{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T04:16:28Z","timestamp":1793592988080,"version":"4.5.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T00:00:00Z","timestamp":1768608000000},"content-version":"am","delay-in-days":350,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["P50AA017823"],"award-info":[{"award-number":["P50AA017823"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["U01 AA019972"],"award-info":[{"award-number":["U01 AA019972"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Alcohol"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.alcohol.2024.10.001","type":"journal-article","created":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T15:46:44Z","timestamp":1729525604000},"page":"71-80","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Sex-dependent effects of ethanol withdrawal from a single- and repeated binge episode exposures on social anxiety-like behavior and neuropeptide gene expression in adolescent rats"],"prefix":"10.1016","volume":"122","author":[{"given":"Peter T.","family":"Penta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanna","family":"Villarreal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin I.","family":"Rameas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3572-8736","authenticated-orcid":false,"given":"Ella C.","family":"Collins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4258-9189","authenticated-orcid":false,"given":"Trevor T.","family":"Towner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena I.","family":"Varlinskaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2914-7706","authenticated-orcid":false,"given":"David F.","family":"Werner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.alcohol.2024.10.001_bib1","article-title":"Binge drinking among adolescents is related to the development of alcohol use disorders: Results from a cross-sectional study","volume":"8","author":"Addolorato","year":"2018","journal-title":"Scientific Reports"},{"issue":"4","key":"10.1016\/j.alcohol.2024.10.001_bib2","first-page":"348","article-title":"Alcohol dependence, withdrawal, and relapse","volume":"31","author":"Becker","year":"2008","journal-title":"Alcohol Research & Health"},{"issue":"8","key":"10.1016\/j.alcohol.2024.10.001_bib3","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1111\/acer.12096","article-title":"The impact of adolescent binge drinking and sustained abstinence on affective state","volume":"37","author":"Bekman","year":"2013","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"4","key":"10.1016\/j.alcohol.2024.10.001_bib4","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0143-4179(95)90029-2","article-title":"Polymodal dose-response curve for oxytocin in the social recognition test","volume":"28","author":"Benelli","year":"1995","journal-title":"Neuropeptides"},{"issue":"8","key":"10.1016\/j.alcohol.2024.10.001_bib5","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1080\/10826084.2023.2201861","article-title":"Emergence of sex differences in U.S. Adolescent substance use","volume":"58","author":"Bhatia","year":"2023","journal-title":"Substance Use & Misuse"},{"issue":"3","key":"10.1016\/j.alcohol.2024.10.001_bib6","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/sj.npp.1300360","article-title":"Profound impairment in social recognition and reduction in anxiety-like behavior in vasopressin V1a receptor knockout mice","volume":"29","author":"Bielsky","year":"2004","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"10.1016\/j.alcohol.2024.10.001_bib7","first-page":"5","article-title":"Adolescent binge drinking","volume":"39","author":"Chung","year":"2018","journal-title":"Alcohol Research: Current Reviews"},{"key":"10.1016\/j.alcohol.2024.10.001_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2022.104560","article-title":"Test, rinse, repeat: A review of carryover effects in rodent behavioral assays","volume":"135","author":"Cnops","year":"2022","journal-title":"Neuroscience & Biobehavioral Reviews"},{"issue":"3","key":"10.1016\/j.alcohol.2024.10.001_bib9","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1210\/endo.133.3.8365352","article-title":"Neurosteroids: 3 alpha-hydroxy-5 alpha-pregnan-20-one and its precursors in the brain, plasma, and steroidogenic glands of male and female rats","volume":"133","author":"Corp\u00e9chot","year":"1993","journal-title":"Endocrinology"},{"issue":"10","key":"10.1016\/j.alcohol.2024.10.001_bib10","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1007\/s00213-018-5003-8","article-title":"Oxytocin and vasopressin modulation of social anxiety following adolescent intermittent ethanol exposure","volume":"235","author":"Dannenhoffer","year":"2018","journal-title":"Psychopharmacology"},{"issue":"11","key":"10.1016\/j.alcohol.2024.10.001_bib11","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1111\/j.1530-0277.2001.tb02176.x","article-title":"Sex differences in rats in the development of and recovery from ethanol dependence assessed by changes in seizure susceptibility","volume":"25","author":"Devaud","year":"2001","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"2","key":"10.1016\/j.alcohol.2024.10.001_bib12","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1677\/JOE-09-0175","article-title":"Reversal of the hypothalamo-pituitary\u2013adrenal response to oestrogens around puberty","volume":"202","author":"Evuarherhe","year":"2009","journal-title":"Journal of Endocrinology"},{"issue":"1","key":"10.1016\/j.alcohol.2024.10.001_bib13","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1476-5381.1978.tb07001.x","article-title":"Can social interaction be used to measure anxiety?","volume":"62","author":"File","year":"1978","journal-title":"British Journal of Pharmacology"},{"issue":"10","key":"10.1016\/j.alcohol.2024.10.001_bib14","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.biopsych.2014.09.008","article-title":"The central amygdala as an integrative hub for anxiety and alcohol use disorders","volume":"77","author":"Gilpin","year":"2015","journal-title":"Biological Psychiatry"},{"issue":"9","key":"10.1016\/j.alcohol.2024.10.001_bib15","doi-asserted-by":"crossref","first-page":"6370","DOI":"10.1073\/pnas.092012099","article-title":"Anxiolytic- and antidepressant-like effects of the non-peptide vasopressin V1b receptor antagonist, SSR149415, suggest an innovative approach for the treatment of stress-related disorders","volume":"99","author":"Griebel","year":"2002","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"10","key":"10.1016\/j.alcohol.2024.10.001_bib16","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1111\/acer.14163","article-title":"Amygdala arginine vasopressin modulates chronic ethanol withdrawal anxiety-like behavior in the social interaction task","volume":"43","author":"Harper","year":"2019","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"2","key":"10.1016\/j.alcohol.2024.10.001_bib17","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1369-1600.2009.00194.x","article-title":"Acute withdrawal, protracted abstinence and negative affect in alcoholism: Are they linked?","volume":"15","author":"Heilig","year":"2010","journal-title":"Addiction Biology"},{"issue":"3","key":"10.1016\/j.alcohol.2024.10.001_bib18","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0892-0362(92)90020-B","article-title":"Principles and pitfalls in the analysis of prenatal treatment effects in multiparous species","volume":"14","author":"Holson","year":"1992","journal-title":"Neurotoxicology and Teratology"},{"key":"10.1016\/j.alcohol.2024.10.001_bib19","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.alcohol.2023.10.039","article-title":"Social behavior and neuronal activation in adolescent female Fos-LacZ transgenic rats: Impact of acute ethanol challenge and baseline levels of social preference","volume":"117","author":"Hosov\u00e1-Kennedy","year":"2024","journal-title":"Alcohol"},{"issue":"6","key":"10.1016\/j.alcohol.2024.10.001_bib20","doi-asserted-by":"crossref","first-page":"3185","DOI":"10.1152\/jn.00189.2007","article-title":"Chronic ethanol and withdrawal differentially modulate pre- and postsynaptic function at glutamatergic synapses in rat basolateral amygdala","volume":"98","author":"L\u00e4ck","year":"2007","journal-title":"Journal of Neurophysiology"},{"issue":"4","key":"10.1016\/j.alcohol.2024.10.001_bib21","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods (San Diego, Calif.)"},{"issue":"11","key":"10.1016\/j.alcohol.2024.10.001_bib22","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1038\/npp.2011.95","article-title":"The neuropeptide oxytocin facilitates pro-social behavior and prevents social avoidance in rats and mice","volume":"36","author":"Lukas","year":"2011","journal-title":"Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology"},{"key":"10.1016\/j.alcohol.2024.10.001_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbb.2021.173229","article-title":"Male, but not female, Sprague Dawley rats display enhanced fear learning following acute ethanol withdrawal (hangover)","volume":"208","author":"Marsland","year":"2021","journal-title":"Pharmacology Biochemistry and Behavior"},{"key":"10.1016\/j.alcohol.2024.10.001_bib24","series-title":"StatPearls","article-title":"Alcohol withdrawal","author":"Newman","year":"2024"},{"issue":"4","key":"10.1016\/j.alcohol.2024.10.001_bib25","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/hup.1023","article-title":"Alcohol hangover: A critical review of explanatory factors","volume":"24","author":"Prat","year":"2009","journal-title":"Human Psychopharmacology"},{"issue":"2","key":"10.1016\/j.alcohol.2024.10.001_bib26","doi-asserted-by":"crossref","first-page":"E320","DOI":"10.1152\/ajpendo.00615.2009","article-title":"Binge-pattern alcohol exposure during puberty induces sexually dimorphic changes in genes regulating the HPA axis","volume":"298","author":"Przybycien-Szymanska","year":"2010","journal-title":"American Journal of Physiology - Endocrinology And Metabolism"},{"issue":"6","key":"10.1016\/j.alcohol.2024.10.001_bib27","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/alcalc\/agp049","article-title":"Sex differences in acoustic startle responses and seizure thresholds between ethanol-withdrawn male and female rats","volume":"44","author":"Reilly","year":"2009","journal-title":"Alcohol and Alcoholism"},{"key":"10.1016\/j.alcohol.2024.10.001_bib28","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1127792","article-title":"Modulation of social behavior by distinct vasopressin sources","volume":"14","author":"Rigney","year":"2023","journal-title":"Frontiers in Endocrinology"},{"issue":"9","key":"10.1016\/j.alcohol.2024.10.001_bib29","doi-asserted-by":"crossref","DOI":"10.1210\/endocr\/bqac111","article-title":"Oxytocin, vasopressin, and social behavior: From neural circuits to clinical opportunities","volume":"163","author":"Rigney","year":"2022","journal-title":"Endocrinology"},{"issue":"4","key":"10.1016\/j.alcohol.2024.10.001_bib30","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0149-7634(00)00014-2","article-title":"The adolescent brain and age-related behavioral manifestations","volume":"24","author":"Spear","year":"2000","journal-title":"Neuroscience & Biobehavioral Reviews"},{"key":"10.1016\/j.alcohol.2024.10.001_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2023.109663","article-title":"Determining the neuronal ensembles underlying sex-specific social impairments following adolescent intermittent ethanol exposure","volume":"238","author":"Towner","year":"2023","journal-title":"Neuropharmacology"},{"issue":"6","key":"10.1016\/j.alcohol.2024.10.001_bib32","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1111\/acer.14847","article-title":"Impact of adolescent intermittent ethanol exposure in male and female rats on social drinking and neuropeptide gene expression","volume":"46","author":"Towner","year":"2022","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"1","key":"10.1016\/j.alcohol.2024.10.001_bib33","first-page":"61","article-title":"Complications of alcohol withdrawal","volume":"22","author":"Trevisan","year":"1998","journal-title":"Alcohol Health & Research World"},{"issue":"1","key":"10.1016\/j.alcohol.2024.10.001_bib34","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1046\/j.1601-183X.2003.0044.x","article-title":"Behavioral alterations induced by repeated testing in C57BL\/6J and 129S2\/Sv mice: Implications for phenotyping screens","volume":"3","author":"V\u00f5ikar","year":"2004","journal-title":"Genes, Brain and Behavior"},{"issue":"2","key":"10.1016\/j.alcohol.2024.10.001_bib35","first-page":"144","article-title":"Alcohol and neurotransmitter interactions","volume":"21","author":"Valenzuela","year":"1997","journal-title":"Alcohol Health & Research World"},{"key":"10.1016\/j.alcohol.2024.10.001_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2019.112292","article-title":"Effects of chronic intermittent ethanol exposure during early and late adolescence on anxiety-like behaviors and behavioral flexibility in adulthood","volume":"378","author":"Varlinskaya","year":"2020","journal-title":"Behavioural Brain Research"},{"issue":"Pt B","key":"10.1016\/j.alcohol.2024.10.001_bib37","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.brainres.2016.03.050","article-title":"Chronic intermittent ethanol exposure during adolescence: Effects on stress-induced social alterations and social drinking in adulthood","volume":"1654","author":"Varlinskaya","year":"2017","journal-title":"Brain Research"},{"issue":"1","key":"10.1016\/j.alcohol.2024.10.001_bib38","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1097\/01.ALC.0000108655.51087.DF","article-title":"Acute ethanol withdrawal (hangover) and social behavior in adolescent and adult male and female Sprague-Dawley rats","volume":"28","author":"Varlinskaya","year":"2004","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1016\/j.alcohol.2024.10.001_bib39","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.physbeh.2014.11.062","article-title":"Social consequences of ethanol: Impact of age, stress, and prior history of ethanol exposure","volume":"148","author":"Varlinskaya","year":"2015","journal-title":"Physiology & Behavior"},{"issue":"4","key":"10.1016\/j.alcohol.2024.10.001_bib40","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S0031-9384(98)00285-6","article-title":"Social behavior and social motivation in adolescent rats: Role of housing conditions and partner's activity","volume":"67","author":"Varlinskaya","year":"1999","journal-title":"Physiology & Behavior"},{"issue":"5","key":"10.1016\/j.alcohol.2024.10.001_bib41","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.alcohol.2014.01.012","article-title":"Chronic intermittent ethanol exposure during adolescence: Effects on social behavior and ethanol sensitivity in adulthood","volume":"48","author":"Varlinskaya","year":"2014","journal-title":"Alcohol (Fayetteville, N.Y.)"},{"issue":"1","key":"10.1016\/j.alcohol.2024.10.001_bib42","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.yhbeh.2011.10.002","article-title":"Vasopressin regulates social recognition in juvenile and adult rats of both sexes, but in sex- and age-specific ways","volume":"61","author":"Veenema","year":"2012","journal-title":"Hormones and Behavior"},{"issue":"3","key":"10.1016\/j.alcohol.2024.10.001_bib43","doi-asserted-by":"crossref","first-page":"823","DOI":"10.3390\/jcm9030823","article-title":"Updating the definition of the alcohol hangover","volume":"9","author":"Verster","year":"2020","journal-title":"Journal of Clinical Medicine"},{"issue":"4","key":"10.1016\/j.alcohol.2024.10.001_bib44","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1017\/S003329171800137X","article-title":"Accelerated alcohol use across adolescence predicts early adult symptoms of alcohol use disorder via reward-related neural function","volume":"49","author":"Waller","year":"2019","journal-title":"Psychological Medicine"},{"issue":"3","key":"10.1016\/j.alcohol.2024.10.001_bib45","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/j.1530-0277.2008.00856.x","article-title":"Sensitization, duration, and pharmacological blockade of anxiety-like behavior following repeated ethanol withdrawal in adolescent and adult rats","volume":"33","author":"Wills","year":"2009","journal-title":"Alcoholism: Clinical and Experimental Research"}],"container-title":["Alcohol"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741832924001277?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741832924001277?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T14:20:45Z","timestamp":1740406845000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0741832924001277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":45,"alternative-id":["S0741832924001277"],"URL":"https:\/\/doi.org\/10.1016\/j.alcohol.2024.10.001","relation":{},"ISSN":["0741-8329"],"issn-type":[{"value":"0741-8329","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sex-dependent effects of ethanol withdrawal from a single- and repeated binge episode exposures on social anxiety-like behavior and neuropeptide gene expression in adolescent rats","name":"articletitle","label":"Article Title"},{"value":"Alcohol","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.alcohol.2024.10.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}