{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T20:23:14Z","timestamp":1787689394614,"version":"build-2784847793"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007786","name":"National Center for Child Health and Development","doi-asserted-by":"publisher","award":["2025A-4"],"award-info":[{"award-number":["2025A-4"]}],"id":[{"id":"10.13039\/100007786","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018984","name":"Institute of Medical Science, University of Tokyo","doi-asserted-by":"publisher","award":["23-3099"],"award-info":[{"award-number":["23-3099"]}],"id":[{"id":"10.13039\/501100018984","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004721","name":"The University of Tokyo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004721","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["26K02450"],"award-info":[{"award-number":["26K02450"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25K22637"],"award-info":[{"award-number":["25K22637"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K19536"],"award-info":[{"award-number":["22K19536"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K27638"],"award-info":[{"award-number":["23K27638"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100032874","name":"Kawano Masanori Memorial Public Interest Incorporated Foundation for Promotion of Pediatrics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100032874","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004053","name":"Masanori Kawano Memorial Public Interest Foundation for Promotion of Pediatrics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012016","name":"Nipponham Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012016","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Allergology International"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.alit.2026.08.002","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T11:32:54Z","timestamp":1787398374000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Continuous succinate administration induces eosinophilic enteritis via the tuft cell-IL-25 axis in mice"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2317-5845","authenticated-orcid":false,"given":"Ryo","family":"Matsuoka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8927-1960","authenticated-orcid":false,"given":"Naoko","family":"Nagano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Sugiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayako","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Orimo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Tamari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1519-5501","authenticated-orcid":false,"given":"Kenichiro","family":"Motomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisataka","family":"Nakazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromichi","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taro","family":"Higuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Ikutani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Arae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichi","family":"Furukawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuko","family":"Sudo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimihiko","family":"Oishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6630-8337","authenticated-orcid":false,"given":"Hirohisa","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susumu","family":"Nakae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0928-8322","authenticated-orcid":false,"given":"Hideaki","family":"Morita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2630-6927","authenticated-orcid":false,"given":"Kenji","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.alit.2026.08.002_bib1","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.coi.2008.07.010","article-title":"Allergy and eosinophil-associated gastrointestinal disorders (EGID)","volume":"20","author":"DeBrosse","year":"2008","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.alit.2026.08.002_bib2","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1097\/MPG.0000000000003877","article-title":"Joint ESPGHAN\/NASPGHAN guidelines on childhood eosinophilic gastrointestinal disorders beyond eosinophilic esophagitis","volume":"78","author":"Papadopoulou","year":"2024","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.alit.2026.08.002_bib3","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1097\/MPG.0000000000000865","article-title":"Prevalence of eosinophilic gastritis, gastroenteritis, and colitis: estimates from a national administrative database","volume":"62","author":"Jensen","year":"2016","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.alit.2026.08.002_bib4","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1016\/j.cgh.2017.05.050","article-title":"Prevalence of eosinophilic gastroenteritis and colitis in a population-based study, from 2012 to 2017","volume":"15","author":"Mansoor","year":"2017","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.alit.2026.08.002_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaip.2021.06.026","article-title":"Comparison of nonesophageal eosinophilic gastrointestinal disorders with eosinophilic esophagitis: a nationwide survey","volume":"9","author":"Yamamoto","year":"2021","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.alit.2026.08.002_bib6","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s12016-015-8489-4","article-title":"Eosinophilic gastroenteritis and colitis: a comprehensive review","volume":"50","author":"Uppal","year":"2016","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.alit.2026.08.002_bib7","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.jaci.2023.05.024","article-title":"Prospective study of an amino acid-based elemental diet in an eosinophilic gastritis and gastroenteritis nutrition trial","volume":"152","author":"Gonsalves","year":"2023","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2026.08.002_bib8","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.alit.2022.11.001","article-title":"Tolerability and safety of a new elimination diet for pediatric eosinophilic gastritis and duodenitis","volume":"72","author":"Nagashima","year":"2023","journal-title":"Allergol Int"},{"key":"10.1016\/j.alit.2026.08.002_bib9","doi-asserted-by":"crossref","first-page":"858","DOI":"10.3390\/diagnostics14080858","article-title":"The dual lens of endoscopy and histology in the diagnosis and management of eosinophilic gastrointestinal Disorders-A comprehensive review","volume":"14","author":"Barchi","year":"2024","journal-title":"Diagnostics (Basel)"},{"key":"10.1016\/j.alit.2026.08.002_bib10","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature16161","article-title":"Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit","volume":"529","author":"von Moltke","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.alit.2026.08.002_bib11","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/nature16527","article-title":"Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites","volume":"529","author":"Gerbe","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.alit.2026.08.002_bib12","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1126\/science.aaf1648","article-title":"Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut","volume":"351","author":"Howitt","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.alit.2026.08.002_bib13","doi-asserted-by":"crossref","first-page":"3332","DOI":"10.1111\/all.14863","article-title":"Characteristics of tissue-resident ILCs and their potential as therapeutic targets in mucosal and skin inflammatory diseases","volume":"76","author":"Orimo","year":"2021","journal-title":"Allergy"},{"key":"10.1016\/j.alit.2026.08.002_bib14","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.immuni.2018.07.002","article-title":"Getting a taste for parasites in the gut","volume":"49","author":"Loke","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.alit.2026.08.002_bib15","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.immuni.2018.06.016","article-title":"Detection of succinate by intestinal tuft cells triggers a type 2 innate immune circuit","volume":"49","author":"Nadjsombati","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.alit.2026.08.002_bib16","doi-asserted-by":"crossref","first-page":"5552","DOI":"10.1073\/pnas.1720758115","article-title":"Activation of intestinal tuft cell-expressed Sucnr1 triggers type 2 immunity in the mouse small intestine","volume":"115","author":"Lei","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.alit.2026.08.002_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2018.05.014","article-title":"A metabolite-triggered tuft Cell-ILC2 circuit drives small intestinal remodeling","volume":"174","author":"Schneider","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.alit.2026.08.002_bib18","first-page":"845","article-title":"Significance of mouse models in dissecting the mechanism of human eosinophilic gastrointestinal diseases (EGID)","volume":"2","author":"Mishra","year":"2013","journal-title":"J Gastroenterol Hepatol Res"},{"key":"10.1016\/j.alit.2026.08.002_bib19","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/978-1-0716-1095-4_21","article-title":"Experimental modeling of eosinophil-associated diseases","volume":"2241","author":"Upparahalli","year":"2021","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.alit.2026.08.002_bib20","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.126219","article-title":"Siglec-8 antibody reduces eosinophils and mast cells in a transgenic mouse model of eosinophilic gastroenteritis","volume":"4","author":"Youngblood","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.alit.2026.08.002_bib21","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.ajpath.2010.11.041","article-title":"Tissue eosinophilia in a mouse model of colitis is highly dependent on TLR2 and independent of mast cells","volume":"178","author":"Albert","year":"2011","journal-title":"Am J Pathol"},{"key":"10.1016\/j.alit.2026.08.002_bib22","doi-asserted-by":"crossref","first-page":"703","DOI":"10.4049\/jimmunol.1101270","article-title":"Identification of innate IL-5-producing cells and their role in lung eosinophil regulation and antitumor immunity","volume":"188","author":"Ikutani","year":"2012","journal-title":"J Immunol"},{"key":"10.1016\/j.alit.2026.08.002_bib23","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/nbt0102-87","article-title":"A variant of yellow fluorescent protein with fast and efficient maturation for cell-biological applications","volume":"20","author":"Nagai","year":"2002","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.alit.2026.08.002_bib24","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.jaci.2011.09.041","article-title":"Innate IL-13-producing nuocytes arise during allergic lung inflammation and contribute to airways hyperreactivity","volume":"129","author":"Barlow","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2026.08.002_bib25","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/nn.2820","article-title":"Skn-1a (Pou2f3) specifies taste receptor cell lineage","volume":"14","author":"Matsumoto","year":"2011","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.alit.2026.08.002_bib26","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1471-2202-15-13","article-title":"Skn-1a\/Pou2f3 is required for the generation of Trpm5-expressing microvillous cells in the mouse main olfactory epithelium","volume":"15","author":"Yamaguchi","year":"2014","journal-title":"BMC Neurosci"},{"key":"10.1016\/j.alit.2026.08.002_bib27","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0385-20.2020","article-title":"Sodium-Taste cells require Skn-1a for generation and share molecular features with sweet, umami, and bitter taste cells","volume":"7","author":"Ohmoto","year":"2020","journal-title":"eNeuro"},{"key":"10.1016\/j.alit.2026.08.002_bib28","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1053\/j.gastro.2022.01.022","article-title":"Evaluating eosinophilic colitis as a unique disease using colonic molecular profiles: a multi-site Study","volume":"162","author":"Shoda","year":"2022","journal-title":"Gastroenterology"},{"key":"10.1016\/j.alit.2026.08.002_bib29","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.jaci.2022.12.814","article-title":"Molecular analysis of duodenal eosinophilia","volume":"151","author":"Shoda","year":"2023","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2026.08.002_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0189340","article-title":"Skn-1a\/Pou2f3 functions as a master regulator to generate Trpm5-expressing chemosensory cells in mice","volume":"12","author":"Yamashita","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.alit.2026.08.002_bib31","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/s41586-018-0353-2","article-title":"Accumulation of succinate controls activation of adipose tissue thermogenesis","volume":"560","author":"Mills","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.alit.2026.08.002_bib32","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3390\/nu11010025","article-title":"The role of succinate in the regulation of intestinal inflammation","volume":"11","author":"Connors","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.alit.2026.08.002_bib33","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S2468-1253(23)00145-0","article-title":"Benralizumab for eosinophilic gastritis: a single-site, randomised, double-blind, placebo-controlled, phase 2 trial","volume":"8","author":"Kliewer","year":"2023","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1016\/j.alit.2026.08.002_bib34","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.anai.2022.06.015","article-title":"Biologics in eosinophilic gastrointestinal diseases","volume":"130","author":"Dellon","year":"2023","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.alit.2026.08.002_bib35","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.jaci.2022.05.012","article-title":"Eosinophilic gastrointestinal diseases make a name for themselves: a new consensus statement with updated nomenclature","volume":"150","author":"Wright","year":"2022","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2026.08.002_bib36","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1038\/s41577-024-01048-y","article-title":"Spatial adaptation of eosinophils and their emerging roles in homeostasis, infection and disease","volume":"24","author":"Arnold","year":"2024","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.alit.2026.08.002_bib37","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.alit.2024.03.002","article-title":"Eosinophilic mucus diseases","volume":"73","author":"Arima","year":"2024","journal-title":"Allergol Int"},{"key":"10.1016\/j.alit.2026.08.002_bib38","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.alit.2020.02.002","article-title":"The roles of IL-5 and anti-IL-5 treatment in eosinophilic diseases: asthma, eosinophilic granulomatosis with polyangiitis, and eosinophilic chronic rhinosinusitis","volume":"69","author":"Nagase","year":"2020","journal-title":"Allergol Int"},{"key":"10.1016\/j.alit.2026.08.002_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2022.12.802","article-title":"STAT6 gain-of-function variant exacerbates multiple allergic symptoms","volume":"151","author":"Takeuchi","year":"2023","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2026.08.002_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2022.09.028","article-title":"A germline STAT6 gain-of-function variant is associated with early-onset allergies","volume":"151","author":"Suratannon","year":"2023","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2026.08.002_bib41","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.it.2023.12.003","article-title":"Human germline gain-of-function in STAT6: from severe allergic disease to lymphoma and beyond","volume":"45","year":"2024","journal-title":"Trends Immunol"},{"key":"10.1016\/j.alit.2026.08.002_bib42","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1016\/j.jaci.2024.09.023","article-title":"Omics in allergy and asthma","volume":"154","author":"Saito","year":"2024","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2026.08.002_bib43","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3390\/biom13010112","article-title":"Dupilumab leads to clinical improvements including the acquisition of tolerance to causative foods in non-eosinophilic esophagitis eosinophilic gastrointestinal disorders","volume":"13","author":"Arakawa","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.alit.2026.08.002_bib44","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1067\/mpd.2002.127663","article-title":"Eosinophil-associated gastrointestinal disorders: a world-wide-web based registry","volume":"141","author":"Guajardo","year":"2002","journal-title":"J Pediatr"},{"key":"10.1016\/j.alit.2026.08.002_bib45","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1172\/JCI19785","article-title":"Mast cells are required for experimental oral allergen-induced diarrhea","volume":"112","author":"Brandt","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.alit.2026.08.002_bib46","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1093\/ibd\/izae168","article-title":"Eosinophil depletion as a potential therapeutic strategy in acute and chronic intestinal inflammation based on a dextran sulfate sodium colitis model","volume":"31","author":"Jacobs","year":"2025","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.alit.2026.08.002_bib47","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1038\/s41590-025-02166-y","article-title":"Succinate drives gut inflammation by promoting FOXP3 degradation through a molecular switch","volume":"26","author":"Wang","year":"2025","journal-title":"Nat Immunol"},{"key":"10.1016\/j.alit.2026.08.002_bib48","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2026307118","article-title":"Up-regulation of gasdermin C in mouse small intestine is associated with lytic cell death in enterocytes in worm-induced type 2 immunity","volume":"118","author":"Xi","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.alit.2026.08.002_bib49","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/j.jaci.2014.07.026","article-title":"Histologic eosinophilic gastritis is a systemic disorder associated with blood and extragastric eosinophilia, TH2 immunity, and a unique gastric transcriptome","volume":"134","author":"Caldwell","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2026.08.002_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaip.2017.03.030","article-title":"Gene expression patterns in distinct endoscopic findings for eosinophilic gastritis in children","volume":"5","author":"Sato","year":"2017","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.alit.2026.08.002_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2016.02.034","article-title":"Allergic skin sensitization promotes eosinophilic esophagitis through the IL-33-basophil axis in mice","volume":"138","author":"Venturelli","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2026.08.002_bib52","first-page":"511","article-title":"Eosinophils beyond the esophagus: a review of Non-EoE eosinophilic gastrointestinal diseases","volume":"21","author":"Lam","year":"2025","journal-title":"Gastroenterol Hepatol (N Y)"},{"key":"10.1016\/j.alit.2026.08.002_bib53","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.cgh.2021.05.053","article-title":"Determination of biopsy yield that optimally detects eosinophilic gastritis And\/or duodenitis in a randomized trial of lirentelimab","volume":"20","author":"Dellon","year":"2022","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.alit.2026.08.002_bib54","first-page":"273","article-title":"Short-term high fat feeding induces inflammatory responses of tuft cells and mucosal barrier cells in the murine stomach","volume":"38","author":"Widmayer","year":"2023","journal-title":"Histol Histopathol"},{"key":"10.1016\/j.alit.2026.08.002_bib55","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.cmet.2016.06.013","article-title":"Microbiota-produced succinate improves glucose homeostasis via intestinal gluconeogenesis","volume":"24","author":"De Vadder","year":"2016","journal-title":"Cell Metab"},{"key":"10.1016\/j.alit.2026.08.002_bib56","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2219431120","article-title":"Cross talk between paneth and tuft cells drives dysbiosis and inflammation in the gut mucosa","volume":"120","author":"Coutry","year":"2023","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.alit.2026.08.002_bib57","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2216908120","article-title":"Tuft cells mediate commensal remodeling of the small intestinal antimicrobial landscape","volume":"120","author":"Fung","year":"2023","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.alit.2026.08.002_bib58","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.cell.2013.12.016","article-title":"Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits","volume":"156","author":"De Vadder","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.alit.2026.08.002_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.immuni.2024.01.002","article-title":"Microbiota-derived butyrate restricts tuft cell differentiation via histone deacetylase 3 to modulate intestinal type 2 immunity","volume":"57","author":"Eshleman","year":"2024","journal-title":"Immunity"},{"key":"10.1016\/j.alit.2026.08.002_bib60","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1016\/j.jaci.2024.03.013","article-title":"Common and disparate clinical presentations and mechanisms in different eosinophilic gastrointestinal diseases","volume":"153","author":"Shoda","year":"2024","journal-title":"J Allergy Clin Immunol"}],"container-title":["Allergology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1323893026000900?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1323893026000900?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T20:04:02Z","timestamp":1787688242000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1323893026000900"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":60,"alternative-id":["S1323893026000900"],"URL":"https:\/\/doi.org\/10.1016\/j.alit.2026.08.002","relation":{},"ISSN":["1323-8930"],"issn-type":[{"value":"1323-8930","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Continuous succinate administration induces eosinophilic enteritis via the tuft cell-IL-25 axis in mice","name":"articletitle","label":"Article Title"},{"value":"Allergology International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.alit.2026.08.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Japanese Society of Allergology. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}