{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:13:11Z","timestamp":1789863191192,"version":"4.0.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,5,22]],"date-time":"2016-05-22T00:00:00Z","timestamp":1463875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Grant-in-Aid for Scientific Research on Innovative Areas","award":["23114714"],"award-info":[{"award-number":["23114714"]}]},{"name":"JST Strategic International Research Cooperative Program, SICP"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Allergology International"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.alit.2016.05.005","type":"journal-article","created":{"date-parts":[[2016,6,26]],"date-time":"2016-06-26T19:50:12Z","timestamp":1466970612000},"page":"75-82","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Suppression of MUC5AC expression in human bronchial epithelial cells by interferon-\u03b3"],"prefix":"10.1016","volume":"66","author":[{"given":"Takahito","family":"Oyanagi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takumi","family":"Takizawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Aizawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orosoo","family":"Solongo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisako","family":"Yagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Nishida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harumi","family":"Koyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Saitoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokazu","family":"Arakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.alit.2016.05.005_bib1","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1164\/ajrccm.163.2.2004039","article-title":"Mild and moderate asthma is associated with airway goblet cell hyperplasia and abnormalities in mucin gene expression","volume":"163","author":"Ordonez","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.alit.2016.05.005_bib2","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1046\/j.1365-2559.2002.01378.x","article-title":"Expression of respiratory mucins in fatal status asthmaticus and mild asthma","volume":"40","author":"Groneberg","year":"2002","journal-title":"Histopathology"},{"key":"10.1016\/j.alit.2016.05.005_bib3","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1152\/physrev.00010.2005","article-title":"Respiratory tract mucin genes and mucin glycoproteins in health and disease","volume":"86","author":"Rose","year":"2006","journal-title":"Physiol Rev"},{"key":"10.1016\/j.alit.2016.05.005_bib4","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/S0002-9343(03)00241-9","article-title":"Characterization of airway plugging in fatal asthma","volume":"115","author":"Kuyper","year":"2003","journal-title":"Am J Med"},{"key":"10.1016\/j.alit.2016.05.005_bib5","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.1073\/pnas.96.6.3081","article-title":"Epidermal growth factor system regulates mucin production in airways","volume":"96","author":"Takeyama","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.alit.2016.05.005_bib6","doi-asserted-by":"crossref","first-page":"293","DOI":"10.4049\/jimmunol.182.1.293","article-title":"Double-stranded RNA and TGF-alpha promote MUC5AC induction in respiratory cells","volume":"182","author":"Tadaki","year":"2009","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.alit.2016.05.005_bib7","doi-asserted-by":"crossref","first-page":"3392","DOI":"10.4049\/jimmunol.1003377","article-title":"CCL20\/CCR6 feedback exaggerates epidermal growth factor receptor-dependent MUC5AC mucin production in human airway epithelial (NCI-H292) cells","volume":"186","author":"Kim","year":"2011","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.alit.2016.05.005_bib8","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.4049\/jimmunol.157.4.1350","article-title":"A\u00a0direct role for IFN-gamma in regulation of Th1 cell development","volume":"157","author":"Bradley","year":"1996","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.alit.2016.05.005_bib9","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.immuni.2009.09.002","article-title":"Cross-regulation of signaling pathways by interferon-gamma: implications for immune responses and autoimmune diseases","volume":"31","author":"Hu","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.alit.2016.05.005_bib10","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.jaci.2014.11.001","article-title":"The 3 major types of innate and adaptive cell-mediated effector immunity","volume":"135","author":"Annunziato","year":"2015","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2016.05.005_bib11","doi-asserted-by":"crossref","first-page":"3546","DOI":"10.1172\/JCI36130","article-title":"The cytokine network in asthma and chronic obstructive pulmonary disease","volume":"118","author":"Barnes","year":"2008","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.alit.2016.05.005_bib12","doi-asserted-by":"crossref","first-page":"253","DOI":"10.2174\/187152806779010909","article-title":"Interferon-gamma as a possible target in chronic asthma","volume":"5","author":"Kumar","year":"2006","journal-title":"Inflamm Allergy Drug Targets"},{"key":"10.1016\/j.alit.2016.05.005_bib13","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/S0264-410X(99)00185-1","article-title":"Intranasal IFN-gamma gene transfer protects BALB\/c mice against respiratory syncytial virus infection","volume":"18","author":"Kumar","year":"1999","journal-title":"Vaccine"},{"key":"10.1016\/j.alit.2016.05.005_bib14","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1002\/1521-4141(200208)32:8<2117::AID-IMMU2117>3.0.CO;2-C","article-title":"Virus clearance and immunopathology by CD8(+) T cells during infection with respiratory syncytial virus are mediated by IFN-gamma","volume":"32","author":"Ostler","year":"2002","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.alit.2016.05.005_bib15","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1247\/csf.12034","article-title":"Chromatin accessibility at a STAT3 target site is altered prior to astrocyte differentiation","volume":"38","author":"Urayama","year":"2013","journal-title":"Cell Struct Funct"},{"key":"10.1016\/j.alit.2016.05.005_bib16","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.alit.2014.11.002","article-title":"Leukotriene E4 induces MUC5AC release from human airway epithelial NCI-H292 cells","volume":"64","author":"Shirasaki","year":"2015","journal-title":"Allergol Int"},{"key":"10.1016\/j.alit.2016.05.005_bib17","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/jcb.10142","article-title":"Interferon regulatory factor-1 mediates interferon-gamma-induced apoptosis in ovarian carcinoma cells","volume":"85","author":"Kim","year":"2002","journal-title":"J\u00a0Cell Biochem"},{"key":"10.1016\/j.alit.2016.05.005_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cyto.2009.11.021","article-title":"Gene modulation and immunoregulatory roles of interferon gamma","volume":"50","author":"Saha","year":"2010","journal-title":"Cytokine"},{"key":"10.1016\/j.alit.2016.05.005_bib19","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/j.1742-4658.2012.08716.x","article-title":"Dual-specificity MAP kinase phosphatases (MKPs): shaping the outcome of MAP kinase signalling","volume":"280","author":"Caunt","year":"2013","journal-title":"FEBS J"},{"key":"10.1016\/j.alit.2016.05.005_bib20","doi-asserted-by":"crossref","first-page":"451","DOI":"10.2332\/allergolint.11-OA-0411","article-title":"Glucocorticoids inhibit MUC5AC production induced by transforming growth factor-alpha in human respiratory cells","volume":"61","author":"Takami","year":"2012","journal-title":"Allergol Int"},{"key":"10.1016\/j.alit.2016.05.005_bib21","doi-asserted-by":"crossref","first-page":"27948","DOI":"10.1074\/jbc.M111.334375","article-title":"Cigarette smoke induces MUC5AC protein expression through the activation of Sp1","volume":"287","author":"Di","year":"2012","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.alit.2016.05.005_bib22","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/nature12807","article-title":"Muc5b is required for airway defence","volume":"505","author":"Roy","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.alit.2016.05.005_bib23","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1056\/NEJMra0910061","article-title":"Airway mucus function and dysfunction","volume":"363","author":"Fahy","year":"2010","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.alit.2016.05.005_bib24","doi-asserted-by":"crossref","first-page":"16528","DOI":"10.1073\/pnas.1206552109","article-title":"Overexpressing mouse model demonstrates the protective role of Muc5ac in the lungs","volume":"109","author":"Ehre","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.alit.2016.05.005_bib25","doi-asserted-by":"crossref","first-page":"209","DOI":"10.4049\/jimmunol.0802712","article-title":"IFN-gamma attenuates antigen-induced overall immune response in the airway as a Th1-type immune regulatory cytokine","volume":"183","author":"Nakagome","year":"2009","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.alit.2016.05.005_bib26","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/j.febslet.2007.03.002","article-title":"Interferon gamma-dependent transactivation of epidermal growth factor receptor","volume":"581","author":"Burova","year":"2007","journal-title":"FEBS Lett"},{"key":"10.1016\/j.alit.2016.05.005_bib27","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1074\/jbc.M111.318139","article-title":"Interferon-gamma alters downstream signaling originating from epidermal growth factor receptor in intestinal epithelial cells: functional consequences for ion transport","volume":"287","author":"Paul","year":"2012","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.alit.2016.05.005_bib28","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1600-0625.1995.tb00218.x","article-title":"Interferon-gamma downregulates epidermal growth factor receptors on human melanoma cells","volume":"4","author":"Worm","year":"1995","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.alit.2016.05.005_bib29","first-page":"375","article-title":"Interferon-gamma inhibits integrin-mediated extracellular signal-regulated kinase activation stimulated by fibronectin binding in thyroid cells","volume":"36","author":"Russo","year":"2013","journal-title":"J\u00a0Endocrinol Invest"},{"key":"10.1016\/j.alit.2016.05.005_bib30","doi-asserted-by":"crossref","first-page":"8107","DOI":"10.1093\/nar\/gkt589","article-title":"Deciphering the modulation of gene expression by type I and II interferons combining 4sU-tagging, translational arrest and in silico promoter analysis","volume":"41","author":"Trilling","year":"2013","journal-title":"Nucleic Acids Res"}],"container-title":["Allergology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1323893016300600?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1323893016300600?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:06:52Z","timestamp":1761156412000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1323893016300600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["S1323893016300600"],"URL":"https:\/\/doi.org\/10.1016\/j.alit.2016.05.005","relation":{},"ISSN":["1323-8930"],"issn-type":[{"value":"1323-8930","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Suppression of MUC5AC expression in human bronchial epithelial cells by interferon-\u03b3","name":"articletitle","label":"Article Title"},{"value":"Allergology International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.alit.2016.05.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016, Japanese Society of Allergology. Production and hosting by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}