{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T09:11:52Z","timestamp":1790154712219,"version":"4.0.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,10,21]],"date-time":"2016-10-21T00:00:00Z","timestamp":1477008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Allergology International"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1016\/j.alit.2016.10.004","type":"journal-article","created":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T10:13:28Z","timestamp":1479291208000},"page":"418-424","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["Discrepancies in the diagnosis and classification of nonsteroidal anti-inflammatory drug hypersensitivity reactions in children"],"prefix":"10.1016","volume":"66","author":[{"given":"Tu\u011fba","family":"Arikoglu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulen","family":"Aslan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didem Derici","family":"Yildirim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sehra Birgul","family":"Batmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Semanur","family":"Kuyucu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.alit.2016.10.004_bib1","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1111\/j.1398-9995.2011.02557.x","article-title":"Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) \u2013 classification, diagnosis and management: review of the EAACI\/ENDA(#) and GA2LEN\/HANNA*","volume":"66","author":"Kowalski","year":"2011","journal-title":"Allergy"},{"key":"10.1016\/j.alit.2016.10.004_bib2","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1093\/ije\/28.4.717","article-title":"Prevalence of asthma, aspirin intolerance, nasal polyposis and chronic obstructive pulmonary disease in a population-based study","volume":"28","author":"Hedman","year":"1999","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.alit.2016.10.004_bib3","first-page":"363","article-title":"Drug hypersensitivity reactions: response patterns, drug involved, and temporal variations in a large series of patients","volume":"22","author":"Dona","year":"2012","journal-title":"J\u00a0Investig Allergol Clin Immunol"},{"key":"10.1016\/j.alit.2016.10.004_bib4","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1398-9995.1980.tb01730.x","article-title":"Aspirin intolerance and recurrent urticaria in normal adults and children. Epidemiology and review","volume":"35","author":"Settipane","year":"1980","journal-title":"Allergy"},{"key":"10.1016\/j.alit.2016.10.004_bib5","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1136\/bmj.328.7437.434","article-title":"Systematic review of prevalence of aspirin induced asthma and its implications for clinical practice","volume":"328","author":"Jenkins","year":"2004","journal-title":"BMJ"},{"key":"10.1016\/j.alit.2016.10.004_bib6","first-page":"561","article-title":"Hypersensitivity to cyclooxygenase inhibitory drugs in children: a study of 164 cases","volume":"18","author":"Hassani","year":"2008","journal-title":"Eur J Dermatol"},{"key":"10.1016\/j.alit.2016.10.004_bib7","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/cea.12013","article-title":"Value of the clinical history in the diagnosis of urticaria\/angioedema induced by NSAIDs with cross-intolerance","volume":"43","author":"Blanca-Lopez","year":"2013","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.alit.2016.10.004_bib8","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1111\/all.12266","article-title":"Challenge-proven nonsteroidal anti-inflammatory drug hypersensitivity in children","volume":"68","author":"Y\u0131lmaz","year":"2013","journal-title":"Allergy"},{"key":"10.1016\/j.alit.2016.10.004_bib9","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S1081-1206(10)62748-2","article-title":"Atopy is a risk factor for non-steroidal anti-inflammatory drug sensitivity","volume":"84","author":"Sanchez-Borges","year":"2000","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.alit.2016.10.004_bib10","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/pai.12039","article-title":"Drug provocation tests in the diagnosis of hypersensitivity reactions to non-steroidal anti-inflammatory drugs in children","volume":"24","author":"Zambonino","year":"2013","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.alit.2016.10.004_bib11","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1365-2222.2007.02870.x","article-title":"Drug allergy claims in children: from self-reporting to confirmed diagnosis","volume":"38","author":"Gomes","year":"2008","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.alit.2016.10.004_bib12","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/j.1399-3038.2011.01134.x","article-title":"Diagnosis of drug hypersensitivity in children and adolescents: discrepancy between physician-based assessment and results of testing","volume":"22","author":"Seitz","year":"2011","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.alit.2016.10.004_bib13","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1111\/all.12260","article-title":"Classification and practical approach to the diagnosis and management of hypersensitivity to nonsteroidal anti-inflammatory drugs","volume":"68","author":"Kowalski","year":"2013","journal-title":"Allergy"},{"key":"10.1016\/j.alit.2016.10.004_bib14","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.iac.2014.04.001","article-title":"Hypersensitivity reactions to nonsteroidal anti-inflammatory drugs","volume":"34","author":"Torres","year":"2014","journal-title":"Immunol Allergy Clin North Am"},{"key":"10.1016\/j.alit.2016.10.004_bib15","first-page":"259","article-title":"Hypersensitivity to nonsteroidal anti-inflammatory drugs in children and adolescents: cross-intolerance reactions","volume":"25","author":"Blanca-Lopez","year":"2015","journal-title":"J\u00a0Investig Allergol Clin Immunol"},{"key":"10.1016\/j.alit.2016.10.004_bib16","first-page":"385","article-title":"Hypersensitivity to nonsteroidal anti-inflammatory drugs in children and adolescents: selective reactions","volume":"25","author":"Blanca-Lopez","year":"2015","journal-title":"J\u00a0Investig Allergol Clin Immunol"},{"key":"10.1016\/j.alit.2016.10.004_bib17","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1159\/000337660","article-title":"How can we better classify NSAID hypersensitivity reactions?\u2013validation from a large database","volume":"159","author":"Caimmi","year":"2012","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.alit.2016.10.004_bib18","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1034\/j.1398-9995.1999.00247.x","article-title":"Drug hypersensitivity: questionnaire. EAACI Interest group on drug hypersensitivity","volume":"54","author":"Demoly","year":"1999","journal-title":"Allergy"},{"key":"10.1016\/j.alit.2016.10.004_bib19","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1111\/all.12142","article-title":"Skin test concentrations for systemically administered drugs-an ENDA\/EAACI Drug Allergy Interest Group position paper","volume":"68","author":"Brockow","year":"2013","journal-title":"Allergy"},{"key":"10.1016\/j.alit.2016.10.004_bib20","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1046\/j.0105-4538.2001.00001.x-i8","article-title":"General considerations for skin test procedures in the diagnosis of drug hypersensitivity","volume":"57","author":"Brockow","year":"2002","journal-title":"Allergy"},{"key":"10.1016\/j.alit.2016.10.004_bib21","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1034\/j.1398-9995.2003.00279.x","article-title":"Drug provocation testing in the diagnosis of drug hypersensitivity reactions: general considerations","volume":"58","author":"Aberer","year":"2003","journal-title":"Allergy"},{"key":"10.1016\/j.alit.2016.10.004_bib22","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.2174\/138161208786369731","article-title":"Provocation tests in diagnosing drug hypersensitivity","volume":"14","author":"Bousquet","year":"2008","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.alit.2016.10.004_bib23","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1111\/j.1398-9995.2007.01409.x","article-title":"EAACI\/GA2LEN guideline: aspirin provocation tests for diagnosis of aspirin hypersensitivity","volume":"62","author":"Nizankowska-Mogilnicka","year":"2007","journal-title":"Allergy"},{"key":"10.1016\/j.alit.2016.10.004_bib24","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1097\/01.all.0000173785.81024.33","article-title":"Epidemiology of hypersensitivity drug reactions","volume":"5","author":"Gomes","year":"2005","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2016.10.004_bib25","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.anai.2014.06.019","article-title":"Multinational experience with hypersensitivity drug reactions in Latin America","volume":"113","author":"Jares","year":"2014","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.alit.2016.10.004_bib26","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/pds.2134","article-title":"Clinical characteristics of patients with drug hypersensitivity in Norway: a single-centre study","volume":"20","author":"Chalabianloo","year":"2011","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"10.1016\/j.alit.2016.10.004_bib27","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/s11096-015-0100-9","article-title":"Diagnostic evaluation and risk factors for drug allergies in children: from clinical history to skin and challenge tests","volume":"37","author":"Arikoglu","year":"2015","journal-title":"Int J Clin Pharm"},{"key":"10.1016\/j.alit.2016.10.004_bib28","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1111\/all.12689","article-title":"Evaluation of hypersensitivity reactions to nonsteroidal anti-inflammatory drugs according to the latest classification","volume":"70","author":"Demir","year":"2015","journal-title":"Allergy"},{"key":"10.1016\/j.alit.2016.10.004_bib29","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s13601-015-0052-0","article-title":"Hypersensitivity to non-steroidal anti-inflammatory drugs (NSAIDs): classification of a Danish patient cohort according to EAACI\/ENDA guidelines","volume":"5","author":"Nissen","year":"2015","journal-title":"Clin Transl Allergy"},{"key":"10.1016\/j.alit.2016.10.004_bib30","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/j.1365-2222.2010.03651.x","article-title":"Characteristics of subjects experiencing hypersensitivity to non-steroidal anti-inflammatory drugs: patterns of response","volume":"41","author":"Dona","year":"2011","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.alit.2016.10.004_bib31","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1046\/j.1525-1470.2001.018001066.x","article-title":"Allergic reactions due to ibuprofen in children","volume":"18","author":"Diaz-Jara","year":"2001","journal-title":"Pediatr Dermatol"},{"key":"10.1016\/j.alit.2016.10.004_bib32","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1111\/pai.12596","article-title":"Phenotypical characterization of children with hypersensitivity reactions to NSAIDs","volume":"27","author":"Cousin","year":"2016","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.alit.2016.10.004_bib33","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1159\/000438992","article-title":"Different Phenotypes of non-steroidal anti-inflammatory drug hypersensitivity during childhood","volume":"167","author":"Cavkaytar","year":"2015","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.alit.2016.10.004_bib34","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1159\/000335213","article-title":"Paracetamol hypersensitivity: clinical features, mechanism and role of specific IgE","volume":"159","author":"Rutkowski","year":"2012","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.alit.2016.10.004_bib35","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.jaci.2006.07.024","article-title":"Clinical and pathologic perspectives on aspirin sensitivity and asthma","volume":"118","author":"Stevenson","year":"2006","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2016.10.004_bib36","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2500\/aap.2016.37.3917","article-title":"The value of the clinical history for the diagnosis of immediate nonsteroidal anti-inflammatory drug hypersensitivity and safe alternative drugs in children","volume":"37","author":"Topal","year":"2016","journal-title":"Allergy Asthma Proc"},{"key":"10.1016\/j.alit.2016.10.004_bib37","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.jaci.2006.10.002","article-title":"The A-444C polymorphism of leukotriene C4 synthase gene is associated with IgE antibodies to Dermatophagoides pteronyssinus in a Colombian population","volume":"119","author":"Acevedo","year":"2007","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2016.10.004_bib38","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.jaci.2005.12.1329","article-title":"Leukotriene D4 enhances immunoglobulin production in CD4-activated human B lymphocytes","volume":"117","author":"Lamoureux","year":"2006","journal-title":"J\u00a0Allergy Clin Immunol"}],"container-title":["Allergology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1323893016301587?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1323893016301587?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:08:07Z","timestamp":1761156487000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1323893016301587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["S1323893016301587"],"URL":"https:\/\/doi.org\/10.1016\/j.alit.2016.10.004","relation":{},"ISSN":["1323-8930"],"issn-type":[{"value":"1323-8930","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discrepancies in the diagnosis and classification of nonsteroidal anti-inflammatory drug hypersensitivity reactions in children","name":"articletitle","label":"Article Title"},{"value":"Allergology International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.alit.2016.10.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016, Japanese Society of Allergology. Production and hosting by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}