{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T05:41:13Z","timestamp":1794030073979,"version":"4.8.0"},"reference-count":195,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:00:00Z","timestamp":1752105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000098","name":"Clinical Center","doi-asserted-by":"publisher","award":["Z99CL999999"],"award-info":[{"award-number":["Z99CL999999"]}],"id":[{"id":"10.13039\/100000098","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["1I01CX000361"],"award-info":[{"award-number":["1I01CX000361"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I01 BX006202"],"award-info":[{"award-number":["I01 BX006202"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["K08 AA027837 05"],"award-info":[{"award-number":["K08 AA027837 05"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R21 AA030654"],"award-info":[{"award-number":["R21 AA030654"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R01 AA029106"],"award-info":[{"award-number":["R01 AA029106"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R01 AA030741"],"award-info":[{"award-number":["R01 AA030741"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013709","name":"Dell Medical School, University of Texas at Austin","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013709","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["D34 HP31027"],"award-info":[{"award-number":["D34 HP31027"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["P30 AR073761"],"award-info":[{"award-number":["P30 AR073761"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010249","name":"School of Medicine, Indiana University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010249","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000938","name":"Australian Government Department of Veterans Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000938","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Alcohol"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.alcohol.2025.07.001","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T15:13:04Z","timestamp":1752592384000},"page":"1-12","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Alcohol, aging, and the gut microbiome: Intersections of immunity, barrier dysfunction, and disease"],"prefix":"10.1016","volume":"128","author":[{"given":"Esther","family":"Melamed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiramon","family":"Rungratanawanich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suthat","family":"Liangpunsakul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine A.","family":"Maki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca L.","family":"McCullough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8135-9186","authenticated-orcid":false,"given":"Cristina","family":"Llorente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.alcohol.2025.07.001_bib1","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/acer.14271","article-title":"Interaction between alcohol use and metabolic risk factors for liver disease: A critical review of epidemiological studies","volume":"44","author":"\u00c5berg","year":"2020","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1016\/j.alcohol.2025.07.001_bib2","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/s41582-021-00616-3","article-title":"Blood GFAP as an emerging biomarker in brain and spinal cord disorders","volume":"18","author":"Abdelhak","year":"2022","journal-title":"Nature Reviews Neurology"},{"key":"10.1016\/j.alcohol.2025.07.001_bib3","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/toxsci\/kfm280","article-title":"Tissue distribution, ontogeny, and regulation of aldehyde dehydrogenase (Aldh) enzymes mRNA by prototypical microsomal enzyme inducers in mice","volume":"101","author":"Alnouti","year":"2008","journal-title":"Toxicological Sciences"},{"key":"10.1016\/j.alcohol.2025.07.001_bib4","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1177\/1352458518795418","article-title":"Alcohol consumption in adolescence is associated with a lower risk of multiple sclerosis in a Danish cohort","volume":"25","author":"Andersen","year":"2019","journal-title":"Multiple Sclerosis"},{"key":"10.1016\/j.alcohol.2025.07.001_bib5","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/978-3-031-81908-7_10","article-title":"Excessive alcohol use as a risk factor for Alzheimer's Disease: Epidemiological and preclinical evidence","volume":"1473","author":"Anton","year":"2025","journal-title":"Advances in Experimental Medicine & Biology"},{"key":"10.1016\/j.alcohol.2025.07.001_bib6","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.alcohol.2022.08.012","article-title":"Profiling the oxylipidome in aged mice after chronic ethanol feeding: Identifying lipid metabolites as drivers of hepatocyte stress","volume":"107","author":"Anton","year":"2023","journal-title":"Alcohol"},{"key":"10.1016\/j.alcohol.2025.07.001_bib7","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.bbi.2023.12.034","article-title":"Binge ethanol exposure in advanced age elevates neuroinflammation and early indicators of neurodegeneration and cognitive impairment in female mice","volume":"116","author":"Anton","year":"2024","journal-title":"Brain, Behavior, and Immunity"},{"key":"10.1016\/j.alcohol.2025.07.001_bib8","doi-asserted-by":"crossref","DOI":"10.1093\/jleuko\/qiaf024","article-title":"Suppression of NF-kappaB\/NLRP3 by nanoligomer therapy mitigates ethanol and advanced age-related neuroinflammation","author":"Anton","year":"2025","journal-title":"Journal of Leukocyte Biology"},{"key":"10.1016\/j.alcohol.2025.07.001_bib9","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/sj.npp.1300849","article-title":"Motor stimulant effects of ethanol injected into the substantia nigra pars reticulata: Importance of catalase-mediated metabolism and the role of acetaldehyde","volume":"31","author":"Arizzi-LaFrance","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.alcohol.2025.07.001_bib10","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1038\/s41467-020-15855-z","article-title":"Ethanol consumption inhibits TFH cell responses and the development of autoimmune arthritis","volume":"11","author":"Azizov","year":"2020","journal-title":"Nature Communications"},{"key":"10.1016\/j.alcohol.2025.07.001_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2023.101755","article-title":"Chronic inflammation and the hallmarks of aging","volume":"74","author":"Baechle","year":"2023","journal-title":"Molecular Metabolism"},{"key":"10.1016\/j.alcohol.2025.07.001_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3000599","article-title":"A proteomic atlas of senescence-associated secretomes for aging biomarker development","volume":"18","author":"Basisty","year":"2020","journal-title":"PLoS Biology"},{"key":"10.1016\/j.alcohol.2025.07.001_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000902","article-title":"Muc2 protects against lethal infectious colitis by disassociating pathogenic and commensal bacteria from the colonic mucosa","volume":"6","author":"Bergstrom","year":"2010","journal-title":"PLoS Pathogens"},{"key":"10.1016\/j.alcohol.2025.07.001_bib14","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1126\/science.aaf7419","article-title":"A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion","volume":"352","author":"Birchenough","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.alcohol.2025.07.001_bib15","doi-asserted-by":"crossref","first-page":"163","DOI":"10.35946\/arcr.v38.2.02","article-title":"Alcohol and gut-derived inflammation","volume":"38","author":"Bishehsari","year":"2017","journal-title":"Alcohol Research"},{"key":"10.1016\/j.alcohol.2025.07.001_bib16","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S0168-8278(87)80003-X","article-title":"Endotoxemia in patients with alcoholic and non-alcoholic cirrhosis and in subjects with no evidence of chronic liver disease following acute alcohol excess","volume":"4","author":"Bode","year":"1987","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.alcohol.2025.07.001_bib17","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/nrm.2016.93","article-title":"Slowing ageing by design: The rise of NAD(+) and sirtuin-activating compounds","volume":"17","author":"Bonkowski","year":"2016","journal-title":"Nature Reviews Molecular Cell Biology"},{"key":"10.1016\/j.alcohol.2025.07.001_bib18","doi-asserted-by":"crossref","first-page":"e50","DOI":"10.1371\/journal.pmed.1000050","article-title":"The alcohol flushing response: An unrecognized risk factor for esophageal cancer from alcohol consumption","volume":"6","author":"Brooks","year":"2009","journal-title":"PLoS Medicine"},{"key":"10.1016\/j.alcohol.2025.07.001_bib19","doi-asserted-by":"crossref","first-page":"307","DOI":"10.7150\/ijbs.53589","article-title":"A perspective of intestinal immune-microbiome interactions in alcohol-associated liver disease","volume":"17","author":"Bruellman","year":"2021","journal-title":"International Journal of Biological Sciences"},{"key":"10.1016\/j.alcohol.2025.07.001_bib20","series-title":"National population projections tables: Main series, 2023","year":"2023"},{"key":"10.1016\/j.alcohol.2025.07.001_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104442","article-title":"The microbiome-gut-brain axis regulates social cognition & craving in young binge drinkers","volume":"89","author":"Carbia","year":"2023","journal-title":"EBioMedicine"},{"key":"10.1016\/j.alcohol.2025.07.001_bib22","doi-asserted-by":"crossref","first-page":"25808","DOI":"10.1073\/pnas.1912359116","article-title":"Alcohol shifts gut microbial networks and ameliorates a murine model of neuroinflammation in a sex-specific pattern","volume":"116","author":"Caslin","year":"2019","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10.1016\/j.alcohol.2025.07.001_bib23","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2021.1916278","article-title":"Alcohol as friend or foe in autoimmune diseases: A role for gut microbiome?","volume":"13","author":"Caslin","year":"2021","journal-title":"Gut Microbes"},{"key":"10.1016\/j.alcohol.2025.07.001_bib24","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.cld.2012.08.002","article-title":"Alcohol metabolism","volume":"16","author":"Cederbaum","year":"2012","journal-title":"Clinics in Liver Disease"},{"key":"10.1016\/j.alcohol.2025.07.001_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/cells13221906","article-title":"Inflammation: The cause of all diseases","volume":"13","author":"Chavda","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.alcohol.2025.07.001_bib26","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1186\/s12964-023-01177-2","article-title":"Involvement of the SIRT1-NLRP3 pathway in the inflammatory response","volume":"21","author":"Chen","year":"2023","journal-title":"Cell Communication and Signaling"},{"key":"10.1016\/j.alcohol.2025.07.001_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2020.102753","article-title":"Novel and prevalent Non-East Asian ALDH2 variants; implications for global susceptibility to aldehydes' toxicity","volume":"55","author":"Chen","year":"2020","journal-title":"EBioMedicine"},{"key":"10.1016\/j.alcohol.2025.07.001_bib28","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/nature11319","article-title":"Gut microbiota composition correlates with diet and health in the elderly","volume":"488","author":"Claesson","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.alcohol.2025.07.001_bib29","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1111\/jgh.13731","article-title":"Prophylactic tributyrin treatment mitigates chronic-binge ethanol-induced intestinal barrier and liver injury","volume":"32","author":"Cresci","year":"2017","journal-title":"Journal of Gastroenterology and Hepatology"},{"key":"10.1016\/j.alcohol.2025.07.001_bib30","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s13041-015-0117-y","article-title":"Characterization of Aldh2 (-\/-) mice as an age-related model of cognitive impairment and Alzheimer's disease","volume":"8","author":"D'Souza","year":"2015","journal-title":"Molecular Brain"},{"key":"10.1016\/j.alcohol.2025.07.001_bib31","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1097\/HEP.0000000000000298","article-title":"Alcohol-induced extracellular ASC specks perpetuate liver inflammation and damage in alcohol-associated hepatitis even after alcohol cessation","volume":"78","author":"de Carvalho Ribeiro","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.alcohol.2025.07.001_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21113858","article-title":"Relevance of SIRT1-NF-kappaB axis as therapeutic target to ameliorate inflammation in liver disease","volume":"21","author":"de Gregorio","year":"2020","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/j.alcohol.2025.07.001_bib33","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1378\/chest.129.5.1219","article-title":"Impact of alcohol abuse in the etiology and severity of community-acquired pneumonia","volume":"129","author":"de Roux","year":"2006","journal-title":"Chest"},{"key":"10.1016\/j.alcohol.2025.07.001_bib34","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0165-5728(95)00148-4","article-title":"The influence of cytokines on the integrity of the blood-brain barrier in vitro","volume":"64","author":"de Vries","year":"1996","journal-title":"Journal of Neuroimmunology"},{"key":"10.1016\/j.alcohol.2025.07.001_bib35","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.neuro.2018.06.005","article-title":"Aldehyde dehydrogenase 2 in the spotlight: The link between mitochondria and neurodegeneration","volume":"68","author":"Deza-Ponzio","year":"2018","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.alcohol.2025.07.001_bib36","doi-asserted-by":"crossref","first-page":"354","DOI":"10.3945\/ajcn.2008.26661","article-title":"Alcohol consumption and n\u20133 polyunsaturated fatty acids in healthy men and women from 3 European populations","volume":"89","author":"di Giuseppe","year":"2009","journal-title":"The American Journal of Clinical Nutrition"},{"key":"10.1016\/j.alcohol.2025.07.001_bib37","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s11739-023-03374-w","article-title":"Gut microbiota, intestinal permeability, and systemic inflammation: A narrative review","volume":"19","author":"Di Vincenzo","year":"2024","journal-title":"Internal and Emergency Medicine"},{"key":"10.1016\/j.alcohol.2025.07.001_bib38","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.msard.2017.06.011","article-title":"The effect of alcohol and red wine consumption on clinical and MRI outcomes in multiple sclerosis","volume":"17","author":"Diaz-Cruz","year":"2017","journal-title":"Multiple Sclerosis and Related Disorders"},{"key":"10.1016\/j.alcohol.2025.07.001_bib39","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.1014853","article-title":"Osteopontin - The stirring multifunctional regulatory factor in multisystem aging","volume":"13","author":"Du","year":"2022","journal-title":"Frontiers in Endocrinology"},{"key":"10.1016\/j.alcohol.2025.07.001_bib40","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/s41586-019-1742-x","article-title":"Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease","volume":"575","author":"Duan","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.alcohol.2025.07.001_bib41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0184274","article-title":"The effect of age on the intestinal mucus thickness, microbiota composition and immunity in relation to sex in mice","volume":"12","author":"Elderman","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.alcohol.2025.07.001_bib42","article-title":"Senolytic CAR T cells reverse aging-associated defects in intestinal regeneration and fitness","author":"Eskiocak","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.alcohol.2025.07.001_bib43","article-title":"Evidence that the loss of colonic anti-microbial peptides may promote dysbiotic Gram-negative inflammaging-associated bacteria in aging mice","volume":"5","author":"Forsyth","year":"2024","journal-title":"Frontiers in Aging Series"},{"key":"10.1016\/j.alcohol.2025.07.001_bib44","first-page":"S4","article-title":"Chronic inflammation (Inflammaging) and its potential contribution to age-associated diseases","volume":"69","author":"Franceschi","year":"2014","journal-title":"The Journals of Gerontology: Series A"},{"key":"10.1016\/j.alcohol.2025.07.001_bib45","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.cell.2020.03.007","article-title":"Challenges, progress, and prospects of developing therapies to treat autoimmune diseases","volume":"181","author":"Fugger","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.alcohol.2025.07.001_bib46","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s12016-021-08899-6","article-title":"Immunology of aging: The birth of inflammaging","volume":"64","author":"Fulop","year":"2023","journal-title":"Clinical Reviews in Allergy and Immunology"},{"key":"10.1016\/j.alcohol.2025.07.001_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.devcel.2023.11.013","article-title":"Aged intestinal stem cells propagate cell-intrinsic sources of inflammaging in mice","volume":"58","author":"Funk","year":"2023","journal-title":"Developmental Cell"},{"key":"10.1016\/j.alcohol.2025.07.001_bib48","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1038\/s41591-019-0675-0","article-title":"Chronic inflammation in the etiology of disease across the life span","volume":"25","author":"Furman","year":"2019","journal-title":"Nature Medicine"},{"key":"10.1016\/j.alcohol.2025.07.001_bib49","doi-asserted-by":"crossref","DOI":"10.1136\/egastro-2024-100104","article-title":"Cell-to-cell and organ-to-organ crosstalk in the pathogenesis of alcohol-associated liver disease","volume":"2","author":"Gao","year":"2024","journal-title":"eGastroenterology"},{"key":"10.1016\/j.alcohol.2025.07.001_bib50","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S1474-4422(18)30295-3","article-title":"Global, regional, and national burden of Parkinson's disease, 1990-2016: A systematic analysis for the Global Burden of Disease Study 2016","volume":"17","author":"GbdpsD","year":"2018","journal-title":"The Lancet Neurology"},{"key":"10.1016\/j.alcohol.2025.07.001_bib51","doi-asserted-by":"crossref","first-page":"149","DOI":"10.15288\/jsa.1999.60.149","article-title":"An examination of ALDH2 genotypes, alcohol metabolism and the flushing response in Native Americans","volume":"60","author":"Gill","year":"1999","journal-title":"Journal of Studies on Alcohol"},{"key":"10.1016\/j.alcohol.2025.07.001_bib52","article-title":"Therapeutic potential of nicotinamide and ABT263 in alcohol-associated liver disease through targeting cellular senescence","volume":"6","author":"Gold","year":"2020","journal-title":"MedComm"},{"key":"10.1016\/j.alcohol.2025.07.001_bib53","doi-asserted-by":"crossref","first-page":"4772","DOI":"10.3390\/molecules25204772","article-title":"Association of moderate beer consumption with the gut microbiota and SCFA of healthy adults","volume":"25","author":"Gonz\u00e1lez-Zancada","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.alcohol.2025.07.001_bib54","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1136\/gutjnl-2016-313432","article-title":"Recovery of ethanol-induced Akkermansia muciniphila depletion ameliorates alcoholic liver disease","volume":"67","author":"Grander","year":"2018","journal-title":"Gut"},{"key":"10.1016\/j.alcohol.2025.07.001_bib55","first-page":"218a","article-title":"Alcohol-associated impact of siga-coated intestinal bacteria on pulmonary host defense during Streptococcus pneumoniae infection","volume":"45","author":"Gu","year":"2021","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1016\/j.alcohol.2025.07.001_bib56","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2019.5172","article-title":"Association between alcohol use disorders and outcomes of patients hospitalized with community-acquired pneumonia","volume":"2","author":"Gupta","year":"2019","journal-title":"JAMA Network Open"},{"key":"10.1016\/j.alcohol.2025.07.001_bib57","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1056\/NEJMra2306511","article-title":"Identification and treatment of alcohol use disorder","volume":"392","author":"Haber","year":"2025","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.alcohol.2025.07.001_bib58","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/hep.26321","article-title":"Deficiency of intestinal mucin-2 ameliorates experimental alcoholic liver disease in mice","volume":"58","author":"Hartmann","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.alcohol.2025.07.001_bib59","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2012.07.099","article-title":"Toll-like receptor 2-mediated intestinal injury and enteric tumor necrosis factor receptor I contribute to liver fibrosis in mice","volume":"143","author":"Hartmann","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.alcohol.2025.07.001_bib60","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.cger.2021.11.005","article-title":"The burden of osteoarthritis in older adults","volume":"38","author":"Hawker","year":"2022","journal-title":"Clinics in Geriatric Medicine"},{"key":"10.1016\/j.alcohol.2025.07.001_bib61","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1001\/jamaneurol.2013.5858","article-title":"Alcohol as a modifiable lifestyle factor affecting multiple sclerosis risk","volume":"71","author":"Hedstr\u00f6m","year":"2014","journal-title":"JAMA Neurology"},{"key":"10.1016\/j.alcohol.2025.07.001_bib62","doi-asserted-by":"crossref","first-page":"273","DOI":"10.2165\/00003088-198713050-00001","article-title":"Clinical pharmacokinetics of ethanol","volume":"13","author":"Holford","year":"1987","journal-title":"Clinical Pharmacokinetics"},{"key":"10.1016\/j.alcohol.2025.07.001_bib63","doi-asserted-by":"crossref","DOI":"10.1097\/HEP.0000000000000885","article-title":"Non-invasive tests for alcohol-associated liver disease","author":"Israelsen","year":"2024","journal-title":"Hepatology"},{"key":"10.1016\/j.alcohol.2025.07.001_bib64","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1097\/01.alc.0000187161.07820.21","article-title":"Aldehyde dehydrogenase 2 gene targeting mouse lacking enzyme activity shows high acetaldehyde level in blood, brain, and liver after ethanol gavages","volume":"29","author":"Isse","year":"2005","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1016\/j.alcohol.2025.07.001_bib65","doi-asserted-by":"crossref","DOI":"10.1111\/acel.14315","article-title":"The connection between aging, cellular senescence and gut microbiome alterations: A comprehensive review","volume":"23","author":"Jang","year":"2024","journal-title":"Aging Cell"},{"key":"10.1016\/j.alcohol.2025.07.001_bib66","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s13578-024-01209-5","article-title":"Single nuclear RNA sequencing of terminal ileum in patients with cirrhosis demonstrates multi-faceted alterations in the intestinal barrier","volume":"14","author":"Jiang","year":"2024","journal-title":"Cell & Bioscience"},{"key":"10.1016\/j.alcohol.2025.07.001_bib67","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/6782872","article-title":"The beneficial roles of SIRT1 in neuroinflammation-related diseases","volume":"2020","author":"Jiao","year":"2020","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"10.1016\/j.alcohol.2025.07.001_bib68","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/s42255-021-00357-z","article-title":"Brain ethanol metabolism by astrocytic ALDH2 drives the behavioural effects of ethanol intoxication","volume":"3","author":"Jin","year":"2021","journal-title":"Nature Metabolism"},{"key":"10.1016\/j.alcohol.2025.07.001_bib69","first-page":"258","volume":"104","author":"Jonsson","year":"2007"},{"key":"10.1016\/j.alcohol.2025.07.001_bib70","doi-asserted-by":"crossref","first-page":"30","DOI":"10.14309\/ajg.0000000000002572","article-title":"ACG clinical guideline: Alcohol-associated liver disease","volume":"119","author":"Jophlin","year":"2024","journal-title":"American Journal of Gastroenterology"},{"key":"10.1016\/j.alcohol.2025.07.001_bib71","doi-asserted-by":"crossref","first-page":"e65","DOI":"10.1161\/CIR.0000000000001256","article-title":"Forecasting the burden of cardiovascular disease and stroke in the United States through 2050-Prevalence of risk factors and disease: A presidential advisory from the American heart association","volume":"150","author":"Joynt Maddox","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.alcohol.2025.07.001_bib72","doi-asserted-by":"crossref","first-page":"4038","DOI":"10.3390\/cells11244038","article-title":"Role of endogenous lipopolysaccharides in neurological disorders","volume":"11","author":"Kalyan","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.alcohol.2025.07.001_bib73","doi-asserted-by":"crossref","first-page":"H1135","DOI":"10.1152\/ajpheart.00381.2024","article-title":"Biomarkers of intestinal permeability are associated with inflammation in metabolically healthy obesity but not normal-weight obesity","volume":"327","author":"Keirns","year":"2024","journal-title":"American Journal of Physiology - Heart and Circulatory Physiology"},{"key":"10.1016\/j.alcohol.2025.07.001_bib74","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.jhep.2008.10.028","article-title":"Evidence that chronic alcohol exposure promotes intestinal oxidative stress, intestinal hyperpermeability and endotoxemia prior to development of alcoholic steatohepatitis in rats","volume":"50","author":"Keshavarzian","year":"2009","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.alcohol.2025.07.001_bib75","doi-asserted-by":"crossref","DOI":"10.3390\/cells12202475","article-title":"Alcohol and the brain-gut axis: The involvement of microglia and enteric glia in the process of neuro-enteric inflammation","volume":"12","author":"Khan","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.alcohol.2025.07.001_bib76","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.137943","article-title":"Synchronization of mothers and offspring promotes tolerance and limits allergy","volume":"5","author":"Knoop","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.alcohol.2025.07.001_bib77","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/mi.2014.58","article-title":"Microbial sensing by goblet cells controls immune surveillance of luminal antigens in the colon","volume":"8","author":"Knoop","year":"2015","journal-title":"Mucosal Immunology"},{"key":"10.1016\/j.alcohol.2025.07.001_bib78","doi-asserted-by":"crossref","first-page":"5389","DOI":"10.2147\/JIR.S470520","article-title":"Restore intestinal barrier integrity: An approach for inflammatory bowel disease therapy","volume":"17","author":"Kong","year":"2024","journal-title":"Journal of Inflammation Research"},{"key":"10.1016\/j.alcohol.2025.07.001_bib79","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1183\/09031936.00000611","article-title":"Alcohol drinking and risk of subsequent hospitalisation with pneumonia","volume":"39","author":"Kornum","year":"2012","journal-title":"European Respiratory Journal"},{"key":"10.1016\/j.alcohol.2025.07.001_bib80","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.134049","article-title":"Intestinal alkaline phosphatase targets the gut barrier to prevent aging","volume":"5","author":"Kuhn","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.alcohol.2025.07.001_bib81","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/s41385-019-0240-7","article-title":"Goblet cell associated antigen passages support the induction and maintenance of oral tolerance","volume":"13","author":"Kulkarni","year":"2020","journal-title":"Mucosal Immunology"},{"key":"10.1016\/j.alcohol.2025.07.001_bib82","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s40168-014-0050-9","article-title":"Microbial shifts in the aging mouse gut","volume":"2","author":"Langille","year":"2014","journal-title":"Microbiome"},{"key":"10.1016\/j.alcohol.2025.07.001_bib83","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1080\/03602532.2019.1679169","article-title":"Ethanol and its metabolites: Update on toxicity, benefits, and focus on immunomodulatory effects","volume":"51","author":"Le Dar\u00e9","year":"2019","journal-title":"Drug metabolism reviews"},{"key":"10.1016\/j.alcohol.2025.07.001_bib84","doi-asserted-by":"crossref","first-page":"E4485","DOI":"10.1073\/pnas.1415174111","article-title":"Intestinal permeability, gut-bacterial dysbiosis, and behavioral markers of alcohol-dependence severity","volume":"111","author":"Leclercq","year":"2014","journal-title":"Proceedings of the National Academy of Sciences of the U S A"},{"key":"10.1016\/j.alcohol.2025.07.001_bib85","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s00018-023-05061-7","article-title":"Contributing roles of mitochondrial dysfunction and hepatocyte apoptosis in liver diseases through oxidative stress, post-translational modifications, inflammation, and intestinal barrier dysfunction","volume":"81","author":"LeFort","year":"2024","journal-title":"Cellular and Molecular Life Sciences"},{"key":"10.1016\/j.alcohol.2025.07.001_bib86","first-page":"843","article-title":"The vicious cycle between (neuro)inflammation and alcohol use disorder: An opportunity to develop new medications?","volume":"47","author":"Leko","year":"2023","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1016\/j.alcohol.2025.07.001_bib87","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106902","article-title":"Host ALDH2 deficiency aggravates nonalcoholic steatohepatitis through gut-liver axis","volume":"196","author":"Li","year":"2023","journal-title":"Pharmacological Research"},{"key":"10.1016\/j.alcohol.2025.07.001_bib88","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jncc.2024.05.002","article-title":"Nowcasting and forecasting global aging and cancer burden: Analysis of data from the GLOBOCAN and Global Burden of Disease Study","volume":"4","author":"Li","year":"2024","journal-title":"Journal of the National Cancer Center"},{"key":"10.1016\/j.alcohol.2025.07.001_bib89","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1186\/s12974-022-02666-w","article-title":"NLRP3 deficiency decreases alcohol intake controlling anxiety-like behavior via modification of glutamatergic transmission in corticostriatal circuits","volume":"19","author":"Li","year":"2022","journal-title":"Journal of Neuroinflammation"},{"key":"10.1016\/j.alcohol.2025.07.001_bib90","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1111\/add.14935","article-title":"Effect of alcohol use disorders and alcohol intake on the risk of subsequent depressive symptoms: A systematic review and meta-analysis of cohort studies","volume":"115","author":"Li","year":"2020","journal-title":"Addiction"},{"key":"10.1016\/j.alcohol.2025.07.001_bib91","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0168-8278(00)80420-1","article-title":"Alcoholic liver disease: New insights in pathogenesis lead to new treatments","volume":"32","author":"Lieber","year":"2000","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.alcohol.2025.07.001_bib92","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1189\/jlb.1212659","article-title":"Alcohol-induced IL-1beta in the brain is mediated by NLRP3\/ASC inflammasome activation that amplifies neuroinflammation","volume":"94","author":"Lippai","year":"2013","journal-title":"Journal of Leukocyte Biology"},{"key":"10.1016\/j.alcohol.2025.07.001_bib93","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2022.101763","article-title":"Mesencephalic astrocyte-derived neurotrophic factor (MANF): Structure, functions and therapeutic potential","volume":"82","author":"Liu","year":"2022","journal-title":"Ageing Research Reviews"},{"key":"10.1016\/j.alcohol.2025.07.001_bib94","first-page":"1466","article-title":"Commentary on the gut microbiome in alcohol use disorder and alcohol-associated liver disease","volume":"48","author":"Llorente","year":"2024","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1016\/j.alcohol.2025.07.001_bib95","article-title":"IL6ST\u2013induced muscarinic receptor opens goblet cell associated antigen passages to suppress alcoholic liver disease","author":"Llorente","year":"2021","journal-title":"Research Square"},{"key":"10.1016\/j.alcohol.2025.07.001_bib96","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1038\/s41467-017-00796-x","article-title":"Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus","volume":"8","author":"Llorente","year":"2017","journal-title":"Nature Communications"},{"key":"10.1016\/j.alcohol.2025.07.001_bib97","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.jcmgh.2015.04.003","article-title":"The gut microbiota and liver disease","volume":"1","author":"Llorente","year":"2015","journal-title":"Cellular and Molecular Gastroenterology and Hepatology"},{"key":"10.1016\/j.alcohol.2025.07.001_bib98","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1186\/s12974-020-01972-5","article-title":"Chronic alcohol-induced neuroinflammation involves CCR2\/5-dependent peripheral macrophage infiltration and microglia alterations","volume":"17","author":"Lowe","year":"2020","journal-title":"Journal of Neuroinflammation"},{"key":"10.1016\/j.alcohol.2025.07.001_bib99","doi-asserted-by":"crossref","first-page":"3554","DOI":"10.1002\/art.27739","article-title":"Alcohol consumption and markers of inflammation in women with preclinical rheumatoid arthritis","volume":"62","author":"Lu","year":"2010","journal-title":"Arthritis & Rheumatism"},{"key":"10.1016\/j.alcohol.2025.07.001_bib100","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.3389\/fimmu.2018.01302","article-title":"The clinical significance and potential role of C-Reactive protein in chronic inflammatory and neurodegenerative diseases","volume":"9","author":"Luan","year":"2018","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/j.alcohol.2025.07.001_bib101","first-page":"1499","article-title":"Senolytic treatment improve small intestine regeneration in aging","volume":"15","author":"Luo","year":"2024","journal-title":"Aging and Disease"},{"key":"10.1016\/j.alcohol.2025.07.001_bib102","first-page":"1261","article-title":"The gut-brain axis in individuals with alcohol use disorder: An exploratory study of associations among clinical symptoms, brain morphometry, and the gut microbiome","volume":"48","author":"Maki","year":"2024","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1016\/j.alcohol.2025.07.001_bib103","doi-asserted-by":"crossref","first-page":"567","DOI":"10.34172\/aim.2023.83","article-title":"Impact of alcohol consumption on multiple sclerosis using model-based standardization and misclassification adjustment via probabilistic bias analysis","volume":"26","author":"Malekifar","year":"2023","journal-title":"Archives of Iranian Medicine"},{"key":"10.1016\/j.alcohol.2025.07.001_bib104","doi-asserted-by":"crossref","first-page":"3398","DOI":"10.4049\/jimmunol.173.5.3398","article-title":"Inhibition of myeloid dendritic cell accessory cell function and induction of T cell anergy by alcohol correlates with decreased IL-12 production","volume":"173","author":"Mandrekar","year":"2004","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.alcohol.2025.07.001_bib105","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1530-0277.2006.00012.x","article-title":"Moderate alcohol intake in humans attenuates monocyte inflammatory responses: Inhibition of nuclear regulatory factor kappa B and induction of interleukin 10","volume":"30","author":"Mandrekar","year":"2006","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1016\/j.alcohol.2025.07.001_bib106","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.3390\/biom5042477","article-title":"Potential role of the gut\/liver\/lung axis in alcohol-induced tissue pathology","volume":"5","author":"Massey","year":"2015","journal-title":"Biomolecules"},{"key":"10.1016\/j.alcohol.2025.07.001_bib107","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1111\/acer.12462","article-title":"Ethanol reduces lifespan, body weight, and serum alanine aminotransferase level of aldehyde dehydrogenase 2 knockout mouse","volume":"38","author":"Matsumoto","year":"2014","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1016\/j.alcohol.2025.07.001_bib108","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nature10863","article-title":"Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine","volume":"483","author":"McDole","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.alcohol.2025.07.001_bib109","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.alcohol.2022.08.011","article-title":"Changes in gut microbiome correlate with intestinal barrier dysfunction and inflammation following a 3-day ethanol exposure in aged mice","volume":"107","author":"McMahan","year":"2023","journal-title":"Alcohol"},{"key":"10.1016\/j.alcohol.2025.07.001_bib110","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12979-021-00247-8","article-title":"A novel murine model of multi-day moderate ethanol exposure reveals increased intestinal dysfunction and liver inflammation with age","volume":"18","author":"McMahan","year":"2021","journal-title":"Immunity & Ageing"},{"key":"10.1016\/j.alcohol.2025.07.001_bib111","first-page":"21","article-title":"Age, alcohol metabolism and liver disease","volume":"11","author":"Meier","year":"2008","journal-title":"Current Opinion in Clinical Nutrition and Metabolic Care"},{"key":"10.1016\/j.alcohol.2025.07.001_bib112","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.vaccine.2013.10.076","article-title":"Moderate alcohol consumption enhances vaccine-induced responses in rhesus macaques","volume":"32","author":"Messaoudi","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.alcohol.2025.07.001_bib113","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1093\/ageing\/afy025","article-title":"Longitudinal changes in physical function and physical activity in older adults","volume":"47","author":"Metti","year":"2018","journal-title":"Age and Ageing"},{"key":"10.1016\/j.alcohol.2025.07.001_bib114","article-title":"Altered Sirtuin1 and Sirtuin6 expression in aging: A systematic review and meta-analysis","volume":"10","author":"Mun","year":"2023","journal-title":"Annals of Vascular Medicine and Research"},{"key":"10.1016\/j.alcohol.2025.07.001_bib115","series-title":"Janeway's immunobiology","author":"Murphy","year":"2022"},{"key":"10.1016\/j.alcohol.2025.07.001_bib116","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/add.13451","article-title":"Selection biases in observational studies affect associations between 'moderate' alcohol consumption and mortality","volume":"112","author":"Naimi","year":"2017","journal-title":"Addiction"},{"key":"10.1016\/j.alcohol.2025.07.001_bib118","doi-asserted-by":"crossref","DOI":"10.1016\/S2468-1253(24)00390-X","article-title":"The intestinal barrier: A pivotal role in health, inflammation, and cancer","author":"Neurath","year":"2025","journal-title":"The Lancet Gastroenterology & Hepatology"},{"key":"10.1016\/j.alcohol.2025.07.001_bib119","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1152\/physrev.00022.2011","article-title":"Sirtuin 1 and sirtuin 3: Physiological modulators of metabolism","volume":"92","author":"Nogueiras","year":"2012","journal-title":"Physiological Reviews"},{"key":"10.1016\/j.alcohol.2025.07.001_bib120","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2024.24495","article-title":"Alcohol consumption patterns and mortality among older adults with health-related or socioeconomic risk factors","volume":"7","author":"Ortol\u00e1","year":"2024","journal-title":"JAMA Network Open"},{"key":"10.1016\/j.alcohol.2025.07.001_bib121","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3389\/fimmu.2019.00277","article-title":"Short chain fatty acids (SCFAs)-mediated gut epithelial and immune regulation and its relevance for inflammatory bowel diseases","volume":"10","author":"Parada Venegas","year":"2019","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/j.alcohol.2025.07.001_bib122","doi-asserted-by":"crossref","DOI":"10.1080\/21688370.2017.1343172","article-title":"The impact of aging on epithelial barriers","volume":"5","author":"Parrish","year":"2017","journal-title":"Tissue Barriers"},{"key":"10.1016\/j.alcohol.2025.07.001_bib123","doi-asserted-by":"crossref","DOI":"10.1016\/j.chstcc.2025.100143","article-title":"Association of central nervous system-related biomarkers with hospital delirium in patients with respiratory failure in the ICU","volume":"3","author":"Pham","year":"2025","journal-title":"CHEST Critical Care"},{"key":"10.1016\/j.alcohol.2025.07.001_bib124","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.jceh.2022.01.001","article-title":"Long-term outcomes of stool transplant in alcohol-associated hepatitis-analysis of clinical outcomes, relapse, gut microbiota and comparisons with standard care","volume":"12","author":"Philips","year":"2022","journal-title":"Journal of Clinical and Experimental Hepatology"},{"key":"10.1016\/j.alcohol.2025.07.001_bib125","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1093\/jnen\/60.7.686","article-title":"Expression and activities of aldo-keto oxidoreductases in Alzheimer disease","volume":"60","author":"Picklo","year":"2001","journal-title":"Journal of Neuropathology & Experimental Neurology"},{"key":"10.1016\/j.alcohol.2025.07.001_bib126","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.3945\/ajcn.111.027847","article-title":"Influence of red wine polyphenols and ethanol on the gut microbiota ecology and biochemical biomarkers","volume":"95","author":"Queipo-Ortu\u00f1o","year":"2012","journal-title":"The American Journal of Clinical Nutrition"},{"key":"10.1016\/j.alcohol.2025.07.001_bib127","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/S0369-8114(01)00232-2","article-title":"Research advances in ethanol metabolism","volume":"49","author":"Ramchandani","year":"2001","journal-title":"Pathologie Biologie"},{"key":"10.1016\/j.alcohol.2025.07.001_bib128","article-title":"Mitochondrial aldehyde dehydrogenase 2 (ALDH2) protects against binge alcohol-mediated gut and brain injury","volume":"13","author":"Ray","year":"2024"},{"key":"10.1016\/j.alcohol.2025.07.001_bib129","doi-asserted-by":"crossref","DOI":"10.1097\/HEP.0000000000000924","article-title":"Gut-liver axis: Recent concepts in pathophysiology in alcohol-associated liver disease","author":"Raya Tonetti","year":"2024","journal-title":"Hepatology"},{"key":"10.1016\/j.alcohol.2025.07.001_bib130","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1002\/hep.32152","article-title":"Aging exaggerates acute-on-chronic alcohol-induced liver injury in mice and humans by inhibiting neutrophilic sirtuin 1-C\/EBPalpha-miRNA-223 axis","volume":"75","author":"Ren","year":"2022","journal-title":"Hepatology"},{"key":"10.1016\/j.alcohol.2025.07.001_bib131","doi-asserted-by":"crossref","first-page":"3174","DOI":"10.7150\/ijbs.49535","article-title":"Emerging roles of SIRT1 in alcoholic liver disease","volume":"16","author":"Ren","year":"2020","journal-title":"International Journal of Biological Sciences"},{"key":"10.1016\/j.alcohol.2025.07.001_bib132","doi-asserted-by":"crossref","first-page":"3439","DOI":"10.1021\/acsptsci.4c00068","article-title":"Large- and small-animal studies of safety, pharmacokinetics, and biodistribution of inflammasome-targeting nanoligomer in the brain and other target organs","volume":"7","author":"Risen","year":"2024","journal-title":"ACS Pharmacology & Translational Science"},{"key":"10.1016\/j.alcohol.2025.07.001_bib133","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1159\/000107679","article-title":"Changes in the immune system after moderate beer consumption","volume":"51","author":"Romeo","year":"2007","journal-title":"Annals of Nutrition & Metabolism"},{"key":"10.1016\/j.alcohol.2025.07.001_bib134","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0140-6736(05)17870-2","article-title":"Alcohol and public health","volume":"365","author":"Room","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.alcohol.2025.07.001_bib135","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2023.108547","article-title":"Post-translational modifications of histone and non-histone proteins in epigenetic regulation and translational applications in alcohol-associated liver disease: Challenges and research opportunities","volume":"251","author":"Rungratanawanich","year":"2023","journal-title":"Pharmacology & Therapeutics"},{"key":"10.1016\/j.alcohol.2025.07.001_bib136","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102577","article-title":"ALDH2 deficiency increases susceptibility to binge alcohol-induced gut leakiness, endotoxemia, and acute liver injury in mice through the gut-liver axis","volume":"59","author":"Rungratanawanich","year":"2023","journal-title":"Redox Biology"},{"key":"10.1016\/j.alcohol.2025.07.001_bib137","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/s12276-021-00561-7","article-title":"Advanced glycation end products (AGEs) and other adducts in aging-related diseases and alcohol-mediated tissue injury","volume":"53","author":"Rungratanawanich","year":"2021","journal-title":"Experimental & Molecular Medicine"},{"key":"10.1016\/j.alcohol.2025.07.001_bib138","first-page":"1895","article-title":"Senolytic combination of dasatinib and quercetin alleviates intestinal senescence and inflammation and modulates the gut microbiome in aged mice","volume":"76","author":"Saccon","year":"2021","journal-title":"Journals of Gerontology: Series A, Biological Sciences and Medical Sciences"},{"key":"10.1016\/j.alcohol.2025.07.001_bib139","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006426","article-title":"Alcohol-associated intestinal dysbiosis impairs pulmonary host defense against Klebsiella pneumoniae","volume":"13","author":"Samuelson","year":"2017","journal-title":"PLoS Pathogens"},{"key":"10.1016\/j.alcohol.2025.07.001_bib140","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines12122757","article-title":"The gut-lung axis during ethanol exposure and a Pseudomonas aeruginosa bacterial challenge","volume":"12","author":"Santilli","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.alcohol.2025.07.001_bib141","doi-asserted-by":"crossref","DOI":"10.3390\/antiox13040472","article-title":"Tributyrin supplementation rescues chronic-binge ethanol-induced oxidative stress in the gut-lung axis in mice","volume":"13","author":"Santilli","year":"2024","journal-title":"Antioxidants"},{"key":"10.1016\/j.alcohol.2025.07.001_bib142","doi-asserted-by":"crossref","DOI":"10.1093\/pnasnexus\/pgaf121","article-title":"Epigenetic biomarkers of socioeconomic status are associated with age-related chronic diseases and mortality in older adults","author":"Schmitz","year":"2025","journal-title":"PNAS Nexus"},{"key":"10.1016\/j.alcohol.2025.07.001_bib143","doi-asserted-by":"crossref","first-page":"e124","DOI":"10.1016\/S2468-2667(18)30022-7","article-title":"Contribution of alcohol use disorders to the burden of dementia in France 2008-13: A nationwide retrospective cohort study","volume":"3","author":"Schwarzinger","year":"2018","journal-title":"The Lancet Public Health"},{"key":"10.1016\/j.alcohol.2025.07.001_bib144","doi-asserted-by":"crossref","DOI":"10.3390\/cells9061552","article-title":"The NLRP3 inflammasome as a critical actor in the inflammaging process","volume":"9","author":"Sebastian-Valverde","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.alcohol.2025.07.001_bib145","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/0016-5085(89)90082-6","article-title":"Effect of aging on in vivo and in vitro ethanol metabolism and its toxicity in F344 rats","volume":"97","author":"Seitz","year":"1989","journal-title":"Gastroenterology"},{"key":"10.1016\/j.alcohol.2025.07.001_bib146","doi-asserted-by":"crossref","DOI":"10.3390\/nu15020445","article-title":"Potential synergistic supplementation of NAD+ promoting compounds as a strategy for increasing healthspan","volume":"15","author":"Sharma","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.alcohol.2025.07.001_bib147","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2018-022344","article-title":"Alcohol and the risk of pneumonia: A systematic review and meta-analysis","volume":"8","author":"Simou","year":"2018","journal-title":"BMJ Open"},{"key":"10.1016\/j.alcohol.2025.07.001_bib148","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s40168-025-02089-8","article-title":"Life-long microbiome rejuvenation improves intestinal barrier function and inflammaging in mice","volume":"13","author":"Sommer","year":"2025","journal-title":"Microbiome"},{"key":"10.1016\/j.alcohol.2025.07.001_bib149","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/978-3-030-22254-3_6","article-title":"Contributing roles of CYP2E1 and other cytochrome P450 isoforms in alcohol-related tissue injury and carcinogenesis","volume":"1164","author":"Song","year":"2019","journal-title":"Advances in Experimental Medicine & Biology"},{"key":"10.1016\/j.alcohol.2025.07.001_bib150","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/bs.apha.2015.04.002","article-title":"Translational implications of the alcohol-metabolizing enzymes, including cytochrome P450-2E1, in alcoholic and nonalcoholic liver disease","volume":"74","author":"Song","year":"2015","journal-title":"Advances in Pharmacology"},{"key":"10.1016\/j.alcohol.2025.07.001_bib151","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1038\/s41598-018-35228-3","article-title":"Age-associated impairment of the mucus barrier function is associated with profound changes in microbiota and immunity","volume":"9","author":"Sovran","year":"2019","journal-title":"Scientific Reports"},{"key":"10.1016\/j.alcohol.2025.07.001_bib152","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202300510","article-title":"Akkermansia muciniphila and alcohol-related liver diseases. A systematic review","volume":"68","author":"Sparfel","year":"2024","journal-title":"Molecular Nutrition & Food Research"},{"key":"10.1016\/j.alcohol.2025.07.001_bib153","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1042\/CS20171055","article-title":"Intestinal dysbiosis and permeability: The yin and yang in alcohol dependence and alcoholic liver disease","volume":"132","author":"St\u00e4rkel","year":"2018","journal-title":"Clinical Science"},{"key":"10.1016\/j.alcohol.2025.07.001_bib154","doi-asserted-by":"crossref","first-page":"185","DOI":"10.15288\/jsad.2016.77.185","article-title":"Do \"moderate\" drinkers have reduced mortality risk? A systematic review and meta-analysis of alcohol consumption and all-cause mortality","volume":"77","author":"Stockwell","year":"2016","journal-title":"Journal of Studies on Alcohol and Drugs"},{"key":"10.1016\/j.alcohol.2025.07.001_bib155","doi-asserted-by":"crossref","first-page":"845","DOI":"10.3390\/ijms26020845","article-title":"Alcohol consumption and autoimmune diseases","volume":"26","author":"Terracina","year":"2025","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/j.alcohol.2025.07.001_bib156","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26020845","article-title":"Alcohol consumption and autoimmune diseases","volume":"26","author":"Terracina","year":"2025","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/j.alcohol.2025.07.001_bib157","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.alcohol.2016.10.007","article-title":"Alcohol exposure differentially effects anti-tumor immunity in females by altering dendritic cell function","volume":"57","author":"Thompson","year":"2016","journal-title":"Alcohol"},{"key":"10.1016\/j.alcohol.2025.07.001_bib158","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1186\/s12974-024-03230-4","article-title":"Neuroinflammatory responses and blood\u2013brain barrier injury in chronic alcohol exposure: Role of purinergic P2 \u00d7 7 receptor signaling","volume":"21","author":"Togre","year":"2024","journal-title":"Journal of Neuroinflammation"},{"key":"10.1016\/j.alcohol.2025.07.001_bib159","article-title":"Goblet cells: Guardians of gut immunity and their role in gastrointestinal diseases","volume":"2","author":"Tonetti","year":"2024","journal-title":"eGastroenterology"},{"key":"10.1016\/j.alcohol.2025.07.001_bib160","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2025.01.114","article-title":"TISSUE-DIRECTED gene therapy for inflammatory bowel disease","volume":"168","author":"Toth","year":"2025","journal-title":"Gastroenterology"},{"key":"10.1016\/j.alcohol.2025.07.001_bib161","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1006\/abbi.1999.1477","article-title":"Cytochrome P4502E (CYP2E) in brain: Constitutive expression, induction by ethanol and localization by fluorescence in situ hybridization","volume":"373","author":"Upadhya","year":"2000","journal-title":"Archives of Biochemistry and Biophysics"},{"key":"10.1016\/j.alcohol.2025.07.001_bib162","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1111\/acer.13630","article-title":"Introduction to the virtual issue alcohol and epigenetic regulation: Do the products of alcohol metabolism drive epigenetic control of gene expression in alcohol-related disorders?","volume":"42","author":"Vadigepalli","year":"2018","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1016\/j.alcohol.2025.07.001_bib163","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1111\/acer.14669","article-title":"Increased toll-like Receptor-MyD88-NFkappaB-Proinflammatory neuroimmune signaling in the orbitofrontal cortex of humans with alcohol use disorder","volume":"45","author":"Vetreno","year":"2021","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1016\/j.alcohol.2025.07.001_bib164","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/s41522-024-00558-w","article-title":"Natural killer cell effector function is critical for host defense against alcohol-associated bacterial pneumonia","volume":"10","author":"Villageliu","year":"2024","journal-title":"NPJ Biofilms Microbiomes"},{"key":"10.1016\/j.alcohol.2025.07.001_bib165","first-page":"209","article-title":"Alcohol, inflammation, and blood-brain barrier function in health and disease across development","volume":"161","author":"Vore","year":"2022","journal-title":"International Review of Neurobiology"},{"key":"10.1016\/j.alcohol.2025.07.001_bib166","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1186\/s12974-024-03182-9","article-title":"Nanoligomers targeting NF-kappaB and NLRP3 reduce neuroinflammation and improve cognitive function with aging and tauopathy","volume":"21","author":"Wahl","year":"2024","journal-title":"Journal of Neuroinflammation"},{"key":"10.1016\/j.alcohol.2025.07.001_bib167","doi-asserted-by":"crossref","first-page":"13","DOI":"10.15288\/jsa.2000.61.13","article-title":"Hangover symptoms in Asian Americans with variations in the aldehyde dehydrogenase (ALDH2) gene","volume":"61","author":"Wall","year":"2000","journal-title":"Journal of Studies on Alcohol"},{"key":"10.1016\/j.alcohol.2025.07.001_bib168","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1002\/JLB.3RI0620-405RR","article-title":"Age-related changes in intestinal immunity and the microbiome","volume":"109","author":"Walrath","year":"2021","journal-title":"Journal of Leukocyte Biology"},{"key":"10.1016\/j.alcohol.2025.07.001_bib169","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.3748\/wjg.v16.i11.1304","article-title":"Alcohol, inflammation, and gut-liver-brain interactions in tissue damage and disease development","volume":"16","author":"Wang","year":"2010","journal-title":"World Journal of Gastroenterology"},{"key":"10.1016\/j.alcohol.2025.07.001_bib170","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2021.109400","article-title":"Blood-brain barrier integrity is the primary target of alcohol abuse","volume":"337","author":"Wei","year":"2021","journal-title":"Chemico-Biological Interactions"},{"key":"10.1016\/j.alcohol.2025.07.001_bib171","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1093\/ibd\/izab089","article-title":"The impact of alcohol in inflammatory bowel diseases","volume":"28","author":"White","year":"2022","journal-title":"Inflammatory Bowel Diseases"},{"key":"10.1016\/j.alcohol.2025.07.001_bib172","doi-asserted-by":"crossref","DOI":"10.3390\/nu15163578","article-title":"Natural phytochemicals as SIRT activators-focus on potential biochemical mechanisms","volume":"15","author":"Wicinski","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.alcohol.2025.07.001_bib173","doi-asserted-by":"crossref","first-page":"1","DOI":"10.35946\/arcr.v44.1.01","article-title":"Gut-liver-brain axis and alcohol use disorder: Treatment potential of fecal microbiota transplantation","volume":"44","author":"Wolstenholme","year":"2024","journal-title":"Alcohol Research"},{"key":"10.1016\/j.alcohol.2025.07.001_bib174","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.7150\/ijbs.38962","article-title":"ALDH 2 conferred neuroprotection on cerebral ischemic injury by alleviating mitochondria-related apoptosis through JNK\/caspase-3 signing pathway","volume":"16","author":"Xia","year":"2020","journal-title":"International Journal of Biological Sciences"},{"key":"10.1016\/j.alcohol.2025.07.001_bib175","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2023.103552","article-title":"Therapeutic strategies of small molecules in the microbiota\u2013gut\u2013brain axis for alcohol use disorder","volume":"28","author":"Xie","year":"2023","journal-title":"Drug Discovery Today"},{"key":"10.1016\/j.alcohol.2025.07.001_bib176","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1186\/s12866-019-1616-2","article-title":"Aging progression of human gut microbiota","volume":"19","author":"Xu","year":"2019","journal-title":"BMC Microbiology"},{"key":"10.1016\/j.alcohol.2025.07.001_bib177","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s11010-005-9109-z","article-title":"Expression of constitutive and inducible cytochrome P450 2E1 in rat brain","volume":"286","author":"Yadav","year":"2006","journal-title":"Molecular and Cellular Biochemistry"},{"key":"10.1016\/j.alcohol.2025.07.001_bib178","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1002\/hep.24018","article-title":"Enteric dysbiosis associated with a mouse model of alcoholic liver disease","volume":"53","author":"Yan","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.alcohol.2025.07.001_bib179","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/s41392-023-01673-4","article-title":"Gut liver brain axis in diseases: The implications for therapeutic interventions","volume":"8","author":"Yan","year":"2023","journal-title":"Signal Transduction and Targeted Therapy"},{"key":"10.1016\/j.alcohol.2025.07.001_bib180","doi-asserted-by":"crossref","DOI":"10.3390\/biology10080737","article-title":"Aldehyde dehydrogenase mutation exacerbated high-fat-diet-induced nonalcoholic fatty liver disease with gut microbiota remodeling in Male mice","volume":"10","author":"Yang","year":"2021","journal-title":"Biology"},{"key":"10.1016\/j.alcohol.2025.07.001_bib181","doi-asserted-by":"crossref","DOI":"10.1177\/1934578X211045465","article-title":"Resveratrol and quercetin potentiate the cell protection and rescue effects of NAD+ precursors in HEK293 cells challenged by DNA damaging agent, N-Methyl-N\u2032-nitro-N-nitrosoguanidine","volume":"16","author":"Yang","year":"2021","journal-title":"Natural Product Communications"},{"key":"10.1016\/j.alcohol.2025.07.001_bib182","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0278111","article-title":"Alcohol inhibits the metabolism of dimethyl fumarate to the active metabolite responsible for decreasing relapse frequency in the treatment of multiple sclerosis","volume":"17","author":"Yang","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.alcohol.2025.07.001_bib183","first-page":"1227","article-title":"Alcohol flushing, alcohol and aldehyde dehydrogenase genotypes, and risk for esophageal squamous cell carcinoma in Japanese men","volume":"12","author":"Yokoyama","year":"2003","journal-title":"Cancer Epidemiology Biomarkers & Prevention"},{"key":"10.1016\/j.alcohol.2025.07.001_bib184","doi-asserted-by":"crossref","first-page":"535","DOI":"10.3109\/15376510903401708","article-title":"Characteristics of aldehyde dehydrogenase 2 (Aldh2) knockout mice","volume":"19","author":"Yu","year":"2009","journal-title":"Toxicology Mechanisms and Methods"},{"key":"10.1016\/j.alcohol.2025.07.001_bib185","first-page":"279","article-title":"Impairment of aldehyde dehydrogenase 2 increases accumulation of acetaldehyde-derived DNA damage in the esophagus after ethanol ingestion","volume":"4","author":"Yukawa","year":"2014","journal-title":"American Journal of Cancer Research"},{"key":"10.1016\/j.alcohol.2025.07.001_bib186","first-page":"245","article-title":"Overview: How is alcohol metabolized by the body?","volume":"29","author":"Zakhari","year":"2006","journal-title":"Alcohol Research & Health"},{"key":"10.1016\/j.alcohol.2025.07.001_bib187","doi-asserted-by":"crossref","first-page":"56","DOI":"10.2174\/1874473710801010056","article-title":"Alcohol abuse, immunosuppression, and pulmonary infection","volume":"1","author":"Zhang","year":"2008","journal-title":"Current Drug Abuse Reviews"},{"key":"10.1016\/j.alcohol.2025.07.001_bib188","doi-asserted-by":"crossref","first-page":"313","DOI":"10.14283\/jpad.2021.15","article-title":"The epidemiology of Alzheimer's disease modifiable risk factors and prevention","volume":"8","author":"Zhang","year":"2021","journal-title":"Journal of Prevention of Alzheimer's Disease"},{"key":"10.1016\/j.alcohol.2025.07.001_bib189","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.6185","article-title":"Association between daily alcohol intake and risk of all-cause mortality: A systematic review and meta-analyses","volume":"6","author":"Zhao","year":"2023","journal-title":"JAMA Network Open"},{"key":"10.1016\/j.alcohol.2025.07.001_bib190","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1029948","article-title":"The impact of aging on intestinal mucosal immune function and clinical applications","volume":"13","author":"Zheng","year":"2022","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/j.alcohol.2025.07.001_bib191","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.3945\/jn.115.216093","article-title":"Preventing gut leakiness and endotoxemia contributes to the protective effect of zinc on alcohol-induced steatohepatitis in rats","volume":"145","author":"Zhong","year":"2015","journal-title":"Journal of Nutrition"},{"key":"10.1016\/j.alcohol.2025.07.001_bib192","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.cell.2015.12.057","article-title":"NF-kappaB restricts inflammasome activation via elimination of damaged mitochondria","volume":"164","author":"Zhong","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.alcohol.2025.07.001_bib193","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1111\/acer.14405","article-title":"Deficiency of intestinal alpha1-2-Fucosylation exacerbates ethanol-induced liver disease in mice","volume":"44","author":"Zhou","year":"2020","journal-title":"Alcoholism: Clinical and Experimental Research"},{"key":"10.1016\/j.alcohol.2025.07.001_bib194","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.livres.2017.12.004","article-title":"Targeting the gut barrier for the treatment of alcoholic liver disease","volume":"1","author":"Zhou","year":"2017","journal-title":"Liver Research"},{"key":"10.1016\/j.alcohol.2025.07.001_bib195","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1093\/oxfordjournals.alcalc.a008128","article-title":"Distribution of catalase in rat brain: Aminergic neurons as possible targets for ethanol effects","volume":"31","author":"Zimatkin","year":"1996","journal-title":"Alcohol and Alcoholism"},{"key":"10.1016\/j.alcohol.2025.07.001_bib196","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1111\/j.1530-0277.2006.00181.x","article-title":"Enzymatic mechanisms of ethanol oxidation in the brain","volume":"30","author":"Zimatkin","year":"2006","journal-title":"Alcoholism: Clinical and Experimental Research"}],"container-title":["Alcohol"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741832925000849?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741832925000849?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T23:00:53Z","timestamp":1778540453000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0741832925000849"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":195,"alternative-id":["S0741832925000849"],"URL":"https:\/\/doi.org\/10.1016\/j.alcohol.2025.07.001","relation":{},"ISSN":["0741-8329"],"issn-type":[{"value":"0741-8329","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alcohol, aging, and the gut microbiome: Intersections of immunity, barrier dysfunction, and disease","name":"articletitle","label":"Article Title"},{"value":"Alcohol","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.alcohol.2025.07.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}