{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T14:21:55Z","timestamp":1790259715865,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100021778","name":"National Agency for the Promotion of Research Technological Development and Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021778","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002923","name":"National Scientific and Technical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006668","name":"Fondo para la Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT-2021-I-A-00035"],"award-info":[{"award-number":["PICT-2021-I-A-00035"]}],"id":[{"id":"10.13039\/501100006668","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006668","name":"Fondo para la Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PIP 11220210100017CO"],"award-info":[{"award-number":["PIP 11220210100017CO"]}],"id":[{"id":"10.13039\/501100006668","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006668","name":"Fondo para la Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PUE-CONICET 22920160100135CO"],"award-info":[{"award-number":["PUE-CONICET 22920160100135CO"]}],"id":[{"id":"10.13039\/501100006668","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006668","name":"Fondo para la Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PIDTA2023"],"award-info":[{"award-number":["PIDTA2023"]}],"id":[{"id":"10.13039\/501100006668","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Alcohol"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.alcohol.2025.04.001","type":"journal-article","created":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T08:55:12Z","timestamp":1744188912000},"page":"25-33","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Analysis of the synergy between prenatal ethanol and postnatal adolescent ethanol exposure"],"prefix":"10.1016","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2532-1586","authenticated-orcid":false,"given":"Leonardo","family":"Marengo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Garc\u00eda","family":"Virgolini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Mujica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6492-768X","authenticated-orcid":false,"given":"Mar\u00eda Carolina","family":"Fabio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1876-2321","authenticated-orcid":false,"given":"Ricardo Marcos","family":"Pautassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.alcohol.2025.04.001_bib1","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.1002\/ar.24370","article-title":"Moderate prenatal ethanol exposure in the rat promotes kidney cell apoptosis, nephron deficits, and sex-specific kidney dysfunction in adult offspring","volume":"303","author":"Akison","year":"2020","journal-title":"The Anatomical Record"},{"issue":"3","key":"10.1016\/j.alcohol.2025.04.001_bib2","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1097\/01.ALC.0000156115.35817.21","article-title":"Increased preference for ethanol in the infant rat after prenatal ethanol exposure, expressed on intake and taste reactivity tests","volume":"29","author":"Arias","year":"2005","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"3","key":"10.1016\/j.alcohol.2025.04.001_bib3","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.pbb.2005.09.015","article-title":"Increased palatability of ethanol after prenatal ethanol exposure is mediated by the opioid system","volume":"82","author":"Arias","year":"2005","journal-title":"Pharmacology, Biochemistry and Behavior"},{"issue":"4","key":"10.1016\/j.alcohol.2025.04.001_bib4","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.pbb.2008.02.017","article-title":"Acute sensitivity and acute tolerance to ethanol in preweanling rats with or without prenatal experience with the drug","volume":"89","author":"Arias","year":"2008","journal-title":"Pharmacology, Biochemistry and Behavior"},{"key":"10.1016\/j.alcohol.2025.04.001_bib5","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3389\/fnbeh.2016.00195","article-title":"Post-weaning environmental enrichment, but not chronic maternal isolation, enhanced ethanol intake during periadolescence and early adulthood","volume":"10","author":"Berardo","year":"2016","journal-title":"Frontiers in Behavioral Neuroscience"},{"issue":"2","key":"10.1016\/j.alcohol.2025.04.001_bib6","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.neubiorev.2006.06.021","article-title":"Increased ethanol intake after prenatal ethanol exposure: Studies with animals","volume":"31","author":"Chotro","year":"2007","journal-title":"Neuroscience & Biobehavioral Reviews"},{"issue":"11","key":"10.1016\/j.alcohol.2025.04.001_bib7","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1111\/j.1530-0277.2000.tb01973.x","article-title":"Binge ethanol consumption causes differential brain damage in young adolescent rats compared with adult rats","volume":"24","author":"Crews","year":"2000","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1016\/j.alcohol.2025.04.001_bib8","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3389\/fnbeh.2020.00082","article-title":"Lingering effects of prenatal alcohol exposure on basal and ethanol-evoked expression of inflammatory-related genes in the CNS of adolescent and adult rats","volume":"14","author":"Doremus-Fitzwater","year":"2020","journal-title":"Frontiers in Behavioral Neuroscience"},{"issue":"12","key":"10.1016\/j.alcohol.2025.04.001_bib9","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1111\/ejn.12913","article-title":"Prenatal ethanol increases ethanol intake throughout adolescence, alters ethanol-mediated aversive learning, and affects \u03bc but not \u03b4 or \u03ba opioid receptor mRNA expression","volume":"41","author":"Fabio","year":"2015","journal-title":"European Journal of Neuroscience"},{"issue":"3","key":"10.1016\/j.alcohol.2025.04.001_bib10","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1002\/dev.21101","article-title":"Binge ethanol intoxication heightens subsequent ethanol intake in adolescent, but not adult, rats","volume":"56","author":"Fabio","year":"2014","journal-title":"Developmental Psychobiology"},{"issue":"4","key":"10.1016\/j.alcohol.2025.04.001_bib11","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1037\/a0026110","article-title":"Acute tolerance to alcohol in at-risk binge drinkers","volume":"26","author":"Fillmore","year":"2012","journal-title":"Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors"},{"issue":"1","key":"10.1016\/j.alcohol.2025.04.001_bib12","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-56860-7","article-title":"Improving the practicality of using non-aversive handling methods to reduce background stress and anxiety in laboratory mice","volume":"9","author":"Gouveia","year":"2019","journal-title":"Scientific Reports"},{"issue":"1","key":"10.1016\/j.alcohol.2025.04.001_bib13","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/acer.12227","article-title":"Prenatal ethanol (EtOH) exposure alters the sensitivity of the adult dentate gyrus to acute EtOH exposure","volume":"38","author":"Helfer","year":"2014","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"10","key":"10.1016\/j.alcohol.2025.04.001_bib14","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1111\/acer.14686","article-title":"Effects of prenatal alcohol exposure on cognitive and behavioral development: Findings from a hierarchical meta-analysis of data from six prospective longitudinal U.S. cohorts","volume":"45","author":"Jacobson","year":"2021","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1016\/j.alcohol.2025.04.001_bib15","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.alcohol.2015.10.003","article-title":"Dose-dependent effects of alcohol administration on behavioral profiles in the MCSF test","volume":"50","author":"Karlsson","year":"2016","journal-title":"Alcohol"},{"issue":"1","key":"10.1016\/j.alcohol.2025.04.001_bib16","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0149-7634(94)00027-X","article-title":"Alcohol, palatability, and taste reactivity","volume":"19","author":"Kiefer","year":"1995","journal-title":"Neuroscience & Biobehavioral Reviews"},{"key":"10.1016\/j.alcohol.2025.04.001_bib17","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3389\/fnbeh.2020.00092","article-title":"Anxious behavior of adult CD1 mice perinatally exposed to low concentrations of ethanol correlates with morphological changes in cingulate cortex and amygdala","volume":"14","author":"Madarnas","year":"2020","journal-title":"Frontiers in Behavioral Neuroscience"},{"issue":"7","key":"10.1016\/j.alcohol.2025.04.001_bib18","doi-asserted-by":"crossref","DOI":"10.1002\/dev.22426","article-title":"Neurobehavioral alterations induced by third-trimester gestation-equivalent ethanol exposure are inhibited by folate administration","volume":"65","author":"Marengo","year":"2023","journal-title":"Developmental Psychobiology"},{"issue":"9","key":"10.1016\/j.alcohol.2025.04.001_bib19","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1111\/j.1530-0277.2006.00177.x","article-title":"The alcoholism generator","volume":"30","author":"Miller","year":"2006","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"3","key":"10.1016\/j.alcohol.2025.04.001_bib20","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/j.1530-0277.1991.tb00537.x","article-title":"Chronic tolerance and sensitization to alcohol in sons of alcoholics","volume":"15","author":"Newlin","year":"1991","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"6","key":"10.1016\/j.alcohol.2025.04.001_bib21","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1111\/adb.12461","article-title":"Gender differences in the inflammatory cytokine and chemokine profiles induced by binge ethanol drinking in adolescence","volume":"22","author":"Pascual","year":"2017","journal-title":"Addiction Biology"},{"issue":"11","key":"10.1016\/j.alcohol.2025.04.001_bib22","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1111\/j.1530-0277.2008.00789.x","article-title":"Adolescent but not adult rats exhibit ethanol-mediated appetitive second-order conditioning","volume":"32","author":"Pautassi","year":"2008","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"6","key":"10.1016\/j.alcohol.2025.04.001_bib23","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.alcohol.2012.05.004","article-title":"Prenatal ethanol exposure leads to greater ethanol-induced appetitive reinforcement","volume":"46","author":"Pautassi","year":"2012","journal-title":"Alcohol"},{"key":"10.1016\/j.alcohol.2025.04.001_bib24","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.alcohol.2024.10.001","article-title":"Sex-dependent effects of ethanol withdrawal from a single- and repeated binge episode exposures on social anxiety-like behavior and neuropeptide gene expression in adolescent rats","volume":"122","author":"Penta","year":"2025","journal-title":"Alcohol"},{"issue":"1","key":"10.1016\/j.alcohol.2025.04.001_bib25","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.physbeh.2010.10.009","article-title":"Prenatal and postnatal ethanol experiences modulate consumption of the drug in rat pups, without impairment in the granular cell layer of the main olfactory bulb","volume":"102","author":"Pueta","year":"2011","journal-title":"Physiology & Behavior"},{"key":"10.1016\/j.alcohol.2025.04.001_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2021.772857","article-title":"Adolescent binge-type ethanol exposure in rats mirrors age-related cognitive decline by suppressing cholinergic tone and hippocampal neurogenesis","volume":"15","author":"Reitz","year":"2021","journal-title":"Frontiers in Behavioral Neuroscience"},{"issue":"11","key":"10.1016\/j.alcohol.2025.04.001_bib27","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1111\/acer.14950","article-title":"Early developmental alcohol exposure alters behavioral outcomes following adolescent re-exposure in a rat model","volume":"46","author":"Risbud","year":"2022","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1016\/j.alcohol.2025.04.001_bib28","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.physbeh.2016.01.011","article-title":"The ontogeny of ethanol aversion","volume":"156","author":"Saalfield","year":"2016","journal-title":"Physiology & Behavior"},{"key":"10.1016\/j.alcohol.2025.04.001_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.drugalcdep.2024.111338","article-title":"Ethanol drinking at adulthood is sensitive to S1-R antagonism and is promoted by binge ethanol self-administration at adolescence","volume":"260","author":"Salguero","year":"2024","journal-title":"Drug and Alcohol Dependence"},{"issue":"4","key":"10.1016\/j.alcohol.2025.04.001_bib30","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nrn.2018.10","article-title":"Effects of adolescent alcohol consumption on the brain and behaviour","volume":"19","author":"Spear","year":"2018","journal-title":"Nature Reviews Neuroscience"},{"key":"10.1016\/j.alcohol.2025.04.001_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.841657","article-title":"Impact of adolescent intermittent ethanol exposure on social investigation, social preference, and neuronal activation in cFos-LacZ male and female rats","volume":"13","author":"Towner","year":"2022","journal-title":"Frontiers in Pharmacology"},{"issue":"45","key":"10.1016\/j.alcohol.2025.04.001_bib32","article-title":"Adolescent ethanol exposure: Anxiety-like behavioral alterations","volume":"14","author":"Towner","year":"2020","journal-title":"Ethanol Intake, and Sensitivity"},{"issue":"5","key":"10.1016\/j.alcohol.2025.04.001_bib33","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1038\/npp.2016.190","article-title":"Binge-like alcohol exposure during adolescence disrupts dopaminergic neurotransmission in the adult prelimbic cortex","volume":"42","author":"Trantham-Davidson","year":"2017","journal-title":"Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology"},{"key":"10.1016\/j.alcohol.2025.04.001_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbb.2024.173741","article-title":"Adolescent alcohol exposure modifies adult anxiety-like behavior and amygdala sensitivity to alcohol in rats: Increased c-Fos activity and sex-dependent microRNA-182 expression","volume":"238","author":"V\u00e1zquez-\u00c1gredos","year":"2024","journal-title":"Pharmacology, Biochemistry and Behavior"},{"issue":"4","key":"10.1016\/j.alcohol.2025.04.001_bib35","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.pbb.2008.09.017","article-title":"Age-related differences in the blood alcohol levels of Wistar rats","volume":"91","author":"Walker","year":"2009","journal-title":"Pharmacology, Biochemistry and Behavior"},{"key":"10.1016\/j.alcohol.2025.04.001_bib36","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.pnpbp.2018.04.005","article-title":"Prenatal ethanol induces an anxiety phenotype and alters expression of dynorphin & nociceptin\/orphanin FQ genes","volume":"85","author":"Wille-Bille","year":"2018","journal-title":"Progress in Neuro-Psychopharmacology & Biological Psychiatry"},{"issue":"13","key":"10.1016\/j.alcohol.2025.04.001_bib37","doi-asserted-by":"crossref","first-page":"5359","DOI":"10.1073\/pnas.0809804106","article-title":"Fetal ethanol exposure increases ethanol intake by making it smell and taste better","volume":"106","author":"Youngentob","year":"2009","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"6","key":"10.1016\/j.alcohol.2025.04.001_bib38","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1037\/0735-7044.121.6.1293","article-title":"Experience-induced fetal plasticity: The effect of gestational ethanol exposure on the behavioral and neurophysiologic olfactory response to ethanol odor in early postnatal and adult rats","volume":"121","author":"Youngentob","year":"2007","journal-title":"Behavioral Neuroscience"}],"container-title":["Alcohol"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741832925000515?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741832925000515?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T17:45:04Z","timestamp":1746812704000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0741832925000515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":38,"alternative-id":["S0741832925000515"],"URL":"https:\/\/doi.org\/10.1016\/j.alcohol.2025.04.001","relation":{},"ISSN":["0741-8329"],"issn-type":[{"value":"0741-8329","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Analysis of the synergy between prenatal ethanol and postnatal adolescent ethanol exposure","name":"articletitle","label":"Article Title"},{"value":"Alcohol","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.alcohol.2025.04.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}