{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:13:31Z","timestamp":1791213211160,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,11]],"date-time":"2022-06-11T00:00:00Z","timestamp":1654905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007786","name":"National Center for Child Health and Development","doi-asserted-by":"publisher","award":["2019E-1"],"award-info":[{"award-number":["2019E-1"]}],"id":[{"id":"10.13039\/100007786","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K10545"],"award-info":[{"award-number":["22K10545"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Allergology International"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.alit.2022.05.012","type":"journal-article","created":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T03:25:25Z","timestamp":1656645925000},"page":"107-115","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Eczema phenotypes and IgE component sensitization in adolescents: A population-based birth cohort"],"prefix":"10.1016","volume":"72","author":[{"given":"Tomoyuki","family":"Kiguchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1288-9620","authenticated-orcid":false,"given":"Kiwako","family":"Yamamoto-Hanada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayako","family":"Saito-Abe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuki","family":"Fukuie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukihiro","family":"Ohya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.alit.2022.05.012_bib1","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1016\/j.jaip.2021.02.017","article-title":"Management of severe atopic dermatitis in pediatric patients","volume":"9","author":"Mancuso","year":"2021","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.alit.2022.05.012_bib2","doi-asserted-by":"crossref","first-page":"adv00160","DOI":"10.2340\/00015555-3510","article-title":"Prevalence and incidence of atopic dermatitis: a systematic review","volume":"100","author":"Bylund","year":"2020","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.alit.2022.05.012_bib3","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1172\/JCI57416","article-title":"Epidermal barrier dysfunction and cutaneous sensitization in atopic diseases","volume":"122","author":"Kubo","year":"2012","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.alit.2022.05.012_bib4","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.alit.2019.02.010","article-title":"Four phenotypes of atopic dermatitis in Japanese children: a general population birth cohort study","volume":"68","author":"Yamamoto-Hanada","year":"2019","journal-title":"Allergol Int"},{"key":"10.1016\/j.alit.2022.05.012_bib5","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1111\/1346-8138.16085","article-title":"Comparison of the time course of atopic dermatitis from birth to 19 years old among generations of patients in Japan","volume":"48","author":"Tanaka","year":"2021","journal-title":"J\u00a0Dermatol"},{"key":"10.1016\/j.alit.2022.05.012_bib6","doi-asserted-by":"crossref","first-page":"e0156077","DOI":"10.1371\/journal.pone.0156077","article-title":"IgE sensitization profiles differ between adult patients with severe and moderate atopic dermatitis","volume":"11","author":"Mittermann","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.alit.2022.05.012_bib7","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s40413-017-0157-0","article-title":"Allergic profiles of mothers and fathers in the Japan Environment and Children's Study (JECS): a nationwide birth cohort study","volume":"10","author":"Yamamoto-Hanada","year":"2017","journal-title":"World Allergy Organ J"},{"key":"10.1016\/j.alit.2022.05.012_bib8","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s40413-018-0199-y","article-title":"Allergy diagnosis from symptoms to molecules, or from molecules to symptoms: a comparative clinical study","volume":"11","author":"Mothes-Luksch","year":"2018","journal-title":"World Allergy Organ J"},{"key":"10.1016\/j.alit.2022.05.012_bib9","doi-asserted-by":"crossref","first-page":"e0249649","DOI":"10.1371\/journal.pone.0249649","article-title":"Pollen-food allergy syndrome and component sensitization in adolescents: a Japanese population-based study","volume":"16","author":"Kiguchi","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.alit.2022.05.012_bib10","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.alit.2016.02.012","article-title":"Preconceptional exposure to oral contraceptive pills and the risk of wheeze, asthma and rhinitis in children","volume":"65","author":"Yamamoto-Hanada","year":"2016","journal-title":"Allergol Int"},{"key":"10.1016\/j.alit.2022.05.012_bib11","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.anai.2017.05.013","article-title":"Influence of antibiotic use in early childhood on asthma and allergic diseases at age 5","volume":"119","author":"Yamamoto-Hanada","year":"2017","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.alit.2022.05.012_bib12","doi-asserted-by":"crossref","first-page":"e0234161","DOI":"10.1371\/journal.pone.0234161","article-title":"Impact of swimming school attendance in 3-year-old children with wheeze and rhinitis at age 5 years: a prospective birth cohort study in Tokyo","volume":"15","author":"Irahara","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.alit.2022.05.012_bib13","doi-asserted-by":"crossref","first-page":"100105","DOI":"10.1016\/j.waojou.2020.100105","article-title":"IgE responses to multiple allergen components among school-aged children in a general population birth cohort in Tokyo","volume":"13","author":"Yamamoto-Hanada","year":"2020","journal-title":"World Allergy Organ J"},{"key":"10.1016\/j.alit.2022.05.012_bib14","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1111\/cea.12761","article-title":"Multiplex component-based allergen microarray in recent clinical studies","volume":"46","author":"Patelis","year":"2016","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.alit.2022.05.012_bib15","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/bmt.2012.244","article-title":"Investigation of the freely available easy-to-use software 'EZR' for medical statistics","volume":"48","author":"Kanda","year":"2013","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.alit.2022.05.012_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jdermsci.2010.02.008","article-title":"Extrinsic and intrinsic types of atopic dermatitis","volume":"58","author":"Tokura","year":"2010","journal-title":"J\u00a0Dermatol Sci"},{"key":"10.1016\/j.alit.2022.05.012_bib17","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1111\/bjd.13901","article-title":"Atopic and nonatopic eczema in adolescence: is there a difference?","volume":"173","author":"Johansson","year":"2015","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.alit.2022.05.012_bib18","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jdermsci.2016.08.003","article-title":"Timing of eczema onset and risk of food allergy at 3 years of age: a hospital-based prospective birth cohort study","volume":"84","author":"Shoda","year":"2016","journal-title":"J\u00a0Dermatol Sci"},{"key":"10.1016\/j.alit.2022.05.012_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-5945-12-11","article-title":"Eczema in early childhood is strongly associated with the development of asthma and rhinitis in a prospective cohort","volume":"12","author":"Von Kobyletzki","year":"2012","journal-title":"BMC Dermatol"},{"key":"10.1016\/j.alit.2022.05.012_bib20","doi-asserted-by":"crossref","first-page":"e0260447","DOI":"10.1371\/journal.pone.0260447","article-title":"Persistent eczema leads to both impaired growth and food allergy: JECS birth cohort","volume":"16","author":"Yamamoto-Hanada","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.alit.2022.05.012_bib21","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jaci.2018.11.006","article-title":"The atopic march and atopic multimorbidity: many trajectories, many pathways","volume":"143","author":"Paller","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2022.05.012_bib22","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.anai.2019.07.022","article-title":"Pollen food allergy syndrome (PFAS): a review of current available literature","volume":"123","author":"Carlson","year":"2019","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.alit.2022.05.012_bib23","doi-asserted-by":"crossref","first-page":"641","DOI":"10.3390\/medicina55100641","article-title":"Pollen-food allergy syndrome: a not so rare disease in childhood","volume":"55","author":"Mastrorilli","year":"2019","journal-title":"Medicina (Kaunas)"},{"key":"10.1016\/j.alit.2022.05.012_bib24","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1111\/all.15109","article-title":"Perceptions of adolescents and young adults with allergy and\/or asthma and their parents on EAACI guideline recommendations about transitional care: a European survey","volume":"77","author":"Khaleva","year":"2022","journal-title":"Allergy"},{"key":"10.1016\/j.alit.2022.05.012_bib25","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.1016\/j.jaip.2020.05.034","article-title":"A\u00a0gap between asthma guidelines and management for adolescents and young adults","volume":"8","author":"\u00d6dling","year":"2020","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.alit.2022.05.012_bib26","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s00403-019-01895-z","article-title":"Determinants of disease severity among patients with atopic dermatitis: association with components of the atopic march","volume":"311","author":"Holm","year":"2019","journal-title":"Arch Dermatol Res"},{"key":"10.1016\/j.alit.2022.05.012_bib27","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1016\/j.jaip.2019.11.036","article-title":"Earlier aggressive treatment to shorten the duration of eczema in infants resulted in fewer food allergies at 2 years of age","volume":"8","author":"Miyaji","year":"2020","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.alit.2022.05.012_bib28","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1001\/jamapediatrics.2017.0556","article-title":"Phenotypes of atopic dermatitis depending on the timing of onset and progression in childhood","volume":"171","author":"Roduit","year":"2017","journal-title":"JAMA Pediatr"},{"key":"10.1016\/j.alit.2022.05.012_bib29","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1111\/cea.13993","article-title":"Atopic dermatitis trajectories to age 8 years in the GUSTO cohort","volume":"51","author":"Suaini","year":"2021","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.alit.2022.05.012_bib30","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.anai.2021.02.019","article-title":"Better maternal quality of life in pregnancy yields better offspring respiratory outcomes: a birth cohort","volume":"126","author":"Yamamoto-Hanada","year":"2021","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.alit.2022.05.012_bib31","doi-asserted-by":"crossref","first-page":"100479","DOI":"10.1016\/j.waojou.2020.100479","article-title":"Allergy and immunology in young children of Japan: the JECS cohort","volume":"13","author":"Yamamoto-Hanada","year":"2020","journal-title":"World Allergy Organ J"},{"key":"10.1016\/j.alit.2022.05.012_bib32","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.alit.2022.01.002","article-title":"Fluctuations of aeroallergen-specific immunoglobulins and children\u2019s allergic profiles: Japan Environment & Children\u2019s Study of a pilot cohort","volume":"71","author":"Irahara","year":"2022","journal-title":"Allergol Int"},{"key":"10.1016\/j.alit.2022.05.012_bib33","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.alit.2019.02.005","article-title":"Egg antigen was more abundant than mite antigen in children's bedding: findings of the pilot study of the Japan Environment and Children's Study (JECS)","volume":"68","author":"Kitazawa","year":"2019","journal-title":"Allergol Int"}],"container-title":["Allergology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1323893022000703?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1323893022000703?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:12:10Z","timestamp":1761156730000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1323893022000703"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["S1323893022000703"],"URL":"https:\/\/doi.org\/10.1016\/j.alit.2022.05.012","relation":{},"ISSN":["1323-8930"],"issn-type":[{"value":"1323-8930","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Eczema phenotypes and IgE component sensitization in adolescents: A population-based birth cohort","name":"articletitle","label":"Article Title"},{"value":"Allergology International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.alit.2022.05.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Japanese Society of Allergology. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}