{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:30:19Z","timestamp":1790886619558,"version":"4.1.0"},"reference-count":106,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,5,15]],"date-time":"2015-05-15T00:00:00Z","timestamp":1431648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Allergology International"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1016\/j.alit.2015.05.004","type":"journal-article","created":{"date-parts":[[2015,6,14]],"date-time":"2015-06-14T08:38:06Z","timestamp":1434271086000},"page":"304-311","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":167,"title":["Hierarchy and molecular properties of house dust mite allergens"],"prefix":"10.1016","volume":"64","author":[{"given":"Wayne R.","family":"Thomas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.alit.2015.05.004_bib1","doi-asserted-by":"crossref","first-page":"e69900","DOI":"10.1371\/journal.pone.0069900","article-title":"Most personal exposure to house dust mite aeroallergen occurs during the day","volume":"8","author":"Tovey","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.alit.2015.05.004_bib2","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1365-2222.2012.04059.x","article-title":"Innate affairs of allergens","volume":"43","author":"Thomas","year":"2013","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.alit.2015.05.004_bib3","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1159\/000093707","article-title":"Production and proteomic characterization of pharmaceutical-grade Dermatophagoides pteronyssinus and Dermatophagoides farinae extracts for allergy vaccines","volume":"140","author":"Batard","year":"2006","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.alit.2015.05.004_bib4","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.4049\/jimmunol.1202288","article-title":"Identification of Der p 23, a peritrophin-like protein, as a new major Dermatophagoides pteronyssinus allergen associated with the peritrophic matrix of mite fecal pellets","volume":"190","author":"Weghofer","year":"2013","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.alit.2015.05.004_bib5","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1046\/j.1365-2745.2002.01455.x","article-title":"Use of a chimeric ELISA to investigate immunoglobulin E antibody responses to Der p 1 and Der p 2 in mite-allergic patients with asthma, wheezing and\/or rhinitis","volume":"32","author":"Trombone","year":"2002","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.alit.2015.05.004_bib6","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1111\/j.1365-2222.2005.02345.x","article-title":"Comparison of purified Dermatophagoides pteronyssinus allergens and extract by two-dimensional immunoblotting and quantitative immunoglobulin E inhibitions","volume":"35","author":"Weghofer","year":"2005","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.alit.2015.05.004_bib7","first-page":"275","article-title":"IgE and IgG anti-house dust mite specificities in allergic disease","volume":"117","author":"Hales","year":"2006","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2015.05.004_bib8","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/j.1399-3038.2010.01094.x","article-title":"Mite component-specific IgE repertoire and phenotypes of allergic disease in childhood: the tropical perspective","volume":"22","author":"Kidon","year":"2011","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.alit.2015.05.004_bib9","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1111\/j.1365-2362.2008.02048.x","article-title":"Variability of IgE reactivity profiles among European mite allergic patients","volume":"38","author":"Weghofer","year":"2008","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.alit.2015.05.004_bib10","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/j.1365-2222.1993.tb00343.x","article-title":"Allergens from Dermatophagoides mites with chymotryptic activity","volume":"23","author":"Yasueda","year":"1993","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.alit.2015.05.004_bib11","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1111\/j.1365-2222.2009.03252.x","article-title":"Anti-bacterial IgE in the antibody responses of house dust mite allergic children convalescent from asthma exacerbation","volume":"39","author":"Hales","year":"2009","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.alit.2015.05.004_bib12","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S0091-6749(96)70121-5","article-title":"The isolation and characterization of a novel collagenolytic serine protease allergen (Der p 9) from the dust mite Dermatophagoides pteronyssinus","volume":"98","author":"King","year":"1996","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2015.05.004_bib13","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1111\/cea.12452","article-title":"Development of recombinant stable house dust mite allergen Der p 3 molecules for component-resolved diagnosis and specific immunotherapy","volume":"45","author":"Bouaziz","year":"2015","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.alit.2015.05.004_bib14","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0165-2427(00)00258-0","article-title":"Characterization and cloning of a major high molecular weight house dust mite allergen (Der f 15) for dogs","volume":"78","author":"McCall","year":"2001","journal-title":"Vet Immunol Immunopathol"},{"key":"10.1016\/j.alit.2015.05.004_bib15","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1067\/mai.2003.1602","article-title":"Identification, characterization, and cloning of a complementary DNA encoding a 60-kd house dust mite allergen (Der f 18) for human beings and dogs","volume":"112","author":"Weber","year":"2003","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2015.05.004_bib16","unstructured":"McCall CA, Hunter SW, Weber ER. Dermatophagoides proteins and fragments thereof. United States Patent. 7128921, 2006"},{"key":"10.1016\/j.alit.2015.05.004_bib17","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1159\/000339760","article-title":"Quantitation of IgE binding to the chitinase and chitinase-like house dust mite allergens Der p 15 and Der p 18 compared to the major and mid-range allergens","volume":"160","author":"Hales","year":"2013","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.alit.2015.05.004_bib18","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.jaci.2005.11.032","article-title":"Three-dimensional structure and IgE-binding properties of mature fully active Der p 1, a clinically relevant major allergen","volume":"117","author":"de Halleux","year":"2006","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2015.05.004_bib19","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.jmb.2008.12.049","article-title":"Crystal structures of mite allergens Der f 1 and Der p 1 reveal differences in surface-exposed residues that may influence antibody binding","volume":"386","author":"Chruszcz","year":"2009","journal-title":"J\u00a0Mol Biol"},{"key":"10.1016\/j.alit.2015.05.004_bib20","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1067\/mai.2001.114652","article-title":"Allergens of wild house dust mites: environmental Der p 1 and Der p 2 sequence polymorphisms","volume":"107","author":"Smith","year":"2001","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2015.05.004_bib21","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/j.1365-2222.2006.02464.x","article-title":"Genetic polymorphisms of major dust mite allergens","volume":"36","author":"Piboonpocanun","year":"2006","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.alit.2015.05.004_bib22","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1046\/j.1365-2745.2002.01407.x","article-title":"Stimulatory and inhibitory epitopes in T-cell responses of mice to Der p 1","volume":"32","author":"Jarnicki","year":"2002","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.alit.2015.05.004_bib23","doi-asserted-by":"crossref","first-page":"e114636","DOI":"10.1371\/journal.pone.0114636","article-title":"Group 1 allergen genes in two species of house dust mites, Dermatophagoides farinae and D.\u00a0pteronyssinus (Acari: Pyroglyphidae): direct sequencing, characterization and polymorphism","volume":"9","author":"Shafique","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.alit.2015.05.004_bib24","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s10493-012-9553-x","article-title":"Sequence polymorphisms of Der f 1, Der p 1, Der f 2 and Der p 2 from Korean house dust mite isolates","volume":"58","author":"Jeong","year":"2012","journal-title":"Exp Appl Acarol"},{"key":"10.1016\/j.alit.2015.05.004_bib25","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0022-2836(02)00027-X","article-title":"The crystal structure of a major dust mite allergen Der p 2, and its biological implications","volume":"318","author":"Derewenda","year":"2002","journal-title":"J\u00a0Mol Biol"},{"key":"10.1016\/j.alit.2015.05.004_bib26","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1093\/jb\/mvi039","article-title":"NMR study on the major mite allergen Der f 2: its refined tertiary structure, epitopes for monoclonal antibodies and characteristics shared by ML protein group members","volume":"137","author":"Ichikawa","year":"2005","journal-title":"J\u00a0Biochem"},{"key":"10.1016\/j.alit.2015.05.004_bib27","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1016\/j.febslet.2004.11.115","article-title":"Structure of the house dust mite allergen Der f 2: implications for function and molecular basis of IgE cross-reactivity","volume":"579","author":"Johannessen","year":"2005","journal-title":"FEBS Lett"},{"key":"10.1016\/j.alit.2015.05.004_bib28","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1111\/j.1365-2443.2009.01334.x","article-title":"Lipopolysaccharide binding of the mite allergen Der f 2","volume":"14","author":"Ichikawa","year":"2009","journal-title":"Genes Cells"},{"key":"10.1016\/j.alit.2015.05.004_bib29","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1111\/j.1365-2222.1996.tb00615.x","article-title":"Analyses of sequence polymorphisms of a major mite allergen Der p 2","volume":"26","author":"Chua","year":"1996","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.alit.2015.05.004_bib30","first-page":"199","article-title":"Bioinformatic studies on the group 2 allergens of Dermatophagoides farinae from China","volume":"25","author":"Cui","year":"2007","journal-title":"Asian Pac J Allergy Immunol"},{"key":"10.1016\/j.alit.2015.05.004_bib31","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1046\/j.1365-2222.2002.01421.x","article-title":"Der p 2 isoallergens have different allergenicity, and quantification with 2-site ELISA using monoclonal antibodies is influenced by the isoallergens","volume":"32","author":"Park","year":"2002","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.alit.2015.05.004_bib32","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1067\/mai.2001.115629","article-title":"The molecular basis of antigenic cross reactivity between the group 2 mite allergens","volume":"107","author":"Smith","year":"2001","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2015.05.004_bib33","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1046\/j.1365-2745.2002.01500.x","article-title":"Genetic variation of Der p 2 allergens: effects on T-cell responses and IgE binding","volume":"32","author":"Hales","year":"2002","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.alit.2015.05.004_bib34","article-title":"Effect of amino acid polymorphisms of house dust mite Der p 2 variants on allergic sensitisation: comparison of two geographically distinct HDM-allergic populations","author":"Tanyaratsrisakul","year":"2015","journal-title":"Allergy Asthma Immunol Res"},{"key":"10.1016\/j.alit.2015.05.004_bib35","doi-asserted-by":"crossref","first-page":"4966","DOI":"10.4049\/jimmunol.0904038","article-title":"Isoallergen variations contribute to the overall complexity of effector cell degranulation: effect mediated through differentiated IgE affinity","volume":"184","author":"Christensen","year":"2010","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.alit.2015.05.004_bib36","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jaci.2006.02.046","article-title":"Periostin: a novel component of subepithelial fibrosis of bronchial asthma downstream of IL-4 and IL-13 signals","volume":"118","author":"Takayama","year":"2006","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2015.05.004_bib37","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1471-2091-13-3","article-title":"Enzymatic activity and immunoreactivity of Aca s 4, an alpha-amylase allergen from the storage mite Acarus siro","volume":"13","author":"Pytelkova","year":"2012","journal-title":"BMC Biochem"},{"key":"10.1016\/j.alit.2015.05.004_bib38","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1111\/j.1365-2222.2007.02786.x","article-title":"Distinctive IgE and IgG4 anti-house dust allergen binding specificities in a tropical Australian Aboriginal Community","volume":"37","author":"Hales","year":"2007","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.alit.2015.05.004_bib39","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1159\/000176303","article-title":"Mite amylase from Blomia tropicalis (Blo t 4): differential allergenicity linked to geographical regions","volume":"149","author":"Cheong","year":"2009","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.alit.2015.05.004_bib40","doi-asserted-by":"crossref","DOI":"10.1111\/cea.12553","article-title":"Analysis of IgE binding patterns to house dust mite allergens in scabies endemic communities: insights for both diseases","author":"Walton","year":"2015","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.alit.2015.05.004_bib41","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1111\/j.1398-9995.2008.01647.x","article-title":"Characterization of Der p 21, a new important allergen derived from the gut of house dust mites","volume":"63","author":"Weghofer","year":"2008","journal-title":"Allergy"},{"key":"10.1016\/j.alit.2015.05.004_bib42","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1164\/ajrccm.155.1.9001334","article-title":"Sensitization to Blomia tropicalis in patients with asthma and identification of allergen Blo t 5","volume":"155","author":"Arruda","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.alit.2015.05.004_bib43","doi-asserted-by":"crossref","first-page":"34776","DOI":"10.1074\/jbc.M112.348730","article-title":"NMR structure and IgE epitopes of Blo t 21, a major dust mite allergen from Blomia tropicalis","volume":"287","author":"Tan","year":"2012","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.alit.2015.05.004_bib44","doi-asserted-by":"crossref","first-page":"25394","DOI":"10.1074\/jbc.M110.128306","article-title":"Der p 5 crystal structure provides insight into the group 5 dust mite allergens","volume":"285","author":"Mueller","year":"2010","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.alit.2015.05.004_bib45","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.str.2007.10.022","article-title":"Roles of structure and structural dynamics in the antibody recognition of the allergen proteins: an NMR study on Blomia tropicalis major allergen","volume":"6","author":"Naik","year":"2008","journal-title":"Structure"},{"key":"10.1016\/j.alit.2015.05.004_bib46","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.4049\/jimmunol.181.4.2586","article-title":"Nuclear magnetic resonance structure and IgE epitopes of Blo t 5, a major dust mite allergen","volume":"181","author":"Chan","year":"2008","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.alit.2015.05.004_bib47","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.jaci.2009.12.016","article-title":"The structure of the dust mite allergen Der p 7 reveals similarities to innate immune proteins","volume":"125","author":"Mueller","year":"2010","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2015.05.004_bib48","doi-asserted-by":"crossref","first-page":"e44850","DOI":"10.1371\/journal.pone.0044850","article-title":"Crystal structure of Der f 7, a dust mite allergen from Dermatophagoides farinae","volume":"7","author":"Tan","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.alit.2015.05.004_bib49","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/icb.2010.77","article-title":"Homology modeling and monoclonal antibody binding of the Der f 7 dust mite allergen","volume":"89","author":"Shen","year":"2011","journal-title":"Immunol Cell Biol"},{"key":"10.1016\/j.alit.2015.05.004_bib50","first-page":"824","article-title":"Characterization of the allergen Der f 7 from house dust mite extracts by species-specific and crossreactive monoclonal antibodies","volume":"27","author":"Shen","year":"1997","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.alit.2015.05.004_bib51","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s10493-010-9349-9","article-title":"Monoclonal antibodies against recombinant Der f 3 reveal localization of Der f 3 in the gut and faecal pellets of Dermatophagoides farinae","volume":"52","author":"Zhan","year":"2010","journal-title":"Exp Appl Acarol"},{"key":"10.1016\/j.alit.2015.05.004_bib52","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/j.1365-2222.2006.02447.x","article-title":"Characterization of glutathione S-transferase from dust mite, Der p 8 and its immunoglobulin E cross-reactivity with cockroach glutathione S-transferase","volume":"36","author":"Huang","year":"2006","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.alit.2015.05.004_bib53","doi-asserted-by":"crossref","DOI":"10.4168\/aair.2015.7.5.483","article-title":"Profiles of IgE sensitization to Der f 1, Der f 2, Der f 6, Der f 8, Der f 10, and Der f 20 in Korean house dust mite allergy patients","author":"Jeong","year":"2015","journal-title":"Allergy Asthma Immunol Res"},{"key":"10.1016\/j.alit.2015.05.004_bib54","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S0091-6749(95)70035-8","article-title":"Immunochemical characterization of recombinant and native tropomyosins as a new allergen from the house dust mite, Dermatophagoides farinae","volume":"96","author":"Aki","year":"1995","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2015.05.004_bib55","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.alit.2014.08.004","article-title":"IgE Abs to Der p 1 and Der p 2 as diagnostic markers of house dust mite allergy as defined by a bronchoprovocation test","volume":"64","author":"Minami","year":"2015","journal-title":"Allergol Int"},{"key":"10.1016\/j.alit.2015.05.004_bib56","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1111\/j.1365-2222.2011.03798.x","article-title":"Molecular characterization of Der p 10: a diagnostic marker for broad sensitization in house dust mite allergy","volume":"41","author":"Resch","year":"2011","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.alit.2015.05.004_bib57","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1159\/000065172","article-title":"Molecular basis of arthropod cross-reactivity: IgE-binding cross-reactive epitopes of shrimp, house dust mite and cockroach tropomyosins","volume":"129","author":"Ayuso","year":"2002","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.alit.2015.05.004_bib58","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1111\/j.1398-9995.2011.02663.x","article-title":"Tropomyosin IgE-positive results are a good predictor of shrimp allergy","volume":"66","author":"Gamez","year":"2011","journal-title":"Allergy"},{"key":"10.1016\/j.alit.2015.05.004_bib59","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.jaci.2005.01.018","article-title":"Specific IgE and IgG antibody-binding patterns to recombinant cockroach allergens","volume":"115","author":"Satinover","year":"2005","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2015.05.004_bib60","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1111\/j.1398-9995.2005.00637.x","article-title":"Molecular cloning and characterization of full-length cDNAs encoding a novel high-molecular-weight Dermatophagoides pteronyssinus mite allergen, Der p 11","volume":"60","author":"Tsai","year":"2005","journal-title":"Allergy"},{"key":"10.1016\/j.alit.2015.05.004_bib61","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/jid.2014.271","article-title":"Der p 11 is a major allergen for house dust mite-allergic patients suffering from atopic dermatitis","volume":"135","author":"Banerjee","year":"2015","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.alit.2015.05.004_bib62","doi-asserted-by":"crossref","first-page":"4852","DOI":"10.4049\/jimmunol.176.8.4852","article-title":"Nuclear magnetic resonance structure-based epitope mapping and modulation of dust mite group 13 allergen as a hypoallergen","volume":"176","author":"Chan","year":"2006","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.alit.2015.05.004_bib63","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S1389-1723(02)80166-9","article-title":"Toward elucidating the full spectrum of mite allergens\u2013state of the art","volume":"94","author":"Kawamoto","year":"2002","journal-title":"J\u00a0Biosci Bioeng"},{"key":"10.1016\/j.alit.2015.05.004_bib64","doi-asserted-by":"crossref","first-page":"5470","DOI":"10.4049\/jimmunol.167.9.5470","article-title":"Molecular and immunological characterization of arginine kinase from the Indianmeal moth, Plodia interpunctella, a novel cross-reactive invertebrate pan-allergen","volume":"167","author":"Binder","year":"2001","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.alit.2015.05.004_bib65","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1046\/j.1365-2222.1998.00433.x","article-title":"Altered antigenicity of M-177, a 177-kDa allergen from the house dust mite Dermatophagoides farinae, in stored extract","volume":"28","author":"Fujikawa","year":"1998","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.alit.2015.05.004_bib66","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1159\/000024266","article-title":"High-molecular-weight allergens of the house dust mite: an apolipophorin-like cDNA has sequence identity with the major M-177 allergen and the IgE-binding peptide fragments Mag1 and Mag3","volume":"120","author":"Epton","year":"1999","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.alit.2015.05.004_bib67","series-title":"Human Immune Responses to House Dust Mite Allergens","author":"Malainual","year":"2002"},{"key":"10.1016\/j.alit.2015.05.004_bib68","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.diagmicrobio.2011.09.007","article-title":"A\u00a0diagnostic test for scabies: IgE specificity for a recombinant allergen of Sarcoptes scabiei","volume":"71","author":"Jayaraj","year":"2011","journal-title":"Diagn Microbiol Infect Dis"},{"key":"10.1016\/j.alit.2015.05.004_bib69","doi-asserted-by":"crossref","first-page":"e62009","DOI":"10.1371\/journal.pone.0062009","article-title":"Vitellogenins are new high molecular weight components and allergens (Api m 12 and Ves v. 6) of Apis mellifera and Vespula vulgaris venom","volume":"8","author":"Blank","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.alit.2015.05.004_bib70","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.1021\/jf8031759","article-title":"Major allergen and its IgE cross-reactivity among salmonid fish roe allergy","volume":"57","author":"Shimizu","year":"2009","journal-title":"J\u00a0Agric Food Chem"},{"key":"10.1016\/j.alit.2015.05.004_bib71","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.jaci.2014.09.031","article-title":"The draft genome, transcriptome, and microbiome of Dermatophagoides farinae reveal a broad spectrum of dust mite allergens","volume":"135","author":"Chan","year":"2015","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2015.05.004_bib72","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1074\/mcp.M112.027136","article-title":"Dermatophagoides farinae allergens diversity identification by proteomics","volume":"12","author":"An","year":"2013","journal-title":"Mol Cell Proteomics"},{"key":"10.1016\/j.alit.2015.05.004_bib73","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1046\/j.1365-2222.2002.01473.x","article-title":"Non-allergenic antigens in allergic sensitisation: responses to the mite ferritin heavy chain by allergic and non-allergic subjects","volume":"32","author":"Epton","year":"2002","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.alit.2015.05.004_bib74","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1007\/s11882-005-0012-1","article-title":"Structural biology of allergens","volume":"5","author":"Thomas","year":"2005","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.alit.2015.05.004_bib75","first-page":"141","article-title":"Mite allergens: an overview","volume":"43","author":"Bessot","year":"2011","journal-title":"Eur Ann Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2015.05.004_bib76","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1084\/jem.190.12.1897","article-title":"The cysteine protease activity of the major dust mite allergen Der p 1 selectively enhances the immunoglobulin E antibody response","volume":"190","author":"Gough","year":"1999","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.alit.2015.05.004_bib77","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.4049\/jimmunol.177.3.1609","article-title":"Crucial commitment of proteolytic activity of a purified recombinant major house dust mite allergen Der p1 to sensitization toward IgE and IgG responses","volume":"177","author":"Kikuchi","year":"2006","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.alit.2015.05.004_bib78","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.4049\/jimmunol.178.5.2794","article-title":"Effect of UVB irradiation and histamine receptor function on allergic responses to an inhaled allergen","volume":"178","author":"McGlade","year":"2007","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.alit.2015.05.004_bib79","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1159\/000334280","article-title":"Sensitizing and Th2 adjuvant activity of cysteine protease allergens","volume":"158","author":"Cunningham","year":"2012","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.alit.2015.05.004_bib80","doi-asserted-by":"crossref","first-page":"4489","DOI":"10.4049\/jimmunol.1201212","article-title":"IL-33-mediated innate response and adaptive immune cells contribute to maximum responses of protease allergen-induced allergic airway inflammation","volume":"190","author":"Kamijo","year":"2013","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.alit.2015.05.004_bib81","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1603\/ME12154","article-title":"Enzymatic activity of allergenic house dust and storage mite extracts","volume":"50","author":"Morales","year":"2013","journal-title":"J\u00a0Med Entomol"},{"key":"10.1016\/j.alit.2015.05.004_bib82","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1046\/j.1365-2222.2000.00815.x","article-title":"Allergens from house dust and storage mites: similarities and differences, with emphasis on the storage mite Lepidoglyphus destructor","volume":"30","author":"Olsson","year":"2000","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.alit.2015.05.004_bib83","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jaci.2007.02.028","article-title":"Limited IgE cross-reactivity between Dermatophagoides pteronyssinus and Glycyphagus domesticus in patients naturally exposed to both mite species","volume":"120","author":"Arias-Irigoyen","year":"2007","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2015.05.004_bib84","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S1081-1206(10)60014-2","article-title":"In\u00a0vivo and in\u00a0vitro allergenicity of the domestic mite Chortoglyphus arcuatus","volume":"97","author":"Boquete","year":"2006","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.alit.2015.05.004_bib85","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.jaci.2008.05.010","article-title":"Nonlinear relationship of mite allergen exposure to mite sensitization and asthma in a birth cohort","volume":"122","author":"Tovey","year":"2008","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2015.05.004_bib86","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1111\/j.1365-2222.2004.1922.x","article-title":"Production of monoclonal antibodies for immunoaffinity purification and quantitation of Blo t 1 allergen in mite and dust extracts","volume":"34","author":"Ramos","year":"2004","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.alit.2015.05.004_bib87","doi-asserted-by":"crossref","first-page":"e53337","DOI":"10.1371\/journal.pone.0053337","article-title":"Dual function of novel pollen coat (surface) proteins: IgE-binding capacity and proteolytic activity disrupting the airway epithelial barrier","volume":"8","author":"Bashir","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.alit.2015.05.004_bib88","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2015.03.001","article-title":"Identification of the cysteine protease Amb a 11 as a novel major allergen from short ragweed","author":"Bouley","year":"2015","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2015.05.004_bib89","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.jaci.2012.09.009","article-title":"Kiwifruit allergy across Europe: clinical manifestation and IgE recognition patterns to kiwifruit allergens","volume":"131","author":"Le","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2015.05.004_bib90","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1111\/j.1365-2222.2007.02776.x","article-title":"Kiwifruit allergy: actinidin is not a major allergen in the United Kingdom","volume":"37","author":"Lucas","year":"2007","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.alit.2015.05.004_bib91","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/nature07548","article-title":"Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein","volume":"457","author":"Trompette","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.alit.2015.05.004_bib92","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1111\/all.12399","article-title":"Epicutaneously applied Der p 2 induces a strong TH 2-biased antibody response in C57BL\/6 mice, independent of functional TLR4","volume":"69","author":"Stremnitzer","year":"2014","journal-title":"Allergy"},{"key":"10.1016\/j.alit.2015.05.004_bib93","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.coi.2008.10.002","article-title":"Chitin regulation of immune responses: an old molecule with new roles","volume":"20","author":"Lee","year":"2008","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.alit.2015.05.004_bib94","doi-asserted-by":"crossref","first-page":"e1004701","DOI":"10.1371\/journal.ppat.1004701","article-title":"Chitin recognition via chitotriosidase promotes pathologic type-2 helper T cell responses to cryptococcal infection","volume":"11","author":"Wiesner","year":"2015","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.alit.2015.05.004_bib95","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1159\/000356482","article-title":"The influence of chitin on the immune response to the house dust mite allergen Blo t 12","volume":"163","author":"Zakzuk","year":"2014","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.alit.2015.05.004_bib96","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1007\/s11882-014-0432-x","article-title":"Allergen ligands in the initiation of allergic sensitization","volume":"14","author":"Thomas","year":"2014","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.alit.2015.05.004_bib97","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1111\/j.1365-2222.2012.04035.x","article-title":"Component-resolved diagnosis with commercially available D.\u00a0pteronyssinus Der p 1, Der p 2 and Der p 10: relevant markers for house dust mite allergy","volume":"42","author":"Bronnert","year":"2012","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.alit.2015.05.004_bib98","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1159\/000337654","article-title":"Varying allergen composition and content affects the in\u00a0vivo allergenic activity of commercial Dermatophagoides pteronyssinus extracts","volume":"159","author":"Casset","year":"2012","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.alit.2015.05.004_bib99","doi-asserted-by":"crossref","first-page":"e0003452","DOI":"10.1371\/journal.pntd.0003452","article-title":"Scabies and impetigo prevalence and risk factors in fiji: a national survey","volume":"9","author":"Romani","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.alit.2015.05.004_bib100","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1097\/QCO.0b013e32835eb851","article-title":"Epidemiology of scabies","volume":"26","author":"Fuller","year":"2013","journal-title":"Curr Opin Infect Dis"},{"key":"10.1016\/j.alit.2015.05.004_bib101","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1111\/j.1398-9995.1998.tb03979.x","article-title":"Reactivity to recombinant house dust mite allergens in asthma and rhinitis in a tropical situation","volume":"53","author":"Lynch","year":"1998","journal-title":"Allergy"},{"key":"10.1016\/j.alit.2015.05.004_bib102","doi-asserted-by":"crossref","first-page":"e718","DOI":"10.1111\/j.1399-3038.2010.01019.x","article-title":"Specific profiles of house dust mite sensitization in children with asthma and in children with eczema","volume":"21","author":"Shek","year":"2010","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.alit.2015.05.004_bib103","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1111\/j.1365-2222.2004.1930.x","article-title":"Component-resolved diagnosis of house dust mite allergy with purified natural and recombinant mite allergens","volume":"34","author":"Pittner","year":"2004","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.alit.2015.05.004_bib104","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.jaci.2005.06.032","article-title":"IgE antibody quantification and the probability of wheeze in preschool children","volume":"116","author":"Simpson","year":"2005","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2015.05.004_bib105","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1034\/j.1398-9995.2003.00227.x","article-title":"A\u00a0further evaluation of the clinical use of specific IgE antibody testing in allergic diseases","volume":"58","author":"Soderstrom","year":"2003","journal-title":"Allergy"},{"key":"10.1016\/j.alit.2015.05.004_bib106","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.molmed.2010.04.008","article-title":"House dust mite allergens in asthma and allergy","volume":"16","author":"Thomas","year":"2010","journal-title":"Trends Mol Med"}],"container-title":["Allergology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1323893015001124?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1323893015001124?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:05:52Z","timestamp":1761156352000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1323893015001124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":106,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["S1323893015001124"],"URL":"https:\/\/doi.org\/10.1016\/j.alit.2015.05.004","relation":{},"ISSN":["1323-8930"],"issn-type":[{"value":"1323-8930","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hierarchy and molecular properties of house dust mite allergens","name":"articletitle","label":"Article Title"},{"value":"Allergology International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.alit.2015.05.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Japanese Society of Allergology. Production and hosting by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}