{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:30:40Z","timestamp":1786984240834,"version":"build-2736575974"},"reference-count":32,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,7,17]],"date-time":"2015-07-17T00:00:00Z","timestamp":1437091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["S1101010"],"award-info":[{"award-number":["S1101010"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Allergology International"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.alit.2015.07.003","type":"journal-article","created":{"date-parts":[[2015,8,12]],"date-time":"2015-08-12T02:16:34Z","timestamp":1439345794000},"page":"44-51","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Presensitization to Ascaris antigens promotes induction of mite-specific IgE upon mite antigen inhalation in mice"],"prefix":"10.1016","volume":"65","author":[{"given":"Mayu","family":"Suzuki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mutsuko","family":"Hara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saori","family":"Ichikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Kamijo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Nakazawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Hatanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Akiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideoki","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ko","family":"Okumura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiro","family":"Takai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.alit.2015.07.003_bib1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1164\/ajrccm.156.1.9606081","article-title":"Clinical improvement of asthma after anthelminthic treatment in a tropical situation","volume":"156","author":"Lynch","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.alit.2015.07.003_bib2","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/S0091-6749(98)70129-0","article-title":"Ascaris-specific IgE and allergic sensitization in a cohort of school children in the former East Germany","volume":"102","author":"Dold","year":"1998","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2015.07.003_bib3","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1164\/rccm.2107020","article-title":"Ascaris lumbricoides infection is associated with increased risk of childhood asthma and atopy in rural China","volume":"165","author":"Palmer","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.alit.2015.07.003_bib4","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1164\/rccm.200603-331OC","article-title":"Asthma and current intestinal parasite infection: systematic review and meta-analysis","volume":"174","author":"Leonardi-Bee","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.alit.2015.07.003_bib5","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/j.1365-2222.2007.02890.x","article-title":"High titre of anti-Ascaris immunoglobulin E associated with bronchial asthma symptoms in 5-year-old rural Bangladeshi children","volume":"38","author":"Takeuchi","year":"2008","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.alit.2015.07.003_bib6","doi-asserted-by":"crossref","first-page":"77","DOI":"10.2149\/tmh.2013-19","article-title":"Ascaris lumbricoids infection as a risk factor for asthma and atopy in rural Bangladeshi children","volume":"42","author":"Hawlader","year":"2014","journal-title":"Trop Med Health"},{"key":"10.1016\/j.alit.2015.07.003_bib7","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s40413-015-0058-z","article-title":"The IgE response to Ascaris molecular components is associated with clinical indicators of asthma severity","volume":"8","author":"Buendia","year":"2015","journal-title":"World Allergy Organ J"},{"key":"10.1016\/j.alit.2015.07.003_bib8","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1111\/cea.12513","article-title":"IgE responses to Ascaris and mite tropomyosins are risk factors for asthma","volume":"45","author":"Ahumada","year":"2015","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.alit.2015.07.003_bib9","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/S0140-6736(01)06579-5","article-title":"Independent effects of intestinal parasite infection and domestic allergen exposure on risk of wheeze in Ethiopia: a nested case-control study","volume":"358","author":"Scrivener","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.alit.2015.07.003_bib10","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1067\/mai.2003.1348","article-title":"Reduced risk of atopy among school-age children infected with geohelminth parasites in a rural area of the tropics","volume":"111","author":"Cooper","year":"2003","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2015.07.003_bib11","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1164\/rccm.200210-1204OC","article-title":"Wheezing, allergy, and parasite infection in children in urban and rural Ethiopia","volume":"167","author":"Dagoye","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.alit.2015.07.003_bib12","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1111\/j.1365-2222.2010.03559.x","article-title":"Long-term periodic anthelmintic treatments are associated with increased allergen skin reactivity","volume":"40","author":"Endara","year":"2010","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.alit.2015.07.003_bib13","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1111\/j.1398-9995.2009.02084.x","article-title":"IgE cross-reactivity between Ascaris and domestic mite allergens: the role of tropomyosin and the nematode polyprotein ABA-1","volume":"64","author":"Acevedo","year":"2009","journal-title":"Allergy"},{"key":"10.1016\/j.alit.2015.07.003_bib14","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1365-3024.2011.01288.x","article-title":"IgE cross-reactivity between Ascaris lumbricoides and mite allergens: possible influences on allergic sensitization and asthma","volume":"33","author":"Acevedo","year":"2011","journal-title":"Parasite Immunol"},{"key":"10.1016\/j.alit.2015.07.003_bib15","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1271\/bbb.120626","article-title":"Immunization of rabbits with nematode Ascaris lumbricoides antigens induces antibodies cross-reactive to house dust mite Dermatophagoides farinae antigens","volume":"77","author":"Nakazawa","year":"2013","journal-title":"Biosci Biotechnol Biochem"},{"key":"10.1016\/j.alit.2015.07.003_bib16","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1159\/000095458","article-title":"Application of immunoreaction enhancer solutions to an enzyme-linked immunosorbent assay for antigen-specific IgE in mice immunized with recombinant major mite allergens or ovalbumin","volume":"141","author":"Kikuchi","year":"2006","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.alit.2015.07.003_bib17","doi-asserted-by":"crossref","first-page":"225","DOI":"10.2332\/allergolint.08-OA-0039","article-title":"Enzyme-linked immunosorbent assays with high sensitivity for antigen-specific and total murine IgE: a useful tool for the study of allergies in mouse models","volume":"58","author":"Takai","year":"2009","journal-title":"Allergol Int"},{"key":"10.1016\/j.alit.2015.07.003_bib18","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.4049\/jimmunol.177.3.1609","article-title":"Crucial commitment of proteolytic activity of a purified recombinant major house dust mite allergen Der p1 to sensitization toward IgE and IgG responses","volume":"177","author":"Kikuchi","year":"2006","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.alit.2015.07.003_bib19","doi-asserted-by":"crossref","first-page":"25","DOI":"10.2332\/allergolint.10-RAI-0273","article-title":"Barrier dysfunction caused by environmental proteases in the pathogenesis of allergic diseases","volume":"60","author":"Takai","year":"2011","journal-title":"Allergol Int"},{"key":"10.1016\/j.alit.2015.07.003_bib20","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2332\/allergolint.11-RAI-0395","article-title":"TSLP expression: cellular sources, triggers, and regulatory mechanisms","volume":"61","author":"Takai","year":"2012","journal-title":"Allergol Int"},{"key":"10.1016\/j.alit.2015.07.003_bib21","doi-asserted-by":"crossref","first-page":"13","DOI":"10.2332\/allergolint.13-RAI-0538","article-title":"Role of interleukin-33 in innate-type immune cells in allergy","volume":"62","author":"Nakae","year":"2013","journal-title":"Allergol Int"},{"issue":"Suppl\u00a01","key":"10.1016\/j.alit.2015.07.003_bib22","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2332\/allergolint.13-RA-0657","article-title":"Innate-type and acquired-type allergy regulated by IL-33","volume":"63","author":"Yoshimoto","year":"2014","journal-title":"Allergol Int"},{"key":"10.1016\/j.alit.2015.07.003_bib23","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1165\/rcmb.2012-0304OC","article-title":"Transcription of interleukin-25 and extracellular release of the protein is regulated by allergen proteases in airway epithelial cells","volume":"49","author":"Kouzaki","year":"2013","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.alit.2015.07.003_bib24","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/pim.12194","article-title":"Looking beyond the induction of Th2 responses to explain immunomodulation by helminths","volume":"37","author":"Nutman","year":"2015","journal-title":"Parasite Immunol"},{"key":"10.1016\/j.alit.2015.07.003_bib25","doi-asserted-by":"crossref","first-page":"93","DOI":"10.4049\/jimmunol.1401638","article-title":"Helminth infection alters IgE responses to allergens structurally related to parasite proteins","volume":"194","author":"Santiago Hda","year":"2015","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.alit.2015.07.003_bib26","doi-asserted-by":"crossref","first-page":"219","DOI":"10.2332\/allergolint.13-OA-0621","article-title":"Epicutaneous administration of papain induces IgE and IgG responses in a cysteine protease activity-dependent manner","volume":"63","author":"Iida","year":"2014","journal-title":"Allergol Int"},{"key":"10.1016\/j.alit.2015.07.003_bib27","doi-asserted-by":"crossref","first-page":"4489","DOI":"10.4049\/jimmunol.1201212","article-title":"IL-33-mediated innate response and adaptive immune cells contribute to maximum responses of protease allergen-induced allergic airway inflammation","volume":"190","author":"Kamijo","year":"2013","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.alit.2015.07.003_bib28","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1038\/nm.2920","article-title":"The toll-like receptor 5 ligand flagellin promotes asthma by priming allergic responses to indoor allergens","volume":"18","author":"Wilson","year":"2012","journal-title":"Nat Med"},{"key":"10.1016\/j.alit.2015.07.003_bib29","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1084\/jem.20102229","article-title":"Invariant NKT cells are required for airway inflammation induced by environmental antigens","volume":"208","author":"Wingender","year":"2011","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.alit.2015.07.003_bib30","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/nature07548","article-title":"Allergenicity resulting from functional mimicry of a toll-like receptor complex protein","volume":"457","author":"Trompette","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.alit.2015.07.003_bib31","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1172\/JCI24422","article-title":"ROS generated by pollen NADPH oxidase provide a signal that augments antigen-induced allergic airway inflammation","volume":"115","author":"Boldogh","year":"2005","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.alit.2015.07.003_bib32","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1084\/jem.20041065","article-title":"Pollen-associated phytoprostanes inhibit dendritic cell interleukin-12 production and augment T helper type 2 cell polarization","volume":"201","author":"Traidl-Hoffmann","year":"2005","journal-title":"J\u00a0Exp Med"}],"container-title":["Allergology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1323893015001525?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1323893015001525?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:06:04Z","timestamp":1761156364000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1323893015001525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["S1323893015001525"],"URL":"https:\/\/doi.org\/10.1016\/j.alit.2015.07.003","relation":{},"ISSN":["1323-8930"],"issn-type":[{"value":"1323-8930","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Presensitization to Ascaris antigens promotes induction of mite-specific IgE upon mite antigen inhalation in mice","name":"articletitle","label":"Article Title"},{"value":"Allergology International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.alit.2015.07.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The Authors. Production and hosting by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}