{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T18:14:20Z","timestamp":1778696060910,"version":"3.51.4"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003653","name":"Korea National Institute of Health","doi-asserted-by":"publisher","award":["2019-ER6404-00"],"award-info":[{"award-number":["2019-ER6404-00"]}],"id":[{"id":"10.13039\/501100003653","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Alcohol"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.alcohol.2026.03.001","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T23:49:53Z","timestamp":1773272993000},"page":"1-10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Epigenetic effects of alcohol consumption on type 2 diabetes"],"prefix":"10.1016","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3683-2488","authenticated-orcid":false,"given":"Mihi","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4994-7980","authenticated-orcid":false,"given":"Minju","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-woo","family":"Seo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye-Ja","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3137-4609","authenticated-orcid":false,"given":"Kyung-Won","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ja-Eun","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.alcohol.2026.03.001_bib1","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.3390\/genes11111369","article-title":"Mapping of diabetes susceptibility LOCI in a domestic cat breed with an unusually high incidence of diabetes mellitus","volume":"11","author":"Balmer","year":"2020","journal-title":"Genes"},{"key":"10.1016\/j.alcohol.2026.03.001_bib3","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s00204-009-0432-0","article-title":"Role of oxidative stress in alcohol-induced liver injury","volume":"83","author":"Cederbaum","year":"2009","journal-title":"Arch Toxicol"},{"key":"10.1016\/j.alcohol.2026.03.001_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2020.102753","article-title":"Novel and prevalent Non-East Asian ALDH2 variants; implications for global susceptibility to aldehydes' toxicity","volume":"55","author":"Chen","year":"2020","journal-title":"EBioMedicine"},{"key":"10.1016\/j.alcohol.2026.03.001_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2105-14-S18-S1","article-title":"Enrichr: Interactive and collaborative HTML5 gene list enrichment analysis tool","volume":"14","author":"Chen","year":"2013","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.alcohol.2026.03.001_bib6","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.alcohol.2020.01.003","article-title":"Association of change in alcohol consumption on fasting serum glucose, insulin resistance, and beta cell function among Korean men","volume":"85","author":"Choi","year":"2020","journal-title":"Alcohol"},{"key":"10.1016\/j.alcohol.2026.03.001_bib7","doi-asserted-by":"crossref","DOI":"10.3402\/jom.v6.26189","article-title":"Comparing the cariogenic species Streptococcus sobrinus and S. mutans on whole genome level","volume":"6","author":"Conrads","year":"2014","journal-title":"Journal of Oral Microbiology"},{"key":"10.1016\/j.alcohol.2026.03.001_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2020.165801","article-title":"Interplay between NADH oxidation by complex I, glutathione redox state and sirtuin-3, and its role in the development of insulin resistance","volume":"1866","author":"Cort\u00e9s-Rojo","year":"2020","journal-title":"Biochimica et Biophysica Acta, Molecular Basis of Disease"},{"key":"10.1016\/j.alcohol.2026.03.001_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2105-11-587","article-title":"Comparison of beta-value and M-value methods for quantifying methylation levels by microarray analysis","volume":"11","author":"Du","year":"2010","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.alcohol.2026.03.001_bib11","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ejim.2023.05.036","article-title":"How epigenetics impacts on human diseases","volume":"114","author":"Farsetti","year":"2023","journal-title":"European Journal of Internal Medicine"},{"key":"10.1016\/j.alcohol.2026.03.001_bib12","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1093\/bioinformatics\/btw691","article-title":"Preprocessing, normalization and integration of the illumina HumanMethylationEPIC array with minfi","volume":"33","author":"Fortin","year":"2017","journal-title":"Bioinformatics"},{"key":"10.1016\/j.alcohol.2026.03.001_bib13","first-page":"1714","article-title":"ACTG1 and TLR3 are biomarkers for alcohol-associated hepatocellular carcinoma","volume":"17","author":"Gao","year":"2019","journal-title":"Oncology Letters"},{"key":"10.1016\/j.alcohol.2026.03.001_bib15","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/s41586-020-2337-2","article-title":"Hepatic NADH reductive stress underlies common variation in metabolic traits","volume":"583","author":"Goodman","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.alcohol.2026.03.001_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1868-7083-5-20","article-title":"Evaluation of IGFBP-7 DNA methylation changes and serum protein variation in Swedish subjects with and without type 2 diabetes","volume":"5","author":"Gu","year":"2013","journal-title":"Clinical Epigenetics"},{"key":"10.1016\/j.alcohol.2026.03.001_bib17","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.alcohol.2015.02.004","article-title":"High-risk drinking is associated with a higher risk of diabetes mellitus in Korean men, based on the 2010\u20132012 KNHANES","volume":"49","author":"Hong","year":"2015","journal-title":"Alcohol"},{"key":"10.1016\/j.alcohol.2026.03.001_bib18","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1089\/met.2016.0122","article-title":"Circulating Zbed3 levels in subjects with and without metabolic syndrome","volume":"15","author":"Hu","year":"2017","journal-title":"Metabolic Syndrome and Related Disorders"},{"key":"10.1016\/j.alcohol.2026.03.001_bib19","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s13036-024-00428-1","article-title":"Mimicking chronic alcohol effects through a controlled and sustained ethanol release device","volume":"18","author":"Kim","year":"2024","journal-title":"Journal of Biological Engineering"},{"key":"10.1016\/j.alcohol.2026.03.001_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.102147","article-title":"Astrocyte ethanol exposure reveals persistent and defined calcium response subtypes and associated gene signatures","volume":"298","author":"Kim","year":"2022","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.alcohol.2026.03.001_bib23","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1093\/cvr\/cvaf058","article-title":"A new protein isoform encoded by human circular RNA circSLC8a1 contributes to cardiac remodelling","volume":"121","author":"Li","year":"2025","journal-title":"Cardiovascular Research"},{"key":"10.1016\/j.alcohol.2026.03.001_bib24","article-title":"Mechanisms underlying the pathophysiology of type 2 diabetes: From risk factors to oxidative stress, metabolic dysfunction, and hyperglycemia","volume":"874\u2013875","author":"Lima","year":"2022","journal-title":"Mutation Research, Genetic Toxicology and Environmental Mutagenesis"},{"key":"10.1016\/j.alcohol.2026.03.001_bib25","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.1007\/s12015-021-10267-y","article-title":"Chronic ethanol exposure induces deleterious changes in cardiomyocytes derived from human induced pluripotent stem cells","volume":"17","author":"Liu","year":"2021","journal-title":"Stem Cell Reviews and Reports"},{"key":"10.1016\/j.alcohol.2026.03.001_bib26","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/512618","article-title":"Roles of pyruvate, NADH, and mitochondrial complex I in redox balance and imbalance in \u03b2 cell function and dysfunction","volume":"2015","author":"Luo","year":"2015","journal-title":"Journal of Diabetes Research"},{"key":"10.1016\/j.alcohol.2026.03.001_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2024.156049","article-title":"ZBED3 exacerbates hyperglycemia by promoting hepatic gluconeogenesis through CREB signaling","volume":"162","author":"Luo","year":"2025","journal-title":"Metabolism Clinical and Experimental"},{"key":"10.1016\/j.alcohol.2026.03.001_bib30","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/jdi.13650","article-title":"Impaired insulin secretion and related factors in East Asian individuals","volume":"13","author":"Nakamura","year":"2021","journal-title":"Journal of Diabetes Investigation"},{"key":"10.1016\/j.alcohol.2026.03.001_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1756-8935-6-4","article-title":"Additional annotation enhances potential for biologically-relevant analysis of the illumina infinium HumanMethylation450 BeadChip array","volume":"6","author":"Price","year":"2013","journal-title":"Epigenetics & Chromatin"},{"key":"10.1016\/j.alcohol.2026.03.001_bib32","doi-asserted-by":"crossref","first-page":"255","DOI":"10.35946\/arcr.v38.2.08","article-title":"Pathophysiology of the effects of alcohol abuse on the endocrine system","volume":"38","author":"Rachdaoui","year":"2017","journal-title":"Alcohol Research: Current Reviews"},{"key":"10.1016\/j.alcohol.2026.03.001_bib34","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"Limma powers differential expression analyses for RNA-Sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Research"},{"key":"10.1016\/j.alcohol.2026.03.001_bib35","first-page":"17","article-title":"Protein-protein interaction networks (PPI) and complex diseases","volume":"7","author":"Safari-Alighiarloo","year":"2014","journal-title":"Gastroenterology and Hepatology from bed to bench"},{"key":"10.1016\/j.alcohol.2026.03.001_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2022.113102","article-title":"Omics approaches in bioremediation of environmental contaminants: An integrated approach for environmental safety and sustainability","volume":"211","author":"Sharma","year":"2022","journal-title":"Environmental Research"},{"key":"10.1016\/j.alcohol.2026.03.001_bib37","doi-asserted-by":"crossref","first-page":"155","DOI":"10.35946\/arcr.v35.2.06","article-title":"Chronic diseases and conditions related to alcohol use","volume":"35","author":"Shield","year":"2014","journal-title":"Alcohol Research: Current Reviews"},{"key":"10.1016\/j.alcohol.2026.03.001_bib38","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1152\/physiol.2025.40.S1.1717","article-title":"Acute alcohol withdrawal increased sodium chloride Co-Transporter expression in rat kidneys","volume":"40","author":"Syed","year":"2025","journal-title":"Physiology"},{"key":"10.1016\/j.alcohol.2026.03.001_bib39","doi-asserted-by":"crossref","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","article-title":"The STRING database in 2023: Protein\u2013protein association networks and functional enrichment analyses for any sequenced genome of interest","volume":"51","author":"Szklarczyk","year":"2023","journal-title":"Nucleic Acids Research"},{"key":"10.1016\/j.alcohol.2026.03.001_bib40","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19113425","article-title":"The impact of nutrition and environmental epigenetics on human health and disease","volume":"19","author":"Tiffon","year":"2018","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/j.alcohol.2026.03.001_bib42","doi-asserted-by":"crossref","first-page":"2872","DOI":"10.3390\/biomedicines10112872","article-title":"Mitochondrial dysfunction and oxidative stress in aging and disease","volume":"10","author":"Tsang","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.alcohol.2026.03.001_bib43","first-page":"1","article-title":"Alcohol consumption and risk of type 2 diabetes: Gender and race differences","volume":"2","author":"Wang","year":"2014","journal-title":"International Journal of Diabetology & Vascular Disease Research"},{"key":"10.1016\/j.alcohol.2026.03.001_bib44","unstructured":"World Health Organization (WHO), Alcohol, https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/alcohol, 28 June 2024."},{"key":"10.1016\/j.alcohol.2026.03.001_bib45","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.gendis.2020.08.009","article-title":"Ccrl2 deficiency deteriorates obesity and insulin resistance through increasing adipose tissue macrophages infiltration","volume":"9","author":"Xu","year":"2022","journal-title":"Genes & Diseases"},{"key":"10.1016\/j.alcohol.2026.03.001_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.103099","article-title":"Proteomic pathways to metabolic disease and type 2 diabetes in the pancreatic islet","volume":"24","author":"Yau","year":"2021","journal-title":"iScience"},{"key":"10.1016\/j.alcohol.2026.03.001_bib47","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jhep.2018.10.037","article-title":"Effect of ethanol on lipid metabolism","volume":"70","author":"You","year":"2019","journal-title":"Journal of Hepatology"},{"key":"10.1016\/j.alcohol.2026.03.001_bib48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jmcb\/mjy052","article-title":"The SLC transporter in nutrient and metabolic sensing, regulation, and drug development","volume":"11","author":"Zhang","year":"2019","journal-title":"Journal of Molecular Cell Biology"}],"container-title":["Alcohol"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741832926001722?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0741832926001722?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T17:29:47Z","timestamp":1778693387000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0741832926001722"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":39,"alternative-id":["S0741832926001722"],"URL":"https:\/\/doi.org\/10.1016\/j.alcohol.2026.03.001","relation":{},"ISSN":["0741-8329"],"issn-type":[{"value":"0741-8329","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epigenetic effects of alcohol consumption on type 2 diabetes","name":"articletitle","label":"Article Title"},{"value":"Alcohol","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.alcohol.2026.03.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}