{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:53:17Z","timestamp":1791499997866,"version":"4.3.4"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K08240"],"award-info":[{"award-number":["22K08240"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP23ek0410110"],"award-info":[{"award-number":["JP23ek0410110"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013236","name":"MSD Life Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013236","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001697","name":"Keio University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001697","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Allergology International"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.alit.2026.09.004","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:56:51Z","timestamp":1790913411000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Adeno-associated virus-mediated epithelial IL-33 silencing attenuates type 2 airway inflammation"],"prefix":"10.1016","author":[{"given":"Saki","family":"Tomiyasu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8853-6149","authenticated-orcid":false,"given":"Hiroki","family":"Kabata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuto","family":"Akiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takunori","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaoru","family":"Koyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Momoko","family":"Kurihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsunori","family":"Masaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Miyata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Mizukami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Fukunaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.alit.2026.09.004_bib1","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/nature08636","article-title":"Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells","volume":"463","author":"Moro","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.alit.2026.09.004_bib2","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.immuni.2011.12.020","article-title":"Lung natural helper cells are a critical source of Th2 cell-type cytokines in protease allergen-induced airway inflammation","volume":"36","author":"Halim","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.alit.2026.09.004_bib3","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1056\/NEJMoa0906312","article-title":"A large-scale, consortium-based genomewide association study of asthma","volume":"363","author":"Moffatt","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.alit.2026.09.004_bib4","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/ng.888","article-title":"Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations","volume":"43","author":"Torgerson","year":"2011","journal-title":"Nat Genet"},{"key":"10.1016\/j.alit.2026.09.004_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.immuni.2020.03.006","article-title":"Interleukin-33 signaling controls the development of iron-recycling macrophages","volume":"52","author":"Lu","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.alit.2026.09.004_bib6","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1146\/annurev-immunol-101320-124243","article-title":"Emerging functions of IL-33 in homeostasis and immunity","volume":"40","author":"Dwyer","year":"2022","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.alit.2026.09.004_bib7","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.it.2012.04.005","article-title":"Interleukin-33 and the function of innate lymphoid cells","volume":"33","author":"Mirchandani","year":"2012","journal-title":"Trends Immunol"},{"key":"10.1016\/j.alit.2026.09.004_bib8","doi-asserted-by":"crossref","first-page":"9825","DOI":"10.1038\/s41598-023-36642-y","article-title":"Tozorakimab (MEDI3506): an anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE\/EGFR to reduce inflammation and epithelial dysfunction","volume":"13","author":"England","year":"2023","journal-title":"Sci Rep"},{"key":"10.1016\/j.alit.2026.09.004_bib9","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.02210-2022","article-title":"Oxidised IL-33 drives COPD epithelial pathogenesis via ST2-independent RAGE\/EGFR signalling complex","volume":"62","author":"Strickson","year":"2023","journal-title":"Eur Respir J"},{"key":"10.1016\/j.alit.2026.09.004_bib10","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1016\/j.jaci.2020.04.010","article-title":"Epithelial barriers in allergy and asthma","volume":"145","author":"Hellings","year":"2020","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2026.09.004_bib11","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.mucimm.2025.03.003","article-title":"Airway epithelial cells as drivers of severe asthma pathogenesis","volume":"18","author":"Dorscheid","year":"2025","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.alit.2026.09.004_bib12","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1038\/ncomms3675","article-title":"Thymic stromal lymphopoietin induces corticosteroid resistance in natural helper cells during airway inflammation","volume":"4","author":"Kabata","year":"2013","journal-title":"Nat Commun"},{"key":"10.1016\/j.alit.2026.09.004_bib13","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.jaci.2021.03.044","article-title":"Astegolimab (anti-ST2) efficacy and safety in adults with severe asthma: a randomized clinical trial","volume":"148","author":"Kelsen","year":"2021","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2026.09.004_bib14","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1056\/NEJMoa2024257","article-title":"Efficacy and safety of Itepekimab in patients with moderate-to-severe asthma","volume":"385","author":"Wechsler","year":"2021","journal-title":"N Engl J Med"},{"key":"10.1016\/j.alit.2026.09.004_bib15","doi-asserted-by":"crossref","first-page":"8568","DOI":"10.1128\/JVI.72.11.8568-8577.1998","article-title":"Circular intermediates of recombinant adeno-associated virus have defined structural characteristics responsible for long-term episomal persistence in muscle tissue","volume":"72","author":"Duan","year":"1998","journal-title":"J Virol"},{"key":"10.1016\/j.alit.2026.09.004_bib16","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.ymthe.2004.09.011","article-title":"Adeno-associated virus and the development of adeno-associated virus vectors: a historical perspective","volume":"10","author":"Carter","year":"2004","journal-title":"Mol Ther"},{"key":"10.1016\/j.alit.2026.09.004_bib17","doi-asserted-by":"crossref","first-page":"8915","DOI":"10.1073\/pnas.91.19.8915","article-title":"Adeno-associated virus vectors preferentially transduce cells in S phase","volume":"91","author":"Russell","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.alit.2026.09.004_bib18","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/nm0397-306","article-title":"Recombinant adeno-associated virus for muscle directed gene therapy","volume":"3","author":"Fisher","year":"1997","journal-title":"Nat Med"},{"key":"10.1016\/j.alit.2026.09.004_bib19","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/1743-422X-10-74","article-title":"A survey of ex vivo\/in vitro transduction efficiency of mammalian primary cells and cell lines with nine natural adeno-associated virus (AAV1-9) and one engineered adeno-associated virus serotype","volume":"10","author":"Ellis","year":"2013","journal-title":"Virol J"},{"key":"10.1016\/j.alit.2026.09.004_bib20","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.1016\/j.jtha.2024.07.012","article-title":"Adeno-associated viral vector integration: implications for long-term efficacy and safety","volume":"22","author":"Batty","year":"2024","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.alit.2026.09.004_bib21","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s00439-006-0165-6","article-title":"Treatment of human disease by adeno-associated viral gene transfer","volume":"119","author":"Warrington","year":"2006","journal-title":"Hum Genet"},{"key":"10.1016\/j.alit.2026.09.004_bib22","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1016\/j.ymthe.2025.04.045","article-title":"Current clinical applications of AAV-mediated gene therapy","volume":"33","author":"Byrne","year":"2025","journal-title":"Mol Ther"},{"key":"10.1016\/j.alit.2026.09.004_bib23","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/s41434-020-0125-0","article-title":"Utility of microminipigs for evaluating liver-mediated gene expression in the presence of neutralizing antibody against vector capsid","volume":"27","author":"Watano","year":"2020","journal-title":"Gene Ther"},{"key":"10.1016\/j.alit.2026.09.004_bib24","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1134\/S0006297918010029","article-title":"The role of interleukin-33 in pathogenesis of bronchial asthma. New experimental data","volume":"83","author":"Khaitov","year":"2018","journal-title":"Biochemistry (Mosc)"},{"key":"10.1016\/j.alit.2026.09.004_bib25","doi-asserted-by":"crossref","first-page":"12993","DOI":"10.1073\/pnas.0601433103","article-title":"Adeno-associated virus serotype 9 vectors transduce murine alveolar and nasal epithelia and can be readministered","volume":"103","author":"Limberis","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.alit.2026.09.004_bib26","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.31299","article-title":"Therapeutic effects of telomerase in mice with pulmonary fibrosis induced by damage to the lungs and short telomeres","volume":"7","author":"Povedano","year":"2018","journal-title":"eLife"},{"key":"10.1016\/j.alit.2026.09.004_bib27","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1186\/s12985-024-02575-9","article-title":"Tropism of adeno-associated virus serotypes in mouse lungs via intratracheal instillation","volume":"21","author":"Wu","year":"2024","journal-title":"Virol J"},{"key":"10.1016\/j.alit.2026.09.004_bib28","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1128\/jvi.70.5.3227-3234.1996","article-title":"Second-strand synthesis is a rate-limiting step for efficient transduction by recombinant adeno-associated virus vectors","volume":"70","author":"Ferrari","year":"1996","journal-title":"J Virol"},{"key":"10.1016\/j.alit.2026.09.004_bib29","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/ni.3309","article-title":"Interferon and IL-27 antagonize the function of group 2 innate lymphoid cells and type 2 innate immune responses","volume":"17","author":"Moro","year":"2016","journal-title":"Nat Immunol"},{"key":"10.1016\/j.alit.2026.09.004_bib30","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1016\/j.celrep.2016.07.062","article-title":"The RNA binding protein Mex-3B is required for IL-33 induction in the development of allergic airway inflammation","volume":"16","author":"Yamazumi","year":"2016","journal-title":"Cell Rep"},{"key":"10.1016\/j.alit.2026.09.004_bib31","doi-asserted-by":"crossref","first-page":"7501","DOI":"10.4049\/jimmunol.0713433","article-title":"Small interfering RNA against transcription factor STAT6 inhibits allergic airway inflammation and hyperreactivity in mice","volume":"182","author":"Darcan-Nicolaisen","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.alit.2026.09.004_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2007.12.1175","article-title":"Effective prevention and therapy of experimental allergic asthma using a GATA-3-specific DNAzyme","volume":"121","author":"Sel","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2026.09.004_bib33","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/gt.2008.15","article-title":"Small interfering RNA against interleukin-5 decreases airway eosinophilia and hyper-responsiveness","volume":"15","author":"Huang","year":"2008","journal-title":"Gene Ther"},{"key":"10.1016\/j.alit.2026.09.004_bib34","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/jgm.1408","article-title":"Synergistic therapeutic effects of combined adenovirus-mediated interleukin-10 and interleukin-12 gene therapy on airway inflammation in asthmatic mice","volume":"12","author":"Hsu","year":"2010","journal-title":"J Gene Med"},{"key":"10.1016\/j.alit.2026.09.004_bib35","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/sj.mt.6300309","article-title":"Lentiviral-mediated GATA-3 RNAi decreases allergic airway inflammation and hyperresponsiveness","volume":"16","author":"Lee","year":"2008","journal-title":"Mol Ther"},{"key":"10.1016\/j.alit.2026.09.004_bib36","doi-asserted-by":"crossref","DOI":"10.1183\/23120541.01202-2025","article-title":"IL-33 blockade in asthma: a story of hype, hope and hindsight","volume":"12","author":"Georas","year":"2026","journal-title":"ERJ Open Res"},{"key":"10.1016\/j.alit.2026.09.004_bib37","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.jaci.2019.02.034","article-title":"Endothelial Sox17 promotes allergic airway inflammation","volume":"144","author":"Ha","year":"2019","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.alit.2026.09.004_bib38","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.immuni.2015.01.016","article-title":"The interleukin-33-p38 kinase axis confers memory T helper 2 cell pathogenicity in the airway","volume":"42","author":"Endo","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.alit.2026.09.004_bib39","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1038\/sj.gt.3300994","article-title":"Immune responses to adenovirus and adeno-associated virus in humans","volume":"6","author":"Chirmule","year":"1999","journal-title":"Gene Ther"},{"key":"10.1016\/j.alit.2026.09.004_bib40","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1002\/(SICI)1096-9071(199911)59:3<406::AID-JMV22>3.0.CO;2-N","article-title":"Update on the prevalence of serum antibodies (IgG and IgM) to adeno-associated virus (AAV)","volume":"59","author":"Erles","year":"1999","journal-title":"J Med Virol"},{"key":"10.1016\/j.alit.2026.09.004_bib41","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1002\/jmv.23818","article-title":"The prevalence of neutralizing antibodies against adeno-associated virus capsids is reduced in young Japanese individuals","volume":"86","author":"Mimuro","year":"2014","journal-title":"J Med Virol"}],"container-title":["Allergology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1323893026001188?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1323893026001188?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:38:17Z","timestamp":1791499097000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1323893026001188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":41,"alternative-id":["S1323893026001188"],"URL":"https:\/\/doi.org\/10.1016\/j.alit.2026.09.004","relation":{},"ISSN":["1323-8930"],"issn-type":[{"value":"1323-8930","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adeno-associated virus-mediated epithelial IL-33 silencing attenuates type 2 airway inflammation","name":"articletitle","label":"Article Title"},{"value":"Allergology International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.alit.2026.09.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Japanese Society of Allergology. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}