{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T01:32:31Z","timestamp":1787880751602,"version":"build-2784847793"},"reference-count":113,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T00:00:00Z","timestamp":1660262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009231","name":"Dartmouth College Geisel School of Medicine","doi-asserted-by":"publisher","award":["F30AA029261"],"award-info":[{"award-number":["F30AA029261"]}],"id":[{"id":"10.13039\/100009231","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009231","name":"Dartmouth College Geisel School of Medicine","doi-asserted-by":"publisher","award":["R01AA027754"],"award-info":[{"award-number":["R01AA027754"]}],"id":[{"id":"10.13039\/100009231","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009231","name":"Dartmouth College Geisel School of Medicine","doi-asserted-by":"publisher","award":["R01AG072900"],"award-info":[{"award-number":["R01AG072900"]}],"id":[{"id":"10.13039\/100009231","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Alcohol"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.alcohol.2022.08.003","type":"journal-article","created":{"date-parts":[[2022,8,28]],"date-time":"2022-08-28T11:41:00Z","timestamp":1661686860000},"page":"56-72","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Precocious emergence of cognitive and synaptic dysfunction in 3xTg-AD mice exposed prenatally to ethanol"],"prefix":"10.1016","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5525-4882","authenticated-orcid":false,"given":"Adelaide R.","family":"Tousley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela W.L.","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6733-3692","authenticated-orcid":false,"given":"Hermes H.","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.alcohol.2022.08.003_bib1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3389\/fnagi.2015.00030","article-title":"Regional and sub-regional differences in hippocampal GABAergic neuronal vulnerability in the TgCRND8 mouse model of Alzheimer's disease","volume":"7","author":"Albuquerque","year":"2015","journal-title":"Frontiers in Aging Neuroscience"},{"issue":"4","key":"10.1016\/j.alcohol.2022.08.003_bib2","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.3233\/JAD-181190","article-title":"Parvalbumin-positive neuron loss and amyloid-\u03b2 deposits in the frontal cortex of Alzheimer's disease-related mice","volume":"72","author":"Ali","year":"2019","journal-title":"Journal of Alzheimer's Disease"},{"issue":"7","key":"10.1016\/j.alcohol.2022.08.003_bib3","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.tins.2021.03.006","article-title":"Circuit organization of the rodent medial prefrontal cortex","volume":"44","author":"Anastasiades","year":"2021","journal-title":"Trends in Neurosciences"},{"issue":"41","key":"10.1016\/j.alcohol.2022.08.003_bib4","doi-asserted-by":"crossref","first-page":"13707","DOI":"10.1523\/JNEUROSCI.4040-10.2010","article-title":"Apolipoprotein E4 causes age- and tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice","volume":"30","author":"Andrews-Zwilling","year":"2010","journal-title":"Journal of Neuroscience"},{"issue":"1","key":"10.1016\/j.alcohol.2022.08.003_bib5","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/0006-8993(87)90974-7","article-title":"Loss of parvalbumin-immunoreactive neurones from cortex in Alzheimer-type dementia","volume":"418","author":"Arai","year":"1987","journal-title":"Brain Research"},{"issue":"1","key":"10.1016\/j.alcohol.2022.08.003_bib6","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s00401-009-0536-x","article-title":"Synaptic degeneration in Alzheimer's disease","volume":"118","author":"Arendt","year":"2009","journal-title":"Acta Neuropathologica"},{"issue":"2","key":"10.1016\/j.alcohol.2022.08.003_bib7","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1530-0277.1996.tb01630.x","article-title":"Ethanol consumption and taste preferences in C57BL\/6ByJ and 129\/J mice","volume":"20","author":"Bachmanov","year":"1996","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"6","key":"10.1016\/j.alcohol.2022.08.003_bib8","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/S1474-4422(16)00063-6","article-title":"Dementia in Down's syndrome","volume":"15","author":"Ballard","year":"2016","journal-title":"The Lancet Neurology"},{"key":"10.1016\/j.alcohol.2022.08.003_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.884170","article-title":"Adolescent binge alcohol enhances early Alzheimer's disease pathology in adulthood through proinflammatory neuroimmune activation","volume":"13","author":"Barnett","year":"2022","journal-title":"Frontiers in Pharmacology"},{"key":"10.1016\/j.alcohol.2022.08.003_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.pneurobio.2020.101801","article-title":"Presynaptic failure in Alzheimer's disease","volume":"194","author":"Barthet","year":"2020","journal-title":"Progress in Neurobiology"},{"key":"10.1016\/j.alcohol.2022.08.003_bib11","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0070-2153(09)01203-4","article-title":"The developmental integration of cortical interneurons into a functional network","volume":"87","author":"Batista-Brito","year":"2009","journal-title":"Current Topics in Developmental Biology"},{"issue":"4","key":"10.1016\/j.alcohol.2022.08.003_bib12","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1093\/pch\/14.4.231","article-title":"Diagnosing fetal alcohol spectrum disorder: History, challenges and future directions","volume":"14","author":"Benz","year":"2009","journal-title":"Paediatrics and Child Health"},{"issue":"5","key":"10.1016\/j.alcohol.2022.08.003_bib13","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.neuron.2005.01.040","article-title":"Intraneuronal abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice","volume":"45","author":"Billings","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.alcohol.2022.08.003_bib14","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.neuroscience.2018.05.003","article-title":"Long-term reductions in the population of GABAergic interneurons in the mouse hippocampus following developmental ethanol exposure","volume":"383","author":"Bird","year":"2018","journal-title":"Neuroscience"},{"issue":"4","key":"10.1016\/j.alcohol.2022.08.003_bib15","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/S0306-4522(97)00068-7","article-title":"Parvalbumin-immunoreactive neurons in the hippocampal formation of Alzheimer's diseased brain","volume":"80","author":"Brady","year":"1997","journal-title":"Neuroscience"},{"issue":"2","key":"10.1016\/j.alcohol.2022.08.003_bib16","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/dvdy.10092","article-title":"Characterization of transgene expression and Cre recombinase activity in a panel of Thy-1 promoter-Cre transgenic mice","volume":"224","author":"Campsall","year":"2002","journal-title":"Developmental Dynamics"},{"issue":"1","key":"10.1016\/j.alcohol.2022.08.003_bib17","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0165-0270(96)00121-5","article-title":"Overexpression of growth-associated proteins in the neurons of adult transgenic mice","volume":"71","author":"Caroni","year":"1997","journal-title":"Journal of Neuroscience Methods"},{"issue":"1","key":"10.1016\/j.alcohol.2022.08.003_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF02741375","article-title":"Effects of ethanol on calcium homeostasis in the nervous system","volume":"19","author":"Catlin","year":"1999","journal-title":"Molecular Neurobiology"},{"issue":"1","key":"10.1016\/j.alcohol.2022.08.003_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13024-021-00434-7","article-title":"Enhancing GABAergic signaling ameliorates aberrant gamma oscillations of olfactory bulb in AD mouse models","volume":"16","author":"Chen","year":"2021","journal-title":"Molecular Neurodegeneration"},{"issue":"3","key":"10.1016\/j.alcohol.2022.08.003_bib20","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1523\/JNEUROSCI.1446-19.2019","article-title":"SIRT3 haploinsufficiency aggravates loss of GABAergic interneurons and neuronal network hyperexcitability in an Alzheimer's disease model","volume":"40","author":"Cheng","year":"2019","journal-title":"Journal of Neuroscience"},{"issue":"7","key":"10.1016\/j.alcohol.2022.08.003_bib21","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1111\/j.1530-0277.2011.01465.x","article-title":"Strain differences in developmental vulnerability to alcohol exposure via embryo culture in mice","volume":"35","author":"Chen","year":"2011","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"5","key":"10.1016\/j.alcohol.2022.08.003_bib22","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/8438","article-title":"Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation","volume":"5","author":"Chui","year":"1999","journal-title":"Nature Medicine"},{"issue":"1","key":"10.1016\/j.alcohol.2022.08.003_bib23","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0306-4522(01)00171-3","article-title":"Translating developmental time across mammalian species","volume":"105","author":"Clancy","year":"2001","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.alcohol.2022.08.003_bib24","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.nbd.2007.06.013","article-title":"Age-dependent sexual dimorphism in cognition and stress response in the 3xTg-AD mice","volume":"28","author":"Clinton","year":"2007","journal-title":"Neurobiology of Disease"},{"issue":"8","key":"10.1016\/j.alcohol.2022.08.003_bib25","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1523\/JNEUROSCI.5110-07.2008","article-title":"Ethanol consumption during early pregnancy alters the disposition of tangentially migrating GABAergic interneurons in the fetal cortex","volume":"28","author":"Cuzon","year":"2008","journal-title":"Journal of Neuroscience"},{"issue":"1","key":"10.1016\/j.alcohol.2022.08.003_bib26","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/wcs.1202","article-title":"Cognitive aspects of fetal alcohol spectrum disorder","volume":"4","author":"Davis","year":"2013","journal-title":"Wiley Interdisciplinary Reviews Cognitive Science"},{"issue":"5","key":"10.1016\/j.alcohol.2022.08.003_bib27","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/ana.410270502","article-title":"Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity","volume":"27","author":"DeKosky","year":"1990","journal-title":"Annals of Neurology"},{"key":"10.1016\/j.alcohol.2022.08.003_bib28","doi-asserted-by":"crossref","DOI":"10.21926\/obm.neurobiol.1701002","article-title":"FASD and brain development: Perspectives on where we are and where we need to go","volume":"1","author":"Delatour","year":"2017","journal-title":"OBM Neurobiology"},{"issue":"5","key":"10.1016\/j.alcohol.2022.08.003_bib29","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1093\/cercor\/bhy094","article-title":"Ethanol exposure in utero disrupts radial migration and pyramidal cell development in the somatosensory cortex","volume":"29","author":"Delatour","year":"2019","journal-title":"Cerebral Cortex"},{"issue":"3","key":"10.1016\/j.alcohol.2022.08.003_bib30","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1093\/cercor\/bhz199","article-title":"Prenatal exposure to ethanol alters synaptic activity in layer V\/VI pyramidal neurons of the somatosensory cortex","volume":"30","author":"Delatour","year":"2019","journal-title":"Cerebral Cortex"},{"issue":"16","key":"10.1016\/j.alcohol.2022.08.003_bib31","doi-asserted-by":"crossref","first-page":"365","DOI":"10.15585\/mmwr.mm6816a1","article-title":"Consumption of alcohol beverages and binge drinking among pregnant women aged 18\u201344 years \u2013 United States, 2015\u20132017","volume":"68","author":"Denny","year":"2019","journal-title":"MMWR Morbidity and Mortality Weekly Report"},{"issue":"7","key":"10.1016\/j.alcohol.2022.08.003_bib32","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1111\/j.1530-0277.2009.00949.x","article-title":"Ethanol teratogenesis in five inbred strains of mice","volume":"33","author":"Downing","year":"2009","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1016\/j.alcohol.2022.08.003_bib33","article-title":"Modifiable risk factors for Alzheimer's disease","volume":"11","author":"Edwards","year":"2019","journal-title":"Frontiers in Aging Neuroscience"},{"issue":"6","key":"10.1016\/j.alcohol.2022.08.003_bib34","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.biopsych.2009.06.015","article-title":"Intraneuronal beta-amyloid accumulation in the amygdala enhances fear and anxiety in Alzheimer's disease transgenic mice","volume":"67","author":"Espa\u00f1a","year":"2010","journal-title":"Biological Psychiatry"},{"key":"10.1016\/j.alcohol.2022.08.003_bib35","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.nlm.2012.10.010","article-title":"Effects of a metabotropic glutamate receptor 5 positive allosteric modulator, CDPPB, on spatial learning task performance in rodents","volume":"99","author":"Fowler","year":"2013","journal-title":"Neurobiology of Learning and Memory"},{"issue":"5","key":"10.1016\/j.alcohol.2022.08.003_bib36","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s00401-010-0679-9","article-title":"Intraneuronal beta-amyloid accumulation and synapse pathology in Alzheimer's disease","volume":"119","author":"Gouras","year":"2010","journal-title":"Acta Neuropathologica"},{"issue":"3","key":"10.1016\/j.alcohol.2022.08.003_bib37","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.conb.2007.03.014","article-title":"Structural aspects of AMPA receptor activation, desensitization and deactivation","volume":"17","author":"Hansen","year":"2007","journal-title":"Current Opinion in Neurobiology"},{"issue":"5580","key":"10.1016\/j.alcohol.2022.08.003_bib38","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1126\/science.1072994","article-title":"The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics","volume":"297","author":"Hardy","year":"2002","journal-title":"Science"},{"issue":"9","key":"10.1016\/j.alcohol.2022.08.003_bib39","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1093\/jnen\/62.9.917","article-title":"Parallel compensatory and pathological events associated with tau pathology in middle aged individuals with Down syndrome","volume":"62","author":"Head","year":"2003","journal-title":"Journal of Neuropathology and Experimental Neurology"},{"issue":"12","key":"10.1016\/j.alcohol.2022.08.003_bib40","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.2174\/1567205013666160603005035","article-title":"The association between alcohol use and the progression of Alzheimer's disease","volume":"13","author":"Heymann","year":"2016","journal-title":"Current Alzheimer Research"},{"issue":"12","key":"10.1016\/j.alcohol.2022.08.003_bib41","doi-asserted-by":"crossref","first-page":"3380","DOI":"10.1038\/s41380-019-0483-4","article-title":"Early restoration of parvalbumin interneuron activity prevents memory loss and network hyperexcitability in a mouse model of Alzheimer's disease","volume":"25","author":"Hijazi","year":"2019","journal-title":"Molecular Psychiatry"},{"key":"10.1016\/j.alcohol.2022.08.003_bib42","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/bs.irn.2019.10.017","article-title":"Alcohol drinking exacerbates neural and behavioral pathology in the 3xTg-AD mouse model of Alzheimer's disease","volume":"148","author":"Hoffman","year":"2019","journal-title":"International Review of Neurobiology"},{"issue":"3","key":"10.1016\/j.alcohol.2022.08.003_bib43","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.3892\/etm.2016.3455","article-title":"Association between alcohol and Alzheimer's disease","volume":"12","author":"Huang","year":"2016","journal-title":"Experimental and Therapeutic Medicine"},{"key":"10.1016\/j.alcohol.2022.08.003_bib44","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.cophys.2018.02.002","article-title":"Kinetic models for activation and modulation of NMDA receptor subtypes","volume":"2","author":"Iacobucci","year":"2018","journal-title":"Current Opinion in Physiology"},{"key":"10.1016\/j.alcohol.2022.08.003_bib45","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/2051-5960-2-61","article-title":"Intracellular A\u03b2 pathology and early cognitive impairments in a transgenic rat overexpressing human amyloid precursor protein: A multidimensional study","volume":"2","author":"Iulita","year":"2014","journal-title":"Acta Neuropathologica Communications"},{"issue":"10","key":"10.1016\/j.alcohol.2022.08.003_bib46","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1111\/acer.14686","article-title":"Effects of prenatal alcohol exposure on cognitive and behavioral development: Findings from a hierarchical meta-analysis of data from six prospective longitudinal U.S. cohorts","volume":"45","author":"Jacobson","year":"2021","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1016\/j.alcohol.2022.08.003_bib47","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.neurobiolaging.2019.01.019","article-title":"Prenatal noise stress aggravates cognitive decline and the onset and progression of beta amyloid pathology in a mouse model of Alzheimer's disease","volume":"77","author":"Jafari","year":"2019","journal-title":"Neurobiology of Aging"},{"key":"10.1016\/j.alcohol.2022.08.003_bib48","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/S0140-6736(73)91092-1","article-title":"Recognition of the fetal alcohol syndrome in early infancy","volume":"302","author":"Jones","year":"1973","journal-title":"Lancet"},{"issue":"9","key":"10.1016\/j.alcohol.2022.08.003_bib49","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1016\/j.ajpath.2016.05.013","article-title":"Biphasic alteration of the inhibitory synapse scaffold protein gephyrin in early and late stages of an Alzheimer disease model","volume":"186","author":"Kiss","year":"2016","journal-title":"American Journal of Pathology"},{"issue":"1","key":"10.1016\/j.alcohol.2022.08.003_bib50","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41572-021-00269-y","article-title":"Alzheimer disease","volume":"7","author":"Knopman","year":"2021","journal-title":"Nature Reviews Disease Primers"},{"issue":"2","key":"10.1016\/j.alcohol.2022.08.003_bib51","doi-asserted-by":"crossref","first-page":"509","DOI":"10.3233\/JAD-190834","article-title":"Alcohol consumption, brain amyloid-\u03b2 deposition, and brain structural integrity among older adults free of dementia","volume":"74","author":"Koch","year":"2020","journal-title":"Journal of Alzheimer's Disease"},{"issue":"6","key":"10.1016\/j.alcohol.2022.08.003_bib52","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1523\/JNEUROSCI.20-06-02166.2000","article-title":"Regulation of kinetic properties of GluR2 AMPA receptor channels by alternative splicing","volume":"20","author":"Koike","year":"2000","journal-title":"Journal of Neuroscience"},{"issue":"4\u20135","key":"10.1016\/j.alcohol.2022.08.003_bib53","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0031-9384(03)00171-9","article-title":"Assessment of spatial learning abilities of mice in a new circular maze","volume":"79","author":"Koopmans","year":"2003","journal-title":"Physiology & Behavior"},{"issue":"5","key":"10.1016\/j.alcohol.2022.08.003_bib54","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1111\/ene.15043","article-title":"Inhibitory synapse loss and accumulation of amyloid beta in inhibitory presynaptic terminals in Alzheimer's disease","volume":"29","author":"Kurucu","year":"2021","journal-title":"European Journal of Neurology"},{"issue":"1","key":"10.1016\/j.alcohol.2022.08.003_bib55","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0359-21.2021","article-title":"L-type calcium channels contribute to ethanol-induced aberrant tangential migration of primordial cortical GABAergic interneurons in the embryonic medial prefrontal cortex","volume":"9","author":"Lee","year":"2022","journal-title":"eNeuro"},{"issue":"1","key":"10.1016\/j.alcohol.2022.08.003_bib56","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3233\/JAD-2010-1349","article-title":"A\u00a0novel transgenic rat model with a full Alzheimer's-like amyloid pathology displays pre-plaque intracellular amyloid-\u03b2-associated cognitive impairment","volume":"20","author":"Leon","year":"2010","journal-title":"Journal of Alzheimer's Disease"},{"issue":"3","key":"10.1016\/j.alcohol.2022.08.003_bib57","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0741-8329(90)90011-Z","article-title":"Ethanol and neuronal calcium channels","volume":"7","author":"Leslie","year":"1990","journal-title":"Alcohol"},{"issue":"12","key":"10.1016\/j.alcohol.2022.08.003_bib58","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0053569","article-title":"Apolipoprotein E4 causes age- and sex-dependent impairments of hilar GABAergic interneurons and learning and memory deficits in mice","volume":"7","author":"Leung","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.alcohol.2022.08.003_bib59","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/brb3.29","article-title":"Responses to ethanol in C57BL\/6 versus C57BL\/6\u00a0\u00d7 129 hybrid mice","volume":"2","author":"Lim","year":"2012","journal-title":"Brain and Behavior"},{"issue":"31","key":"10.1016\/j.alcohol.2022.08.003_bib60","article-title":"Implications of GABAergic neurotransmission in Alzheimer's disease","volume":"8","author":"Li","year":"2016","journal-title":"Frontiers in Aging Neuroscience"},{"issue":"1","key":"10.1016\/j.alcohol.2022.08.003_bib61","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/s13195-021-00859-8","article-title":"Reversible GABAergic dysfunction involved in hippocampal hyperactivity predicts early-stage Alzheimer disease in a mouse model","volume":"13","author":"Li","year":"2021","journal-title":"Alzheimer's Research & Therapy"},{"key":"10.1016\/j.alcohol.2022.08.003_bib62","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/164_2017_76","article-title":"Presynaptic ethanol actions: Potential roles in ethanol seeking","volume":"248","author":"Lovinger","year":"2018","journal-title":"Handbook of Experimental Pharmacology"},{"issue":"7","key":"10.1016\/j.alcohol.2022.08.003_bib63","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1111\/acer.13114","article-title":"Alcohol-induced developmental origins of adult-onset diseases","volume":"40","author":"Lunde","year":"2016","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1016\/j.alcohol.2022.08.003_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2019.134700","article-title":"Moderate prenatal alcohol exposure reduces parvalbumin expressing GABAergic interneurons in the dorsal hippocampus of adult male and female rat offspring","volume":"718","author":"Madden","year":"2020","journal-title":"Neuroscience Letters"},{"issue":"1","key":"10.1016\/j.alcohol.2022.08.003_bib65","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1186\/s40478-020-01089-z","article-title":"Prenatal alcohol exposure is a leading cause of interneuronopathy in humans","volume":"8","author":"Marguet","year":"2020","journal-title":"Acta Neuropathologica Communications"},{"issue":"1","key":"10.1016\/j.alcohol.2022.08.003_bib66","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.neuron.2018.02.029","article-title":"Nav1.1-Overexpressing interneuron transplants restore brain rhythms and cognition in a mouse model of Alzheimer's disease","volume":"98","author":"Martinez-Losa","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.alcohol.2022.08.003_bib67","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/1471-2202-9-81","article-title":"Detailed immunohistochemical characterization of temporal and spatial progression of Alzheimer's disease-related pathologies in male triple-transgenic mice","volume":"9","author":"Mastrangelo","year":"2008","journal-title":"BMC Neuroscience"},{"issue":"2","key":"10.1016\/j.alcohol.2022.08.003_bib68","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s11065-011-9167-9","article-title":"Fetal alcohol spectrum disorders: Neuropsychological and behavioral features","volume":"21","author":"Mattson","year":"2011","journal-title":"Neuropsychology Review"},{"issue":"1","key":"10.1016\/j.alcohol.2022.08.003_bib69","first-page":"15","article-title":"Maternal risk factors for fetal alcohol spectrum disorders: Not as simple as it might seem","volume":"34","author":"May","year":"2011","journal-title":"Alcohol Research & Health"},{"issue":"7","key":"10.1016\/j.alcohol.2022.08.003_bib70","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.tips.2008.04.004","article-title":"Regulation of AMPA receptor gating and pharmacology by TARP auxiliary subunits","volume":"29","author":"Milstein","year":"2008","journal-title":"Trends in Pharmacological Sciences"},{"issue":"10","key":"10.1016\/j.alcohol.2022.08.003_bib71","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1016\/j.neurobiolaging.2013.04.010","article-title":"Altered synapses and gliotransmission in Alzheimer's disease and AD model mice","volume":"34","author":"Mitew","year":"2013","journal-title":"Neurobiology of Aging"},{"issue":"3","key":"10.1016\/j.alcohol.2022.08.003_bib72","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s40474-015-0053-7","article-title":"What happens when children with fetal alcohol spectrum disorders become adults?","volume":"2","author":"Moore","year":"2015","journal-title":"Current Developmental Disorders Reports"},{"issue":"1","key":"10.1016\/j.alcohol.2022.08.003_bib73","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/j.1742-7843.2012.00879.x","article-title":"Acute effects of ethanol on glutamate receptors","volume":"111","author":"M\u00f6ykkynen","year":"2012","journal-title":"Basic and Clinical Pharmacology and Toxicology"},{"issue":"2","key":"10.1016\/j.alcohol.2022.08.003_bib74","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.neurobiolaging.2014.10.017","article-title":"Low concentrations of ethanol protect against synaptotoxicity induced by A\u03b2 in hippocampal neurons","volume":"36","author":"Mu\u00f1oz","year":"2015","journal-title":"Neurobiology of Aging"},{"issue":"3","key":"10.1016\/j.alcohol.2022.08.003_bib75","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/nn.2751","article-title":"Parvalbumin-positive CA1 interneurons are required for spatial working but not for reference memory","volume":"14","author":"Murray","year":"2011","journal-title":"Nature Neuroscience"},{"key":"10.1016\/j.alcohol.2022.08.003_bib76","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2021.679960","article-title":"The role of parvalbumin interneurons in neurotransmitter balance and neurological disease","volume":"12","author":"Nahar","year":"2021","journal-title":"Frontiers in Psychiatry"},{"key":"10.1016\/j.alcohol.2022.08.003_bib77","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.neulet.2019.04.022","article-title":"The complexity of tau in Alzheimer's disease","volume":"705","author":"Naseri","year":"2019","journal-title":"Neuroscience Letters"},{"issue":"3","key":"10.1016\/j.alcohol.2022.08.003_bib78","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0896-6273(03)00434-3","article-title":"Triple-transgenic model of Alzheimer's disease with plaques and tangles: Intracellular Abeta and synaptic dysfunction","volume":"39","author":"Oddo","year":"2003","journal-title":"Neuron"},{"issue":"5","key":"10.1016\/j.alcohol.2022.08.003_bib79","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1097\/01.ALC.0000163495.71181.10","article-title":"Differential teratogenic effect of alcohol on embryonic development between C57BL\/6 and DBA\/2 mice: A new view","volume":"29","author":"Ogawa","year":"2005","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1016\/j.alcohol.2022.08.003_bib80","doi-asserted-by":"crossref","DOI":"10.4061\/2010\/780102","article-title":"Staging of Alzheimer's pathology in triple transgenic mice: A light and electron microscopic analysis","volume":"2010","author":"Oh","year":"2010","journal-title":"International Journal of Alzheimer's Disease"},{"issue":"12","key":"10.1016\/j.alcohol.2022.08.003_bib81","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/nrn.2016.141","article-title":"Network abnormalities and interneuron dysfunction in Alzheimer disease","volume":"17","author":"Palop","year":"2016","journal-title":"Nature Reviews Neuroscience"},{"key":"10.1016\/j.alcohol.2022.08.003_bib82","series-title":"World Alzheimer report 2018. The state of the art of dementia research: New frontiers","author":"Patterson","year":"2018"},{"issue":"7","key":"10.1016\/j.alcohol.2022.08.003_bib83","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.3390\/ijms21072316","article-title":"Role of alcohol drinking in Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis","volume":"21","author":"Peng","year":"2020","journal-title":"International Journal of Molecular Sciences"},{"issue":"4","key":"10.1016\/j.alcohol.2022.08.003_bib84","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1037\/a0012520","article-title":"Age-dependent phenotypic characteristics of a triple transgenic mouse model of Alzheimer disease","volume":"122","author":"Pietropaolo","year":"2008","journal-title":"Behavioral Neuroscience"},{"issue":"4","key":"10.1016\/j.alcohol.2022.08.003_bib85","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.biopsych.2017.05.014","article-title":"Untangling genetic risk for Alzheimer's disease","volume":"83","author":"Pimenova","year":"2018","journal-title":"Biological Psychiatry"},{"issue":"3","key":"10.1016\/j.alcohol.2022.08.003_bib86","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109008","article-title":"Alzheimer's pathology causes impaired inhibitory connections and reactivation of spatial codes during spatial navigation","volume":"35","author":"Prince","year":"2021","journal-title":"Cell Reports"},{"issue":"2","key":"10.1016\/j.alcohol.2022.08.003_bib87","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.conb.2011.01.007","article-title":"Differential regulation of spontaneous and evoked neurotransmitter release at central synapses","volume":"21","author":"Ramirez","year":"2011","journal-title":"Current Opinion in Neurobiology"},{"issue":"8","key":"10.1016\/j.alcohol.2022.08.003_bib88","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1097\/01.alc.0000175040.91007.d0","article-title":"Executive functioning and working memory in fetal alcohol spectrum disorder","volume":"29","author":"Rasmussen","year":"2005","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1016\/j.alcohol.2022.08.003_bib89","doi-asserted-by":"crossref","first-page":"123","DOI":"10.2147\/DNND.S228939","article-title":"Alzheimer's disease \u2013 Why we need early diagnosis","volume":"9","author":"Rasmussen","year":"2019","journal-title":"Degenerative Neurological and Neuromuscular Disease"},{"issue":"2","key":"10.1016\/j.alcohol.2022.08.003_bib90","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/j.1530-0277.2006.00030.x","article-title":"Actions of acute and chronic ethanol on presynaptic terminals","volume":"30","author":"Roberto","year":"2006","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1016\/j.alcohol.2022.08.003_bib91","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.neuropharm.2017.01.013","article-title":"Synaptic targets: Chronic alcohol actions","volume":"122","author":"Roberto","year":"2017","journal-title":"Neuropharmacology"},{"issue":"2","key":"10.1016\/j.alcohol.2022.08.003_bib92","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/bpa.12785","article-title":"Distinct disease-sensitive GABAergic neurons in the perirhinal cortex of Alzheimer's mice and patients","volume":"30","author":"Sanchez-Mejias","year":"2020","journal-title":"Brain Pathology"},{"issue":"10","key":"10.1016\/j.alcohol.2022.08.003_bib93","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1016\/j.neurobiolaging.2005.09.012","article-title":"Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment","volume":"27","author":"Scheff","year":"2006","journal-title":"Neurobiology of Aging"},{"issue":"7","key":"10.1016\/j.alcohol.2022.08.003_bib94","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: An open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nature Methods"},{"issue":"4","key":"10.1016\/j.alcohol.2022.08.003_bib95","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1159\/000439568","article-title":"Early life epidemiology of Alzheimer's disease \u2013 A critical review","volume":"45","author":"Seifan","year":"2015","journal-title":"Neuroepidemiology"},{"issue":"5594","key":"10.1016\/j.alcohol.2022.08.003_bib96","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1126\/science.1074069","article-title":"Alzheimer's disease is a synaptic failure","volume":"298","author":"Selkoe","year":"2002","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.alcohol.2022.08.003_bib97","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.pharmthera.2005.01.006","article-title":"The tipsy terminal: Presynaptic effects of ethanol","volume":"107","author":"Siggins","year":"2005","journal-title":"Pharmacology & Therapeutics"},{"issue":"31","key":"10.1016\/j.alcohol.2022.08.003_bib98","doi-asserted-by":"crossref","first-page":"10977","DOI":"10.1523\/JNEUROSCI.1462-15.2015","article-title":"Persistent interneuronopathy in the prefrontal cortex of young adult offspring exposed to ethanol in utero","volume":"35","author":"Skorput","year":"2015","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.alcohol.2022.08.003_bib99","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.48648","article-title":"The NKCC1 antagonist bumetanide mitigates interneuronopathy associated with ethanol exposure in utero","volume":"8","author":"Skorput","year":"2019","journal-title":"eLife"},{"key":"10.1016\/j.alcohol.2022.08.003_bib100","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.bbr.2014.10.033","article-title":"Reference and working memory deficits in the 3xTg-AD mouse between 2 and 15-months of age: A cross-sectional study","volume":"278","author":"Stevens","year":"2015","journal-title":"Behavioural Brain Research"},{"key":"10.1016\/j.alcohol.2022.08.003_bib101","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3389\/fnsyn.2015.00007","article-title":"Different AMPA receptor subtypes mediate the distinct kinetic components of a biphasic EPSC in hippocampal interneurons","volume":"7","author":"Stincic","year":"2015","journal-title":"Frontiers in Synaptic Neuroscience"},{"key":"10.1016\/j.alcohol.2022.08.003_bib102","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.bbr.2015.04.012","article-title":"Early detection of cognitive deficits in the 3xTg-AD mouse model of Alzheimer's disease","volume":"289","author":"Stover","year":"2015","journal-title":"Behavioural Brain Research"},{"issue":"5","key":"10.1016\/j.alcohol.2022.08.003_bib103","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1016\/S0002-9440(10)64463-X","article-title":"Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology","volume":"161","author":"Takahashi","year":"2002","journal-title":"American Journal of Pathology"},{"issue":"4","key":"10.1016\/j.alcohol.2022.08.003_bib104","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","article-title":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors","volume":"126","author":"Takahashi","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.alcohol.2022.08.003_bib105","doi-asserted-by":"crossref","first-page":"423","DOI":"10.3389\/fnins.2015.00423","article-title":"Synaptic activity and Alzheimer's disease: A critical update","volume":"9","author":"Tampellini","year":"2015","journal-title":"Frontiers in Neuroscience"},{"issue":"11 Pt B","key":"10.1016\/j.alcohol.2022.08.003_bib106","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1016\/j.bbamcr.2018.07.018","article-title":"Calcium signaling in Alzheimer's disease & therapies","volume":"1865","author":"Tong","year":"2018","journal-title":"Biochimica et Biophysica Acta Molecular Cell Research"},{"issue":"3","key":"10.1016\/j.alcohol.2022.08.003_bib107","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.cell.2012.02.046","article-title":"Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model","volume":"149","author":"Verret","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.alcohol.2022.08.003_bib108","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.neuroscience.2012.08.046","article-title":"Adolescent binge drinking increases expression of the danger signal receptor agonist HMGB1 and Toll-like receptors in the adult prefrontal cortex","volume":"226","author":"Vetreno","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.alcohol.2022.08.003_bib109","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1002\/aur.2590","article-title":"The prevalence and incidence of early-onset dementia among adults with autism spectrum disorder","volume":"10","author":"Vivanti","year":"2021","journal-title":"Autism Research"},{"issue":"6","key":"10.1016\/j.alcohol.2022.08.003_bib110","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1007\/s00401-018-1922-z","article-title":"Evidence of intraneuronal A\u03b2 accumulation preceding tau pathology in the entorhinal cortex","volume":"136","author":"Welikovitch","year":"2018","journal-title":"Acta Neuropathologica"},{"issue":"8","key":"10.1016\/j.alcohol.2022.08.003_bib111","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/S1474-4422(19)30150-4","article-title":"Clinical presentation, diagnosis, and management of fetal alcohol spectrum disorder","volume":"18","author":"Wozniak","year":"2019","journal-title":"The Lancet Neurology"},{"key":"10.1016\/j.alcohol.2022.08.003_bib112","doi-asserted-by":"crossref","first-page":"660","DOI":"10.3389\/fnins.2020.00660","article-title":"GABAergic inhibitory interneuron deficits in Alzheimer's disease: Implications for treatment","volume":"14","author":"Xu","year":"2020","journal-title":"Frontiers in Neuroscience"},{"issue":"11","key":"10.1016\/j.alcohol.2022.08.003_bib113","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1136\/jnnp-2019-321913","article-title":"Evidence-based prevention of Alzheimer's disease: Systematic review and meta-analysis of 243 observational prospective studies and 153 randomised controlled trials","volume":"91","author":"Yu","year":"2020","journal-title":"Journal of Neurology, Neurosurgery, and Psychiatry"}],"container-title":["Alcohol"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741832922000738?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741832922000738?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T20:51:24Z","timestamp":1760043084000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0741832922000738"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":113,"alternative-id":["S0741832922000738"],"URL":"https:\/\/doi.org\/10.1016\/j.alcohol.2022.08.003","relation":{},"ISSN":["0741-8329"],"issn-type":[{"value":"0741-8329","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Precocious emergence of cognitive and synaptic dysfunction in 3xTg-AD mice exposed prenatally to ethanol","name":"articletitle","label":"Article Title"},{"value":"Alcohol","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.alcohol.2022.08.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}