{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:45:56Z","timestamp":1790207156972,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP25ek0109736h"],"award-info":[{"award-number":["JP25ek0109736h"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Allergology International"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.alit.2025.05.003","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T16:01:46Z","timestamp":1749571306000},"page":"356-360","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Updates on the ocular manifestations and treatment of SJS\/TEN"],"prefix":"10.1016","volume":"74","author":[{"given":"Chie","family":"Sotozono","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayumi","family":"Ueta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.alit.2025.05.003_bib1","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.jtos.2016.02.001","article-title":"Acute and chronic ophthalmic involvement in Stevens-Johnson syndrome\/toxic epidermal necrolysis - a comprehensive review and guide to therapy. II. Ophthalmic disease","volume":"14","author":"Kohanim","year":"2016","journal-title":"Ocul Surf"},{"key":"10.1016\/j.alit.2025.05.003_bib2","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ajo.2015.05.002","article-title":"Predictive factors associated with acute ocular involvement in Stevens-Johnson syndrome and toxic epidermal necrolysis","volume":"160","author":"Sotozono","year":"2015","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.alit.2025.05.003_bib3","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.ophtha.2008.12.048","article-title":"Diagnosis and treatment of Stevens-Johnson syndrome and toxic epidermal necrolysis with ocular complications","volume":"116","author":"Sotozono","year":"2009","journal-title":"Ophthalmology"},{"key":"10.1016\/j.alit.2025.05.003_bib4","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.survophthal.2016.01.004","article-title":"Stevens-Johnson syndrome: the role of an ophthalmologist","volume":"61","author":"Jain","year":"2016","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.alit.2025.05.003_bib5","article-title":"Japan: diagnosis and management of Stevens-Johnson syndrome\/toxic epidermal necrolysis with severe ocular complications","volume":"8","author":"Sotozono","year":"2021","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.alit.2025.05.003_bib6","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1016\/j.ophtha.2016.04.041","article-title":"New grading system and treatment guidelines for the acute ocular manifestations of Stevens-Johnson syndrome","volume":"123","author":"Gregory","year":"2016","journal-title":"Ophthalmology"},{"key":"10.1016\/j.alit.2025.05.003_bib7","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S1350-9462(01)00007-6","article-title":"Characteristics of the human ocular surface epithelium","volume":"20","author":"Kinoshita","year":"2001","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.alit.2025.05.003_bib8","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/j.ajo.2008.12.040","article-title":"Successful treatment of Stevens-Johnson syndrome with steroid pulse therapy at disease onset","volume":"147","author":"Araki","year":"2009","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.alit.2025.05.003_bib9","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.ajo.2021.06.015","article-title":"Corticosteroid pulse therapy for Stevens-Johnson syndrome and toxic epidermal necrolysis patients with acute ocular involvement","volume":"231","author":"Mieno","year":"2021","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.alit.2025.05.003_bib10","first-page":"1637","article-title":"Clinical guidelines for erythema exsudativum multiforme major, Stevens-Johnson syndrome and toxic epidermal necrolysis","volume":"126","author":"Shiohara","year":"2016","journal-title":"J Dermatol"},{"key":"10.1016\/j.alit.2025.05.003_bib11","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ajo.2024.05.011","article-title":"Improvement of the ocular prognosis of Stevens-Johnson syndrome and toxic epidermal necrolysis: a national survey in Japan","volume":"267","author":"Kojima","year":"2024","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.alit.2025.05.003_bib12","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1136\/bjo.2010.196295","article-title":"Cytokine storm arising on the ocular surface in a patient with Stevens-Johnson syndrome","volume":"95","author":"Yagi","year":"2011","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.alit.2025.05.003_bib13","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.ajo.2023.05.010","article-title":"Topical betamethasone treatment of Stevens-Johnson syndrome and toxic epidermal necrolysis with ocular involvement in the acute phase","volume":"253","author":"Matsumoto","year":"2023","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.alit.2025.05.003_bib14","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S1542-0124(12)70273-2","article-title":"The ophthalmologic management of acute Stevens-Johnson syndrome","volume":"6","author":"Gregory","year":"2008","journal-title":"Ocul Surf"},{"key":"10.1016\/j.alit.2025.05.003_bib15","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.survophthal.2009.03.004","article-title":"Amniotic membrane transplantation as a new therapy for the acute ocular manifestations of Stevens-Johnson syndrome and toxic epidermal necrolysis","volume":"54","author":"Shay","year":"2009","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.alit.2025.05.003_bib16","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.ophtha.2011.01.046","article-title":"Treatment of acute Stevens-Johnson syndrome and toxic epidermal necrolysis using amniotic membrane: a review of 10 consecutive cases","volume":"118","author":"Gregory","year":"2011","journal-title":"Ophthalmology"},{"key":"10.1016\/j.alit.2025.05.003_bib17","article-title":"USA: ophthalmologic evaluation and management of acute Stevens-Johnson syndrome","volume":"8","author":"Gregory","year":"2021","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.alit.2025.05.003_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0260730","article-title":"Multi-state model for predicting ocular progression in acute Stevens-Johnson syndrome\/toxic epidermal necrolysis","volume":"16","author":"Kinoshita","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.alit.2025.05.003_bib19","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ajo.2018.01.028","article-title":"Chronic ocular sequelae of Stevens-Johnson syndrome in children: long-term impact of appropriate therapy on natural history of disease","volume":"189","author":"Basu","year":"2018","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.alit.2025.05.003_bib20","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.preteyeres.2012.05.003","article-title":"Ocular surface inflammation is regulated by innate immunity","volume":"31","author":"Ueta","year":"2012","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.alit.2025.05.003_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.741654","article-title":"Categorization of the ocular microbiome in Japanese Stevens-Johnson syndrome patients with severe ocular complications","volume":"11","author":"Ueta","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.alit.2025.05.003_bib22","doi-asserted-by":"crossref","first-page":"S94","DOI":"10.1097\/01.ico.0000263127.84015.3f","article-title":"Methicillin-resistant Staphylococcus aureus and methicillin-resistant Staphylococcus epidermidis infections in the cornea","volume":"21","author":"Sotozono","year":"2002","journal-title":"Cornea"},{"key":"10.1016\/j.alit.2025.05.003_bib23","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jaci.2010.08.007","article-title":"Association between prostaglandin E receptor 3 polymorphisms and Stevens-Johnson syndrome identified by means of a genome-wide association study","volume":"126","author":"Ueta","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2025.05.003_bib24","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jaci.2014.12.1916","article-title":"IKZF1, a new susceptibility gene for cold medicine-related Stevens-Johnson syndrome\/toxic epidermal necrolysis with severe mucosal involvement","volume":"135","author":"Ueta","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2025.05.003_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0025209","article-title":"Prostaglandin E receptor subtype EP3 expression in human conjunctival epithelium and its changes in various ocular surface disorders","volume":"6","author":"Ueta","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.alit.2025.05.003_bib26","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/all.13308","article-title":"Mucocutaneous inflammation in the Ikaros family Zinc finger 1-keratin 5-specific transgenic mice","volume":"73","author":"Ueta","year":"2018","journal-title":"Allergy"},{"key":"10.1016\/j.alit.2025.05.003_bib27","first-page":"285","article-title":"Triggering of TLR3 by polyI:C in human corneal epithelial cells to induce inflammatory cytokines. Biochem Biophys Res Commun","volume":"331","author":"Ueta","year":"2005"},{"key":"10.1016\/j.alit.2025.05.003_bib28","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1136\/bjo.2006.113449","article-title":"Toll-like receptor 3 gene polymorphisms in Japanese patients with Stevens-Johnson syndrome","volume":"91","author":"Ueta","year":"2007","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.alit.2025.05.003_bib29","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.jaci.2008.09.044","article-title":"Prostaglandin E receptor subtype EP3 in conjunctival epithelium regulates late-phase reaction of experimental allergic conjunctivitis","volume":"123","author":"Ueta","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2025.05.003_bib30","doi-asserted-by":"crossref","DOI":"10.1038\/hgv.2015.23","article-title":"HLA-A\u221702:06 and PTGER3 polymorphism exert additive effects in cold medicine-related Stevens-Johnson syndrome with severe ocular complications","volume":"2","author":"Ueta","year":"2015","journal-title":"Hum Genome Var"},{"key":"10.1016\/j.alit.2025.05.003_bib31","doi-asserted-by":"crossref","first-page":"S57","DOI":"10.1097\/ICO.0b013e31826a7f41","article-title":"Epistatic interactions associated with Stevens-Johnson syndrome","volume":"31","author":"Ueta","year":"2012","journal-title":"Cornea"},{"key":"10.1016\/j.alit.2025.05.003_bib32","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1016\/j.ophtha.2006.10.029","article-title":"New grading system for the evaluation of chronic ocular manifestations in patients with Stevens-Johnson syndrome","volume":"114","author":"Sotozono","year":"2007","journal-title":"Ophthalmology"},{"key":"10.1016\/j.alit.2025.05.003_bib33","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1097\/ICO.0000000000002263","article-title":"Long-term progression of ocular surface disease in Stevens-Johnson syndrome and toxic epidermal necrolysis","volume":"39","author":"Yoshikawa","year":"2020","journal-title":"Cornea"},{"key":"10.1016\/j.alit.2025.05.003_bib34","doi-asserted-by":"crossref","first-page":"DES80","DOI":"10.1167\/iovs.18-24019","article-title":"Severe dry eye with combined mechanisms is involved in the ocular sequelae of SJS\/TEN at the chronic stage","volume":"59","author":"Sotozono","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.alit.2025.05.003_bib35","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ajo.2013.11.010","article-title":"A multicenter, open-label, 52-week study of 2% rebamipide (OPC-12759) ophthalmic suspension in patients with dry eye","volume":"157","author":"Kinoshita","year":"2014","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.alit.2025.05.003_bib36","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1097\/ICO.0000000000000680","article-title":"Treatment modalities and clinical outcomes in ocular sequelae of Stevens-Johnson syndrome over 25 years--A paradigm shift","volume":"35","author":"Iyer","year":"2016","journal-title":"Cornea"},{"key":"10.1016\/j.alit.2025.05.003_bib37","doi-asserted-by":"crossref","first-page":"785","DOI":"10.4103\/ijo.IJO_429_21","article-title":"Mucous membrane grafting for lid margin keratinization in Stevens Johnson syndrome - an eye opening saga","volume":"69","author":"Iyer","year":"2021","journal-title":"Indian J Ophthalmol"},{"key":"10.1016\/j.alit.2025.05.003_bib38","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.ajo.2009.07.006","article-title":"Vision-related function after scleral lens fitting in ocular complications of Stevens-Johnson syndrome and toxic epidermal necrolysis","volume":"148","author":"Tougeron-Brousseau","year":"2009","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.alit.2025.05.003_bib39","doi-asserted-by":"crossref","first-page":"279","DOI":"10.4103\/0301-4738.81994","article-title":"Boston ocular surface prosthesis: an Indian experience","volume":"59","author":"Rathi","year":"2011","journal-title":"Indian J Ophthalmol"},{"key":"10.1016\/j.alit.2025.05.003_bib40","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.ajo.2014.07.012","article-title":"Tear exchangeable limbal rigid contact lens for ocular sequelae resulting from Stevens-Johnson syndrome or toxic epidermal necrolysis","volume":"158","author":"Sotozono","year":"2014","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.alit.2025.05.003_bib41","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.clae.2020.05.007","article-title":"Clinical trial to evaluate the therapeutic benefits of limbal-supported contact lens wear for ocular sequelae due to Stevens-Johnson syndrome\/toxic epidermal necrolysis","volume":"43","author":"Itoi","year":"2020","journal-title":"Cont Lens Anterior Eye"},{"key":"10.1016\/j.alit.2025.05.003_bib42","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1097\/ICL.0000000000000989","article-title":"Long-term benefits of tear exchangeable limbal-rigid contact lens wear therapy in Stevens-Johnson syndrome cases","volume":"49","author":"Yoshikawa","year":"2023","journal-title":"Eye Contact Lens"},{"key":"10.1016\/j.alit.2025.05.003_bib43","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ophtha.2012.07.053","article-title":"Visual improvement after cultivated oral mucosal epithelial transplantation","volume":"120","author":"Sotozono","year":"2013","journal-title":"Ophthalmology"},{"key":"10.1016\/j.alit.2025.05.003_bib44","doi-asserted-by":"crossref","first-page":"e447","DOI":"10.1111\/aos.12397","article-title":"Cultivated oral mucosal epithelial transplantation for persistent epithelial defect in severe ocular surface diseases with acute inflammatory activity","volume":"92","author":"Sotozono","year":"2014","journal-title":"Acta Ophthalmol"},{"key":"10.1016\/j.alit.2025.05.003_bib45","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ophtha.2016.07.011","article-title":"Long-term visual outcomes and complications of Boston Keratoprosthesis Type II implantation","volume":"124","author":"Lee","year":"2017","journal-title":"Ophthalmology"},{"key":"10.1016\/j.alit.2025.05.003_bib46","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jtos.2018.08.003","article-title":"Boston Type 2 keratoprosthesis- mid term outcomes from a tertiary eye care centre in India","volume":"17","author":"Iyer","year":"2019","journal-title":"Ocul Surf"},{"key":"10.1016\/j.alit.2025.05.003_bib47","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.ajo.2022.06.022","article-title":"Restoration of vision in severe, cicatricial, ocular surface disease with the Boston Keratoprosthesis Type II","volume":"243","author":"Saini","year":"2022","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.alit.2025.05.003_bib48","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1080\/08820530590931386","article-title":"The osteo-odonto-keratoprosthesis (OOKP)","volume":"20","author":"Liu","year":"2005","journal-title":"Semin Ophthalmol"},{"key":"10.1016\/j.alit.2025.05.003_bib49","doi-asserted-by":"crossref","first-page":"S56","DOI":"10.1097\/ICO.0b013e31817f1fe4","article-title":"Osteo-odonto-keratoprosthesis in Japan","volume":"27","author":"Fukuda","year":"2008","journal-title":"Cornea"},{"key":"10.1016\/j.alit.2025.05.003_bib50","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ajo.2022.05.015","article-title":"Osteo-odonto-keratoprosthesis according to Strampelli original technique: a retrospective study with up to 30 years of follow-up","volume":"242","author":"Iannetti","year":"2022","journal-title":"Am J Ophthalmol"}],"container-title":["Allergology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S132389302500053X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S132389302500053X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T19:17:25Z","timestamp":1750965445000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S132389302500053X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S132389302500053X"],"URL":"https:\/\/doi.org\/10.1016\/j.alit.2025.05.003","relation":{},"ISSN":["1323-8930"],"issn-type":[{"value":"1323-8930","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Updates on the ocular manifestations and treatment of SJS\/TEN","name":"articletitle","label":"Article Title"},{"value":"Allergology International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.alit.2025.05.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Japanese Society of Allergology. Published by Elsevier B.V\u00e9","name":"copyright","label":"Copyright"}]}}