{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T15:35:42Z","timestamp":1781710542588,"version":"3.54.5"},"reference-count":29,"publisher":"Codon Publications","issue":"2","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Allergologia et Immunopathologia"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1016\/j.aller.2014.02.005","type":"journal-article","created":{"date-parts":[[2014,6,16]],"date-time":"2014-06-16T21:02:44Z","timestamp":1402952564000},"page":"174-179","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Methacholine challenge test by wheezing and oxygen saturation in preschool children with asthma"],"prefix":"10.15586","volume":"43","author":[{"given":"S.","family":"Caussade","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.A.","family":"Castro-Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Contreras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Bugue\u00f1o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Ramirez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Padilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Einisman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Holmgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6228","reference":[{"key":"10.1016\/j.aller.2014.02.005_bib0005","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1164\/ajrccm\/146.4.888","article-title":"A community-based study of the epidemiology of asthma. Incidence rates, 1964\u20131983","volume":"146","author":"Yunginger","year":"1992","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.aller.2014.02.005_bib0010","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S0140-6736(06)69283-0","article-title":"Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC phases one and three repeat multicountry crossectional surveys","volume":"368","author":"Asher","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.aller.2014.02.005_bib0015","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.jaci.2012.04.025","article-title":"Diagnosis and management of early asthma in preschool-aged children","volume":"130","author":"Bacharier","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.aller.2014.02.005_bib0020","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3132\/pcrj.2007.00001","article-title":"Diagnosis of asthma in children under five","volume":"16","author":"Bush","year":"2007","journal-title":"Prim Care Respir J"},{"key":"10.1016\/j.aller.2014.02.005_bib0025","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1164\/ajrccm.162.1.9811005","article-title":"Relationship between increased airway responsiveness and asthma severity in the childhood asthma management program","volume":"162","author":"Weiss","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.aller.2014.02.005_bib0030","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1056\/NEJMoa022363","article-title":"A longitudinal, population-based, cohort study of childhood asthma followed to adulthood","volume":"349","author":"Sears","year":"2003","journal-title":"N Engl J Med"},{"issue":"2 Suppl.","key":"10.1016\/j.aller.2014.02.005_bib0035","doi-asserted-by":"crossref","first-page":"18S","DOI":"10.1378\/chest.10-0088","article-title":"Direct challenge tests. Airway hyperresponsiveness in asthma: its measurement and clinical significance","volume":"138","author":"Cockroft","year":"2010","journal-title":"Chest"},{"key":"10.1016\/j.aller.2014.02.005_bib0040","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1016\/j.rmed.2007.07.002","article-title":"Methacholine challenge in pre-school children. Which outcome measure?","volume":"101","author":"Kivastik","year":"2007","journal-title":"Respir Med"},{"key":"10.1016\/j.aller.2014.02.005_bib0045","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1164\/ajrccm.162.3.9910037","article-title":"Efficacy and safety of methacholine bronchial challenge performed by auscultation in young asthmatic children","volume":"162","author":"Springer","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.aller.2014.02.005_bib0050","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1183\/09031936.99.14511759","article-title":"Methacholine challenge in preschool children: methacholine-induced wheeze versus transcutaneous oximetry","volume":"14","author":"Yong","year":"1999","journal-title":"Eur Respir J"},{"key":"10.1016\/j.aller.2014.02.005_bib0055","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1111\/j.1651-2227.2007.00396.x","article-title":"Wheeze detection as a measure of bronchial challenge in young children with cough-variant asthma and with classic asthma","volume":"96","author":"Koh","year":"2007","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.aller.2014.02.005_bib0060","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1164\/rccm.200605-642ST","article-title":"An official American Thoracic Society\/European Respiratory Society Statement: Pulmonary function testing in preschool children","volume":"175","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.aller.2014.02.005_bib0065","first-page":"10","article-title":"Infantile and preschool asthma","volume":"56","author":"Castro-Rodriguez","year":"2012","journal-title":"Eur Respir Monogr"},{"key":"10.1016\/j.aller.2014.02.005_bib0070","series-title":"Global strategy for asthma management and prevention updated","author":"Global Initiative for Asthma","year":"2011"},{"key":"10.1016\/j.aller.2014.02.005_bib0075","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1164\/ajrccm.161.1.ats11-99","article-title":"Guidelines for Methacholine and Exercise Challenge Testing\u20141999. The Official Statement of the American Thoracic Society","volume":"161","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.aller.2014.02.005_bib0080","series-title":"ATS 2008 Toronto international conference","first-page":"A708","article-title":"PC wheezing in preschool children with asthma","author":"Paz","year":"2008"},{"key":"10.1016\/j.aller.2014.02.005_bib0085","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1183\/09031936.95.08111942","volume":"8","author":"Meslier","year":"1995","journal-title":"Wheezes Eur Respir J"},{"issue":"Suppl.","key":"10.1016\/j.aller.2014.02.005_bib0090","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/ppul.70097","article-title":"Acoustic markers of airway responses during inhalation challenge in children","volume":"26","author":"Pasterkamp","year":"2004","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.aller.2014.02.005_bib0095","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/ppul.10434","article-title":"Is clinical wheezing reliable as the endpoint for bronchial challenges in preschool children","volume":"37","author":"Godfrey","year":"2004","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.aller.2014.02.005_bib0100","first-page":"1271","article-title":"Acoustic analysis of respiratory sounds during methacholine challenge in preschool children","volume":"129","author":"Sanchez","year":"2001","journal-title":"Rev Med Chile"},{"key":"10.1016\/j.aller.2014.02.005_bib0105","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1002\/ppul.20178","article-title":"Timing and nature of wheezing at the endpoint of a bronchial challenge in preschool children","volume":"39","author":"Godfrey","year":"2005","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.aller.2014.02.005_bib0110","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1471-2431-5-19","article-title":"Methacholine bronchial provocation measured by spirometry versus wheeze detection in preschool children","volume":"5","author":"Bentur","year":"2005","journal-title":"BMC Pediatr"},{"key":"10.1016\/j.aller.2014.02.005_bib0115","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1378\/chest.118.5.1378","article-title":"Routine pulse oximetry during methacholine challenges is unnecessary for safety","volume":"118","author":"Cockroft","year":"2000","journal-title":"Chest"},{"key":"10.1016\/j.aller.2014.02.005_bib0120","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/ppul.1950040308","article-title":"Histamine-induced airway obstruction in infancy: changes in oxygenation","volume":"4","author":"Prendiville","year":"1988","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.aller.2014.02.005_bib0125","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1080\/02770900500498972","article-title":"Evaluation of bronchial hyperresponsiveness by monitoring of transcutaneous oxygen tension and arterial oxygen saturation during methacholine challenge in asthmatic children","volume":"43","author":"Wang","year":"2006","journal-title":"J Asthma"},{"key":"10.1016\/j.aller.2014.02.005_bib0130","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1378\/chest.95.1.65","article-title":"Effect on bronchial challenge on breathing patterns and arterial oxygenation in stable asthma","volume":"95","author":"Steward","year":"1989","journal-title":"Chest"},{"key":"10.1016\/j.aller.2014.02.005_bib0135","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.arbres.2010.07.010","article-title":"Bronchial hyperresponsiveness to methacholine in children under 4 years with recurrent bronchitis","volume":"46","author":"De Mir Messa","year":"2010","journal-title":"Arch Bronconeumol"},{"key":"10.1016\/j.aller.2014.02.005_bib0140","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1164\/ajrccm\/144.1.36","article-title":"Bronchial provocation tests in young children using tracheal auscultation","volume":"144","author":"Avital","year":"1991","journal-title":"Am Respir Dis"},{"key":"10.1016\/j.aller.2014.02.005_bib0145","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1164\/ajrccm.152.2.7633710","article-title":"The effect of size and age of subject on airway responsiveness in children","volume":"152","author":"Le Souef","year":"1995","journal-title":"Am J Respir Crit Care Med"}],"container-title":["Allergologia et Immunopathologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301054614000585?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301054614000585?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T22:49:52Z","timestamp":1609454992000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301054614000585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["S0301054614000585"],"URL":"https:\/\/doi.org\/10.1016\/j.aller.2014.02.005","relation":{},"ISSN":["0301-0546"],"issn-type":[{"value":"0301-0546","type":"print"}],"subject":[],"published":{"date-parts":[[2015,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Methacholine challenge test by wheezing and oxygen saturation in preschool children with asthma","name":"articletitle","label":"Article Title"},{"value":"Allergologia et Immunopathologia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aller.2014.02.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 SEICAP. Published by Elsevier Espa\u00f1a, S.L. All rights reserved.","name":"copyright","label":"Copyright"}]}}