{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:02:01Z","timestamp":1790622121039,"version":"4.1.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,6,2]],"date-time":"2017-06-02T00:00:00Z","timestamp":1496361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Health and Labor Sciences Research"},{"name":"Ministry of Health, Labor and Welfare of Japan"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Allergology International"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.alit.2017.06.001","type":"journal-article","created":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T18:30:12Z","timestamp":1498156212000},"page":"90-95","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["The thymus and activation-regulated chemokine (TARC) level in serum at an early stage of a drug eruption is a prognostic biomarker of severity of systemic inflammation"],"prefix":"10.1016","volume":"67","author":[{"given":"Takayoshi","family":"Komatsu-Fujii","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Chinuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Niihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Hayashida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masataka","family":"Ohta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryota","family":"Okazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakae","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eishin","family":"Morita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.alit.2017.06.001_bib1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jaad.2007.08.039","article-title":"Effects of treatments on the mortality of Stevens-Johnson syndrome and toxic epidermal necrolysis: a retrospective study on patients included in the prospective EuroSCAR Study","volume":"58","author":"Schneck","year":"2008","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.alit.2017.06.001_bib2","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1111\/j.1365-2133.2007.07807.x","article-title":"The diagnosis of a DRESS syndrome has been sufficiently established on the basis of typical clinical features and viral reactivations","volume":"156","author":"Shiohara","year":"2007","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.alit.2017.06.001_bib3","doi-asserted-by":"crossref","first-page":"10","DOI":"10.12788\/j.sder.0058","article-title":"Stevens-Johnson syndrome and toxic epidermal necrolysis: clinical patterns, diagnostic considerations, etiology, and therapeutic management","volume":"33","author":"Mockenhaupt","year":"2014","journal-title":"Semin Cutan Med Surg"},{"key":"10.1016\/j.alit.2017.06.001_bib4","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.amjcard.2010.03.062","article-title":"Usefulness of neutrophil to lymphocyte ratio in predicting short- and long-term mortality after non-ST-elevation myocardial infarction","volume":"106","author":"Azab","year":"2010","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.alit.2017.06.001_bib5","doi-asserted-by":"crossref","first-page":"409","DOI":"10.2459\/JCM.0000000000000184","article-title":"The systemic inflammation-based Glasgow Prognostic Score as a prognostic factor in patients with acute heart failure","volume":"16","author":"Namiuchi","year":"2015","journal-title":"J\u00a0Cardiovasc Med"},{"key":"10.1016\/j.alit.2017.06.001_bib6","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/sj.bjc.6601242","article-title":"Evaluation of cumulative prognostic scores based on the systemic inflammatory response in patients with inoperable non-small-cell lung cancer","volume":"89","author":"Forrest","year":"2003","journal-title":"Br J Cancer"},{"key":"10.1016\/j.alit.2017.06.001_bib7","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1056\/NEJMoa1415236","article-title":"Systemic inflammatory response syndrome criteria in defining severe sepsis","volume":"372","author":"Kaukonen","year":"2015","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.alit.2017.06.001_bib8","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1097\/CCM.0b013e3182995799","article-title":"Eosinophilia: a diagnostic clue for nonbacterial diseases in patients with systemic inflammatory response syndrome","volume":"41","author":"Mitre","year":"2013","journal-title":"Crit Care Med"},{"key":"10.1016\/j.alit.2017.06.001_bib9","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1684\/ejd.2011.1550","article-title":"Identifying prognostic factors for drug rash with eosinophilia and systemic symptoms (DRESS)","volume":"21","author":"Wei","year":"2011","journal-title":"Eur J Dermatol"},{"key":"10.1016\/j.alit.2017.06.001_bib10","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1046\/j.1523-1747.2000.00061.x","article-title":"SCORTEN: a severity-of-illness score for toxic epidermal necrolysis","volume":"115","author":"Bastuji-Garin","year":"2000","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.alit.2017.06.001_bib11","doi-asserted-by":"crossref","first-page":"15036","DOI":"10.1074\/jbc.272.23.15036","article-title":"The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4","volume":"272","author":"Imai","year":"1997","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.alit.2017.06.001_bib12","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/S0167-5699(98)01346-2","article-title":"Chemokines and chemokine receptors in T cell priming and Th1\/Th2 mediated responses","volume":"19","author":"Sallusto","year":"1998","journal-title":"Immunol Today"},{"key":"10.1016\/j.alit.2017.06.001_bib13","doi-asserted-by":"crossref","first-page":"5111","DOI":"10.4049\/jimmunol.161.10.5111","article-title":"Selective up-regulation of chemokine receptors CCR4 and CCR8 upon activation of polarized human type 2 Th cells","volume":"161","author":"D'Ambrosio","year":"1998","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.alit.2017.06.001_bib14","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/bjd.12948","article-title":"Elevated serum thymus and activation-regulated chemokine (TARC\/CCL17) relates to reactivation of human herpesvirus 6 in drug reaction with eosinophilia and systemic symptoms (DRESS)\/drug-induced hypersensitivity syndrome (DIHS)","volume":"171","author":"Ogawa","year":"2014","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.alit.2017.06.001_bib15","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jdermsci.2012.10.002","volume":"69","author":"Ogawa","year":"2013","journal-title":"J\u00a0Dermatol Sci"},{"key":"10.1016\/j.alit.2017.06.001_bib16","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1684\/ejd.2014.2477","volume":"25","author":"Miyagawa","year":"2015","journal-title":"Eur J Dermatol"},{"key":"10.1016\/j.alit.2017.06.001_bib17","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.alit.2016.06.003","article-title":"Serum TARC level is strongly correlated to blood eosinophil count in the patients with drug eruptions","volume":"66","author":"Komatsu-Fujii","year":"2017","journal-title":"Allergol Int"},{"key":"10.1016\/j.alit.2017.06.001_bib18","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/S1085-5629(96)80038-1","article-title":"Drug-induced pseudolymphoma and drug hypersensitivity syndrome (drug rash with eosinophilia and systemic symptoms: DRESS)","volume":"15","author":"Bocquet","year":"1996","journal-title":"Semin Cutan Med Surg"},{"key":"10.1016\/j.alit.2017.06.001_bib19","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.alit.2015.06.007","article-title":"Usefulness of rapid measurement of serum thymus and activation-regulated chemokine level in diagnosing drug-induced hypersensitivity syndrome","volume":"64","author":"Komatsu-Fujii","year":"2015","journal-title":"Allergol Int"},{"key":"10.1016\/j.alit.2017.06.001_bib20","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.amjcard.2015.04.021","article-title":"Value of neutrophil-lymphocyte ratio in predicting outcomes in Kawasaki disease","volume":"116","author":"Ha","year":"2015","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.alit.2017.06.001_bib21","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.amjcard.2014.10.008","article-title":"Usefulness of neutrophil-to-lymphocyte ratio in risk stratification of patients with advanced heart failure","volume":"115","author":"Benites-Zapata","year":"2015","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.alit.2017.06.001_bib22","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.amjcard.2008.05.006","article-title":"Association between admission neutrophil to lymphocyte ratio and outcomes in patients with acute coronary syndrome","volume":"102","author":"Tamhane","year":"2008","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.alit.2017.06.001_bib23","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1001\/jama.2016.0288","article-title":"Assessment of clinical criteria for sepsis: for the Third International Consensus. Definitions for sepsis and septic shock (Sepsis-3)","volume":"315","author":"Seymour","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.alit.2017.06.001_bib24","doi-asserted-by":"crossref","first-page":"R59","DOI":"10.1186\/cc6883","article-title":"Eosinopenia is a reliable marker of sepsis on admission to medical intensive care units","volume":"12","author":"Abidi","year":"2008","journal-title":"Crit Care"},{"key":"10.1016\/j.alit.2017.06.001_bib25","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.jcrc.2010.03.002","article-title":"Eosinopenia: is it a good marker of sepsis in comparison to procalcitonin and C-reactive protein levels for patients admitted to a critical care unit in an urban hospital?","volume":"25","author":"Shaaban","year":"2010","journal-title":"J\u00a0Crit Care"},{"key":"10.1016\/j.alit.2017.06.001_bib26","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1067\/mai.2001.113237","article-title":"Thymus and activation-regulated chemokine in atopic dermatitis: serum thymus and activation-regulated chemokine level is closely related with disease activity","volume":"107","author":"Kakinuma","year":"2001","journal-title":"J\u00a0Allergy Clin Immunol"}],"container-title":["Allergology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1323893017300655?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1323893017300655?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:08:47Z","timestamp":1761156527000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1323893017300655"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["S1323893017300655"],"URL":"https:\/\/doi.org\/10.1016\/j.alit.2017.06.001","relation":{},"ISSN":["1323-8930"],"issn-type":[{"value":"1323-8930","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The thymus and activation-regulated chemokine (TARC) level in serum at an early stage of a drug eruption is a prognostic biomarker of severity of systemic inflammation","name":"articletitle","label":"Article Title"},{"value":"Allergology International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.alit.2017.06.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Japanese Society of Allergology. Production and hosting by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}