{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:46:26Z","timestamp":1792525586277,"version":"4.5.0"},"reference-count":99,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T00:00:00Z","timestamp":1604448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Allergology International"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.alit.2020.11.001","type":"journal-article","created":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T02:31:13Z","timestamp":1606185073000},"page":"9-18","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":86,"title":["The multiple functions and subpopulations of eosinophils in tissues under steady-state and pathological conditions"],"prefix":"10.1016","volume":"70","author":[{"given":"Akira","family":"Kanda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasutaka","family":"Yun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan Van","family":"Bui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linh Manh","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensuke","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akitoshi","family":"Mitani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Sawada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoko","family":"Hamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikiya","family":"Asako","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Iwai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.alit.2020.11.001_bib1","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/cea.12480","article-title":"The early history of the eosinophil","volume":"45","author":"Kay","year":"2015","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.alit.2020.11.001_bib2","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1248\/bpb.b19-00892","article-title":"Multiple biological aspects of eosinophils in host defense, eosinophil-associated diseases, immunoregulation, and homeostasis: is their role beneficial, detrimental, regulator, or bystander?","volume":"43","author":"Kanda","year":"2020","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.alit.2020.11.001_bib3","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0065-2776(08)01003-1","article-title":"Biology of the eosinophil","volume":"101","author":"Blanchard","year":"2009","journal-title":"Adv Immunol"},{"key":"10.1016\/j.alit.2020.11.001_bib4","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nri3341","article-title":"Eosinophils: changing perspectives in health and disease","volume":"13","author":"Rosenberg","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.alit.2020.11.001_bib5","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1146\/annurev.immunol.24.021605.090720","article-title":"The eosinophil","volume":"24","author":"Rothenberg","year":"2006","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.alit.2020.11.001_bib6","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3389\/fmed.2017.00115","article-title":"Transcription factors in eosinophil development and as therapeutic targets","volume":"4","author":"Fulkerson","year":"2017","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.alit.2020.11.001_bib7","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3389\/fphar.2013.00033","article-title":"Integrin activation States and eosinophil recruitment in asthma","volume":"4","author":"Johansson","year":"2013","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.alit.2020.11.001_bib8","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1007\/s12016-015-8525-4","article-title":"The eosinophil in infection","volume":"50","author":"Ravin","year":"2016","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.alit.2020.11.001_bib9","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/s41385-020-0281-y","article-title":"The emerging roles of eosinophils in mucosal homeostasis","volume":"13","author":"Shah","year":"2020","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.alit.2020.11.001_bib10","first-page":"117","article-title":"Hypodense eosinophils: characterization of surface molecule expression","volume":"23","author":"Conesa","year":"2002","journal-title":"Allergy Asthma Proc"},{"key":"10.1016\/j.alit.2020.11.001_bib11","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1159\/000234893","article-title":"Heterogeneity of human peripheral blood eosinophils: variability in cell density and cytotoxic ability in relation to the level and the origin of hypereosinophilia","volume":"72","author":"Prin","year":"1983","journal-title":"Int Arch Allergy Appl Immunol"},{"key":"10.1016\/j.alit.2020.11.001_bib12","doi-asserted-by":"crossref","first-page":"3279","DOI":"10.1172\/JCI85664","article-title":"Lung-resident eosinophils represent a distinct regulatory eosinophil subset","volume":"126","author":"Mesnil","year":"2016","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.alit.2020.11.001_bib13","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1038\/nri.2017.95","article-title":"Functions of tissue-resident eosinophils","volume":"17","author":"Weller","year":"2017","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.alit.2020.11.001_bib14","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1189\/jlb.3CE0415-178RR","article-title":"Editorial: \"Crowning\" eosinophils in adipose tissue: does location matter?","volume":"98","author":"Goldberg","year":"2015","journal-title":"J\u00a0Leukoc Biol"},{"key":"10.1016\/j.alit.2020.11.001_bib15","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1126\/science.1201475","article-title":"Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis","volume":"332","author":"Wu","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.alit.2020.11.001_bib16","doi-asserted-by":"crossref","first-page":"4515","DOI":"10.1210\/endo.142.10.8459","article-title":"Eotaxin is required for eosinophil homing into the stroma of the pubertal and cycling uterus","volume":"142","author":"Gouon-Evans","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.alit.2020.11.001_bib17","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/BF01008072","article-title":"Estimation of kinetic parameters of neutrophilic, eosinophilic, and basophilic granulocytes in human blood","volume":"39","author":"Steinbach","year":"1979","journal-title":"Blut"},{"key":"10.1016\/j.alit.2020.11.001_bib18","doi-asserted-by":"crossref","first-page":"87","DOI":"10.4168\/aair.2010.2.2.87","article-title":"Eosinophil survival and apoptosis in health and disease","volume":"2","author":"Park","year":"2010","journal-title":"Allergy Asthma Immunol Res"},{"key":"10.1016\/j.alit.2020.11.001_bib19","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/JLB.3MR0120-390R","article-title":"Eosinophils in wound healing and epithelial remodeling: is coagulation a missing link?","volume":"108","author":"Coden","year":"2020","journal-title":"J\u00a0Leukoc Biol"},{"key":"10.1016\/j.alit.2020.11.001_bib20","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3389\/fmed.2017.00101","article-title":"Homeostatic eosinophils: characteristics and functions","volume":"4","author":"Marichal","year":"2017","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.alit.2020.11.001_bib21","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.cell.2014.05.025","article-title":"Eosinophils in fat: pink is the new brown","volume":"157","author":"Lee","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.alit.2020.11.001_bib22","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1084\/jem.20121964","article-title":"Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages","volume":"210","author":"Molofsky","year":"2013","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.alit.2020.11.001_bib23","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1146\/annurev.immunol.021908.132532","article-title":"Alternative activation of macrophages: an immunologic functional perspective","volume":"27","author":"Martinez","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.alit.2020.11.001_bib24","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1189\/jlb.3HI0115-018R","article-title":"CCR2 deficiency leads to increased eosinophils, alternative macrophage activation, and type 2 cytokine expression in adipose tissue","volume":"98","author":"Bolus","year":"2015","journal-title":"J\u00a0Leukoc Biol"},{"key":"10.1016\/j.alit.2020.11.001_bib25","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/j.jaci.2018.02.004","article-title":"Obesity and asthma","volume":"141","author":"Peters","year":"2018","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2020.11.001_bib26","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/nri3830","article-title":"The impact of diet on asthma and allergic diseases","volume":"15","author":"Julia","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.alit.2020.11.001_bib27","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1164\/rccm.201208-1470OC","article-title":"Elevated sputum interleukin-5 and submucosal eosinophilia in obese individuals with severe asthma","volume":"188","author":"Desai","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.alit.2020.11.001_bib28","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.2215\/CJN.03330509","article-title":"Eosinophil count is positively correlated with albumin excretion rate in men with type 2 diabetes","volume":"4","author":"Fukui","year":"2009","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.alit.2020.11.001_bib29","doi-asserted-by":"crossref","first-page":"e67613","DOI":"10.1371\/journal.pone.0067613","article-title":"Eosinophil inversely associates with type 2 diabetes and insulin resistance in Chinese adults","volume":"8","author":"Zhu","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.alit.2020.11.001_bib30","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1016\/j.celrep.2017.01.071","article-title":"First-breath-induced type 2 pathways shape the lung immune environment","volume":"18","author":"Saluzzo","year":"2017","journal-title":"Cell Rep"},{"key":"10.1016\/j.alit.2020.11.001_bib31","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/j.immuni.2016.10.031","article-title":"Perinatal activation of the Interleukin-33 pathway promotes type 2 immunity in the developing lung","volume":"45","author":"de Kleer","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.alit.2020.11.001_bib32","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1182\/blood-2013-05-502443","article-title":"Activated mouse eosinophils protect against lethal respiratory virus infection","volume":"123","author":"Percopo","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.alit.2020.11.001_bib33","doi-asserted-by":"crossref","first-page":"538","DOI":"10.3389\/fcimb.2017.00538","article-title":"Emerging role of proteases in the pathogenesis of chronic rhinosinusitis with nasal polyps","volume":"7","author":"Wu","year":"2017","journal-title":"Front Cel Infect Microbiol"},{"key":"10.1016\/j.alit.2020.11.001_bib34","doi-asserted-by":"crossref","first-page":"3236","DOI":"10.1182\/blood-2011-11-391532","article-title":"Asthma and coagulation","volume":"119","author":"de Boer","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.alit.2020.11.001_bib35","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1056\/NEJMcibr1311045","article-title":"Asthma and coagulation","volume":"369","author":"Lambrecht","year":"2013","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.alit.2020.11.001_bib36","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.alit.2019.03.003","article-title":"Eosinophilic gastrointestinal diseases - pathogenesis, diagnosis, and treatment","volume":"68","author":"Kinoshita","year":"2019","journal-title":"Allergol Int"},{"key":"10.1016\/j.alit.2020.11.001_bib37","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1053\/j.gastro.2018.07.009","article-title":"Updated international consensus diagnostic criteria for eosinophilic esophagitis: proceedings of the AGREE Conference","volume":"155","author":"Dellon","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.alit.2020.11.001_bib38","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.immuni.2014.02.014","article-title":"Eosinophils promote generation and maintenance of immunoglobulin-A-expressing plasma cells and contribute to gut immune homeostasis","volume":"40","author":"Chu","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.alit.2020.11.001_bib39","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1038\/mi.2014.123","article-title":"IL-1\u03b2 in eosinophil-mediated small intestinal homeostasis and IgA production","volume":"8","author":"Jung","year":"2015","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.alit.2020.11.001_bib40","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1084\/jem.20141388","article-title":"Small intestinal eosinophils regulate Th17 cells by producing IL-1 receptor antagonist","volume":"213","author":"Sugawara","year":"2016","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.alit.2020.11.001_bib41","doi-asserted-by":"crossref","first-page":"e0142881","DOI":"10.1371\/journal.pone.0142881","article-title":"Eosinophils from murine lamina propria induce differentiation of na\u00efve T cells into regulatory T cells via TGF-\u03b21 and retinoic acid","volume":"10","author":"Chen","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.alit.2020.11.001_bib42","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/ni.1981","article-title":"Eosinophils are required for the maintenance of plasma cells in the bone marrow","volume":"12","author":"Chu","year":"2011","journal-title":"Nat Immunol"},{"key":"10.1016\/j.alit.2020.11.001_bib43","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1002\/eji.201141953","article-title":"Immunization induces activation of bone marrow eosinophils required for plasma cell survival","volume":"42","author":"Chu","year":"2012","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.alit.2020.11.001_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbrc.2014.09.004","article-title":"Potential role of myeloid cell\/eosinophil-derived IL-17 in LPS-induced endotoxin shock","volume":"453","author":"Shimura","year":"2014","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.alit.2020.11.001_bib45","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/S0002-9149(00)00841-9","article-title":"Clinical and echocardiographic features of hypereosinophilic syndromes","volume":"86","author":"Ommen","year":"2000","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.alit.2020.11.001_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00005792-197501000-00001","article-title":"The hypereosinophilic syndrome: analysis of fourteen cases with review of the literature","volume":"54","author":"Chusid","year":"1975","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.alit.2020.11.001_bib47","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jaci.2010.03.042","article-title":"Refining the definition of hypereosinophilic syndrome","volume":"126","author":"Simon","year":"2010","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2020.11.001_bib48","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1172\/JCI116382","article-title":"Eosinophil cationic granule proteins impair thrombomodulin function. A potential mechanism for thromboembolism in hypereosinophilic heart disease","volume":"91","author":"Slungaard","year":"1993","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.alit.2020.11.001_bib49","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1097\/MCA.0000000000000186","article-title":"Significance of eosinophil accumulation in the thrombus and decrease in peripheral blood in patients with acute coronary syndrome","volume":"26","author":"Jiang","year":"2015","journal-title":"Coron Artery Dis"},{"key":"10.1016\/j.alit.2020.11.001_bib50","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1182\/blood.2019000518","article-title":"Eosinophil-platelet interactions promote atherosclerosis and stabilize thrombosis with eosinophil extracellular traps","volume":"134","author":"Marx","year":"2019","journal-title":"Blood"},{"key":"10.1016\/j.alit.2020.11.001_bib51","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.4049\/jimmunol.165.4.1965","article-title":"CD11c+ eosinophils in the murine thymus: developmental regulation and recruitment upon MHC class I-restricted thymocyte deletion","volume":"165","author":"Throsby","year":"2000","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.alit.2020.11.001_bib52","doi-asserted-by":"crossref","first-page":"e11439","DOI":"10.1371\/journal.pone.0011439","article-title":"Selective depletion of eosinophils or neutrophils in mice impacts the efficiency of apoptotic cell clearance in the thymus","volume":"5","author":"Kim","year":"2010","journal-title":"PloS One"},{"key":"10.1016\/j.alit.2020.11.001_bib53","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1242\/dev.127.11.2269","article-title":"Postnatal mammary gland development requires macrophages and eosinophils","volume":"127","author":"Gouon-Evans","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.alit.2020.11.001_bib54","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1210\/en.2013-1933","article-title":"Epidermal growth factor receptor (EGFR) signaling is a key mediator of hormone-induced leukocyte infiltration in the pubertal female mammary gland","volume":"155","author":"Aupperlee","year":"2014","journal-title":"Endocrinology"},{"key":"10.1016\/j.alit.2020.11.001_bib55","first-page":"53","article-title":"Decreased size and survival of weanling mice in litters of IL-5-\/-mice are a consequence of the IL-5 deficiency in nursing dams","volume":"44","author":"Colbert","year":"2005","journal-title":"Contemp Top Lab Anim Sci"},{"key":"10.1016\/j.alit.2020.11.001_bib56","doi-asserted-by":"crossref","first-page":"E6892","DOI":"10.1073\/pnas.1621253114","article-title":"IL-4-secreting eosinophils promote endometrial stromal cell proliferation and prevent Chlamydia-induced upper genital tract damage","volume":"114","author":"Vicetti Miguel","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.alit.2020.11.001_bib57","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1016\/S0002-9440(10)65030-4","article-title":"Degranulating eosinophils in human endometriosis","volume":"156","author":"Blumenthal","year":"2000","journal-title":"Am J Pathol"},{"key":"10.1016\/j.alit.2020.11.001_bib58","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1111\/all.12644","article-title":"Novel scoring system and algorithm for classifying chronic rhinosinusitis: the JESREC Study","volume":"70","author":"Tokunaga","year":"2015","journal-title":"Allergy"},{"key":"10.1016\/j.alit.2020.11.001_bib59","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.chest.2019.04.101","article-title":"Group 2 innate lymphoid cells in airway diseases","volume":"156","author":"Kato","year":"2019","journal-title":"Chest"},{"key":"10.1016\/j.alit.2020.11.001_bib60","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.jaci.2016.09.011","article-title":"Innate lymphoid cells in allergic and nonallergic inflammation","volume":"138","author":"Morita","year":"2016","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2020.11.001_bib61","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.cell.2018.07.017","article-title":"Innate lymphoid cells: 10 years on","volume":"174","author":"Vivier","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.alit.2020.11.001_bib62","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s40413-016-0094-3","article-title":"Biomarkers of the involvement of mast cells, basophils and eosinophils in asthma and allergic diseases","volume":"9","author":"Metcalfe","year":"2016","journal-title":"World Allergy Organ J"},{"key":"10.1016\/j.alit.2020.11.001_bib63","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.jaci.2012.07.048","article-title":"Dysregulated synthesis of protectin D1 in eosinophils from patients with severe asthma","volume":"131","author":"Miyata","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2020.11.001_bib64","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1084\/jem.190.4.487","article-title":"Expression of CD28 and CD86 by human eosinophils and role in the secretion of type 1 cytokines (interleukin 2 and interferon gamma): inhibition by immunoglobulin a complexes","volume":"190","author":"Woerly","year":"1999","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.alit.2020.11.001_bib65","doi-asserted-by":"crossref","first-page":"S71","DOI":"10.1016\/j.alit.2015.03.006","article-title":"Th2-activated eosinophils release Th1 cytokines that modulate allergic inflammation","volume":"64","author":"Kanda","year":"2015","journal-title":"Allergol Int"},{"key":"10.1016\/j.alit.2020.11.001_bib66","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.jaci.2009.04.031","article-title":"Eosinophil-derived IFN-gamma induces airway hyperresponsiveness and lung inflammation in the absence of lymphocytes","volume":"124","author":"Kanda","year":"2009","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2020.11.001_bib67","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.jaci.2014.08.014","article-title":"Eosinophils contribute to the resolution of lung-allergic responses following repeated allergen challenge","volume":"135","author":"Takeda","year":"2015","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2020.11.001_bib68","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/s41568-020-0283-9","article-title":"A\u00a0new dawn for eosinophils in the tumour microenvironment","author":"Grisaru-Tal","year":"2020","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.alit.2020.11.001_bib69","doi-asserted-by":"crossref","first-page":"650","DOI":"10.2174\/0929867323666160119094313","article-title":"Eosinophils in cancer: favourable or unfavourable?","volume":"23","author":"Sakkal","year":"2016","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.alit.2020.11.001_bib70","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1158\/2326-6066.CIR-13-0196","article-title":"Eosinophils and cancer","volume":"2","author":"Davis","year":"2014","journal-title":"Cancer Immunol Res"},{"key":"10.1016\/j.alit.2020.11.001_bib71","doi-asserted-by":"crossref","first-page":"e1393134","DOI":"10.1080\/2162402X.2017.1393134","article-title":"Eosinophils: the unsung heroes in cancer?","volume":"7","author":"Varricchi","year":"2018","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.alit.2020.11.001_bib72","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1183\/09031936.94.07081452","article-title":"Hypodense eosinophil number relates to clinical severity, airway hyperresponsiveness and response to inhaled corticosteroids in asthmatic subjects","volume":"7","author":"Kuo","year":"1994","journal-title":"Eur Respir J"},{"key":"10.1016\/j.alit.2020.11.001_bib73","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/0091-6749(94)90252-6","article-title":"Blood and bronchoalveolar eosinophils in allergic subjects after segmental antigen challenge: surface phenotype, density heterogeneity, and prostanoid production","volume":"93","author":"Kroegel","year":"1994","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2020.11.001_bib74","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1111\/j.1346-8138.1996.tb04038.x","article-title":"Serum levels of eosinophil cationic protein reflect the state of in\u00a0vitro degranulation of blood hypodense eosinophils in atopic dermatitis","volume":"23","author":"Miyasato","year":"1996","journal-title":"J\u00a0Dermatol"},{"key":"10.1016\/j.alit.2020.11.001_bib75","doi-asserted-by":"crossref","first-page":"5410","DOI":"10.1128\/iai.61.12.5410-5412.1993","article-title":"Class II major histocompatibility complex molecule expression on murine eosinophils activated in\u00a0vivo by Brugia malayi. Infection and immunity","volume":"61","author":"Mawhorter","year":"1993","journal-title":"Infect Immun"},{"key":"10.1016\/j.alit.2020.11.001_bib76","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/PL00006690","article-title":"Murine hypodense eosinophils induce tumour cell apoptosis by a granzyme B-dependent mechanism","volume":"50","author":"Costain","year":"2001","journal-title":"Cancer Immunol Immunother"},{"key":"10.1016\/j.alit.2020.11.001_bib77","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.alit.2019.11.002","article-title":"Increased CD69 expression on activated eosinophils in eosinophilic chronic rhinosinusitis correlates with clinical findings","volume":"69","author":"Yun","year":"2020","journal-title":"Allergol Int"},{"key":"10.1016\/j.alit.2020.11.001_bib78","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1111\/all.13726","article-title":"Dysregulated fatty acid metabolism in nasal polyp-derived eosinophils from patients with chronic rhinosinusitis","volume":"74","author":"Miyata","year":"2019","journal-title":"Allergy"},{"key":"10.1016\/j.alit.2020.11.001_bib79","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1111\/cea.12292","article-title":"Activation states of blood eosinophils in asthma","volume":"44","author":"Johansson","year":"2014","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.alit.2020.11.001_bib80","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3389\/fmed.2017.00075","article-title":"Eosinophil activation status in separate compartments and association with asthma","volume":"4","author":"Johansson","year":"2017","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.alit.2020.11.001_bib81","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1016\/j.jaci.2020.01.022","article-title":"\u03b1(IIb)-Integrin (CD41) associated with blood eosinophils is a potential biomarker for disease activity in eosinophilic esophagitis","volume":"145","author":"Johansson","year":"2020","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2020.11.001_bib82","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/j.1365-2222.1993.tb00882.x","article-title":"Down modulation of L-Selectin expression on eosinophils recovered from bronchoalveolar lavage fluid after allergen provocation","volume":"23","author":"Mengelers","year":"1993","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.alit.2020.11.001_bib83","doi-asserted-by":"crossref","first-page":"6459","DOI":"10.4049\/jimmunol.169.11.6459","article-title":"Decreased expression of membrane IL-5 receptor alpha on human eosinophils: II. IL-5 down-modulates its receptor via a proteinase-mediated process","volume":"169","author":"Liu","year":"2002","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.alit.2020.11.001_bib84","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/S0091-6749(03)01798-6","article-title":"Chemokine receptor expression on human eosinophils from peripheral blood and bronchoalveolar lavage fluid after segmental antigen challenge","volume":"112","author":"Liu","year":"2003","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2020.11.001_bib85","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.alit.2019.06.002","article-title":"Cysteinyl leukotriene metabolism of human eosinophils in allergic disease","volume":"69","author":"Miyata","year":"2020","journal-title":"Allergol Int"},{"key":"10.1016\/j.alit.2020.11.001_bib86","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/nri3754","article-title":"Atypical MHC class II-expressing antigen-presenting cells: can anything replace a dendritic cell?","volume":"14","author":"Kambayashi","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.alit.2020.11.001_bib87","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1365-2249.1991.tb05809.x","article-title":"Sputum eosinophils from asthmatics express ICAM-1 and HLA-DR","volume":"86","author":"Hansel","year":"1991","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.alit.2020.11.001_bib88","first-page":"584","article-title":"Human eosinophils as antigen-presenting cells: relative efficiency for superantigen- and antigen-induced CD4+ T-cell proliferation","volume":"81","author":"Mawhorter","year":"1994","journal-title":"Immunology"},{"key":"10.1016\/j.alit.2020.11.001_bib89","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.4049\/jimmunol.149.6.2130","article-title":"Induction and function of eosinophil intercellular adhesion molecule-1 and HLA-DR","volume":"149","author":"Hansel","year":"1992","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.alit.2020.11.001_bib90","doi-asserted-by":"crossref","first-page":"3372","DOI":"10.4049\/jimmunol.171.7.3372","article-title":"Airway eosinophils accumulate in the mediastinal lymph nodes but lack antigen-presenting potential for naive T cells","volume":"171","author":"van Rijt","year":"2003","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.alit.2020.11.001_bib91","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.jaci.2004.08.011","article-title":"Migration and accumulation of eosinophils toward regional lymph nodes after airway allergen challenge","volume":"114","author":"Duez","year":"2004","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2020.11.001_bib92","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1046\/j.1398-9995.2003.00405.x","article-title":"Endobronchial eosinophils preferentially stimulate T helper cell type 2 responses","volume":"59","author":"Shi","year":"2004","journal-title":"Allergy"},{"key":"10.1016\/j.alit.2020.11.001_bib93","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1172\/JCI8945","article-title":"Lymph node trafficking and antigen presentation by endobronchial eosinophils","volume":"105","author":"Shi","year":"2000","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.alit.2020.11.001_bib94","doi-asserted-by":"crossref","first-page":"7585","DOI":"10.4049\/jimmunol.179.11.7585","article-title":"Airway eosinophils: allergic inflammation recruited professional antigen-presenting cells","volume":"179","author":"Wang","year":"2007","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.alit.2020.11.001_bib95","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1172\/JCI115383","article-title":"Human eosinophils express functional interleukin 2 receptors","volume":"88","author":"Rand","year":"1991","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.alit.2020.11.001_bib96","first-page":"258","article-title":"Granulocyte-macrophage colony-stimulating factor and interleukin-3 induce surface expression of interleukin-2 receptor p55-chain and CD4 by human eosinophils","volume":"70","author":"Riedel","year":"1990","journal-title":"Immunology"},{"key":"10.1016\/j.alit.2020.11.001_bib97","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1084\/jem.169.1.327","article-title":"Human eosinophils express CD4 protein and bind human immunodeficiency virus 1 gp120","volume":"169","author":"Lucey","year":"1989","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.alit.2020.11.001_bib98","doi-asserted-by":"crossref","first-page":"e5926","DOI":"10.1371\/journal.pone.0005926","article-title":"A\u00a0functional gammadeltaTCR\/CD3 complex distinct from gammadeltaT cells is expressed by human eosinophils","volume":"4","author":"Legrand","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.alit.2020.11.001_bib99","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/JLB.1MR1117-442RR","article-title":"Shaping eosinophil identity in the tissue contexts of development, homeostasis, and disease","volume":"104","author":"Abdala-Valencia","year":"2018","journal-title":"J\u00a0Leukoc Biol"}],"updated-by":[{"DOI":"10.1016\/j.alit.2021.01.002","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000}}],"container-title":["Allergology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1323893020301441?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1323893020301441?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T13:00:56Z","timestamp":1697202056000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1323893020301441"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":99,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["S1323893020301441"],"URL":"https:\/\/doi.org\/10.1016\/j.alit.2020.11.001","relation":{},"ISSN":["1323-8930"],"issn-type":[{"value":"1323-8930","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The multiple functions and subpopulations of eosinophils in tissues under steady-state and pathological conditions","name":"articletitle","label":"Article Title"},{"value":"Allergology International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.alit.2020.11.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Japanese Society of Allergology. Production and hosting by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}