{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T21:23:49Z","timestamp":1787174629372,"version":"build-2736575974"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:00:00Z","timestamp":1784937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000646","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25K20158"],"award-info":[{"award-number":["25K20158"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015990","name":"Sanofi KK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015990","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Allergology International"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.alit.2026.07.005","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T11:39:38Z","timestamp":1787053178000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Downregulation of leukocyte immunoglobulin-like receptor B3 is involved in eosinophilic rhinosinusitis"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9413-8267","authenticated-orcid":false,"given":"Yusuke","family":"Nouchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0823-1802","authenticated-orcid":false,"given":"Yuji","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Chiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yui","family":"Kawai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chihiro","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Abiko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7523-8177","authenticated-orcid":false,"given":"Shinichi","family":"Saitoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akemi","family":"Araki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0181-5549","authenticated-orcid":false,"given":"Risako","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4413-6113","authenticated-orcid":false,"given":"Junji","family":"Yokozawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4237-3564","authenticated-orcid":false,"given":"Tsukasa","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1051-4799","authenticated-orcid":false,"given":"Hironobu","family":"Asao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.alit.2026.07.005_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4193\/Rhin20.401","article-title":"European position paper on rhinosinusitis and nasal polyps 2020","volume":"58","author":"Fokkens","year":"2020","journal-title":"Rhinol"},{"key":"10.1016\/j.alit.2026.07.005_bib2","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1111\/all.15074","article-title":"Endotypes of chronic rhinosinusitis: relationships to disease phenotypes, pathogenesis, clinical findings, and treatment approaches","volume":"77","author":"Kato","year":"2022","journal-title":"Allergy"},{"key":"10.1016\/j.alit.2026.07.005_bib3","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1111\/all.12644","article-title":"Novel scoring system and algorithm for classifying chronic rhinosinusitis: the JESREC Study","volume":"70","author":"Tokunaga","year":"2015","journal-title":"Allergy"},{"key":"10.1016\/j.alit.2026.07.005_bib4","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/alr.22487","article-title":"Revision surgery rates in chronic rhinosinusitis with nasal polyps: meta-analysis of risk factors","volume":"10","author":"Loftus","year":"2020","journal-title":"Int Forum Allergy Rhinol"},{"key":"10.1016\/j.alit.2026.07.005_bib5","doi-asserted-by":"crossref","first-page":"171","DOI":"10.2332\/allergolint.13-RAI-0673","article-title":"Expressions and roles of periostin in otolaryngological diseases","volume":"63","author":"Ohta","year":"2014","journal-title":"Allergol Int"},{"key":"10.1016\/j.alit.2026.07.005_bib6","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.alit.2022.08.006","article-title":"Periostin is an aggravating factor and predictive biomarker of eosinophilic chronic rhinosinusitis","volume":"72","author":"Sato","year":"2023","journal-title":"Allergol Int"},{"key":"10.1016\/j.alit.2026.07.005_bib7","doi-asserted-by":"crossref","first-page":"715","DOI":"10.3390\/diagnostics13040715","article-title":"The diagnostic and prognostic role of biomarkers in chronic rhinosinusitis","volume":"13","author":"Seah","year":"2023","journal-title":"Diagnostics"},{"key":"10.1016\/j.alit.2026.07.005_bib8","doi-asserted-by":"crossref","first-page":"193","DOI":"10.2147\/JAA.S176026","article-title":"Adverse outcomes from initiation of systemic corticosteroids for asthma: long-term observational study","volume":"11","author":"Price","year":"2018","journal-title":"J Asthma Allergy"},{"key":"10.1016\/j.alit.2026.07.005_bib9","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1016\/S0140-6736(19)31881-1","article-title":"Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 3 trials","volume":"394","author":"Bachert","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.alit.2026.07.005_bib10","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1056\/NEJMoa1804092","article-title":"Dupilumab efficacy and safety in moderate-to-severe uncontrolled asthma","volume":"378","author":"Castro","year":"2018","journal-title":"N Engl J Med"},{"key":"10.1016\/j.alit.2026.07.005_bib11","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.151553","article-title":"Human inhibitory leukocyte Ig-like receptors: from immunotolerance to immunotherapy","volume":"7","author":"De Louche","year":"2022","journal-title":"JCI insight"},{"key":"10.1016\/j.alit.2026.07.005_bib12","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s00251-021-01240-7","article-title":"Immunoglobulin-like receptors and the generation of innate immune memory","volume":"74","author":"Al-Moussawy","year":"2022","journal-title":"Immunogenetics"},{"key":"10.1016\/j.alit.2026.07.005_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1282874","article-title":"Human leukocyte immunoglobulin-like receptors in health and disease","volume":"14","author":"Redondo-Garc\u00eda","year":"2023","journal-title":"Front Immunol"},{"key":"10.1016\/j.alit.2026.07.005_bib14","first-page":"16","article-title":"Leukocyte immunoglobulin-like receptor subfamily B: therapeutic targets in cancer","volume":"4","author":"Deng","year":"2021","journal-title":"Antib Ther"},{"key":"10.1016\/j.alit.2026.07.005_bib15","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/j.0001-2815.2004.00290.x","article-title":"The LILR family: modulators of innate and adaptive immune pathways in health and disease","volume":"64","author":"Brown","year":"2004","journal-title":"Tissue Antigens"},{"key":"10.1016\/j.alit.2026.07.005_bib16","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1158\/2326-6066.CIR-23-0496","article-title":"LILRB3 supports immunosuppressive activity of myeloid cells and tumor development","volume":"12","author":"Huang","year":"2024","journal-title":"Cancer Immunol Res"},{"key":"10.1016\/j.alit.2026.07.005_bib17","series-title":"Encyclopedia of signaling molecules","first-page":"2869","article-title":"LILRB","author":"Zhang","year":"2018"},{"key":"10.1016\/j.alit.2026.07.005_bib18","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/ni801","article-title":"Impaired dendritic cell maturation and increased TH2 responses in PIR-B-\/- mice","volume":"3","author":"Ujike","year":"2002","journal-title":"Nat Immunol"},{"key":"10.1016\/j.alit.2026.07.005_bib19","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1189\/jlb.1106667","article-title":"Inhibitory receptor gp49B regulates eosinophil infiltration during allergic inflammation","volume":"82","author":"Norris","year":"2007","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.alit.2026.07.005_bib20","doi-asserted-by":"crossref","first-page":"2832","DOI":"10.1182\/blood-2004-01-0268","article-title":"Leukocyte immunoglobulin-like receptors: novel innate receptors for human basophil activation and inhibition","volume":"104","author":"Sloane","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.alit.2026.07.005_bib21","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1016\/S0194-5998(97)70005-6","article-title":"Staging for rhinosinusitis","volume":"117","author":"Lund","year":"1997","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.alit.2026.07.005_bib22","first-page":"91","article-title":"A comparison of computerized tomographic staging systems in chronic sinusitis","volume":"21","author":"Oluwole","year":"1996","journal-title":"Clin Otolaryngol Allied Sci"},{"key":"10.1016\/j.alit.2026.07.005_bib23","doi-asserted-by":"crossref","first-page":"5694","DOI":"10.1182\/blood-2007-12-126748","article-title":"A dual activation and inhibition role for the paired immunoglobulin-like receptor B in eosinophils","volume":"111","author":"Munitz","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.alit.2026.07.005_bib24","doi-asserted-by":"crossref","first-page":"707","DOI":"10.4049\/jimmunol.1501873","article-title":"Paired Ig-like receptor B inhibits IL-13-driven eosinophil accumulation and activation in the esophagus","volume":"197","author":"Ben Baruch-Morgenstern","year":"2016","journal-title":"J Immunol"},{"key":"10.1016\/j.alit.2026.07.005_bib25","doi-asserted-by":"crossref","first-page":"2800","DOI":"10.1002\/eji.200324732","article-title":"A gene signature of inhibitory MHC receptors identifies a BDCA3+ subset of IL-10-induced dendritic cells with reduced allostimulatory capacity in vitro","volume":"34","author":"Velten","year":"2004","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.alit.2026.07.005_bib26","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1096\/fj.04-1617fje","article-title":"HLA-G up-regulates ILT2, ILT3, ILT4, and KIR2DL4 in antigen presenting cells, NK cells, and T cells","volume":"19","author":"LeMaoult","year":"2005","journal-title":"FASEB J"},{"key":"10.1016\/j.alit.2026.07.005_bib27","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1093\/intimm\/dxw044","article-title":"Tolerogenic immunoreceptor ILT3\/LILRB4 paradoxically marks pathogenic auto-antibody-producing plasmablasts and plasma cells in non-treated SLE","volume":"28","author":"Inui","year":"2016","journal-title":"Int Immunol"},{"key":"10.1016\/j.alit.2026.07.005_bib28","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1084\/jem.20011435","article-title":"Interleukin 4 reduces expression of inhibitory receptors on B cells and abolishes CD22 and Fc\u03b3RII-mediated B cell suppression","volume":"195","author":"Rudge","year":"2002","journal-title":"J Exp Med"},{"key":"10.1016\/j.alit.2026.07.005_bib29","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/ni.2757","article-title":"Paired immunoglobulin-like receptor A is an intrinsic, self-limiting suppressor of IL-5\u2013induced eosinophil development","volume":"15","author":"Ben Baruch-Morgenstern","year":"2014","journal-title":"Nat Immunol"},{"key":"10.1016\/j.alit.2026.07.005_bib30","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.jaci.2024.05.014","article-title":"Single cell RNA sequencing of human eosinophils from nasal polyps reveals eosinophil heterogeneity in chronic rhinosinusitis tissue","volume":"154","author":"Iwasaki","year":"2024","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2026.07.005_bib31","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3346\/jkms.2003.18.1.97","article-title":"Eosinophil inflammation of nasal polyp tissue: relationships with matrix metalloproteinases, tissue inhibitor of metalloproteinase-1, and transforming growth factor-\u03b21","volume":"18","author":"Lee","year":"2003","journal-title":"J Korean Med Sci"},{"key":"10.1016\/j.alit.2026.07.005_bib32","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1016\/j.jaci.2021.11.023","article-title":"Elevation of activated neutrophils in chronic rhinosinusitis with nasal polyps","volume":"149","author":"Poposki","year":"2022","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2026.07.005_bib33","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s40463-017-0214-2","article-title":"IL-5 and IL-6 are increased in the frontal recess of eosinophilic chronic rhinosinusitis patients","volume":"46","author":"Kubota","year":"2017","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.alit.2026.07.005_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.amjoto.2022.103561","article-title":"Tissue eosinophils and mucous inflammatory cytokines for the evaluation of olfactory recovery after endoscopic sinus surgery in patients with nasal polyposis","volume":"43","author":"Zhang","year":"2022","journal-title":"Am J Otolaryngol"},{"key":"10.1016\/j.alit.2026.07.005_bib35","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.alit.2022.08.006","article-title":"Periostin is an aggravating factor and predictive biomarker of eosinophilic chronic rhinosinusitis","volume":"72","author":"Sato","year":"2023","journal-title":"Allergol Int"}],"container-title":["Allergology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1323893026000857?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1323893026000857?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:25:35Z","timestamp":1787171135000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1323893026000857"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":35,"alternative-id":["S1323893026000857"],"URL":"https:\/\/doi.org\/10.1016\/j.alit.2026.07.005","relation":{},"ISSN":["1323-8930"],"issn-type":[{"value":"1323-8930","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Downregulation of leukocyte immunoglobulin-like receptor B3 is involved in eosinophilic rhinosinusitis","name":"articletitle","label":"Article Title"},{"value":"Allergology International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.alit.2026.07.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Japanese Society of Allergology. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}