{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T15:50:24Z","timestamp":1777132224636,"version":"3.51.4"},"reference-count":27,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T00:00:00Z","timestamp":1558396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012000","name":"All Japan Coffee Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012351","name":"Mitsubishi Tanabe Pharma Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012351","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Allergology International"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.alit.2019.05.002","type":"journal-article","created":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T16:33:43Z","timestamp":1561653223000},"page":"494-505","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Treatment duration-dependent efficacy of Japanese cedar pollen sublingual immunotherapy: Evaluation of a phase II\/III trial over three pollen dispersal seasons"],"prefix":"10.1016","volume":"68","author":[{"given":"Syuji","family":"Yonekura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Gotoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keishi","family":"Kanazawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshie","family":"Takeuji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimihiro","family":"Okubo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitaka","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.alit.2019.05.002_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2013.11.002","article-title":"Present state of Japanese cedar pollinosis: the national affliction","volume":"133","author":"Yamada","year":"2014","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2019.05.002_bib2","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/S1081-1206(10)63532-6","article-title":"Epidemiology of Japanese cedar pollinosis throughout Japan","volume":"91","author":"Okuda","year":"2003","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.alit.2019.05.002_bib3","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1159\/000084256","article-title":"Increasing prevalence of Japanese cedar pollinosis: a meta-regression analysis","volume":"136","author":"Kaneko","year":"2005","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.alit.2019.05.002_bib4","doi-asserted-by":"crossref","first-page":"155","DOI":"10.2332\/allergolint.08-RAI-0074","article-title":"Present situation of cedar pollinosis in Japan and its immune responses","volume":"58","author":"Okamoto","year":"2009","journal-title":"Allergol Int"},{"key":"10.1016\/j.alit.2019.05.002_bib5","doi-asserted-by":"crossref","first-page":"181","DOI":"10.2332\/allergolint.12-OA-0498","article-title":"Severity assessment of Japanese cedar pollinosis using the practical guideline for the management of allergic rhinitis in Japan and the allergic rhinitis and its impact on asthma guideline","volume":"62","author":"Gotoh","year":"2013","journal-title":"Allergol Int"},{"issue":"Suppl 44","key":"10.1016\/j.alit.2019.05.002_bib6","first-page":"1","article-title":"Allergen immunotherapy: therapeutic vaccines for allergic diseases. Geneva: January 27-29 1997","volume":"53","year":"1998","journal-title":"Allergy"},{"issue":"Suppl 86","key":"10.1016\/j.alit.2019.05.002_bib7","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1398-9995.2007.01620.x","article-title":"Allergic rhinitis and its impact on asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen)","volume":"63","author":"Bousquet","year":"2008","journal-title":"Allergy"},{"key":"10.1016\/j.alit.2019.05.002_bib8","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1111\/j.1398-9995.2007.01451.x","article-title":"Specific immunotherapy has long-term preventive effect of seasonal and perennial asthma: 10-year follow-up on the PAT study","volume":"62","author":"Jacobsen","year":"2007","journal-title":"Allergy"},{"key":"10.1016\/j.alit.2019.05.002_bib9","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/S1081-1206(10)60211-6","article-title":"Preventive effects of sublingual immunotherapy in childhood: an open randomized controlled study","volume":"101","author":"Marogna","year":"2008","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.alit.2019.05.002_bib10","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.jaci.2010.08.030","article-title":"Long-lasting effects of sublingual immunotherapy according to its duration: a 15-year prospective study","volume":"126","author":"Marogna","year":"2010","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2019.05.002_bib11","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.jaci.2017.06.014","article-title":"Results from the 5-year SQ grass sublingual immunotherapy tablet asthma prevention (GAP) trial in children with grass pollen allergy","volume":"141","author":"Valovirta","year":"2018","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2019.05.002_bib12","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13601-015-0057-8","article-title":"Prolonged efficacy of the 300IR 5-grass pollen tablet up to 2 years after treatment cessation, as measured by a recommended daily combined score","volume":"5","author":"Didier","year":"2015","journal-title":"Clin Transl Allergy"},{"key":"10.1016\/j.alit.2019.05.002_bib13","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.alit.2016.11.001","article-title":"Japanese guidelines for allergic rhinitis 2017","volume":"66","author":"Okubo","year":"2017","journal-title":"Allergol Int"},{"key":"10.1016\/j.alit.2019.05.002_bib14","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1159\/000381059","article-title":"Efficacy and safety of sublingual immunotherapy for two seasons in patients with Japanese cedar pollinosis","volume":"166","author":"Okamoto","year":"2015","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.alit.2019.05.002_bib15","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1159\/000112506","article-title":"A\u00a0randomized controlled trial of sublingual immunotherapy for Japanese cedar pollinosis","volume":"146","author":"Horiguchi","year":"2008","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.alit.2019.05.002_bib16","doi-asserted-by":"crossref","first-page":"265","DOI":"10.2332\/allergolint.O-07-514","article-title":"A\u00a0randomized double-blind comparative study of sublingual immunotherapy for cedar pollinosis","volume":"57","author":"Okubo","year":"2008","journal-title":"Allergol Int"},{"key":"10.1016\/j.alit.2019.05.002_bib17","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.clim.2010.12.022","article-title":"Increase of regulatory T cells and the ratio of specific IgE to total IgE are candidates for response monitoring or prognostic biomarkers in 2-year sublingual immunotherapy (SLIT) for Japanese cedar pollinosis","volume":"139","author":"Fujimura","year":"2011","journal-title":"Clin Immunol"},{"key":"10.1016\/j.alit.2019.05.002_bib18","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1159\/000444016","article-title":"Fractionation of source materials leads to a high reproducibility of the SQ house dust mite SLIT-tablets","volume":"169","author":"Henmar","year":"2016","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.alit.2019.05.002_bib19","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1159\/000479693","article-title":"Bioavailability of house dust mite allergens in sublingual allergy tablets is highly dependent on the formulation","volume":"174","author":"Ohashi-Doi","year":"2017","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.alit.2019.05.002_bib20","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1016\/j.jaci.2016.09.043","article-title":"Efficacy and safety of the SQ house dust mite sublingual immunotherapy tablet in Japanese adults and adolescents with house dust mite-induced allergic rhinitis","volume":"139","author":"Okubo","year":"2017","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2019.05.002_bib21","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.jaci.2015.06.036","article-title":"Effective treatment of house dust mite-induced allergic rhinitis with 2 doses of the SQ HDM SLIT-tablet: results from a randomized, double-blind, placebo-controlled phase III trial","volume":"137","author":"Demoly","year":"2016","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2019.05.002_bib22","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1016\/j.jaci.2016.06.044","article-title":"Efficacy of house dust mite sublingual immunotherapy tablet in North American adolescents and adults in a randomized, placebo-controlled trial","volume":"138","author":"Nolte","year":"2016","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2019.05.002_bib23","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.1111\/all.13544","article-title":"Efficacy and safety of SQ house dust mite sublingual immunotherapy-tablet in Japanese children","volume":"73","author":"Masuyama","year":"2018","journal-title":"Allergy"},{"key":"10.1016\/j.alit.2019.05.002_bib24","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.jaip.2018.11.044","article-title":"Long-term efficacy and dose-finding trial of Japanese cedar pollen sublingual immunotherapy tablet","volume":"7","author":"Gotoh","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.alit.2019.05.002_bib25","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.jaci.2011.12.973","article-title":"SQ-standardized sublingual grass immunotherapy: confirmation of disease modification 2 years after 3 years of treatment in a randomized trial","volume":"129","author":"Durham","year":"2012","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2019.05.002_bib26","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1080\/00016480510026944","article-title":"Comparative study of two Japanese rhinoconjunctivitis quality-of-life questionnaires","volume":"125","author":"Okuda","year":"2005","journal-title":"Acta Otolaryngol"},{"key":"10.1016\/j.alit.2019.05.002_bib27","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.jaip.2016.11.009","article-title":"World allergy organization systemic allergic reaction grading system: is a modification needed?","volume":"5","author":"Cox","year":"2017","journal-title":"J\u00a0Allergy Clin Immunol Pract"}],"container-title":["Allergology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1323893019300620?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1323893019300620?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:09:09Z","timestamp":1761156549000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1323893019300620"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["S1323893019300620"],"URL":"https:\/\/doi.org\/10.1016\/j.alit.2019.05.002","relation":{},"ISSN":["1323-8930"],"issn-type":[{"value":"1323-8930","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Treatment duration-dependent efficacy of Japanese cedar pollen sublingual immunotherapy: Evaluation of a phase II\/III trial over three pollen dispersal seasons","name":"articletitle","label":"Article Title"},{"value":"Allergology International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.alit.2019.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Japanese Society of Allergology. Production and hosting by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}