{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T06:46:11Z","timestamp":1770965171288,"version":"3.50.1"},"reference-count":31,"publisher":"Codon Publications","issue":"1","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Allergologia et Immunopathologia"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.aller.2015.02.003","type":"journal-article","created":{"date-parts":[[2015,5,14]],"date-time":"2015-05-14T00:35:49Z","timestamp":1431563749000},"page":"59-65","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Urinary leukotriene and Bcl I polymorphism of glucocorticoid receptor gene in preschoolers with recurrent wheezing and high risk of asthma"],"prefix":"10.15586","volume":"44","author":[{"given":"M.","family":"Morales","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Flores","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Pino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Angulo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"L\u00f3pez-Lastra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.A.","family":"Castro-Rodriguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6228","reference":[{"key":"10.1016\/j.aller.2015.02.003_bib0160","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1097\/ACI.0b013e3283464c4a","article-title":"The Asthma Predictive Index: early diagnosis of asthma","volume":"11","author":"Castro-Rodriguez","year":"2011","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.aller.2015.02.003_bib0165","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1016\/j.jaci.2011.12.979","article-title":"Asthma outcomes: biomarkers","volume":"129","author":"Szefler","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.aller.2015.02.003_bib0170","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1164\/ajrccm.162.4.9912111","article-title":"A clinical index to define risk of asthma in young children with recurrent wheezing","volume":"162","author":"Castro-Rodriguez","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.aller.2015.02.003_bib0175","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.jaci.2012.05.007","article-title":"Predicting who will have asthma at school age among preschool children","volume":"130","author":"Savenije","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.aller.2015.02.003_bib0180","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jaci.2010.06.032","article-title":"The Asthma Predictive Index: a very useful tool for predicting asthma in young children","volume":"126","author":"Castro-Rodriguez","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.aller.2015.02.003_bib0185","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1002\/ppul.21493","article-title":"Discriminative properties of two predictive indices for asthma diagnosis in a sample of preschoolers with recurrent wheezing","volume":"46","author":"Rodr\u00edguez-Mart\u00ednez","year":"2011","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.aller.2015.02.003_bib0190","first-page":"10","article-title":"Infantile and preschool asthma","volume":"56","author":"Castro-Rodriguez","year":"2012","journal-title":"Eur Respir Monogr"},{"key":"10.1016\/j.aller.2015.02.003_bib0195","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.jaci.2008.09.029","article-title":"Episodic use of an inhaled corticosteroid or leukotriene receptor antagonist in preschool children with moderate to severe intermittent wheezing","volume":"122","author":"Bacharier","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.aller.2015.02.003_bib0200","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.anai.2011.01.017","article-title":"Intermittent or daily montelukast versus placebo for episodic asthma in children","volume":"106","author":"Valovirta","year":"2011","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.aller.2015.02.003_bib0205","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ppul.21321","article-title":"Global strategy for the diagnosis and management of asthma in children 5 years and younger","volume":"46","author":"Pedersen","year":"2011","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.aller.2015.02.003_bib0210","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1046\/j.1365-2265.2003.01888.x","article-title":"Identification of the Bcl I polymorphism in the glucocorticoid receptor gene: association with sensitivity to glucocorticoids in vivo and body mass index","volume":"59","author":"Van Rossum","year":"2003","journal-title":"Clin Endocrinol"},{"key":"10.1016\/j.aller.2015.02.003_bib0215","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.jsbmb.2009.01.012","article-title":"High resolution melting (HRM) analysis for the detection of ER22\/23EK, Bcl I, and N363S polymorphisms of the glucocorticoid receptor gene","volume":"113","author":"Maltese","year":"2009","journal-title":"J Steroid Biochem Mol Biol"},{"key":"10.1016\/j.aller.2015.02.003_bib0220","first-page":"245","article-title":"No association of glucocorticoid receptor polymorphisms with asthma and response to glucocorticoids","volume":"5","author":"Szczepankiewicz","year":"2008","journal-title":"Adv Med Sci"},{"key":"10.1016\/j.aller.2015.02.003_bib0225","doi-asserted-by":"crossref","first-page":"3953","DOI":"10.1007\/s11033-010-0512-5","article-title":"The Bcl I single nucleotide polymorphism of the human glucocorticoid receptor gene h-GR\/NR3C1 promoter in patients with bronchial asthma: pilot study","volume":"38","author":"Pietras","year":"2011","journal-title":"Mol Biol Rep"},{"key":"10.1016\/j.aller.2015.02.003_bib0230","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1097\/ACI.0b013e3282f60f61","article-title":"Pediatric biomarkers in asthma: exhaled nitric oxide, sputum eosinophils and leukotriene E4","volume":"8","author":"Gogate","year":"2008","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.aller.2015.02.003_bib0235","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1136\/thorax.2003.006825","article-title":"Increase in urinary leukotriene LTE4 levels in acute asthma: correlation with airflow limitation","volume":"59","author":"Green","year":"2004","journal-title":"Thorax"},{"key":"10.1016\/j.aller.2015.02.003_bib0240","first-page":"22","article-title":"Reference urinary LTE4 levels in normal individuals: a pilot study","volume":"43","author":"Dal Negro","year":"2011","journal-title":"Eur Ann Allergy Clin Immunol"},{"key":"10.1016\/j.aller.2015.02.003_bib0245","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1002\/ppul.20853","article-title":"Effect of secondhand cigarette smoke, RSV bronchiolitis and parental asthma on urinary cysteinyl LTE4","volume":"43","author":"Kott","year":"2008","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.aller.2015.02.003_bib0250","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1111\/j.1398-9995.2009.02206.x","article-title":"Elevated urinary leukotriene E4 excretion in asthma: a comparison of HPLC-mass spectrometry and ELISA","volume":"65","author":"Sanak","year":"2010","journal-title":"Allergy"},{"key":"10.1016\/j.aller.2015.02.003_bib0255","first-page":"120","article-title":"The prevalence of nasal polyps and the corresponding urinary LTE4 levels in severe compared to mild and moderate asthma","volume":"42","author":"Micheletto","year":"2010","journal-title":"Eur Ann Allergy Clin Immunol"},{"key":"10.1016\/j.aller.2015.02.003_bib0260","doi-asserted-by":"crossref","first-page":"6765","DOI":"10.1093\/nar\/15.16.6765","article-title":"RFLP for the glucocorticoid receptor (GRL) located at 5q11\u20135q13","volume":"15","author":"Murray","year":"1987","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.aller.2015.02.003_bib0265","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1034\/j.1399-3003.2000.16d03.x","article-title":"Urinary excretion of leukotriene E4 and eosinophil protein X in children with atopic asthma","volume":"16","author":"Severien","year":"2000","journal-title":"Eur Respir J"},{"key":"10.1016\/j.aller.2015.02.003_bib0270","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.jaci.2011.05.035","article-title":"Urinary leukotriene E4 levels identify children with tobacco smoke exposure at risk for asthma exacerbation","volume":"128","author":"Rabinovitch","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.aller.2015.02.003_bib0275","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.aller.2011.03.012","article-title":"Urinary leukotriene excretion profile in children with exercise-induced asthma compared with controls: a preliminary study","volume":"40","author":"Brockmann","year":"2012","journal-title":"Allergol Immunopathol (Madr)"},{"key":"10.1016\/j.aller.2015.02.003_bib0280","first-page":"165","article-title":"Clinical evaluation of urinary leukotrienes E4 levels in children with atopic dermatitis","volume":"2","author":"Fathy Manal","year":"2010","journal-title":"Int J Acad Res"},{"key":"10.1016\/j.aller.2015.02.003_bib0285","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1183\/09031936.02.00021202","article-title":"Urinary leukotriene E4 in preschool children with acute clinical viral wheeze","volume":"21","author":"Oommen","year":"2003","journal-title":"Eur Respir J"},{"key":"10.1016\/j.aller.2015.02.003_bib0290","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1002\/ppul.21260","article-title":"Do risk factors for persistent asthma modify lung function in infants and young children with recurrent wheeze?","volume":"45","author":"Keklikian","year":"2010","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.aller.2015.02.003_bib0295","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.jaci.2006.05.011","article-title":"Urine leukotriene E4 levels are associated with decreased pulmonary function in children with persistent airway obstruction","volume":"118","author":"Rabinovitch","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.aller.2015.02.003_bib0300","first-page":"795","article-title":"[Application of Asthma Predictive Index-based group therapy in wheezing children under 5 years of age]","volume":"16","author":"Li","year":"2014","journal-title":"Zhongguo Dang Dai Er Ke Za Zhi"},{"key":"10.1016\/j.aller.2015.02.003_bib0305","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.jaci.2010.07.008","article-title":"Urinary leukotriene E4\/exhaled nitric oxide ratio and montelukast response in childhood asthma","volume":"126","author":"Rabinovitch","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.aller.2015.02.003_bib0310","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1111\/j.1365-2362.2010.02297.x","article-title":"Beclomethasone dipropionate blunts allergen-induced early increase in urinary LTE4","volume":"40","author":"Bartoli","year":"2010","journal-title":"Eur J Clin Invest"}],"container-title":["Allergologia et Immunopathologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301054615000567?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301054615000567?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T22:50:22Z","timestamp":1609455022000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301054615000567"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["S0301054615000567"],"URL":"https:\/\/doi.org\/10.1016\/j.aller.2015.02.003","relation":{},"ISSN":["0301-0546"],"issn-type":[{"value":"0301-0546","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Urinary leukotriene and Bcl I polymorphism of glucocorticoid receptor gene in preschoolers with recurrent wheezing and high risk of asthma","name":"articletitle","label":"Article Title"},{"value":"Allergologia et Immunopathologia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aller.2015.02.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 SEICAP. Published by Elsevier Espa\u00f1a, S.L. All rights reserved.","name":"copyright","label":"Copyright"}]}}