{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T23:51:23Z","timestamp":1769039483979,"version":"3.49.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T00:00:00Z","timestamp":1673568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Allergology International"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.alit.2023.01.001","type":"journal-article","created":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T15:22:55Z","timestamp":1675437775000},"page":"418-427","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Individual multidisciplinary clinical phenotypes of nasal and ocular symptoms in hay fever: Crowdsourced cross-sectional study using AllerSearch"],"prefix":"10.1016","volume":"72","author":[{"given":"Takenori","family":"Inomata","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaemyoung","family":"Sung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenta","family":"Fujio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasutsugu","family":"Akasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Nagino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Okumura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Iwagami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichi","family":"Fujimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Ebihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akie","family":"Midorikawa-Inomata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hurramhon","family":"Shokirova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianxiang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunihiko","family":"Hirosawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Miura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mizu","family":"Ohno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Morooka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nanami","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuma","family":"Iwasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.alit.2023.01.001_bib1","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S0140-6736(06)69283-0","article-title":"Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys","volume":"368","author":"Asher","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.alit.2023.01.001_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2013.11.002","article-title":"Present state of Japanese cedar pollinosis: the national affliction","volume":"133","author":"Yamada","year":"2014","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2023.01.001_bib3","doi-asserted-by":"crossref","first-page":"100492","DOI":"10.1016\/j.waojou.2020.100492","article-title":"Prevalence and risk factors associated with allergic rhinitis in Mexican school children: global Asthma Network Phase I","volume":"14","author":"Garc\u00eda-Almaraz","year":"2021","journal-title":"World Allergy Organ J"},{"key":"10.1016\/j.alit.2023.01.001_bib4","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1016\/j.anai.2010.10.014","article-title":"The economic impact of allergic rhinitis and current guidelines for treatment","volume":"106","author":"Meltzer","year":"2011","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.alit.2023.01.001_bib5","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.1016\/j.jaci.2009.05.013","article-title":"Burden of allergic rhinitis: results from the Pediatric Allergies in America survey","volume":"124","author":"Meltzer","year":"2009","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2023.01.001_bib6","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0091-6749(00)90171-4","article-title":"The environmental predictors of allergic disease","volume":"105","author":"von Mutius","year":"2000","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2023.01.001_bib7","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/1475-2891-11-84","article-title":"Dietary factors associated with lifetime asthma or hayfever diagnosis in Australian middle-aged and older adults: a cross-sectional study","volume":"11","author":"Rosenkranz","year":"2012","journal-title":"Nutr J"},{"key":"10.1016\/j.alit.2023.01.001_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaip.2016.09.016","article-title":"Exposure to extreme heat events is associated with increased hay fever prevalence among nationally representative sample of US adults: 1997-2013","volume":"5","author":"Upperman","year":"2017","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.alit.2023.01.001_bib9","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1016\/j.jaci.2013.10.030","article-title":"Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype","volume":"133","author":"Ferreira","year":"2014","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2023.01.001_bib10","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s40413-018-0198-z","article-title":"Epidemiology of allergic rhinitis and associated risk factors in Asia","volume":"11","author":"Chong","year":"2018","journal-title":"World Allergy Organ J"},{"key":"10.1016\/j.alit.2023.01.001_bib11","unstructured":"World Health Organization. mHealth: New horizons for health through mobile technologies: second global survey on eHealth 2011. Available from: https:\/\/www.who.int\/goe\/publications\/goe_mhealth_web.pdf."},{"key":"10.1016\/j.alit.2023.01.001_bib12","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.ophtha.2018.12.013","article-title":"Risk factors for severe dry eye disease: crowdsourced research using DryEyeRhythm","volume":"126","author":"Inomata","year":"2019","journal-title":"Ophthalmology"},{"key":"10.1016\/j.alit.2023.01.001_bib13","doi-asserted-by":"crossref","first-page":"3820","DOI":"10.1111\/all.15078","article-title":"Symptom-based stratification for hay fever: a crowdsourced study using the smartphone application AllerSearch","volume":"76","author":"Inomata","year":"2021","journal-title":"Allergy"},{"key":"10.1016\/j.alit.2023.01.001_bib14","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.alit.2021.12.004","article-title":"Individual characteristics and associated factors of hay fever: a large-scale mHealth study using AllerSearch","volume":"71","author":"Inomata","year":"2022","journal-title":"Allergol Int"},{"key":"10.1016\/j.alit.2023.01.001_bib15","doi-asserted-by":"crossref","first-page":"e38475","DOI":"10.2196\/38475","article-title":"Reliability and validity of electronic patient-reported outcomes using the Smartphone App AllerSearch for hay fever: prospective observational study","volume":"6","author":"Akasaki","year":"2022","journal-title":"JMIR Form Res"},{"key":"10.1016\/j.alit.2023.01.001_bib16","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s40900-022-00382-6","article-title":"Patient and public involvement in mobile health-based research for hay fever: a qualitative study of patient and public involvement implementation process","volume":"8","author":"Fujio","year":"2022","journal-title":"Res Involv Engagem"},{"key":"10.1016\/j.alit.2023.01.001_bib17","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1001\/jama.2013.281053","article-title":"World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects","volume":"310","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.alit.2023.01.001_bib18","doi-asserted-by":"crossref","first-page":"e34","DOI":"10.2196\/jmir.6.3.e34","article-title":"Improving the quality of web surveys: the checklist for reporting results of Internet E-surveys (CHERRIES)","volume":"6","author":"Eysenbach","year":"2004","journal-title":"J\u00a0Med Internet Res"},{"key":"10.1016\/j.alit.2023.01.001_bib19","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1002\/lary.20146","article-title":"The correlation between nasal symptom and mucociliary clearance in allergic rhinitis","volume":"119","author":"Kirtsreesakul","year":"2009","journal-title":"Laryngoscope"},{"key":"10.1016\/j.alit.2023.01.001_bib20","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.alit.2020.06.001","article-title":"New medical big data for P4 medicine on allergic conjunctivitis","volume":"69","author":"Inomata","year":"2020","journal-title":"Allergol Int"},{"key":"10.1016\/j.alit.2023.01.001_bib21","doi-asserted-by":"crossref","first-page":"S742","DOI":"10.1016\/S0091-6749(97)90000-2","article-title":"Measuring health-related quality of life in rhinitis","volume":"99","author":"Juniper","year":"1997","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2023.01.001_bib22","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1080\/00016480510026944","article-title":"Comparative study of two Japanese rhinoconjunctivitis quality-of-life questionnaires","volume":"125","author":"Okuda","year":"2005","journal-title":"Acta Otolaryngol"},{"key":"10.1016\/j.alit.2023.01.001_bib23","first-page":"494","article-title":"[A quality of life questionnaire for Japanese allergic conjunctival disease]","volume":"116","author":"Fukagawa","year":"2012","journal-title":"Nippon Ganka Gakkai Zasshi"},{"key":"10.1016\/j.alit.2023.01.001_bib24","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/s41746-021-00540-2","article-title":"Smartphone-based digital phenotyping for dry eye toward P4 medicine: a crowdsourced cross-sectional study","volume":"4","author":"Inomata","year":"2021","journal-title":"NPJ Digit Med"},{"key":"10.1016\/j.alit.2023.01.001_bib25","unstructured":"Lee MA, Mahmoud O, Hughes D, Wade KH, Corbin LJ, McGuinness LJ, et al. Epiviz: an implementation of Circos plots for epidemiologists 2020. Available from: https:\/\/github.com\/mattlee821\/EpiViz."},{"key":"10.1016\/j.alit.2023.01.001_bib26","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1007\/s11882-010-0087-1","article-title":"Allergic conjunctivitis and the impact of allergic rhinitis","volume":"10","author":"Bielory","year":"2010","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.alit.2023.01.001_bib27","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1016\/j.lpm.2009.05.012","article-title":"[INSTANT: national survey of allergic rhinitis in a French adult population based-sample]","volume":"38","author":"Klossek","year":"2009","journal-title":"Presse Med"},{"issue":"Suppl 2","key":"10.1016\/j.alit.2023.01.001_bib28","first-page":"7","article-title":"Epidemiology of allergic rhinitis in allergy consultations in Spain: alergol\u00f3gica-2005","volume":"19","author":"Navarro","year":"2009","journal-title":"J\u00a0Investig Allergol Clin Immunol"},{"key":"10.1016\/j.alit.2023.01.001_bib29","doi-asserted-by":"crossref","first-page":"S127","DOI":"10.1016\/j.jaci.2008.12.470","article-title":"Epidemiology of ocular allergy: an NHANES III data review, 1988-1994","volume":"123","author":"Axelrod","year":"2009","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2023.01.001_bib30","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1111\/j.1442-9071.2009.02079.x","article-title":"Seasonal and perennial allergic conjunctivitis: the possible role of nasal allergy","volume":"37","author":"Pelikan","year":"2009","journal-title":"Clin Exp Ophthalmol"},{"key":"10.1016\/j.alit.2023.01.001_bib31","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1525-1470.2008.00745.x","article-title":"The course of life of patients with childhood atopic dermatitis","volume":"26","author":"Brenninkmeijer","year":"2009","journal-title":"Pediatr Dermatol"},{"key":"10.1016\/j.alit.2023.01.001_bib32","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2500\/108854197778605482","article-title":"Treatment of allergic rhinitis: effect on occupation productivity and work force costs","volume":"18","author":"Fireman","year":"1997","journal-title":"Allergy Asthma Proc"},{"key":"10.1016\/j.alit.2023.01.001_bib33","first-page":"273","article-title":"Alcohol in alcoholic liver disease is a causative factor for development of allergic skin manifestations","volume":"57","author":"Mujagi\u0107","year":"2003","journal-title":"Med Arh"},{"key":"10.1016\/j.alit.2023.01.001_bib34","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1080\/13556210412331292235","article-title":"Alcohol, IgE and allergy","volume":"9","author":"Gonzalez-Quintela","year":"2004","journal-title":"Addict Biol"},{"key":"10.1016\/j.alit.2023.01.001_bib35","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.anai.2012.01.006","article-title":"Allergic conjunctivitis and dry eye syndrome","volume":"108","author":"Hom","year":"2012","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.alit.2023.01.001_bib36","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1016\/j.ophtha.2015.02.013","article-title":"Seasonal variation in dry eye","volume":"122","author":"Kumar","year":"2015","journal-title":"Ophthalmology"},{"key":"10.1016\/j.alit.2023.01.001_bib37","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1080\/09273948.2020.1841804","article-title":"Allergy and dry eye disease","volume":"29","author":"Leonardi","year":"2021","journal-title":"Ocul Immunol Inflamm"},{"key":"10.1016\/j.alit.2023.01.001_bib38","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.2147\/OPTH.S148650","article-title":"Possible association between subtypes of dry eye disease and seasonal variation","volume":"11","author":"Ayaki","year":"2017","journal-title":"Clin Ophthalmol"},{"key":"10.1016\/j.alit.2023.01.001_bib39","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.ajo.2005.09.032","article-title":"The impact of the onset time of atopic keratoconjunctivitis on the tear function and ocular surface findings","volume":"141","author":"Onguchi","year":"2006","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.alit.2023.01.001_bib40","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1080\/02713680500196715","article-title":"Ocular surface and MUC5AC alterations in atopic patients with corneal shield ulcers","volume":"30","author":"Dogru","year":"2005","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.alit.2023.01.001_bib41","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0161-6420(95)31024-X","article-title":"Dry eye with only decreased tear break-up time is sometimes associated with allergic conjunctivitis","volume":"102","author":"Toda","year":"1995","journal-title":"Ophthalmology"},{"key":"10.1016\/j.alit.2023.01.001_bib42","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1111\/j.1398-9995.2007.01414.x","article-title":"The differences of tear function and ocular surface findings in patients with atopic keratoconjunctivitis and vernal keratoconjunctivitis","volume":"62","author":"Hu","year":"2007","journal-title":"Allergy"},{"key":"10.1016\/j.alit.2023.01.001_bib43","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1080\/09273948.2016.1178303","article-title":"Allergic conjunctivitis and the associated risk of migraine among children: a nationwide population-based cohort study","volume":"25","author":"Wang","year":"2017","journal-title":"Ocul Immunol Inflamm"},{"key":"10.1016\/j.alit.2023.01.001_bib44","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1111\/ped.12381","article-title":"Atopic disorders are more common in childhood migraine and correlated headache phenotype","volume":"56","author":"\u00d6zge","year":"2014","journal-title":"Pediatr Int"},{"key":"10.1016\/j.alit.2023.01.001_bib45","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1289\/ehp.9510354","article-title":"Neurogenic switching: a hypothesis for a mechanism for shifting the site of inflammation in allergy and chemical sensitivity","volume":"103","author":"Meggs","year":"1995","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.alit.2023.01.001_bib46","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s10384-020-00798-1","article-title":"Heterogeneity of eye drop use among symptomatic dry eye individuals in Japan: large-scale crowdsourced research using DryEyeRhythm application","volume":"65","author":"Eguchi","year":"2021","journal-title":"Jpn J Ophthalmol"},{"key":"10.1016\/j.alit.2023.01.001_bib47","doi-asserted-by":"crossref","first-page":"e18996","DOI":"10.2196\/18996","article-title":"Stratification of individual symptoms of contact lens-associated dry eye using the iPhone App DryEyeRhythm: crowdsourced cross-sectional study","volume":"22","author":"Inomata","year":"2020","journal-title":"J Med Internet Res"},{"key":"10.1016\/j.alit.2023.01.001_bib48","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1001\/jamaophthalmol.2019.4815","article-title":"Characteristics and risk factors associated with diagnosed and undiagnosed symptomatic dry eye using a smartphone application","volume":"138","author":"Inomata","year":"2020","journal-title":"JAMA Ophthalmol"},{"key":"10.1016\/j.alit.2023.01.001_bib49","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.jtos.2020.02.007","article-title":"Association between dry eye and depressive symptoms: large-scale crowdsourced research using the DryEyeRhythm iPhone application","volume":"18","author":"Inomata","year":"2020","journal-title":"Ocul Surf"},{"key":"10.1016\/j.alit.2023.01.001_bib50","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jtos.2022.04.005","article-title":"DryEyeRhythm: a reliable and valid smartphone application for the diagnosis assistance of dry eye","volume":"25","author":"Okumura","year":"2022","journal-title":"Ocul Surf"}],"container-title":["Allergology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1323893023000011?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1323893023000011?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:14:04Z","timestamp":1761156844000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1323893023000011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["S1323893023000011"],"URL":"https:\/\/doi.org\/10.1016\/j.alit.2023.01.001","relation":{},"ISSN":["1323-8930"],"issn-type":[{"value":"1323-8930","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Individual multidisciplinary clinical phenotypes of nasal and ocular symptoms in hay fever: Crowdsourced cross-sectional study using AllerSearch","name":"articletitle","label":"Article Title"},{"value":"Allergology International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.alit.2023.01.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Japanese Society of Allergology. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}