{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T03:28:28Z","timestamp":1782185308567,"version":"3.54.5"},"reference-count":39,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T00:00:00Z","timestamp":1554940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014423","name":"Environmental Restoration and Conservation Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014423","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Allergology International"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.alit.2019.03.008","type":"journal-article","created":{"date-parts":[[2019,4,26]],"date-time":"2019-04-26T23:38:06Z","timestamp":1556321886000},"page":"440-449","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Regional differences in the prevalence of sensitization to environmental allergens: Analysis on IgE antibody testing conducted at major clinical testing laboratories throughout Japan from 2002 to 2011"],"prefix":"10.1016","volume":"68","author":[{"given":"Takafumi","family":"Minami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9913-4524","authenticated-orcid":false,"given":"Yuma","family":"Fukutomi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reiko","family":"Inada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Tsuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Sekiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Miyazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumio","family":"Tsuji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masami","family":"Taniguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.alit.2019.03.008_bib1","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/S0091-6749(97)70292-6","article-title":"Indoor allergens and asthma: report of the third international workshop","volume":"100","author":"Platts-Mills","year":"1997","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2019.03.008_bib2","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/all.13072","article-title":"Allergy in severe asthma","volume":"72","author":"Del Giacco","year":"2017","journal-title":"Allergy"},{"key":"10.1016\/j.alit.2019.03.008_bib3","unstructured":"Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention 2018. Available from: https:\/\/ginasthma.org\/2018-gina-report-global-strategy-for-asthma-management-and-prevention\/."},{"key":"10.1016\/j.alit.2019.03.008_bib4","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.jaci.2010.06.047","article-title":"Allergic rhinitis and its impact on asthma (ARIA) guidelines: 2010 revision","volume":"126","author":"Brozek","year":"2010","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2019.03.008_bib5","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.alit.2016.11.003","article-title":"Japanese guidelines for childhood asthma 2017","volume":"66","author":"Arakawa","year":"2017","journal-title":"Allergol Int"},{"key":"10.1016\/j.alit.2019.03.008_bib6","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.alit.2016.12.005","article-title":"Japanese guidelines for adult asthma 2017","volume":"66","author":"Ichinose","year":"2017","journal-title":"Allergol Int"},{"key":"10.1016\/j.alit.2019.03.008_bib7","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.alit.2016.11.001","article-title":"Japanese guidelines for allergic rhinitis 2017","volume":"66","author":"Okubo","year":"2017","journal-title":"Allergol Int"},{"key":"10.1016\/j.alit.2019.03.008_bib8","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1111\/j.1398-9995.2009.02093.x","article-title":"GA(2)LEN skin test study I: GA(2)LEN harmonization of skin prick testing: novel sensitization patterns for inhalant allergens in Europe","volume":"64","author":"Heinzerling","year":"2009","journal-title":"Allergy"},{"key":"10.1016\/j.alit.2019.03.008_bib9","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1111\/j.1398-9995.2009.02089.x","article-title":"GA(2)LEN skin test study II: clinical relevance of inhalant allergen sensitizations in Europe","volume":"64","author":"Burbach","year":"2009","journal-title":"Allergy"},{"key":"10.1016\/j.alit.2019.03.008_bib10","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1080\/01621459.1963.10500845","article-title":"Hierarchical grouping to optimize an objective function","volume":"58","author":"Ward","year":"1963","journal-title":"J\u00a0Am Stat Assoc"},{"key":"10.1016\/j.alit.2019.03.008_bib11","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1111\/j.1398-9995.2005.00824.x","article-title":"Dog factor differences in Can f 1 allergen production","volume":"60","author":"Ramadour","year":"2005","journal-title":"Allergy"},{"key":"10.1016\/j.alit.2019.03.008_bib12","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1080\/15287390801985513","article-title":"Environmental exposure to allergens of different dog breeds and relevance in allergological diagnostics","volume":"71","author":"Heutelbeck","year":"2008","journal-title":"J\u00a0Toxicol Environ Health A"},{"key":"10.1016\/j.alit.2019.03.008_bib13","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/S0091-6749(99)70072-2","article-title":"Role of current and childhood exposure to cat and atopic sensitization. European Community Respiratory Health Survey","volume":"104","author":"Roost","year":"1999","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2019.03.008_bib14","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/0091-6749(91)90388-5","article-title":"Homology of the major birch-pollen allergen, Bet v I, with the major pollen allergens of alder, hazel, and hornbeam at the nucleic acid level as determined by cross-hybridization","volume":"87","author":"Valenta","year":"1991","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2019.03.008_bib15","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S0091-6749(98)70273-8","article-title":"Recombinant birch pollen allergens (rBet v 1 and rBet v 2) contain most of the IgE epitopes present in birch, alder, hornbeam, hazel, and oak pollen: a quantitative IgE inhibition study with sera from different populations","volume":"102","author":"Niederberger","year":"1998","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2019.03.008_bib16","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1046\/j.1365-2222.2003.01773.x","article-title":"Fagales pollen sensitization in a birch-free area: a respiratory cohort survey using Fagales pollen extracts and birch recombinant allergens (rBet v 1, rBet v 2, rBet v 4)","volume":"33","author":"Mari","year":"2003","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.alit.2019.03.008_bib17","doi-asserted-by":"crossref","first-page":"79","DOI":"10.2332\/allergolint.O-07-496","article-title":"Correlations between alder specific IgE and alder-related tree pollen specific IgE by RAST method","volume":"57","author":"Maeda","year":"2008","journal-title":"Allergol Int"},{"key":"10.1016\/j.alit.2019.03.008_bib18","first-page":"97","article-title":"Longitudinal monitoring of tree airborne pollen in Japan","volume":"66","author":"Kishikawa","year":"2017","journal-title":"Arerugi"},{"key":"10.1016\/j.alit.2019.03.008_bib19","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/0091-6749(87)90233-8","volume":"79","author":"Kino","year":"1987","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2019.03.008_bib20","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1398-9995.1995.tb02479.x","article-title":"Causative allergens of allergic rhinitis in Japan with special reference to silkworm moth allergen","volume":"50","author":"Suzuki","year":"1995","journal-title":"Allergy"},{"key":"10.1016\/j.alit.2019.03.008_bib21","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1398-9995.1997.tb02548.x","article-title":"IgE antibodies against midge and moth found in Japanese asthmatic subjects and comparison of allergenicity between these insects","volume":"52","author":"Komase","year":"1997","journal-title":"Allergy"},{"key":"10.1016\/j.alit.2019.03.008_bib22","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.jaci.2003.11.023","article-title":"Alternaria-induced asthma","volume":"113","author":"Bush","year":"2004","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2019.03.008_bib23","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1111\/j.1398-9995.2004.00423.x","article-title":"Alternaria spores at different heights from the ground","volume":"59","author":"Bergamini","year":"2004","journal-title":"Allergy"},{"key":"10.1016\/j.alit.2019.03.008_bib24","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1067\/mai.2002.130179","article-title":"Allergic bronchopulmonary aspergillosis","volume":"110","author":"Greenberger","year":"2002","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2019.03.008_bib25","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1513\/pats.200909-098AL","article-title":"Allergic fungal rhinitis and rhinosinusitis","volume":"7","author":"Hamilos","year":"2010","journal-title":"Proc Am Thorac Soc"},{"key":"10.1016\/j.alit.2019.03.008_bib26","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1164\/rccm.201001-0087OC","article-title":"IgE sensitization to Aspergillus fumigatus is associated with reduced lung function in asthma","volume":"182","author":"Fairs","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.alit.2019.03.008_bib27","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1111\/j.1398-9995.2010.02542.x","article-title":"Aspergillus sensitization is associated with airflow limitation and bronchiectasis in severe asthma","volume":"66","author":"Menzies","year":"2011","journal-title":"Allergy"},{"key":"10.1016\/j.alit.2019.03.008_bib28","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1111\/j.1365-2222.2012.03987.x","article-title":"Isolation of filamentous fungi from sputum in asthma is associated with reduced post-bronchodilator FEV1","volume":"42","author":"Agbetile","year":"2012","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.alit.2019.03.008_bib29","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1183\/09031936.06.00074705","article-title":"The link between fungi and severe asthma: a summary of the evidence","volume":"27","author":"Denning","year":"2006","journal-title":"Eur Respir J"},{"key":"10.1016\/j.alit.2019.03.008_bib30","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/j.1398-9995.1993.tb00736.x","article-title":"Allergens of Pityrosporum ovale and Candida albicans. I. Cross-reactivity of IgE-binding components","volume":"48","author":"Doekes","year":"1993","journal-title":"Allergy"},{"key":"10.1016\/j.alit.2019.03.008_bib31","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1398-9995.1993.tb00737.x","article-title":"Allergens of Pityrosporum ovale and Candida albicans. II. Physicochemical characterization","volume":"48","author":"Doekes","year":"1993","journal-title":"Allergy"},{"key":"10.1016\/j.alit.2019.03.008_bib32","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1006\/bbrc.1998.8944","article-title":"Identification and cloning of two novel allergens from the lipophilic yeast, Malassezia furfur","volume":"248","author":"Yasueda","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.alit.2019.03.008_bib33","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1159\/000063862","article-title":"Immunological and structural analysis of IgE-mediated cross-reactivity between manganese superoxide dismutases","volume":"128","author":"Fluckiger","year":"2002","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.alit.2019.03.008_bib34","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1159\/000234724","article-title":"Comparative analysis of physicochemical and immunochemical properties of the two major allergens from Dermatophagoides pteronyssinus and the corresponding allergens from Dermatophagoides farinae","volume":"88","author":"Yasueda","year":"1989","journal-title":"Int Arch Allergy Appl Immunol"},{"key":"10.1016\/j.alit.2019.03.008_bib35","first-page":"26","article-title":"Cross-reactivity between the pollens of Cupressus sempervirens (common cypress) and of Cryptomeria japonica (Japanese cedar)","volume":"57","author":"Panzani","year":"1986","journal-title":"Ann Allergy"},{"key":"10.1016\/j.alit.2019.03.008_bib36","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0091-6749(76)90148-2","article-title":"The cross-reactivity of IgE antibodies with pollen allergens. I. Analyses of various species of grass pollens","volume":"58","author":"Leiferman","year":"1976","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2019.03.008_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2012.01.031","article-title":"Clinical relevance of IgE to recombinant Gly m 4 in the diagnosis of adult soybean allergy","volume":"129","author":"Fukutomi","year":"2012","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2019.03.008_bib38","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.alit.2014.08.004","article-title":"IgE Abs to Der p 1 and Der p 2 as diagnostic markers of house dust mite allergy as defined by a bronchoprovocation test","volume":"64","author":"Minami","year":"2015","journal-title":"Allergol Int"},{"key":"10.1016\/j.alit.2019.03.008_bib39","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1111\/cea.12590","article-title":"Molecular-based allergy diagnosis of allergic bronchopulmonary aspergillosis in Aspergillus fumigatus-sensitized Japanese patients","volume":"45","author":"Tanimoto","year":"2015","journal-title":"Clin Exp Allergy"}],"container-title":["Allergology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1323893019300528?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1323893019300528?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:09:41Z","timestamp":1761156581000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1323893019300528"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["S1323893019300528"],"URL":"https:\/\/doi.org\/10.1016\/j.alit.2019.03.008","relation":{},"ISSN":["1323-8930"],"issn-type":[{"value":"1323-8930","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Regional differences in the prevalence of sensitization to environmental allergens: Analysis on IgE antibody testing conducted at major clinical testing laboratories throughout Japan from 2002 to 2011","name":"articletitle","label":"Article Title"},{"value":"Allergology International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.alit.2019.03.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Japanese Society of Allergology. Production and hosting by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}