{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:16:31Z","timestamp":1790356591175,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,10,2]],"date-time":"2018-10-02T00:00:00Z","timestamp":1538438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Allergology International"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.alit.2018.09.005","type":"journal-article","created":{"date-parts":[[2018,10,20]],"date-time":"2018-10-20T03:11:08Z","timestamp":1540005068000},"page":"225-232","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"title":["Reduced nasal nitric oxide levels in patients with eosinophilic chronic rhinosinusitis"],"prefix":"10.1016","volume":"68","author":[{"given":"Kanako","family":"Yoshida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuji","family":"Takabayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimasa","family":"Imoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Sakashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihiko","family":"Narita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeharu","family":"Fujieda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.alit.2018.09.005_bib1","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.3109\/02770903.2015.1054404","article-title":"Residual exhaled nitric oxide elevation in asthmatics is associated with eosinophilic chronic rhinosinusitis","volume":"52","author":"Kobayashi","year":"2015","journal-title":"J\u00a0Asthma"},{"key":"10.1016\/j.alit.2018.09.005_bib2","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1111\/all.12644","article-title":"Novel scoring system and algorithm for classifying chronic rhinosinusitis: the JESREC Study","volume":"70","author":"Tokunaga","year":"2015","journal-title":"Allergy Eur J Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2018.09.005_bib3","doi-asserted-by":"crossref","first-page":"247","DOI":"10.2332\/allergolint.10-RAI-0202","article-title":"Pathological mechanisms and clinical features of eosinophilic chronic rhinosinusitis in the Japanese population","volume":"59","author":"Takeno","year":"2010","journal-title":"Allergol Int"},{"key":"10.1016\/j.alit.2018.09.005_bib4","first-page":"1","article-title":"Pathogenesis of eosinophilic chronic rhinosinusitis","volume":"13","author":"Shah","year":"2016","journal-title":"J\u00a0Inflamm"},{"key":"10.1016\/j.alit.2018.09.005_bib5","doi-asserted-by":"crossref","first-page":"239","DOI":"10.2332\/allergolint.10-RAI-0231","article-title":"Eosinophilic chronic rhinosinusitis in Japan","volume":"59","author":"Ishitoya","year":"2010","journal-title":"Allergol Int"},{"key":"10.1016\/j.alit.2018.09.005_bib6","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.jaci.2004.05.033","article-title":"Exhaled nitric oxide as a marker of airway inflammation for an epidemiologic study in schoolchildren","volume":"114","author":"Saito","year":"2004","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2018.09.005_bib7","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1164\/rccm.200907-1079OC","article-title":"Increased fraction of exhaled nitric oxide predicts new-onset wheeze in a general population","volume":"181","author":"Olin","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.alit.2018.09.005_bib8","first-page":"623","article-title":"Fraction of exhaled nitric oxide measurements in the diagnoses of asthma in elderly patients","volume":"11","author":"Godinho Netto","year":"2016","journal-title":"Clin Interv Aging"},{"key":"10.1016\/j.alit.2018.09.005_bib9","doi-asserted-by":"crossref","first-page":"992","DOI":"10.21037\/jtd.2016.03.72","article-title":"Importance of fractional exhaled nitric oxide in diagnosis of bronchiectasis accompanied with bronchial asthma","volume":"8","author":"Chen","year":"2016","journal-title":"J\u00a0Thorac Dis"},{"key":"10.1016\/j.alit.2018.09.005_bib10","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s00011-006-6111-1","article-title":"Review Nitric oxide in upper airways inflammatory diseases","volume":"56","author":"Maniscalco","year":"2007","journal-title":"Inflamm Res"},{"key":"10.1016\/j.alit.2018.09.005_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0046618","article-title":"L-ornithine derived polyamines in cystic fibrosis airways","volume":"7","author":"Grasemann","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.alit.2018.09.005_bib12","doi-asserted-by":"crossref","first-page":"e79141","DOI":"10.1371\/journal.pone.0079141","article-title":"Reduced nasal nitric oxide production in cystic fibrosis patients with elevated systemic inflammation markers","volume":"8","author":"Michl","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.alit.2018.09.005_bib13","doi-asserted-by":"crossref","first-page":"728","DOI":"10.3109\/00016489709113468","article-title":"Low levels of nasal nitric oxide (NO) correlate to impaired mucociliary function in the upper airways","volume":"117","author":"Lindberg","year":"1997","journal-title":"Acta Otolaryngol"},{"key":"10.1016\/j.alit.2018.09.005_bib14","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1136\/thx.54.10.947","article-title":"Nasal nitric oxide in man","volume":"54","author":"Lundberg","year":"1999","journal-title":"Thorax"},{"key":"10.1016\/j.alit.2018.09.005_bib15","doi-asserted-by":"crossref","first-page":"118","DOI":"10.2500\/ar.2017.8.0208","article-title":"Evaluation of a new and simple classification for endoscopic sinus surgery","volume":"8","author":"Kanai","year":"2017","journal-title":"Allergy Rhinol (Providence)"},{"key":"10.1016\/j.alit.2018.09.005_bib16","first-page":"183","article-title":"Staging in rhinosinusitus","volume":"31","author":"Lund","year":"1993","journal-title":"Rhinology"},{"key":"10.1016\/j.alit.2018.09.005_bib17","first-page":"184","article-title":"Lund-mackay staging system in cystic fibrosis: a prognostic factor for revision surgery?","volume":"14","author":"Carter","year":"2014","journal-title":"Ochsner J"},{"key":"10.1016\/j.alit.2018.09.005_bib18","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1001\/jama.2015.19330","article-title":"Effect of subcutaneous dupilumab on nasal polyp burden in patients with chronic sinusitis and nasal polyposis: a randomized clinical trial","volume":"315","author":"Bachert","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.alit.2018.09.005_bib19","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jaci.2012.07.047","article-title":"Omalizumab is effective in allergic and nonallergic patients with nasal polyps and asthma","volume":"131","author":"Gevaert","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2018.09.005_bib20","first-page":"2104","article-title":"Recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide in adults and children-1999","volume":"160","author":"Silkoff","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.alit.2018.09.005_bib21","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.2500\/aap.2012.33.3509","article-title":"Efficacy of mometasone furoate nasal spray for nasal symptoms, quality of life, rhinitis-disturbed sleep, and nasal nitric oxide in patients with perennial allergic rhinitis","volume":"33","author":"Yamada","year":"2012","journal-title":"Allergy Asthma Proc"},{"key":"10.1016\/j.alit.2018.09.005_bib22","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.anl.2016.09.007","article-title":"The role of nasal fractional exhaled nitric oxide as an objective parameter independent of nasal airflow resistance in the diagnosis of allergic rhinitis","volume":"44","author":"Takeno","year":"2017","journal-title":"Auris Nasus Larynx"},{"key":"10.1016\/j.alit.2018.09.005_bib23","first-page":"327","article-title":"[Rhinomanometry guidelines]","volume":"40","author":"Naito","year":"2001","journal-title":"[Japanese J Rhinol]"},{"key":"10.1016\/j.alit.2018.09.005_bib24","article-title":"Exhaled and nasal nitric oxide in relation to lung function, blood cell counts and disease characteristics in cystic fibrosis","volume":"11","author":"Krantz","year":"2017","journal-title":"J\u00a0Breath Res"},{"key":"10.1016\/j.alit.2018.09.005_bib25","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1034\/j.1399-3003.1999.13b15.x","article-title":"Nasal nitric oxide concentration in paranasal sinus inflammatory diseases","volume":"13","author":"Arnal","year":"1999","journal-title":"Eur Respir J"},{"key":"10.1016\/j.alit.2018.09.005_bib26","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1164\/rccm.201207-1292OC","article-title":"Excessive fibrin deposition in nasal polyps caused by fibrinolytic impairment through reduction of tissue plasminogen activator expression","volume":"187","author":"Takabayashi","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.alit.2018.09.005_bib27","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.neuropharm.2011.10.020","article-title":"tPA in the injured central nervous system: different scenarios starring the same actor?","volume":"62","author":"Lemarchant","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.alit.2018.09.005_bib28","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.tins.2008.09.006","article-title":"Tissue-type plasminogen activator in the ischemic brain: more than a thrombolytic","volume":"32","author":"Yepes","year":"2009","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.alit.2018.09.005_bib29","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.anl.2013.02.001","article-title":"Increased exhaled nitric oxide and its oxidation metabolism in eosinophilic chronic rhinosinusitis","volume":"40","author":"Takeno","year":"2013","journal-title":"Auris Nasus Larynx"},{"key":"10.1016\/j.alit.2018.09.005_bib30","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1016\/j.jaci.2007.07.067","article-title":"Signal transduction and oxidative processes in sinonasal polyposis","volume":"120","author":"Cannady","year":"2007","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2018.09.005_bib31","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1749-6632.2001.tb03522.x","article-title":"Fibrin and wound healing","volume":"936","author":"Clark","year":"2001","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.alit.2018.09.005_bib32","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1177\/194589240301700504","article-title":"Nitric oxide and collagen expression in allergic upper-airway disease","volume":"17","author":"Tewfik","year":"2003","journal-title":"Am J Rhinol"},{"key":"10.1016\/j.alit.2018.09.005_bib33","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.jaci.2009.04.013","article-title":"TGF-beta signaling and collagen deposition in chronic rhinosinusitis","volume":"124","author":"Van Bruaene","year":"2009","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2018.09.005_bib34","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.jaci.2012.02.046","article-title":"Glandular mast cells with distinct phenotype are highly elevated in chronic rhinosinusitis with nasal polyps","volume":"130","author":"Takabayashi","year":"2012","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2018.09.005_bib35","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/ni1158","article-title":"Mast cells in the development of adaptive immune responses","volume":"6","author":"Galli","year":"2005","journal-title":"Nat Immunol"},{"key":"10.1016\/j.alit.2018.09.005_bib36","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1111\/j.1365-2222.2007.02838.x","article-title":"Local immunoglobulin production in nasal polyposis is modulated by superantigens","volume":"37","author":"Van Zele","year":"2007","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.alit.2018.09.005_bib37","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1159\/000155739","article-title":"Anti-IgE for the treatment of allergic rhinitis - and eventually nasal polyps?","volume":"148","author":"Verbruggen","year":"2009","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.alit.2018.09.005_bib38","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1378\/chest.07-2541","article-title":"Exhaled nitric oxide measurement is useful for the exclusion of nonasthmatic eosinophilic bronchitis in patients with chronic cough","volume":"134","author":"Oh","year":"2008","journal-title":"Chest"},{"key":"10.1016\/j.alit.2018.09.005_bib39","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1067\/mai.2000.109622","article-title":"A\u00a0comparison of exhaled nitric oxide and induced sputum as markers of airway inflammation","volume":"106","author":"Berlyne","year":"2000","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2018.09.005_bib40","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1164\/ajrccm.164.8.2101145","article-title":"Relationship between exhaled nitric oxide and mucosal eosinophilic inflammation in children with difficult asthma, after treatment with oral prednisolone","volume":"164","author":"Payne","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.alit.2018.09.005_bib41","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1136\/thorax.57.5.383","article-title":"Exhaled nitric oxide correlates with airway eosinophils in childhood asthma","volume":"57","author":"Warke","year":"2002","journal-title":"Thorax"},{"key":"10.1016\/j.alit.2018.09.005_bib42","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1111\/j.1365-2222.2008.02959.x","article-title":"Heterogeneous response of nasal and lung fibroblasts to transforming growth factor-beta1","volume":"38","author":"Nonaka","year":"2008","journal-title":"Clin Exp Allergy"}],"container-title":["Allergology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1323893018301412?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1323893018301412?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:09:24Z","timestamp":1761156564000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1323893018301412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["S1323893018301412"],"URL":"https:\/\/doi.org\/10.1016\/j.alit.2018.09.005","relation":{},"ISSN":["1323-8930"],"issn-type":[{"value":"1323-8930","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reduced nasal nitric oxide levels in patients with eosinophilic chronic rhinosinusitis","name":"articletitle","label":"Article Title"},{"value":"Allergology International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.alit.2018.09.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Japanese Society of Allergology. Production and hosting by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}