{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T15:09:14Z","timestamp":1774278554209,"version":"3.50.1"},"reference-count":41,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T00:00:00Z","timestamp":1681948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Allergology International"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.alit.2023.03.008","type":"journal-article","created":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T16:29:43Z","timestamp":1683131383000},"page":"564-572","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Differences in the expression of multidrug resistance proteins in chronic rhinosinusitis according to endotype"],"prefix":"10.1016","volume":"72","author":[{"given":"Tomohisa","family":"Iinuma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syuji","family":"Yonekura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoshi","family":"Hirahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junya","family":"Kurita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riyo","family":"Yoneda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Arai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuri","family":"Sonobe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rie","family":"Shinmi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitaka","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toyoyuki","family":"Hanazawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.alit.2023.03.008_bib1","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1002\/lary.27852","article-title":"Cost burden and resource utilization in patients with chronic rhinosinusitis and nasal polyps","volume":"129","author":"Bhattacharyya","year":"2019","journal-title":"Laryngoscope"},{"key":"10.1016\/j.alit.2023.03.008_bib2","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1159\/000519296","article-title":"Effect of dupilumab on depression in asthma with eosinophilic chronic rhinosinusitis in the Japanese population","volume":"183","author":"Koya","year":"2022","journal-title":"Int Arch Allergy Immunol"},{"issue":"Suppl S29","key":"10.1016\/j.alit.2023.03.008_bib3","first-page":"1","article-title":"European position paper on rhinosinusitis and nasal polyps 2020","volume":"58","author":"Fokkens","year":"2020","journal-title":"Rhinology"},{"key":"10.1016\/j.alit.2023.03.008_bib4","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1111\/all.12644","article-title":"Novel scoring system and algorithm for classifying chronic rhinosinusitis: the JESREC Study","volume":"70","author":"Tokunaga","year":"2015","journal-title":"Allergy"},{"key":"10.1016\/j.alit.2023.03.008_bib5","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.anai.2015.01.013","article-title":"Interleukin-25 and mucosal T cells in noneosinophilic and eosinophilic chronic rhinosinusitis","volume":"114","author":"Iinuma","year":"2015","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.alit.2023.03.008_bib6","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1016\/j.jaci.2015.10.019","article-title":"IL-25\/IL-33-responsive TH2 cells characterize nasal polyps with a default TH17 signature in nasal mucosa","volume":"137","author":"Lam","year":"2016","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2023.03.008_bib7","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1016\/j.jaip.2021.02.013","article-title":"Innate and adaptive immunity: ILC2 and Th2 cells in upper and lower airway allergic diseases","volume":"9","author":"Scadding","year":"2021","journal-title":"J\u00a0Allergy Clin Immunol Pract"},{"key":"10.1016\/j.alit.2023.03.008_bib8","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.jaci.2020.01.027","article-title":"Formation of nasal polyps: the roles of innate type 2 inflammation and deposition of fibrin","volume":"145","author":"Takabayashi","year":"2020","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2023.03.008_bib9","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/alr.21625","article-title":"Expression of leukotriene and its receptors in eosinophilic chronic rhinosinusitis with nasal polyps","volume":"6","author":"Wu","year":"2016","journal-title":"Int Forum Allergy Rhinol"},{"key":"10.1016\/j.alit.2023.03.008_bib10","doi-asserted-by":"crossref","first-page":"482","DOI":"10.2500\/ajra.2013.27.3976","article-title":"Leukotriene antagonists in nasal polyposis: a meta-analysis and systematic review","volume":"27","author":"Wentzel","year":"2013","journal-title":"Am J Rhinol Allergy"},{"key":"10.1016\/j.alit.2023.03.008_bib11","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.anl.2015.08.014","article-title":"Past, present and future of macrolide therapy for chronic rhinosinusitis in Japan","volume":"43","author":"Shimizu","year":"2016","journal-title":"Auris Nasus Larynx"},{"key":"10.1016\/j.alit.2023.03.008_bib12","first-page":"183","article-title":"Staging in rhinosinusitus","volume":"31","author":"Lund","year":"1993","journal-title":"Rhinology"},{"key":"10.1016\/j.alit.2023.03.008_bib13","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/all.13295","article-title":"Pathogenicity of memory Th2 cells is linked to stage of allergic rhinitis","volume":"73","author":"Iinuma","year":"2018","journal-title":"Allergy"},{"key":"10.1016\/j.alit.2023.03.008_bib14","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nrm1572","article-title":"Regulated exocytosis: new organelles for non-secretory purposes","volume":"6","author":"Chieregatti","year":"2005","journal-title":"Nat Rev Mol Cel Biol"},{"key":"10.1016\/j.alit.2023.03.008_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2021.100743","article-title":"Multidrug resistance proteins (MRPs): structure, function and the overcoming of cancer multidrug resistance","volume":"54","author":"Wang","year":"2021","journal-title":"Drug Resist Updat"},{"key":"10.1016\/j.alit.2023.03.008_bib16","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1002\/cpt.2644","article-title":"Transporters in drug development: international transporter consortium update on emerging transporters of clinical importance","volume":"112","author":"Zamek-Gliszczynski","year":"2022","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.alit.2023.03.008_bib17","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1007\/s12253-018-0386-8","article-title":"Immunohistochemical assessment of the expression of biliary transportation proteins MRP2 and MRP3 in hepatocellular carcinoma and in cholangiocarcinoma","volume":"25","author":"Cirqueira","year":"2019","journal-title":"Pathol Oncol Res"},{"key":"10.1016\/j.alit.2023.03.008_bib18","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1053\/jhep.2001.26213","article-title":"Up-regulation of basolateral multidrug resistance protein 3 (Mrp3) in cholestatic rat liver","volume":"34","author":"Donner","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.alit.2023.03.008_bib19","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1517\/17425255.4.6.721","article-title":"Utilization of membrane vesicle preparations to study drug-ABC transporter interactions","volume":"4","author":"Glavinas","year":"2008","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"10.1016\/j.alit.2023.03.008_bib20","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1124\/jpet.107.131342","article-title":"ATP-dependent transport of leukotrienes B4 and C4 by the multidrug resistance protein ABCC4 (MRP4)","volume":"324","author":"Rius","year":"2008","journal-title":"J\u00a0Pharmacol Exp Ther"},{"key":"10.1016\/j.alit.2023.03.008_bib21","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.2174\/156802610792928040","article-title":"Modulators of multidrug resistance associated proteins in the management of anticancer and antimicrobial drug resistance and the treatment of inflammatory diseases","volume":"10","author":"Yang","year":"2010","journal-title":"Curr Top Med Chem"},{"key":"10.1016\/j.alit.2023.03.008_bib22","doi-asserted-by":"crossref","first-page":"9244","DOI":"10.1073\/pnas.1033060100","article-title":"The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs","volume":"100","author":"Reid","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.alit.2023.03.008_bib23","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.jaci.2005.02.029","article-title":"Prostaglandin, leukotriene, and lipoxin balance in chronic rhinosinusitis with and without nasal polyposis","volume":"115","author":"P\u00e9rez-Novo","year":"2005","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2023.03.008_bib24","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/j.jaci.2009.01.047","article-title":"Prostaglandin E(2) suppresses staphylococcal enterotoxin-induced eosinophilia-associated cellular responses dominantly through an E-prostanoid 2-mediated pathway in nasal polyps","volume":"123","author":"Okano","year":"2009","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2023.03.008_bib25","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1111\/all.13726","article-title":"Dysregulated fatty acid metabolism in nasal polyp-derived eosinophils from patients with chronic rhinosinusitis","volume":"74","author":"Miyata","year":"2019","journal-title":"Allergy"},{"key":"10.1016\/j.alit.2023.03.008_bib26","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1182\/blood-2018-04-842260","article-title":"Charcot-Leyden crystal formation is closely associated with eosinophil extracellular trap cell death","volume":"132","author":"Ueki","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.alit.2023.03.008_bib27","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.neulet.2011.10.018","article-title":"Expression and differential localization of xenobiotic transporters in the rat olfactory neuro-epithelium","volume":"505","author":"Thiebaud","year":"2011","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.alit.2023.03.008_bib28","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1126\/science.2475911","article-title":"Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA","volume":"245","author":"Riordan","year":"1989","journal-title":"Science"},{"key":"10.1016\/j.alit.2023.03.008_bib29","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1160\/TH16-04-0316","article-title":"Enhanced platelet MRP4 expression and correlation with platelet function in\u00a0patients under chronic aspirin treatment","volume":"116","author":"Massimi","year":"2016","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.alit.2023.03.008_bib30","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1124\/jpet.115.225656","article-title":"The pharmacological and physiological role of multidrug-resistant protein 4","volume":"354","author":"Wen","year":"2015","journal-title":"J\u00a0Pharmacol Exp Ther"},{"key":"10.1016\/j.alit.2023.03.008_bib31","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1124\/mol.106.031823","article-title":"Involvement of MRP4 (ABCC4) in the luminal efflux of ceftizoxime and cefazolin in the kidney","volume":"71","author":"Ci","year":"2007","journal-title":"Mol Pharmacol"},{"issue":"Pt 2","key":"10.1016\/j.alit.2023.03.008_bib32","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1042\/bj20021886","article-title":"Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4)","volume":"371","author":"Zelcer","year":"2003","journal-title":"Biochem J"},{"key":"10.1016\/j.alit.2023.03.008_bib33","doi-asserted-by":"crossref","first-page":"33747","DOI":"10.1074\/jbc.M104833200","article-title":"Transport of cyclic nucleotides and estradiol 17-beta-D-glucuronide by multidrug resistance protein 4. Resistance to 6-mercaptopurine and 6-thioguanine","volume":"276","author":"Chen","year":"2001","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.alit.2023.03.008_bib34","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1128\/MCB.19.3.1720","article-title":"Correlation between protein and mRNA abundance in yeast","volume":"19","author":"Gygi","year":"1999","journal-title":"Mol Cel Biol"},{"key":"10.1016\/j.alit.2023.03.008_bib35","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/gb-2003-4-9-117","article-title":"Comparing protein abundance and mRNA expression levels on a genomic scale","volume":"4","author":"Greenbaum","year":"2003","journal-title":"Genome Biol"},{"key":"10.1016\/j.alit.2023.03.008_bib36","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41586-019-1517-4","article-title":"Organization and regulation of gene transcription","volume":"573","author":"Cramer","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.alit.2023.03.008_bib37","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/nature13438","article-title":"Proteogenomic characterization of human colon and rectal cancer","volume":"513","author":"Zhang","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.alit.2023.03.008_bib38","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/s41568-022-00446-5","article-title":"Cancer proteogenomics: current impact and future prospects","volume":"22","author":"Mani","year":"2022","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.alit.2023.03.008_bib39","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.molcel.2019.09.017","article-title":"Alternative splicing regulatory networks: functions, mechanisms, and evolution","volume":"76","author":"Ule","year":"2019","journal-title":"Mol Cel"},{"key":"10.1016\/j.alit.2023.03.008_bib40","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.bcp.2016.09.016","article-title":"Polymorphic variants of MRP4\/ABCC4 differentially modulate the transport of methylated arsenic metabolites and physiological organic anions","volume":"120","author":"Banerjee","year":"2016","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.alit.2023.03.008_bib41","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1007\/s40262-017-0506-8","article-title":"Renal drug transporters and drug interactions","volume":"56","author":"Ivanyuk","year":"2017","journal-title":"Clin Pharmacokinet"}],"container-title":["Allergology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1323893023000436?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1323893023000436?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:14:11Z","timestamp":1761156851000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1323893023000436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["S1323893023000436"],"URL":"https:\/\/doi.org\/10.1016\/j.alit.2023.03.008","relation":{},"ISSN":["1323-8930"],"issn-type":[{"value":"1323-8930","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differences in the expression of multidrug resistance proteins in chronic rhinosinusitis according to endotype","name":"articletitle","label":"Article Title"},{"value":"Allergology International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.alit.2023.03.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Japanese Society of Allergology. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}