yamaji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichiro","family":"Sugimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshio","family":"Fukusato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.alcohol.2020.04.004_bib1","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1002\/hep.29631","article-title":"Interaction between alcohol consumption and metabolic syndrome in predicting severe liver disease in the general population","volume":"67","author":"Aberg","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.alcohol.2020.04.004_bib2","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1002\/hep.30864","article-title":"Risks of light and moderate alcohol use in fatty liver disease: Follow-up of population cohorts","volume":"71","author":"Aberg","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.alcohol.2020.04.004_bib3","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1053\/j.gastro.2005.04.014","article-title":"The natural history of nonalcoholic fatty liver disease: A population-based cohort study","volume":"129","author":"Adams","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.alcohol.2020.04.004_bib4","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.jhep.2012.09.016","article-title":"Activation of toll-like receptor 3 attenuates alcoholic liver injury by stimulating Kupffer cells and stellate cells to produce interleukin-10 in mice","volume":"58","author":"Byun","year":"2013","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.alcohol.2020.04.004_bib5","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/hep.29367","article-title":"The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases","volume":"67","author":"Chalasani","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.alcohol.2020.04.004_bib6","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1002\/hep.30170","article-title":"Nonheavy drinking and worsening of noninvasive fibrosis markers in nonalcoholic fatty liver disease: A cohort study","volume":"69","author":"Chang","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.alcohol.2020.04.004_bib7","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1002\/hep.30867","article-title":"Low levels of alcohol consumption, obesity, and development of fatty liver with and without evidence of advanced fibrosis","volume":"71","author":"Chang","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.alcohol.2020.04.004_bib8","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1053\/jlts.2001.25453","article-title":"Frequency of nonalcoholic steatohepatitis as a cause of advanced liver disease","volume":"7","author":"Charlton","year":"2001","journal-title":"Liver Transplantation"},{"key":"10.1016\/j.alcohol.2020.04.004_bib9","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1097\/MEG.0b013e328328f3ec","article-title":"Effects of light-to-moderate alcohol consumption on steatosis and steatohepatitis in severely obese patients","volume":"21","author":"Cotrim","year":"2009","journal-title":"European Journal of Gastroenterology and Hepatology"},{"key":"10.1016\/j.alcohol.2020.04.004_bib10","doi-asserted-by":"crossref","first-page":"e154","DOI":"10.1038\/nutd.2015.4","article-title":"Effect of multiple binge alcohol on diet-induced liver injury in a mouse model of obesity","volume":"5","author":"Duly","year":"2015","journal-title":"Nutrition & Diabetes"},{"key":"10.1016\/j.alcohol.2020.04.004_bib11","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.jhep.2012.03.024","article-title":"Modest alcohol consumption is associated with decreased prevalence of steatohepatitis in patients with non-alcoholic fatty liver disease (NAFLD)","volume":"57","author":"Dunn","year":"2012","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.alcohol.2020.04.004_bib12","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1002\/hep.22292","article-title":"Modest wine drinking and decreased prevalence of suspected nonalcoholic fatty liver disease","volume":"47","author":"Dunn","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.alcohol.2020.04.004_bib13","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A\u00a0simple method for the isolation and purification of total lipids from animal tissues","volume":"226","author":"Folch","year":"1957","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.alcohol.2020.04.004_bib14","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1038\/ajg.2009.361","article-title":"Light and moderate alcohol consumption significantly reduces the prevalence of fatty liver in the Japanese male population","volume":"104","author":"Gunji","year":"2009","journal-title":"American Journal of Gastroenterology"},{"key":"10.1016\/j.alcohol.2020.04.004_bib15","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1002\/hep.30226","article-title":"Effect of alcohol consumption on survival in nonalcoholic fatty liver disease: A national prospective cohort study","volume":"70","author":"Hajifathalian","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.alcohol.2020.04.004_bib16","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/hep.26946","article-title":"Reduced adiponectin signaling due to weight gain results in nonalcoholic steatohepatitis through impaired mitochondrial biogenesis","volume":"60","author":"Handa","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.alcohol.2020.04.004_bib17","doi-asserted-by":"crossref","first-page":"c1240","DOI":"10.1136\/bmj.c1240","article-title":"Effect of body mass index and alcohol consumption on liver disease: Analysis of data from two prospective cohort studies","volume":"340","author":"Hart","year":"2010","journal-title":"BMJ"},{"key":"10.1016\/j.alcohol.2020.04.004_bib18","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s11894-008-0012-0","article-title":"Nonalcoholic fatty liver disease as a component of the metabolic syndrome","volume":"10","author":"Khashab","year":"2008","journal-title":"Current Gastroenterology Reports"},{"key":"10.1016\/j.alcohol.2020.04.004_bib19","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.alcohol.2020.04.004_bib20","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1038\/ajg.2012.20","article-title":"What should we recommend to our patients with NAFLD regarding alcohol use?","volume":"107","author":"Liangpunsakul","year":"2012","journal-title":"American Journal of Gastroenterology"},{"key":"10.1016\/j.alcohol.2020.04.004_bib21","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1002\/hep.1840100417","article-title":"Experimental methods of ethanol administration","volume":"10","author":"Lieber","year":"1989","journal-title":"Hepatology"},{"key":"10.1016\/j.alcohol.2020.04.004_bib22","doi-asserted-by":"crossref","first-page":"c912","DOI":"10.1136\/bmj.c912","article-title":"Body mass index and risk of liver cirrhosis in middle aged UK women: Prospective study","volume":"340","author":"Liu","year":"2010","journal-title":"BMJ"},{"key":"10.1016\/j.alcohol.2020.04.004_bib23","first-page":"637","article-title":"Non-alcoholic steatohepatitis and metabolic syndrome","volume":"9","author":"Machado","year":"2006","journal-title":"Current Opinion in Clinical Nutrition and Metabolic Care"},{"key":"10.1016\/j.alcohol.2020.04.004_bib24","doi-asserted-by":"crossref","first-page":"G819","DOI":"10.1152\/ajpgi.00041.2014","article-title":"Animals models of gastrointestinal and liver diseases. Animal models of alcohol-induced liver disease: Pathophysiology, translational relevance, and challenges","volume":"306","author":"Mathews","year":"2014","journal-title":"American Journal of Physiology - Gastrointestinal and Liver Physiology"},{"key":"10.1016\/j.alcohol.2020.04.004_bib25","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/j.1365-2036.2010.04520.x","article-title":"Alcohol consumption appears to protect against non-alcoholic fatty liver disease","volume":"33","author":"Moriya","year":"2011","journal-title":"Alimentary Pharmacology & Therapeutics"},{"key":"10.1016\/j.alcohol.2020.04.004_bib26","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.jhep.2014.11.025","article-title":"Roles of alcohol consumption in fatty liver: A longitudinal study","volume":"62","author":"Moriya","year":"2015","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.alcohol.2020.04.004_bib27","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1053\/jhep.2003.50193","article-title":"Nonalcoholic steatohepatitis: Summary of an AASLD single topic conference","volume":"37","author":"Neuschwander-Tetri","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.alcohol.2020.04.004_bib28","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.2174\/138161207781039652","article-title":"Non-alcoholic fatty liver disease in the metabolic syndrome","volume":"13","author":"Palasciano","year":"2007","journal-title":"Current Pharmaceutical Design"},{"key":"10.1016\/j.alcohol.2020.04.004_bib29","first-page":"7927685","article-title":"Alcohol consumption in diabetic patients with nonalcoholic fatty liver disease","author":"Patel","year":"2017","journal-title":"Canadian Journal of Gastroenterology and Hepatology"},{"key":"10.1016\/j.alcohol.2020.04.004_bib30","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1053\/gast.2002.36572","article-title":"AGA technical review on nonalcoholic fatty liver disease","volume":"123","author":"Sanyal","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.alcohol.2020.04.004_bib31","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12876-016-0431-6","article-title":"Influence of light alcohol consumption on lifestyle-related diseases: A predictor of fatty liver with liver enzyme elevation in Japanese females with metabolic syndrome","volume":"16","author":"Sogabe","year":"2016","journal-title":"BMC Gastroenterology"},{"key":"10.1016\/j.alcohol.2020.04.004_bib32","series-title":"Animal models for the study of human disease","first-page":"313","article-title":"Animal models of liver diseases","author":"Takahashi","year":"2017"},{"key":"10.1016\/j.alcohol.2020.04.004_bib33","article-title":"Inhibitory effects of Japanese herbal medicines sho-saiko-to and juzen-taiho-to on nonalcoholic steatohepatitis in mice","volume":"9","author":"Takahashi","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.alcohol.2020.04.004_bib34","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1111\/pin.12199","article-title":"Japanese herbal medicines shosaikoto, inchinkoto, and juzentaihoto inhibit high-fat diet-induced nonalcoholic steatohepatitis in db\/db mice","volume":"64","author":"Takahashi","year":"2014","journal-title":"Pathology International"},{"key":"10.1016\/j.alcohol.2020.04.004_bib35","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/hep.29129","article-title":"Inflammation is independent of steatosis in a murine model of steatohepatitis","volume":"66","author":"Wang","year":"2017","journal-title":"Hepatology"},{"year":"2018","series-title":"Global status report on alcohol and health 2018","key":"10.1016\/j.alcohol.2020.04.004_bib36"},{"key":"10.1016\/j.alcohol.2020.04.004_bib37","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.jhep.2010.12.034","article-title":"Synergistic steatohepatitis by moderate obesity and alcohol in mice despite increased adiponectin and p-AMPK","volume":"55","author":"Xu","year":"2011","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.alcohol.2020.04.004_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0191026","article-title":"Light alcohol consumption has the potential to suppress hepatocellular injury and liver fibrosis in non-alcoholic fatty liver disease","volume":"13","author":"Yamada","year":"2018","journal-title":"PloS One"},{"key":"10.1016\/j.alcohol.2020.04.004_bib39","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.cgh.2011.01.023","article-title":"Characteristics of patients with nonalcoholic steatohepatitis who develop hepatocellular carcinoma","volume":"9","author":"Yasui","year":"2011","journal-title":"Clinical Gastroenterology and Hepatology"},{"key":"10.1016\/j.alcohol.2020.04.004_bib40","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/hep.28431","article-title":"Global epidemiology of nonalcoholic fatty liver disease - meta-analytic assessment of prevalence, incidence, and outcomes","volume":"64","author":"Younossi","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.alcohol.2020.04.004_bib41","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.jcmgh.2018.01.003","article-title":"Neutrophil-hepatic stellate cell interactions promote fibrosis in experimental steatohepatitis","volume":"5","author":"Zhou","year":"2018","journal-title":"Cellular and Molecular Gastroenterology and Hepatology"}],"container-title":["Alcohol"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741832920302093?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741832920302093?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T20:46:53Z","timestamp":1760042813000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0741832920302093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":41,"alternative-id":["S0741832920302093"],"URL":"https:\/\/doi.org\/10.1016\/j.alcohol.2020.04.004","relation":{},"ISSN":["0741-8329"],"issn-type":[{"type":"print","value":"0741-8329"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of low ethanol consumption on nonalcoholic steatohepatitis in mice","name":"articletitle","label":"Article Title"},{"value":"Alcohol","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.alcohol.2020.04.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}