{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:55:23Z","timestamp":1777614923817,"version":"3.51.4"},"reference-count":21,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,6,11]],"date-time":"2017-06-11T00:00:00Z","timestamp":1497139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003993","name":"Ministry of Agriculture, Forestry, and Fisheries of Japan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003993","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Allergology International"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.alit.2017.06.006","type":"journal-article","created":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T09:30:32Z","timestamp":1498901432000},"page":"119-123","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Efficacy of oral immunotherapy with a rice-based edible vaccine containing hypoallergenic Japanese cedar pollen allergens for treatment of established allergic conjunctivitis in mice"],"prefix":"10.1016","volume":"67","author":[{"given":"Ken","family":"Fukuda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waka","family":"Ishida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosuke","family":"Harada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhya","family":"Wakasa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidenori","family":"Takagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumio","family":"Takaiwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuki","family":"Fukushima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.alit.2017.06.006_bib1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.2332\/allergolint.08-RAI-0074","article-title":"Present situation of cedar pollinosis in Japan and its immune responses","volume":"58","author":"Okamoto","year":"2009","journal-title":"Allergol Int"},{"key":"10.1016\/j.alit.2017.06.006_bib2","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.jaci.2010.06.045","article-title":"How adherent to sublingual immunotherapy prescriptions are patients? The manufacturers' viewpoint","volume":"126","author":"Senna","year":"2010","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2017.06.006_bib3","doi-asserted-by":"crossref","first-page":"357","DOI":"10.4161\/hv.7.3.14302","article-title":"Seed-based oral vaccines as allergen-specific immunotherapies","volume":"7","author":"Takaiwa","year":"2011","journal-title":"Hum Vaccin"},{"key":"10.1016\/j.alit.2017.06.006_bib4","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/pbi.12007","article-title":"Oral immunotherapy with transgenic rice seed containing destructed Japanese cedar pollen allergens, Cry j 1 and Cry j 2, against Japanese cedar pollinosis","volume":"11","author":"Wakasa","year":"2013","journal-title":"Plant Biotechnol J"},{"key":"10.1016\/j.alit.2017.06.006_bib5","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1136\/bjophthalmol-2014-305842","article-title":"Prevention of allergic conjunctivitis in mice by a rice-based edible vaccine containing modified Japanese cedar pollen allergens","volume":"99","author":"Fukuda","year":"2015","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.alit.2017.06.006_bib6","doi-asserted-by":"crossref","first-page":"301","DOI":"10.2217\/imt.13.4","article-title":"Update on the use of transgenic rice seeds in oral immunotherapy","volume":"5","author":"Takaiwa","year":"2013","journal-title":"Immunotherapy"},{"key":"10.1016\/j.alit.2017.06.006_bib7","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1248\/bpb.30.1745","article-title":"Cryptomeria japonica-induced allergic conjunctivitis in mice","volume":"30","author":"Fukushima","year":"2007","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.alit.2017.06.006_bib8","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1006\/clin.1997.4507","article-title":"A\u00a0novel murine model of allergic conjunctivitis","volume":"87","author":"Magone","year":"1998","journal-title":"Clin Immunol Immunopathol"},{"key":"10.1016\/j.alit.2017.06.006_bib9","doi-asserted-by":"crossref","first-page":"4897","DOI":"10.4049\/jimmunol.175.8.4897","article-title":"Engagement of 4-1BB inhibits the development of experimental allergic conjunctivitis in mice","volume":"175","author":"Fukushima","year":"2005","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.alit.2017.06.006_bib10","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1136\/bjo.2006.100180","article-title":"Interleukin 10 and transforming growth factor beta contribute to the development of experimentally induced allergic conjunctivitis in mice during the effector phase","volume":"90","author":"Fukushima","year":"2006","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.alit.2017.06.006_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2013.03.013","article-title":"Real-life compliance and persistence among users of subcutaneous and sublingual allergen immunotherapy","volume":"132","author":"Kiel","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2017.06.006_bib12","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1111\/j.0105-2896.2005.00280.x","article-title":"Oral tolerance","volume":"206","author":"Faria","year":"2005","journal-title":"Immunol Rev"},{"key":"10.1016\/j.alit.2017.06.006_bib13","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1136\/bjophthalmol-2012-302639","article-title":"Oral administration of Ag suppresses Ag-induced allergic conjunctivitis in mice: critical timing and dose of Ag","volume":"97","author":"Ishida","year":"2013","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.alit.2017.06.006_bib14","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1080\/02713680490904313","article-title":"Interleukin-4-mediated infiltration of eosinophils into the conjunctiva and its suppression by interferon-gamma","volume":"30","author":"Fukushima","year":"2005","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.alit.2017.06.006_bib15","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1002\/eji.1830270513","article-title":"Insect venom immunotherapy induces interleukin-10 production and a Th2-to-Th1 shift, and changes surface marker expression in venom-allergic subjects","volume":"27","author":"Bellinghausen","year":"1997","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.alit.2017.06.006_bib16","doi-asserted-by":"crossref","first-page":"4187","DOI":"10.4049\/jimmunol.154.8.4187","article-title":"Bee venom immunotherapy results in decrease of IL-4 and IL-5 and increase of IFN-gamma secretion in specific allergen-stimulated T cell cultures","volume":"154","author":"Jutel","year":"1995","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.alit.2017.06.006_bib17","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.anai.2014.12.015","article-title":"Clinical and cytokine responses to house dust mite sublingual immunotherapy","volume":"114","author":"Potter","year":"2015","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.alit.2017.06.006_bib18","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.jaci.2011.08.034","article-title":"Differentiation stage determines pathologic and protective allergen-specific CD4+ T-cell outcomes during specific immunotherapy","volume":"129","author":"Wambre","year":"2012","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2017.06.006_bib19","first-page":"169","article-title":"Sublingual immunotherapy provides an early increase of interferon-gamma production","volume":"22","author":"Ciprandi","year":"2008","journal-title":"J\u00a0Biol Regul Homeost Agents"},{"key":"10.1016\/j.alit.2017.06.006_bib20","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.alit.2015.05.008","article-title":"Spectrum of allergens for Japanese cedar pollinosis and impact of component-resolved diagnosis on allergen-specific immunotherapy","volume":"64","author":"Fujimura","year":"2015","journal-title":"Allergol Int"},{"key":"10.1016\/j.alit.2017.06.006_bib21","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1159\/000076438","article-title":"Two-dimensional IgE-binding spectrum of Japanese cedar (Cryptomeria japonica) pollen allergens","volume":"133","author":"Fujimura","year":"2004","journal-title":"Int Arch Allergy Immunol"}],"container-title":["Allergology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1323893017300709?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1323893017300709?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:07:57Z","timestamp":1761156477000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1323893017300709"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["S1323893017300709"],"URL":"https:\/\/doi.org\/10.1016\/j.alit.2017.06.006","relation":{},"ISSN":["1323-8930"],"issn-type":[{"value":"1323-8930","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy of oral immunotherapy with a rice-based edible vaccine containing hypoallergenic Japanese cedar pollen allergens for treatment of established allergic conjunctivitis in mice","name":"articletitle","label":"Article Title"},{"value":"Allergology International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.alit.2017.06.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Japanese Society of Allergology. Production and hosting by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}