{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T14:31:13Z","timestamp":1781620273190,"version":"3.54.5"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,5,12]],"date-time":"2018-05-12T00:00:00Z","timestamp":1526083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003993","name":"Ministry of Agriculture, Forestry and Fisheries of Japan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003993","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["15K07787"],"award-info":[{"award-number":["15K07787"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006089","name":"Tojuro Iijima Foundation for Food Science and Technology to Kaminuma O","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006089","id-type":"DOI","asserted-by":"publisher"}]},{"name":"4) Nipponham Foundation for the Future of Food to Kaminuma O"},{"name":"Mishima Kaiun Memorial Foundation"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Allergology International"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.alit.2018.05.002","type":"journal-article","created":{"date-parts":[[2018,6,15]],"date-time":"2018-06-15T11:43:51Z","timestamp":1529063031000},"page":"S25-S31","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"S","title":["Effects of anti-allergic drugs on T cell-mediated nasal hyperresponsiveness in a murine model of allergic rhinitis"],"prefix":"10.1016","volume":"67","author":[{"given":"Tomoe","family":"Nishimura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Kaminuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayumi","family":"Saeki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Kitamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Gotoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takachika","family":"Hiroi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.alit.2018.05.002_bib1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1056\/NEJM198507113130201","article-title":"Inflammatory mediators in late antigen-induced rhinitis","volume":"313","author":"Naclerio","year":"1985","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.alit.2018.05.002_bib2","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1164\/ajrccm\/138.2.406","article-title":"The influx of inflammatory cells into nasal washings during the late response to antigen challenge. Effect of systemic steroid pretreatment","volume":"138","author":"Bascom","year":"1988","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.alit.2018.05.002_bib3","first-page":"123","article-title":"Quantitative intranasal pollen challenge. II. Effect of daily pollen challenge, environmental pollen exposure, and placebo challenge on the nasal membrane","volume":"41","author":"Connell","year":"1968","journal-title":"J\u00a0Allergy"},{"key":"10.1016\/j.alit.2018.05.002_bib4","first-page":"50","article-title":"Nasal hyperreactivity","volume":"37","author":"Gerth van Wijk","year":"1999","journal-title":"Rhinology"},{"key":"10.1016\/j.alit.2018.05.002_bib5","first-page":"253","article-title":"Allergic Rhinitis and its impact on asthma update (ARIA 2008). The Belgian perspective","volume":"4","author":"Bachert","year":"2008","journal-title":"B-ENT"},{"key":"10.1016\/j.alit.2018.05.002_bib6","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1016\/S0140-6736(11)60130-X","article-title":"Allergic rhinitis","volume":"378","author":"Greiner","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.alit.2018.05.002_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0146686","article-title":"Essential contribution of CD4+ T cells to antigen-induced nasal hyperresponsiveness in experimental allergic rhinitis","volume":"11","author":"Nishimura","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.alit.2018.05.002_bib8","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/j.1365-2222.2011.03847.x","article-title":"Selective down-regulation of Th2 cell-mediated airway inflammation in mice by pharmacological intervention of CCR4","volume":"42","author":"Kaminuma","year":"2012","journal-title":"Clin Exp Allergy"},{"issue":"Suppl 1","key":"10.1016\/j.alit.2018.05.002_bib9","doi-asserted-by":"crossref","first-page":"29","DOI":"10.2332\/allergolint.13-OA-0635","article-title":"Selective\u00a0suppression of Th2 cell-mediated lung eosinophilic inflammation by anti-major facilitator super family domain containing 10 monoclonal antibody","volume":"63","author":"Nishimura","year":"2014","journal-title":"Allergol Int"},{"issue":"Suppl 1","key":"10.1016\/j.alit.2018.05.002_bib10","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2332\/allergolint.13-LE-0634","article-title":"Antigen-induced mixed and separated inflammation in murine upper and lower airways","volume":"63","author":"Saeki","year":"2014","journal-title":"Allergol Int"},{"key":"10.1016\/j.alit.2018.05.002_bib11","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.4049\/jimmunol.166.3.2055","article-title":"Intervention of thymus and activation-regulated chemokine attenuates the development of allergic airway inflammation and hyperresponsiveness in mice","volume":"166","author":"Kawasaki","year":"2001","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.alit.2018.05.002_bib12","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1111\/j.1467-7652.2011.00613.x","article-title":"Prevention\u00a0of allergic asthma by vaccination with transgenic rice seed expressing mite allergen: induction of allergen-specific oral tolerance without bystander suppression","volume":"9","author":"Suzuki","year":"2011","journal-title":"Plant Biotechnol J"},{"key":"10.1016\/j.alit.2018.05.002_bib13","doi-asserted-by":"crossref","first-page":"3198","DOI":"10.1002\/eji.201141521","article-title":"CD44 is critical for airway accumulation of antigen-specific Th2, but not Th1, cells induced by antigen challenge in mice","volume":"41","author":"Katoh","year":"2011","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.alit.2018.05.002_bib14","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1164\/ajrccm.156.4.97-03017","article-title":"Comparison of murine nasal-associated lymphoid tissue and Peyer's patches","volume":"156","author":"Heritage","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.alit.2018.05.002_bib15","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1398-9995.1997.tb04819.x","article-title":"Allergic rhinitis and inflammation: the effect of nasal corticosteroid therapy","volume":"52","author":"Fokkens","year":"1997","journal-title":"Allergy"},{"key":"10.1016\/j.alit.2018.05.002_bib16","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0091-6749(97)70152-0","article-title":"Expression of IL-16 in allergen-induced late-phase nasal responses and relation to topical glucocorticosteroid treatment","volume":"100","author":"Laberge","year":"1997","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2018.05.002_bib17","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1146\/annurev.immunol.18.1.309","article-title":"Glucocorticoids in T cell development and function","volume":"18","author":"Ashwell","year":"2000","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.alit.2018.05.002_bib18","doi-asserted-by":"crossref","first-page":"5111","DOI":"10.4049\/jimmunol.161.10.5111","article-title":"Selective up-regulation of chemokine receptors CCR4 and CCR8 upon activation of polarized human type 2 Th cells","volume":"161","author":"D'Ambrosio","year":"1998","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.alit.2018.05.002_bib19","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1111\/j.1398-9995.2010.02327.x","article-title":"CC chemokine receptor 4 (CCR4) in human allergen-induced late nasal responses","volume":"65","author":"Banfield","year":"2010","journal-title":"Allergy"},{"key":"10.1016\/j.alit.2018.05.002_bib20","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1164\/ajrccm.164.5.2008132","article-title":"Effects of oral steroids on blood CXCR3+ and CCR4+ T cells in patients with bronchial asthma","volume":"164","author":"Kurashima","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.alit.2018.05.002_bib21","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1365-2249.2004.02337.x","article-title":"IgE-dependent enhancement of Th2 cell-mediated allergic inflammation in the airways","volume":"135","author":"Maezawa","year":"2004","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.alit.2018.05.002_bib22","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1111\/j.1365-2222.1994.tb02724.x","article-title":"Influence of prolonged treatment with topical corticosteroid (fluticasone propionate) on early and late phase nasal responses and cellular infiltration in the nasal mucosa after allergen challenge","volume":"24","author":"Rak","year":"1994","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.alit.2018.05.002_bib23","first-page":"192","article-title":"Topical glucocorticosteroid (fluticasone propionate) inhibits cells expressing cytokine mRNA for interleukin-4 in the nasal mucosa in allergen-induced rhinitis","volume":"82","author":"Masuyama","year":"1994","journal-title":"Immunology"},{"key":"10.1016\/j.alit.2018.05.002_bib24","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1002\/alr.21579","article-title":"Dexamethasone suppresses allergic rhinitis and amplifies CD4(+) Foxp3(+) regulatory T cells in\u00a0vitro","volume":"5","author":"Wang","year":"2015","journal-title":"Int Forum Allergy Rhinol"},{"key":"10.1016\/j.alit.2018.05.002_bib25","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1164\/ajrccm.152.2.7633694","article-title":"Effects of an antibody to interleukin-5 in a monkey model of asthma","volume":"152","author":"Mauser","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.alit.2018.05.002_bib26","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.4049\/jimmunol.181.3.2189","article-title":"IL-6 regulates neutrophil trafficking during acute inflammation via STAT3","volume":"181","author":"Fielding","year":"2008","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.alit.2018.05.002_bib27","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/0091-6749(94)90333-6","article-title":"The effects of glucocorticoids on human eosinophils","volume":"94","author":"Schleimer","year":"1994","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2018.05.002_bib28","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1136\/thx.49.3.207","article-title":"Effect of fluticasone propionate on neutrophil chemotaxis, superoxide generation, and extracellular proteolytic activity in\u00a0vitro","volume":"49","author":"Llewellyn-Jones","year":"1994","journal-title":"Thorax"},{"key":"10.1016\/j.alit.2018.05.002_bib29","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1146\/annurev.immunol.21.120601.141142","article-title":"IL-13 effector functions","volume":"21","author":"Wynn","year":"2003","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.alit.2018.05.002_bib30","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1126\/science.282.5397.2261","article-title":"Requirement for IL-13 independently of IL-4 in experimental asthma","volume":"282","author":"Grunig","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.alit.2018.05.002_bib31","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1084\/jem.187.6.939","article-title":"Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production","volume":"187","author":"Kuperman","year":"1998","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.alit.2018.05.002_bib32","doi-asserted-by":"crossref","first-page":"4668","DOI":"10.4049\/jimmunol.167.8.4668","article-title":"Critical role for IL-13 in the development of allergen-induced airway hyperreactivity","volume":"167","author":"Walter","year":"2001","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.alit.2018.05.002_bib33","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1067\/mai.2003.1451","article-title":"CysLT1 receptor upregulation by TGF-beta and IL-13 is associated with bronchial smooth muscle cell proliferation in response to LTD4","volume":"111","author":"Espinosa","year":"2003","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2018.05.002_bib34","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/S0091-6749(99)70006-0","article-title":"Montelukast, a leukotriene receptor antagonist, inhibits the late airway response to antigen, airway eosinophilia, and IL-5-expressing cells in Brown Norway rats","volume":"104","author":"Ihaku","year":"1999","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2018.05.002_bib35","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1165\/ajrcmb.16.4.9115756","article-title":"Successful transfer of late phase eosinophil infiltration in the lung by infusion of helper T cell clones","volume":"16","author":"Kaminuma","year":"1997","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.alit.2018.05.002_bib36","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1038\/sj.bjp.0701982","article-title":"Evidence that cyclosporin A and dexamethasone inhibit allergic airway eosinophilic inflammation via suppression of interleukin-5 synthesis by T cells","volume":"124","author":"Nakata","year":"1998","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.alit.2018.05.002_bib37","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1046\/j.0022-0477.2001.01248.x","article-title":"Transient contribution of mast cells to pulmonary eosinophilia but not to hyper-responsiveness","volume":"32","author":"Ogawa","year":"2002","journal-title":"Clin Exp Allergy"},{"issue":"Suppl","key":"10.1016\/j.alit.2018.05.002_bib38","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1016\/j.alit.2016.05.003","article-title":"Th9 cells elicit eosinophil-independent bronchial hyperresponsiveness in mice","volume":"65","author":"Saeki","year":"2016","journal-title":"Allergol Int"},{"key":"10.1016\/j.alit.2018.05.002_bib39","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1097\/ACI.0b013e3283630cd8","article-title":"Nonallergic rhinitis: therapeutic options","volume":"13","author":"Bernstein","year":"2013","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2018.05.002_bib40","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.jaci.2016.03.023","article-title":"Allergen endotoxins induce T-cell-dependent and non-IgE-mediated nasal hypersensitivity in mice","volume":"139","author":"Iwasaki","year":"2017","journal-title":"J\u00a0Allergy Clin Immunol"}],"container-title":["Allergology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1323893018300583?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1323893018300583?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:08:01Z","timestamp":1761156481000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1323893018300583"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":40,"alternative-id":["S1323893018300583"],"URL":"https:\/\/doi.org\/10.1016\/j.alit.2018.05.002","relation":{},"ISSN":["1323-8930"],"issn-type":[{"value":"1323-8930","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of anti-allergic drugs on T cell-mediated nasal hyperresponsiveness in a murine model of allergic rhinitis","name":"articletitle","label":"Article Title"},{"value":"Allergology International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.alit.2018.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Japanese Society of Allergology. Production and hosting by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}