{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T11:08:38Z","timestamp":1774696118969,"version":"3.50.1"},"reference-count":77,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000871","name":"Mayo Clinic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010315","name":"University of Wisconsin-Eau Claire","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010315","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Alcohol"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.alcohol.2022.05.003","type":"journal-article","created":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T21:37:40Z","timestamp":1654119460000},"page":"38-43","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Using animal models to identify clinical risk factors in the older population due to alcohol use and misuse"],"prefix":"10.1016","volume":"107","author":[{"given":"Douglas B.","family":"Matthews","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gillian","family":"Rossmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.alcohol.2022.05.003_bib1","doi-asserted-by":"crossref","first-page":"391","DOI":"10.3758\/BF03326662","article-title":"Age-related differences in response to ethanol in the rat","volume":"7","author":"Abel","year":"1979","journal-title":"Physiological Psychology"},{"issue":"3","key":"10.1016\/j.alcohol.2022.05.003_bib2","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0741-8329(01)00127-6","article-title":"Age-independent and dose-response effects of ethanol on spatial memory in rats","volume":"23","author":"Acheson","year":"2001","journal-title":"Alcohol"},{"key":"10.1016\/j.alcohol.2022.05.003_bib3","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.neuropharm.2017.04.028","article-title":"Influence of stress associated with chronic alcohol exposure on drinking","volume":"122","author":"Becker","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.alcohol.2022.05.003_bib4","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/bs.pmbts.2015.10.018","article-title":"Ethanol-associated changes in glutamate reward neurocircuity: A minireview of clinical and preclinical genetic findings","volume":"137","author":"Bell","year":"2016","journal-title":"Progress in Molecular Biology and Translational Science"},{"issue":"10","key":"10.1016\/j.alcohol.2022.05.003_bib5","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1176\/appi.ajp.2009.09010016","article-title":"The epidemiology of at-risk and binge drinking among middle-aged and elderly community adults: National Survey on Drug Use and Health","volume":"166","author":"Blazer","year":"2009","journal-title":"American Journal of Psychiatry"},{"issue":"4","key":"10.1016\/j.alcohol.2022.05.003_bib6","first-page":"765","article-title":"Comparison of accelerod and rotarod sensitivity in detecting ethanol- and acrylamide-induced performance decrement in rats: Review of experimental considerations of rotating rod systems","volume":"2","author":"Bogo","year":"1981","journal-title":"Neurotoxicology"},{"issue":"2","key":"10.1016\/j.alcohol.2022.05.003_bib7","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1037\/0735-7044.116.2.305","article-title":"Physiological and behavioral effects of acute ethanol hangover in juvenile, adolescent, and adult rats","volume":"116","author":"Brasser","year":"2002","journal-title":"Behavioral Neuroscience"},{"issue":"5","key":"10.1016\/j.alcohol.2022.05.003_bib8","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1111\/acer.13365","article-title":"Trends in alcohol consumption among older Americans: National health interview surveys, 1997 to 2014","volume":"41","author":"Breslow","year":"2017","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"6","key":"10.1016\/j.alcohol.2022.05.003_bib9","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1111\/add.15292","article-title":"Cross-country differences in age trends in alcohol consumption among older adults: A cross-sectional study of individuals aged 50 years and older in 22 countries","volume":"116","author":"Calvo","year":"2020","journal-title":"Addiction"},{"key":"10.1016\/j.alcohol.2022.05.003_bib10","unstructured":"Centers for Disease Control and Prevention. (2021)."},{"key":"10.1016\/j.alcohol.2022.05.003_bib11","unstructured":"Centers for Disease Control and Prevention. (2004). Hypothermia-Related Deaths \u2013 United States, 2003. Morbidity and Mortality Weekly Report, 53(8), 172\u2013173. Retrieved from https:\/\/www.cdc.gov\/mmwr\/PDF\/wk\/mm5308.pdf."},{"issue":"1","key":"10.1016\/j.alcohol.2022.05.003_bib12","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.alcohol.2009.10.015","article-title":"Effects of ethanol on hippocampal function during adolescence: A look at the past and thoughts on the future","volume":"44","author":"Chin","year":"2010","journal-title":"Alcohol"},{"issue":"9","key":"10.1016\/j.alcohol.2022.05.003_bib13","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1111\/acer.14154","article-title":"Mechanisms of persistent neurobiological changes following adolescent alcohol exposure: NADIA consortium findings","volume":"43","author":"Crews","year":"2019","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"2","key":"10.1016\/j.alcohol.2022.05.003_bib14","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1093\/alcalc\/agab072","article-title":"Changes in brain dopamine extracellular concentration after ethanol administration; rat microdialysis studies","volume":"57","author":"Dahchour","year":"2022","journal-title":"Alcohol and Alcoholism"},{"issue":"4","key":"10.1016\/j.alcohol.2022.05.003_bib15","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s12311-014-0638-4","article-title":"Ethanol-induced cerebellar ataxia: Cellular and molecular mechanisms","volume":"14","author":"Dar","year":"2015","journal-title":"The Cerebellum"},{"issue":"5","key":"10.1016\/j.alcohol.2022.05.003_bib16","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1111\/j.1530-0277.1998.tb03695.x","article-title":"Effects of moderate alcohol consumption on the central nervous system","volume":"22","author":"Eckardt","year":"1998","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1016\/j.alcohol.2022.05.003_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbb.2021.173155","article-title":"Tolerance to alcohol: A critical yet understudied factor in alcohol addiction","volume":"204","author":"Elvig","year":"2021","journal-title":"Pharmacology, Biochemistry and Behavior"},{"issue":"1","key":"10.1016\/j.alcohol.2022.05.003_bib18","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1139\/H07-175","article-title":"Alcohol consumption: The good, the bad, and the indifferent","volume":"33","author":"Ferreira","year":"2008","journal-title":"Applied Physiology Nutrition and Metabolism"},{"issue":"4","key":"10.1016\/j.alcohol.2022.05.003_bib19","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0024-3205(73)90226-9","article-title":"Hypothermia after acute ethanol and benzyl alcohol administration","volume":"13","author":"Freund","year":"1973","journal-title":"Life Sciences"},{"issue":"2","key":"10.1016\/j.alcohol.2022.05.003_bib20","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/S0022-3565(25)32419-5","article-title":"Effects of acute and chronic 1,3-butanediol treatment on central nervous system function: A comparison with ethanol","volume":"216","author":"Frye","year":"1981","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.alcohol.2022.05.003_bib21","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.neurobiolaging.2017.01.025","article-title":"A\u00a0cross-sectional comparison of ethanol-related cytokine expression in the hippocampus of young and aged Fischer 344 rats","volume":"54","author":"Gano","year":"2017","journal-title":"Neurobiology of Aging"},{"issue":"2","key":"10.1016\/j.alcohol.2022.05.003_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0148601","article-title":"A\u00a0qualitative study of service provision for alcohol related health issues in mid to later life","volume":"11","author":"Haighton","year":"2016","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.alcohol.2022.05.003_bib23","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1111\/jgs.16071","article-title":"Binge drinking among older adults in the United States, 2015 to 2017","volume":"67","author":"Han","year":"2019","journal-title":"Journal of the American Geriatrics Society"},{"issue":"6","key":"10.1016\/j.alcohol.2022.05.003_bib24","first-page":"856","article-title":"Ethanol-induced impairments in spatial working memory are not due to deficits in learning","volume":"25","author":"Hoffmann","year":"2001","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1016\/j.alcohol.2022.05.003_bib25","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.alcohol.2019.06.003","article-title":"Age-dependent impairment of metabotropic glutamate receptor 2-dependent long-term depression in the mouse striatum by chronic ethanol exposure","volume":"82","author":"Johnson","year":"2020","journal-title":"Alcohol"},{"issue":"7836","key":"10.1016\/j.alcohol.2022.05.003_bib26","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/S0140-6736(73)91092-1","article-title":"Recognition of the fetal alcohol syndrome in early infancy","volume":"302","author":"Jones","year":"1973","journal-title":"Lancet"},{"issue":"8","key":"10.1016\/j.alcohol.2022.05.003_bib27","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1111\/acer.14125","article-title":"Alcohol consumption in later life and mortality in the United States: Results from 9 waves of the health and retirement study","volume":"43","author":"Keyes","year":"2019","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"4","key":"10.1016\/j.alcohol.2022.05.003_bib28","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s00213-009-1562-z","article-title":"The role of GABA(A) receptors in the acute and chronic effects of ethanol: A decade of progress","volume":"205","author":"Kumar","year":"2009","journal-title":"Psychopharmacology (Berl)"},{"issue":"1","key":"10.1016\/j.alcohol.2022.05.003_bib29","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s10900-020-00842-8","article-title":"Examining the association between alcohol consumption and health conditions in community dwelling older adults","volume":"46","author":"Laberge","year":"2020","journal-title":"Journal of Community Health"},{"issue":"5","key":"10.1016\/j.alcohol.2022.05.003_bib30","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1377\/hlthaff.2013.1224","article-title":"US health spending trends by age and gender: Selected years 2002\u201310","volume":"33","author":"Lassman","year":"2014","journal-title":"Health Affairs"},{"issue":"2","key":"10.1016\/j.alcohol.2022.05.003_bib31","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0197-0186(99)00054-6","article-title":"5-HT3 receptors and the neural actions of alcohols: An increasingly exciting topic","volume":"35","author":"Lovinger","year":"1999","journal-title":"Neurochemistry International"},{"issue":"3","key":"10.1016\/j.alcohol.2022.05.003_bib32","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/BF00429258","article-title":"Induction of physical dependence upon ethanol and the associated behavioral changes in rats","volume":"43","author":"Majchrowicz","year":"1975","journal-title":"Psychopharmacologia"},{"key":"10.1016\/j.alcohol.2022.05.003_bib33","series-title":"Behavioral neurobiology of alcohol addiction. Current topics in behavioral neuroscience","first-page":"403","article-title":"Modeling relapse in animals","author":"Martin-Fardon","year":"2013"},{"issue":"1","key":"10.1016\/j.alcohol.2022.05.003_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.alcohol.2009.10.018","article-title":"Adolescence and alcohol: Recent advances in understanding the impact of alcohol use during a critical developmental window","volume":"44","author":"Matthews","year":"2010","journal-title":"Alcohol"},{"issue":"1","key":"10.1016\/j.alcohol.2022.05.003_bib35","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3758\/BF03214415","article-title":"Fimbria-fornix lesions facilitate the learning of a nonspatial response task","volume":"2","author":"Matthews","year":"1995","journal-title":"Psychonomic Bulletin & Review"},{"issue":"3","key":"10.1016\/j.alcohol.2022.05.003_bib36","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1006\/nlme.1998.3900","article-title":"Acute ethanol administration impairs spatial performance while facilitating nonspatial performance in rats","volume":"72","author":"Matthews","year":"1999","journal-title":"Neurobiology of Learning and Memory"},{"key":"10.1016\/j.alcohol.2022.05.003_bib37","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.neulet.2017.08.012","article-title":"Age-dependent effects of chronic intermittent ethanol treatment: Gross motor behavior and body weight in aged, adult and adolescent rats","volume":"657","author":"Matthews","year":"2017","journal-title":"Neuroscience Letters"},{"issue":"11","key":"10.1016\/j.alcohol.2022.05.003_bib38","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1111\/j.1530-0277.2002.tb02479.x","article-title":"Acute ethanol administration and acute allopregnanolone administration impair spatial memory in the Morris water task","volume":"26","author":"Matthews","year":"2002","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1016\/j.alcohol.2022.05.003_bib39","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.alcohol.2017.01.012","article-title":"Impact of adolescent alcohol use across the lifespan: Long-lasting tolerance to high-dose alcohol coupled with potentiated spatial memory impairments to moderate-dose alcohol","volume":"61","author":"Matthews","year":"2017","journal-title":"Alcohol"},{"key":"10.1016\/j.alcohol.2022.05.003_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbb.2020.173074","article-title":"Acute ethanol administration produces larger spatial and nonspatial memory impairments in 29\u201333 month old rats compared to adult and 18\u201324 month old rats","volume":"199","author":"Matthews","year":"2020","journal-title":"Pharmacology, Biochemistry and Behavior"},{"issue":"2","key":"10.1016\/j.alcohol.2022.05.003_bib41","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1111\/j.1530-0277.1996.tb01660.x","article-title":"Ethanol alters spatial processing of hippocampal place cells: A mechanism for impaired navigation when intoxicated","volume":"20","author":"Matthews","year":"1996","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1016\/j.alcohol.2022.05.003_bib42","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.alcohol.2018.11.005","article-title":"The impact of low to moderate chronic intermittent ethanol exposure on behavioral endpoints in aged, adult, and adolescent rats","volume":"78","author":"Matthews","year":"2019","journal-title":"Alcohol"},{"issue":"11","key":"10.1016\/j.alcohol.2022.05.003_bib43","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002954","article-title":"Heavy and binge alcohol drinking and parenting status in the United States from 2006 to 2018: An analysis of nationally representative cross-sectional surveys","volume":"16","author":"McKetta","year":"2019","journal-title":"PLoS Medicine"},{"issue":"2","key":"10.1016\/j.alcohol.2022.05.003_bib44","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0306-4522(96)00138-8","article-title":"Hippocampal-dependent learning and experience-dependent activation of the hippocampus are preferentially disrupted by ethanol","volume":"74","author":"Melia","year":"1996","journal-title":"Neuroscience"},{"issue":"4","key":"10.1016\/j.alcohol.2022.05.003_bib45","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1530-0277.1983.tb05492.x","article-title":"Body sway and divided attention performance under the influence of alcohol: Dose-response differences between males and females","volume":"7","author":"Mills","year":"1983","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"3","key":"10.1016\/j.alcohol.2022.05.003_bib46","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s10059-013-0192-9","article-title":"Adenosine signaling in striatal circuits and alcohol use disorders","volume":"36","author":"Nam","year":"2013","journal-title":"Molecules and Cells"},{"issue":"7","key":"10.1016\/j.alcohol.2022.05.003_bib47","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1111\/acer.13098","article-title":"Differences in behavioral responding in adult and aged rats following chronic ethanol exposure","volume":"40","author":"Novier","year":"2016","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"8","key":"10.1016\/j.alcohol.2022.05.003_bib48","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1111\/acer.12110","article-title":"Acute alcohol produces ataxia and cognitive impairments in aged animals: A comparison between young adult and aged rats","volume":"37","author":"Novier","year":"2013","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"2","key":"10.1016\/j.alcohol.2022.05.003_bib49","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.alcohol.2014.12.002","article-title":"The effects of acute alcohol on motor impairments in adolescent, adult, and aged rats","volume":"49","author":"Ornelas","year":"2015","journal-title":"Alcohol"},{"issue":"5","key":"10.1016\/j.alcohol.2022.05.003_bib50","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1093\/ageing\/afv078","article-title":"Do levels of perceived stress increase with increasing age after age 65? A population-based study","volume":"44","author":"Osmanovic-Thunstr\u00f6m","year":"2015","journal-title":"Age and Ageing"},{"key":"10.1016\/j.alcohol.2022.05.003_bib51","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.neuropharm.2017.02.002","article-title":"Epigenetic basis of the dark side of alcohol addiction","volume":"122","author":"Pandey","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.alcohol.2022.05.003_bib52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pbb.2018.07.012","article-title":"Late aging alters behavioral sensitivity to ethanol in a sex-specific manner in Fischer 344 rats","volume":"175","author":"Perkins","year":"2018","journal-title":"Pharmacology, Biochemistry and Behavior"},{"issue":"2","key":"10.1016\/j.alcohol.2022.05.003_bib53","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0149-7634(81)90003-8","article-title":"The interaction of alcohol and stress. A review","volume":"5","author":"Pohorecky","year":"1981","journal-title":"Neuroscience & Biobehavioral Reviews"},{"issue":"2","key":"10.1016\/j.alcohol.2022.05.003_bib54","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.yhbeh.2014.05.005","article-title":"The neurosteroid allopregnanolone impairs object memory and contextual fear memory in male C57BL\/6J mice","volume":"66","author":"Rabinowitz","year":"2014","journal-title":"Hormones and Behavior"},{"issue":"4","key":"10.1016\/j.alcohol.2022.05.003_bib55","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/j.1530-0277.2007.00341.x","article-title":"Differential expression of ethanol-induced hypothermia in adolescent and adult rats induced by pretest familiarization to the handling\/injection procedure","volume":"31","author":"Ristuccia","year":"2007","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"2","key":"10.1016\/j.alcohol.2022.05.003_bib56","doi-asserted-by":"crossref","first-page":"a039339","DOI":"10.1101\/cshperspect.a039339","article-title":"The role of the central amygdala in alcohol dependence","volume":"11","author":"Roberto","year":"2021","journal-title":"Cold Spring Harbor Perspectives in Medicine"},{"issue":"5","key":"10.1016\/j.alcohol.2022.05.003_bib57","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1073\/pnas.0437273100","article-title":"Assessment of genetic susceptibility to ethanol intoxication in mice","volume":"100","author":"Rustay","year":"2003","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"5","key":"10.1016\/j.alcohol.2022.05.003_bib58","doi-asserted-by":"crossref","first-page":"e73","DOI":"10.1016\/j.amepre.2015.05.031","article-title":"2010 national and state costs of excessive alcohol consumption","volume":"49","author":"Sacks","year":"2015","journal-title":"American Journal of Preventive Medicine"},{"issue":"3","key":"10.1016\/j.alcohol.2022.05.003_bib59","doi-asserted-by":"crossref","first-page":"e124","DOI":"10.1016\/S2468-2667(18)30022-7","article-title":"Contribution of alcohol use disorders to the burden of dementia in France 2008\u201313: A nationwide retrospective cohort study","volume":"3","author":"Schwarzinger","year":"2018","journal-title":"The Lancet Public Health"},{"issue":"1","key":"10.1016\/j.alcohol.2022.05.003_bib60","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0741-8329(99)00055-5","article-title":"Ontogeny of ethanol elimination and ethanol-induced hypothermia","volume":"20","author":"Silveri","year":"2000","journal-title":"Alcohol"},{"issue":"4","key":"10.1016\/j.alcohol.2022.05.003_bib61","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nrn.2018.10","article-title":"Effects of adolescent alcohol consumption on the brain and behaviour","volume":"19","author":"Spear","year":"2018","journal-title":"Nature Reviews Neuroscience"},{"key":"10.1016\/j.alcohol.2022.05.003_bib62","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/0-306-48626-1_7","article-title":"Adolescence. Alcohol sensitivity, tolerance, and intake","volume":"17","author":"Spear","year":"2005","journal-title":"Recent Developments in Alcoholism"},{"key":"10.1016\/j.alcohol.2022.05.003_bib63","first-page":"27","article-title":"Substance use disorders in late life: A review of current evidence","volume":"4","author":"Tampi","year":"2015","journal-title":"Healthy Aging Research"},{"issue":"1\u20132","key":"10.1016\/j.alcohol.2022.05.003_bib64","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0006-8993(02)04266-X","article-title":"Effect of acute ethanol administration and acute allopregnanolone administration on spontaneous hippocampal pyramidal cell neural activity","volume":"967","author":"Tokunaga","year":"2003","journal-title":"Brain Research"},{"key":"10.1016\/j.alcohol.2022.05.003_bib65","series-title":"The World Population Prospects: 2015 Revision","year":"2015"},{"key":"10.1016\/j.alcohol.2022.05.003_bib66","unstructured":"United States Department of Health and Human Services. (2019)."},{"issue":"12","key":"10.1016\/j.alcohol.2022.05.003_bib67","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1111\/j.1530-0277.2010.01303.x","article-title":"Behavioral effects of ethanol in cerebellum are age dependent: Potential system and molecular mechanisms","volume":"34","author":"Van Skike","year":"2010","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1016\/j.alcohol.2022.05.003_bib68","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.alcohol.2019.03.006","article-title":"Acute alcohol and cognition: Remembering what it causes us to forget","volume":"79","author":"Van Skike","year":"2019","journal-title":"Alcohol"},{"key":"10.1016\/j.alcohol.2022.05.003_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107573","article-title":"Behavioral, neurobiological, and neurochemical mechanisms of ethanol self-administration: A translational review","volume":"212","author":"Vena","year":"2020","journal-title":"Pharmacology & Therapeutics"},{"issue":"4","key":"10.1016\/j.alcohol.2022.05.003_bib70","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1097\/00000433-199912000-00014","article-title":"Hypothermia: A natural cause of death","volume":"20","author":"Ward","year":"1999","journal-title":"The American Journal of Forensic Medicine and Pathology"},{"key":"10.1016\/j.alcohol.2022.05.003_bib71","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.alcohol.2019.08.001","article-title":"Impact of acute ethanol exposure on body temperatures in aged, adult and adolescent male rats","volume":"82","author":"Watson","year":"2020","journal-title":"Alcohol"},{"issue":"3","key":"10.1016\/j.alcohol.2022.05.003_bib72","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/hipo.10063","article-title":"Alcohol-induced memory impairment in trace fear conditioning: A hippocampus-specific effect","volume":"13","author":"Weitemier","year":"2003","journal-title":"Hippocampus"},{"issue":"1\u20132","key":"10.1016\/j.alcohol.2022.05.003_bib73","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/S0006-8993(00)02629-9","article-title":"Effects of ethanol on hippocampal place-cell and interneuron activity","volume":"876","author":"White","year":"2000","journal-title":"Brain Research"},{"issue":"17","key":"10.1016\/j.alcohol.2022.05.003_bib74","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1001\/jama.2022.4308","article-title":"Alcohol-related deaths during the COVID-19 pandemic","volume":"321","author":"White","year":"2022","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.alcohol.2022.05.003_bib75","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.alcohol.2009.08.011","article-title":"Research on alcohol and adolescent brain development: Opportunities and future directions","volume":"44","author":"Witt","year":"2010","journal-title":"Alcohol"},{"key":"10.1016\/j.alcohol.2022.05.003_bib76","series-title":"Global Status Report on Alcohol and Health","year":"2018"},{"issue":"1\u20132","key":"10.1016\/j.alcohol.2022.05.003_bib77","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1159\/000457395","article-title":"Body water content, ethanol pharmacokinetics, and the responsiveness to ethanol in young and old rats","volume":"4","author":"York","year":"1982","journal-title":"Developmental Pharmacology and Therapeutics"}],"container-title":["Alcohol"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741832922000490?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741832922000490?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T20:52:14Z","timestamp":1760043134000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0741832922000490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":77,"alternative-id":["S0741832922000490"],"URL":"https:\/\/doi.org\/10.1016\/j.alcohol.2022.05.003","relation":{},"ISSN":["0741-8329"],"issn-type":[{"value":"0741-8329","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Using animal models to identify clinical risk factors in the older population due to alcohol use and misuse","name":"articletitle","label":"Article Title"},{"value":"Alcohol","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.alcohol.2022.05.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}