{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T13:01:07Z","timestamp":1778504467304,"version":"3.51.4"},"reference-count":110,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Alcohol"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.alcohol.2024.12.004","type":"journal-article","created":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T16:47:43Z","timestamp":1735058863000},"page":"31-42","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Alcohol drinking is attenuated by PDE4 inhibition but partial microglia depletion is not sufficient to block stress-induced escalation of alcohol intake in female mice"],"prefix":"10.1016","volume":"122","author":[{"given":"Vernon","family":"Garcia-Rivas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1484-4354","authenticated-orcid":false,"given":"Alexa R.","family":"Soares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3430-0912","authenticated-orcid":false,"given":"Merrilee A.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica J.","family":"Na","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asia","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4404-1280","authenticated-orcid":false,"given":"Marina R.","family":"Picciotto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8030-6776","authenticated-orcid":false,"given":"Yann S.","family":"Mineur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.alcohol.2024.12.004_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2022.114222","article-title":"Synergistic effect of mild traumatic brain injury and alcohol aggravates neuroinflammation, amyloidogenesis, tau pathology, neurodegeneration, and blood-brain barrier alterations: Impact on psychological stress","volume":"358","author":"Abdul-Muneer","year":"2022","journal-title":"Experimental Neurology"},{"key":"10.1016\/j.alcohol.2024.12.004_bib2","article-title":"Medial prefrontal cortex acetylcholine signaling mediates the ability to learn an active avoidance response following learned helplessness training","author":"Abdulla","year":"2024","journal-title":"Neuropsychopharmacology"},{"issue":"24","key":"10.1016\/j.alcohol.2024.12.004_bib3","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.2174\/0929867323666161202092908","article-title":"Sex differences in alcohol use disorder","volume":"24","author":"Agabio","year":"2017","journal-title":"Current Medicinal Chemistry"},{"issue":"Pt A","key":"10.1016\/j.alcohol.2024.12.004_bib4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.pnpbp.2017.09.027","article-title":"Trying to make sense of rodents' drug choice behavior","volume":"87","author":"Ahmed","year":"2018","journal-title":"Progress in Neuro-psychopharmacology & Biological Psychiatry"},{"key":"10.1016\/j.alcohol.2024.12.004_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2022.834880","article-title":"Sensitivity and resilience to predator stress-enhanced ethanol drinking is associated with sex-dependent differences in stress-regulating Systems","volume":"16","author":"Alavi","year":"2022","journal-title":"Frontiers in Behavioral Neuroscience"},{"issue":"1\u20132","key":"10.1016\/j.alcohol.2024.12.004_bib6","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.tox.2013.03.001","article-title":"Gender differences in alcohol-induced neurotoxicity and brain damage","volume":"311","author":"Alfonso-Loeches","year":"2013","journal-title":"Toxicology"},{"issue":"1","key":"10.1016\/j.alcohol.2024.12.004_bib7","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0091-3057(74)90131-2","article-title":"Effects of inescapable shock and shock-produced conflict on self selection of alcohol in rats","volume":"2","author":"Anisman","year":"1974","journal-title":"Pharmacology Biochemistry and Behavior"},{"issue":"6395","key":"10.1016\/j.alcohol.2024.12.004_bib8","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1126\/science.aao1157","article-title":"A\u00a0molecular mechanism for choosing alcohol over an alternative reward","volume":"360","author":"Augier","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.alcohol.2024.12.004_bib9","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.neuropharm.2017.08.011","article-title":"Phosphodiesterase 4b expression plays a major role in alcohol-induced neuro-inflammation","volume":"125","author":"Avila","year":"2017","journal-title":"Neuropharmacology"},{"issue":"1","key":"10.1016\/j.alcohol.2024.12.004_bib10","doi-asserted-by":"crossref","first-page":"17","DOI":"10.2174\/187152807780077318","article-title":"Highly selective phosphodiesterase 4 inhibitors for the treatment of allergic skin diseases and psoriasis","volume":"6","author":"B\u00e4umer","year":"2007","journal-title":"Inflammation and Allergy - Drug Targets"},{"key":"10.1016\/j.alcohol.2024.12.004_bib11","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.pnpbp.2015.09.001","article-title":"Opposing effects of alcohol on the immune system","volume":"65","author":"Barr","year":"2016","journal-title":"Progress in Neuro-psychopharmacology & Biological Psychiatry"},{"issue":"10","key":"10.1016\/j.alcohol.2024.12.004_bib12","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3390\/brainsci7100139","article-title":"Investigation of sex differences in the microglial response to binge ethanol and exercise","volume":"7","author":"Barton","year":"2017","journal-title":"Brain Sciences"},{"issue":"1","key":"10.1016\/j.alcohol.2024.12.004_bib13","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s00213-011-2443-9","article-title":"Effects of stress on alcohol drinking: A review of animal studies","volume":"218","author":"Becker","year":"2011","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.alcohol.2024.12.004_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbi.2017.02.006","article-title":"Sex differences in the neuro-immune consequences of stress: Focus on depression and anxiety","volume":"67","author":"Bekhbat","year":"2018","journal-title":"Brain, Behavior, and Immunity"},{"issue":"5","key":"10.1016\/j.alcohol.2024.12.004_bib15","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1111\/adb.12665","article-title":"Craving, cortisol and behavioral alcohol motivation responses to stress and alcohol cue contexts and discrete cues in binge and non-binge drinkers","volume":"24","author":"Blaine","year":"2019","journal-title":"Addiction Biology"},{"key":"10.1016\/j.alcohol.2024.12.004_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2023.109508","article-title":"Selective PDE4B and PDE4D inhibitors produce distinct behavioral responses to ethanol and GABAergic drugs in mice","volume":"231","author":"Blednov","year":"2023","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.alcohol.2024.12.004_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2022.109255","article-title":"Apremilast-induced increases in acute ethanol intoxication and decreases in ethanol drinking in mice involve PKA phosphorylation of GABAA \u03b23 subunits","volume":"220","author":"Blednov","year":"2022","journal-title":"Neuropharmacology"},{"issue":"5","key":"10.1016\/j.alcohol.2024.12.004_bib18","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1111\/acer.13616","article-title":"Apremilast alters behavioral responses to ethanol in mice: I. Reduced consumption and preference","volume":"42","author":"Blednov","year":"2018","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"1","key":"10.1016\/j.alcohol.2024.12.004_bib19","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/j.1369-1600.2010.00284.x","article-title":"Neuroimmune regulation of alcohol consumption: Behavioral validation of genes obtained from genomic studies","volume":"17","author":"Blednov","year":"2012","journal-title":"Addiction Biology"},{"issue":"5","key":"10.1016\/j.alcohol.2024.12.004_bib20","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.addbeh.2013.12.004","article-title":"Individual patterns of alcohol use","volume":"39","author":"Bobashev","year":"2014","journal-title":"Addictive Behaviors"},{"issue":"12","key":"10.1016\/j.alcohol.2024.12.004_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0187631","article-title":"Behavioral stress alters corticolimbic microglia in a sex- and brain region-specific manner","volume":"12","author":"Bollinger","year":"2017","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.alcohol.2024.12.004_bib22","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1111\/acer.13365","article-title":"Trends in alcohol consumption among older Americans: National Health interview surveys, 1997 to 2014","volume":"41","author":"Breslow","year":"2017","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"4","key":"10.1016\/j.alcohol.2024.12.004_bib23","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/S0091-3057(00)00271-9","article-title":"Gender differences in learned helplessness behavior are influenced by genetic background","volume":"66","author":"Caldarone","year":"2000","journal-title":"Pharmacology Biochemistry and Behavior"},{"issue":"1","key":"10.1016\/j.alcohol.2024.12.004_bib24","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1007\/s00213-003-1518-7","article-title":"Sex differences in response to oral amitriptyline in three animal models of depression in C57BL\/6J mice","volume":"170","author":"Caldarone","year":"2003","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.alcohol.2024.12.004_bib25","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.neubiorev.2019.05.014","article-title":"Building better strategies to develop new medications in Alcohol Use Disorder: Learning from past success and failure to shape a brighter future","volume":"103","author":"Cannella","year":"2019","journal-title":"Neuroscience & Biobehavioral Reviews"},{"issue":"5","key":"10.1016\/j.alcohol.2024.12.004_bib26","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1177\/0269881119832753","article-title":"Reduced phosphodiesterase-2 activity in the amygdala results in anxiolytic-like effects on behavior in mice","volume":"33","author":"Chen","year":"2019","journal-title":"Journal of Psychopharmacology"},{"issue":"5","key":"10.1016\/j.alcohol.2024.12.004_bib27","doi-asserted-by":"crossref","first-page":"640","DOI":"10.4088\/JCP.10m06207gry","article-title":"Binge drinking and Axis I psychiatric disorders in community-dwelling middle-aged and older adults: Results from the national epidemiologic survey on alcohol and related conditions (NESARC)","volume":"72","author":"Chou","year":"2011","journal-title":"The Journal of Clinical Psychiatry"},{"issue":"6","key":"10.1016\/j.alcohol.2024.12.004_bib28","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.neuint.2011.08.012","article-title":"Combined anti-inflammatory effects of \u03b22-adrenergic agonists and PDE4 inhibitors on astrocytes by upregulation of intracellular cAMP","volume":"59","author":"Christiansen","year":"2011","journal-title":"Neurochemistry International"},{"key":"10.1016\/j.alcohol.2024.12.004_bib29","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1146\/annurev.biochem.76.060305.150444","article-title":"Biochemistry and physiology of cyclic nucleotide phosphodiesterases: Essential components in cyclic nucleotide signaling","volume":"76","author":"Conti","year":"2007","journal-title":"Annual Review of Biochemistry"},{"issue":"8","key":"10.1016\/j.alcohol.2024.12.004_bib30","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.alcohol.2014.07.015","article-title":"Environmental stressors influence limited-access ethanol consumption by C57BL\/6J mice in a sex-dependent manner","volume":"48","author":"Cozzoli","year":"2014","journal-title":"Alcohol"},{"key":"10.1016\/j.alcohol.2024.12.004_bib31","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/j.1749-6632.2010.05895.x","article-title":"Preclinical studies of alcohol binge drinking","volume":"1216","author":"Crabbe","year":"2011","journal-title":"Annals of the New York Academy of Sciences"},{"key":"10.1016\/j.alcohol.2024.12.004_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.ynstr.2023.100562","article-title":"Sex-dependent factors of alcohol and neuroimmune mechanisms","volume":"26","author":"Cruz","year":"2023","journal-title":"Neurobiology of Stress"},{"issue":"4","key":"10.1016\/j.alcohol.2024.12.004_bib33","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1447-073x.2004.00089.x","article-title":"Involvement of cAMP in neuronal survival and axonal regeneration","volume":"79","author":"Cui","year":"2004","journal-title":"Anatomical Science International"},{"key":"10.1016\/j.alcohol.2024.12.004_bib34","series-title":"Neural-immune interactions in brain function and alcohol related disorders","first-page":"p133","article-title":"Mechanisms of stress-dependent neuroinflammation and their implications for understanding consequences of alcohol exposure","author":"Deak","year":"2013"},{"key":"10.1016\/j.alcohol.2024.12.004_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.physbeh.2023.114159","article-title":"The effects of lipopolysaccharide exposure on social interaction, cytokine expression, and alcohol consumption in male and female mice","volume":"265","author":"Decker Ramirez","year":"2023","journal-title":"Physiology & Behavior"},{"issue":"2","key":"10.1016\/j.alcohol.2024.12.004_bib36","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.neuron.2014.02.040","article-title":"Colony-stimulating factor 1 receptor signaling is necessary for microglia viability, unmasking a microglia progenitor cell in the adult brain","volume":"82","author":"Elmore","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.alcohol.2024.12.004_bib37","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.pbb.2018.12.007","article-title":"Neuroimmune signaling in alcohol use disorder","volume":"177","author":"Erickson","year":"2019","journal-title":"Pharmacology Biochemistry and Behavior"},{"key":"10.1016\/j.alcohol.2024.12.004_bib38","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.alcohol.2018.02.004","article-title":"Sex differences in the synergistic effect of prior binge drinking and traumatic stress on subsequent ethanol intake and neurochemical responses in adult C57BL\/6J mice","volume":"71","author":"Finn","year":"2018","journal-title":"Alcohol"},{"issue":"13","key":"10.1016\/j.alcohol.2024.12.004_bib39","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1007\/s00213-014-3852-3","article-title":"Reduction of alcohol drinking of alcohol-preferring (P) and high-alcohol drinking (HAD1) rats by targeting phosphodiesterase-4 (PDE4)","volume":"232","author":"Franklin","year":"2015","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.alcohol.2024.12.004_bib40","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12974-015-0463-9","article-title":"Cyclic AMP is a key regulator of M1 to M2a phenotypic conversion of microglia in the presence of Th2 cytokines","volume":"13","author":"Ghosh","year":"2016","journal-title":"Journal of Neuroinflammation"},{"issue":"5","key":"10.1016\/j.alcohol.2024.12.004_bib41","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0292-19.2019","article-title":"An open-source, automated home-cage sipper device for monitoring liquid ingestive behavior in rodents","volume":"6","author":"Godynyuk","year":"2019","journal-title":"eNeuro"},{"issue":"5","key":"10.1016\/j.alcohol.2024.12.004_bib42","first-page":"1","article-title":"Apremilast in the treatment of psoriasis and psoriatic arthritis","volume":"20","author":"Gooderham","year":"2015","journal-title":"Skin Therapy Letter"},{"issue":"9","key":"10.1016\/j.alcohol.2024.12.004_bib43","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1001\/jamapsychiatry.2017.2161","article-title":"Prevalence of 12-month alcohol use, high-risk drinking, and DSM-IV alcohol use disorder in the United States, 2001-2002 to 2012-2013: Results from the national epidemiologic survey on alcohol and related conditions","volume":"74","author":"Grant","year":"2017","journal-title":"JAMA Psychiatry"},{"issue":"6","key":"10.1016\/j.alcohol.2024.12.004_bib44","doi-asserted-by":"crossref","DOI":"10.1172\/JCI159103","article-title":"Preclinical and clinical evidence for suppression of alcohol intake by apremilast","volume":"133","author":"Grigsby","year":"2023","journal-title":"The Journal of Clinical Investigation"},{"issue":"2","key":"10.1016\/j.alcohol.2024.12.004_bib45","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/jnc.15689","article-title":"Microglia-dependent remodeling of neuronal circuits","volume":"163","author":"Guedes","year":"2022","journal-title":"Journal of Neurochemistry"},{"issue":"2","key":"10.1016\/j.alcohol.2024.12.004_bib46","first-page":"5","article-title":"The role of stress, trauma, and negative affect in alcohol misuse and alcohol use disorder in women","volume":"40","author":"Guinle","year":"2020","journal-title":"Alcohol Research: Current Reviews"},{"key":"10.1016\/j.alcohol.2024.12.004_bib47","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.toxlet.2017.11.002","article-title":"Microglia and alcohol meet at the crossroads: Microglia as critical modulators of alcohol neurotoxicity","volume":"283","author":"Henriques","year":"2018","journal-title":"Toxicology Letters"},{"key":"10.1016\/j.alcohol.2024.12.004_bib48","first-page":"213","article-title":"Stress-induced use of alcohol by problem drinkers as a function of their sense of identity","volume":"26","author":"Hershenson","year":"1965","journal-title":"The Quarterly Journal of Social Affairs"},{"issue":"2","key":"10.1016\/j.alcohol.2024.12.004_bib49","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s00213-011-2290-8","article-title":"Inhibition of phosphodiesterase-4 decreases ethanol intake in mice","volume":"218","author":"Hu","year":"2011","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.alcohol.2024.12.004_bib50","article-title":"Murine drinking models in the development of pharmacotherapies for alcoholism: Drinking in the dark and two-bottle choice","volume":"143","author":"Huynh","year":"2019","journal-title":"Journal of Visualized Experiments: JoVE"},{"key":"10.1016\/j.alcohol.2024.12.004_bib51","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.bbi.2018.01.012","article-title":"Minocycline blocks traumatic brain injury-induced alcohol consumption and nucleus accumbens inflammation in adolescent male mice","volume":"69","author":"Karelina","year":"2018","journal-title":"Brain, Behavior, and Immunity"},{"issue":"Pt C","key":"10.1016\/j.alcohol.2024.12.004_bib52","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.neuropharm.2013.04.005","article-title":"BDNF-induced local protein synthesis and synaptic plasticity","volume":"76","author":"Leal","year":"2014","journal-title":"Neuropharmacology"},{"issue":"2","key":"10.1016\/j.alcohol.2024.12.004_bib53","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.pbb.2006.08.015","article-title":"The effects of chronic valproate and diazepam in a mouse model of posttraumatic stress disorder","volume":"85","author":"Li","year":"2006","journal-title":"Pharmacology Biochemistry and Behavior"},{"issue":"8","key":"10.1016\/j.alcohol.2024.12.004_bib54","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.alcohol.2015.03.007","article-title":"Phosphodiesterase regulation of alcohol drinking in rodents","volume":"49","author":"Logrip","year":"2015","journal-title":"Alcohol"},{"key":"10.1016\/j.alcohol.2024.12.004_bib55","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.868448","article-title":"Exploring sex-related differences in microglia may Be a game-changer in precision medicine","volume":"14","author":"Lynch","year":"2022","journal-title":"Frontiers in Aging Neuroscience"},{"issue":"9","key":"10.1016\/j.alcohol.2024.12.004_bib56","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S0006-3223(00)01095-7","article-title":"Exposure to the stressor environment prevents the temporal dissipation of behavioral depression\/learned helplessness","volume":"49","author":"Maier","year":"2001","journal-title":"Biological Psychiatry"},{"issue":"6","key":"10.1016\/j.alcohol.2024.12.004_bib57","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1021\/jm900210d","article-title":"Discovery of (S)-N-[2-[1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl] acetamide (apremilast), a potent and orally active phosphodiesterase 4 and tumor necrosis factor-alpha inhibitor","volume":"52","author":"Man","year":"2009","journal-title":"Journal of Medicinal Chemistry"},{"issue":"5","key":"10.1016\/j.alcohol.2024.12.004_bib58","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1159\/000481348","article-title":"Reduced drinking in alcohol dependence treatment, what is the evidence?","volume":"23","author":"Mann","year":"2017","journal-title":"European Addiction Research"},{"key":"10.1016\/j.alcohol.2024.12.004_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2023.111797","article-title":"Sex differences in markers of oxidation and inflammation. Implications for ageing","volume":"211","author":"Mart\u00ednez de Toda","year":"2023","journal-title":"Mechanism of Ageing and Development"},{"issue":"6","key":"10.1016\/j.alcohol.2024.12.004_bib60","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.alcohol.2008.05.001","article-title":"Acute mild footshock alters ethanol drinking and plasma corticosterone levels in C57BL\/6J male mice, but not DBA\/2J or A\/J male mice","volume":"42","author":"Matthews","year":"2008","journal-title":"Alcohol"},{"issue":"11 Suppl","key":"10.1016\/j.alcohol.2024.12.004_bib61","article-title":"Dysregulated cytokine metabolism, altered hepatic methionine metabolism and proteasome dysfunction in alcoholic liver disease","volume":"29","author":"McClain","year":"2005","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"3","key":"10.1016\/j.alcohol.2024.12.004_bib62","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/hep.1840090302","article-title":"Increased tumor necrosis factor production by monocytes in alcoholic hepatitis","volume":"9","author":"McClain","year":"1989","journal-title":"Hepatology"},{"key":"10.1016\/j.alcohol.2024.12.004_bib63","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.bbi.2022.08.017","article-title":"Comparison of inflammatory and behavioral responses to chronic stress in female and male mice","volume":"106","author":"Medina-Rodriguez","year":"2022","journal-title":"Brain, Behavior, and Immunity"},{"issue":"7","key":"10.1016\/j.alcohol.2024.12.004_bib64","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1007\/s00213-022-06120-w","article-title":"Sex differences in stress-induced alcohol intake: A review of preclinical studies focused on amygdala and inflammatory pathways","volume":"239","author":"Mineur","year":"2022","journal-title":"Psychopharmacology"},{"issue":"7","key":"10.1016\/j.alcohol.2024.12.004_bib65","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1111\/acer.13416","article-title":"Nalmefene prevents alcohol-induced neuroinflammation and alcohol drinking preference in adolescent female mice: Role of TLR4","volume":"41","author":"Montesinos","year":"2017","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"3","key":"10.1016\/j.alcohol.2024.12.004_bib66","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/j.1365-2249.1995.tb03123.x","article-title":"The role of cAMP regulation in controlling inflammation","volume":"101","author":"Moore","year":"1995","journal-title":"Clinical and Experimental Immunology"},{"key":"10.1016\/j.alcohol.2024.12.004_bib67","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.alcohol.2024.01.001","article-title":"Stress-enhanced ethanol drinking does not increase sensitivity to the effects of a CRF-R1 antagonist on ethanol intake in male and female mice","volume":"120","author":"Nipper","year":"2024","journal-title":"Alcohol"},{"issue":"2","key":"10.1016\/j.alcohol.2024.12.004_bib68","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/adb.12125","article-title":"Cluster and meta-analyses on factors influencing stress-induced alcohol drinking and relapse in rodents","volume":"19","author":"Noori","year":"2014","journal-title":"Addiction Biology"},{"issue":"3","key":"10.1016\/j.alcohol.2024.12.004_bib69","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0091-3057(02)00715-3","article-title":"Cognitive deficits and CNS damage after a 4-day binge ethanol exposure in rats","volume":"72","author":"Obernier","year":"2002","journal-title":"Pharmacology Biochemistry and Behavior"},{"issue":"11","key":"10.1016\/j.alcohol.2024.12.004_bib70","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1093\/ijnp\/pyac064","article-title":"Inhibition of phosphodiesterase 2 ameliorates post-traumatic stress-induced alcohol intake disorder by regulating cAMP\/cGMP signaling","volume":"25","author":"Pan","year":"2022","journal-title":"The International Journal of Neuropsychopharmacology"},{"issue":"1","key":"10.1016\/j.alcohol.2024.12.004_bib71","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jaad.2015.03.049","article-title":"Apremilast, an oral phosphodiesterase 4 (PDE4) inhibitor, in patients with moderate to severe plaque psoriasis: Results of a phase III, randomized, controlled trial (Efficacy and Safety Trial Evaluating the Effects of Apremilast in Psoriasis [ESTEEM] 1)","volume":"73","author":"Papp","year":"2015","journal-title":"Journal of the American Academy of Dermatology"},{"issue":"2","key":"10.1016\/j.alcohol.2024.12.004_bib72","first-page":"185","article-title":"Impact of alcohol abuse on the adaptive immune system","volume":"37","author":"Pasala","year":"2015","journal-title":"Alcohol Research: Current Reviews"},{"issue":"6","key":"10.1016\/j.alcohol.2024.12.004_bib73","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1111\/adb.12461","article-title":"Gender differences in the inflammatory cytokine and chemokine profiles induced by binge ethanol drinking in adolescence","volume":"22","author":"Pascual","year":"2017","journal-title":"Addiction Biology"},{"issue":"7","key":"10.1016\/j.alcohol.2024.12.004_bib74","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1037\/adb0000801","article-title":"Effects of stress, alcohol prime dose, and sex on ad libitum drinking","volume":"36","author":"Patock-Peckham","year":"2022","journal-title":"Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors"},{"issue":"10","key":"10.1016\/j.alcohol.2024.12.004_bib75","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1002\/glia.22986","article-title":"PDE4B as a microglia target to reduce neuroinflammation","volume":"64","author":"Pearse","year":"2016","journal-title":"Glia"},{"key":"10.1016\/j.alcohol.2024.12.004_bib76","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/940207","article-title":"Phosphodiesterase-5 inhibitors: Action on the signaling pathways of neuroinflammation, neurodegeneration, and cognition","volume":"2015","author":"Peixoto","year":"2015","journal-title":"Mediators of Inflammation"},{"key":"10.1016\/j.alcohol.2024.12.004_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.ynstr.2019.100149","article-title":"Sex differences in stress-related alcohol use","volume":"10","author":"Peltier","year":"2019","journal-title":"Neurobiology of Stress"},{"issue":"8","key":"10.1016\/j.alcohol.2024.12.004_bib78","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1038\/nn.4066","article-title":"The role of ventral striatal cAMP signaling in stress-induced behaviors","volume":"18","author":"Plattner","year":"2015","journal-title":"Nature Neuroscience"},{"issue":"7","key":"10.1016\/j.alcohol.2024.12.004_bib79","doi-asserted-by":"crossref","first-page":"703","DOI":"10.3390\/biomedicines9070703","article-title":"Neuroinflammation in ischemic stroke: Inhibition of cAMP-specific phosphodiesterases (PDEs) to the rescue","volume":"9","author":"Ponsaerts","year":"2021","journal-title":"Biomedicines"},{"issue":"2","key":"10.1016\/j.alcohol.2024.12.004_bib80","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0006-3223(95)00088-7","article-title":"A\u00a0behavioral animal model of posttraumatic stress disorder featuring repeated exposure to situational reminders","volume":"39","author":"Pynoos","year":"1996","journal-title":"Biological Psychiatry"},{"issue":"6","key":"10.1016\/j.alcohol.2024.12.004_bib81","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1523\/JNEUROSCI.23-06-02453.2003","article-title":"A\u00a0critical role for the cannabinoid CB1 receptors in alcohol dependence and stress-stimulated ethanol drinking","volume":"23","author":"Racz","year":"2003","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.alcohol.2024.12.004_bib82","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3389\/fimmu.2016.00123","article-title":"The cAMP pathway as therapeutic target in autoimmune and inflammatory diseases","volume":"7","author":"Raker","year":"2016","journal-title":"Frontiers in Immunology"},{"issue":"1","key":"10.1016\/j.alcohol.2024.12.004_bib83","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.physbeh.2004.10.007","article-title":"Evaluation of a simple model of ethanol drinking to intoxication in C57BL\/6J mice","volume":"84","author":"Rhodes","year":"2005","journal-title":"Physiology & Behavior"},{"issue":"1","key":"10.1016\/j.alcohol.2024.12.004_bib84","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1601-183X.2006.00210.x","article-title":"Mouse inbred strain differences in ethanol drinking to intoxication","volume":"6","author":"Rhodes","year":"2007","journal-title":"Genes, Brain and Behavior"},{"issue":"9","key":"10.1016\/j.alcohol.2024.12.004_bib85","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1517\/14728222.2013.818656","article-title":"PDE4 as a target for cognition enhancement","volume":"17","author":"Richter","year":"2013","journal-title":"Expert Opinion on Therapeutic Targets"},{"issue":"5","key":"10.1016\/j.alcohol.2024.12.004_bib86","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1093\/sleep\/33.5.621","article-title":"Differential effects of controllable and uncontrollable footshock stress on sleep in mice","volume":"33","author":"Sanford","year":"2010","journal-title":"Sleep"},{"issue":"12","key":"10.1016\/j.alcohol.2024.12.004_bib87","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a011148","article-title":"The cyclic AMP pathway","volume":"4","author":"Sassone-Corsi","year":"2012","journal-title":"Cold Spring Harbor Perspectives in Biology"},{"issue":"2","key":"10.1016\/j.alcohol.2024.12.004_bib88","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1165\/rcmb.2008-0091TR","article-title":"Cyclic AMP: Master regulator of innate immune cell function","volume":"39","author":"Serezani","year":"2008","journal-title":"American Journal of Respiratory Cell and Molecular Biology"},{"issue":"3","key":"10.1016\/j.alcohol.2024.12.004_bib89","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/0091-3057(90)90249-H","article-title":"Mouse strain differences in plasma corticosterone following uncontrollable footshock","volume":"36","author":"Shanks","year":"1990","journal-title":"Pharmacology Biochemistry and Behavior"},{"issue":"4","key":"10.1016\/j.alcohol.2024.12.004_bib90","first-page":"432","article-title":"How does stress lead to risk of alcohol relapse?","volume":"34","author":"Sinha","year":"2012","journal-title":"Alcohol Research: Current Reviews"},{"issue":"5","key":"10.1016\/j.alcohol.2024.12.004_bib91","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1038\/npp.2008.78","article-title":"Enhanced negative emotion and alcohol craving, and altered physiological responses following stress and cue exposure in alcohol dependent individuals","volume":"34","author":"Sinha","year":"2009","journal-title":"Neuropsychopharmacology"},{"issue":"10","key":"10.1016\/j.alcohol.2024.12.004_bib92","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2016-011827","article-title":"Birth cohort trends in the global epidemiology of alcohol use and alcohol-related harms in men and women: Systematic review and metaregression","volume":"6","author":"Slade","year":"2016","journal-title":"BMJ Open"},{"issue":"4","key":"10.1016\/j.alcohol.2024.12.004_bib93","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.tins.2014.02.006","article-title":"Stress and alcohol interactions: Animal studies and clinical significance","volume":"37","author":"Spanagel","year":"2014","journal-title":"Trends in Neurosciences"},{"issue":"3","key":"10.1016\/j.alcohol.2024.12.004_bib94","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.physbeh.2011.12.026","article-title":"The neurobiology of binge-like ethanol drinking: Evidence from rodent models","volume":"106","author":"Sprow","year":"2012","journal-title":"Physiology & Behavior"},{"issue":"3","key":"10.1016\/j.alcohol.2024.12.004_bib95","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.alcohol.2013.08.005","article-title":"\"Drinking in the dark\" (DID) procedures: A model of binge-like ethanol drinking in non-dependent mice","volume":"48","author":"Thiele","year":"2014","journal-title":"Alcohol"},{"issue":"4","key":"10.1016\/j.alcohol.2024.12.004_bib96","doi-asserted-by":"crossref","first-page":"p602","DOI":"10.15288\/qjsa.1952.13.602","article-title":"The psychological mechanism of alcohol addiction","volume":"13","author":"Ulman","year":"1952","journal-title":"Quaterly Journal of Studies on Alcohol"},{"issue":"4","key":"10.1016\/j.alcohol.2024.12.004_bib97","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1360-0443.1987.tb01494.x","article-title":"Uncontrollable events and alcohol drinking","volume":"82","author":"Volpicelli","year":"1987","journal-title":"British Journal of Addiction"},{"issue":"4","key":"10.1016\/j.alcohol.2024.12.004_bib98","first-page":"256","article-title":"The role of uncontrollable trauma in the development of PTSD and alcohol addiction","volume":"23","author":"Volpicelli","year":"1999","journal-title":"Alcohol Research & Health"},{"issue":"6","key":"10.1016\/j.alcohol.2024.12.004_bib99","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1111\/j.1530-0277.1990.tb01837.x","article-title":"The bidirectional effects of shock on alcohol preference in rats","volume":"14","author":"Volpicelli","year":"1990","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"75","key":"10.1016\/j.alcohol.2024.12.004_bib100","doi-asserted-by":"crossref","first-page":"ra28","DOI":"10.1126\/scisignal.2000202","article-title":"Suppression of LPS-induced TNF-alpha production in macrophages by cAMP is mediated by PKA-AKAP95-p105","volume":"2","author":"Wall","year":"2009","journal-title":"Science Signaling"},{"issue":"12","key":"10.1016\/j.alcohol.2024.12.004_bib101","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1111\/acer.13511","article-title":"Alcohol and stress activation of microglia and neurons: Brain regional effects","volume":"41","author":"Walter","year":"2017","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"1","key":"10.1016\/j.alcohol.2024.12.004_bib102","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1385\/MN:27:1:99","article-title":"Signaling from cAMP\/PKA to MAPK and synaptic plasticity","volume":"27","author":"Waltereit","year":"2003","journal-title":"Molecular Neurobiology"},{"issue":"12","key":"10.1016\/j.alcohol.2024.12.004_bib103","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.7150\/ijbs.26230","article-title":"Targeting phosphodiesterase 4 as a potential therapeutic strategy for enhancing neuroplasticity following ischemic stroke","volume":"14","author":"Wang","year":"2018","journal-title":"International Journal of Biological Sciences"},{"issue":"2","key":"10.1016\/j.alcohol.2024.12.004_bib104","doi-asserted-by":"crossref","DOI":"10.1111\/adb.12889","article-title":"Microglia depletion and alcohol: Transcriptome and behavioral profiles","volume":"26","author":"Warden","year":"2021","journal-title":"Addiction Biology"},{"issue":"12","key":"10.1016\/j.alcohol.2024.12.004_bib105","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.biopsych.2020.05.011","article-title":"Microglia control escalation of drinking in alcohol-dependent mice: Genomic and synaptic drivers","volume":"88","author":"Warden","year":"2020","journal-title":"Biological Psychiatry"},{"issue":"1","key":"10.1016\/j.alcohol.2024.12.004_bib106","article-title":"Biobehavioral interactions between stress and alcohol","volume":"40","author":"Weera","year":"2019","journal-title":"Alcohol Research: Current Reviews"},{"issue":"6","key":"10.1016\/j.alcohol.2024.12.004_bib107","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1007\/s00213-018-4895-7","article-title":"Cyclic nucleotide phosphodiesterases: Potential therapeutic targets for alcohol use disorder","volume":"235","author":"Wen","year":"2018","journal-title":"Psychopharmacology"},{"issue":"2","key":"10.1016\/j.alcohol.2024.12.004_bib108","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.intimp.2015.02.019","article-title":"Selective modulation of microglia polarization to M2 phenotype for stroke treatment","volume":"25","author":"Xia","year":"2015","journal-title":"International Immunopharmacology"},{"key":"10.1016\/j.alcohol.2024.12.004_bib109","doi-asserted-by":"crossref","first-page":"204","DOI":"10.3389\/fnagi.2018.00204","article-title":"Inhibition of phosphodiesterase-4 reverses A\u03b2-induced memory impairment by regulation of HPA Axis related cAMP signaling","volume":"10","author":"Xu","year":"2018","journal-title":"Frontiers in Aging Neuroscience"},{"issue":"2","key":"10.1016\/j.alcohol.2024.12.004_bib110","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.bbi.2010.10.015","article-title":"Immune modulation of learning, memory, neural plasticity and neurogenesis","volume":"25","author":"Yirmiya","year":"2011","journal-title":"Brain, Behavior, and Immunity"}],"container-title":["Alcohol"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741832924001939?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741832924001939?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T14:20:59Z","timestamp":1740406859000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0741832924001939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":110,"alternative-id":["S0741832924001939"],"URL":"https:\/\/doi.org\/10.1016\/j.alcohol.2024.12.004","relation":{},"ISSN":["0741-8329"],"issn-type":[{"value":"0741-8329","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alcohol drinking is attenuated by PDE4 inhibition but partial microglia depletion is not sufficient to block stress-induced escalation of alcohol intake in female mice","name":"articletitle","label":"Article Title"},{"value":"Alcohol","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.alcohol.2024.12.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}