{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:27:43Z","timestamp":1790785663004,"version":"4.1.0"},"reference-count":39,"publisher":"Codon Publications","issue":"5","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Allergologia et Immunopathologia"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.aller.2015.09.001","type":"journal-article","created":{"date-parts":[[2016,1,19]],"date-time":"2016-01-19T16:31:27Z","timestamp":1453221087000},"page":"393-399","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Factors associated to recurrent wheezing in infants under one year of age in the province of Salamanca, Spain: Is intervention possible? A predictive model"],"prefix":"10.15586","volume":"44","author":[{"given":"J.","family":"Pellegrini-Belinch\u00f3n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Lorente-Toledano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Galindo-Villard\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Gonz\u00e1lez-Carvajal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Mart\u00edn-Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Mallol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Garc\u00eda-Marcos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6228","reference":[{"key":"10.1016\/j.aller.2015.09.001_bib0200","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1136\/thx.2009.115188","article-title":"International prevalence of recurrent wheezing during the first year of life: variability, treatment patterns and use of health resources","volume":"65","author":"Mallol","year":"2010","journal-title":"Thorax"},{"key":"10.1016\/j.aller.2015.09.001_bib0205","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1002\/ppul.21225","article-title":"Role of emerging respiratory viruses in children with severe acute wheezing","volume":"45","author":"Garc\u00eda-Garc\u00eda","year":"2010","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.aller.2015.09.001_bib0210","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1002\/ppul.20486","article-title":"Health-related quality of life of pre-school children with wheezing illness","volume":"41","author":"Oostenbrink","year":"2006","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.aller.2015.09.001_bib0215","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1097\/MLR.0b013e3180546879","article-title":"Determinants of health care utilization for respiratory symptoms in the first year of life","volume":"45","author":"de Jong","year":"2007","journal-title":"Med Care"},{"key":"10.1016\/j.aller.2015.09.001_bib0220","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1183\/09031936.03.00057002","article-title":"The economic impact of preschool asthma and wheeze","volume":"21","author":"Stevens","year":"2003","journal-title":"Eur Respir J"},{"key":"10.1016\/j.aller.2015.09.001_bib0225","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1002\/ppul.20456","article-title":"Prevalence and clinical characteristics of human metapneumovirus infections in hospitalized infants in Spain","volume":"41","author":"Garc\u00eda-Garc\u00eda","year":"2006","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.aller.2015.09.001_bib0230","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1097\/01.inf.0000168747.94999.aa","article-title":"Frequency of detection of picornaviruses and seven other respiratory pathogens in infants","volume":"24","author":"Legg","year":"2005","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.aller.2015.09.001_bib0235","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1086\/499274","article-title":"The role of human metapneumovirus in upper respiratory tract infections in children: a 20-year experience","volume":"193","author":"Williams","year":"2006","journal-title":"J Infect Dis"},{"key":"10.1016\/j.aller.2015.09.001_bib0240","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1016\/j.jaci.2004.09.020","article-title":"Atopic characteristics of children with recurrent wheezing at high risk for the development of childhood asthma","volume":"114","author":"Guilbert","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.aller.2015.09.001_bib0245","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S1526-0542(02)00189-6","article-title":"The development of childhood asthma: lessons from the German Multicentre Allergy Study (MAS)","volume":"3","author":"Lau","year":"2002","journal-title":"Paediatr Respir Rev"},{"key":"10.1016\/j.aller.2015.09.001_bib0250","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1046\/j.0905-6157.2003.00101.x","article-title":"Mode of delivery and development of atopic disease during the first 2 years of life","volume":"15","author":"Negele","year":"2004","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.aller.2015.09.001_bib0255","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1164\/rccm.200310-1348OC","article-title":"A prospective study of Fel d1 and Der p1 exposure in infancy and childhood wheezing","volume":"170","author":"Polk","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.aller.2015.09.001_bib0260","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1164\/rccm.200312-1647OC","article-title":"Cytokine response patterns, exposure to viruses, and respiratory infections in the first year of life","volume":"170","author":"Copenhaver","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.aller.2015.09.001_bib0265","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1164\/rccm.200304-499OC","article-title":"Reduced interferon gamma production and soluble CD14 levels in early life predict recurrent wheezing by 1 year of age","volume":"169","author":"Guerra","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.aller.2015.09.001_bib0270","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1093\/ije\/dyn070","article-title":"Pre-natal exposure to paracetamol and risk of wheezing and asthma in children: a birth cohort study","volume":"37","author":"Rebordosa","year":"2008","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.aller.2015.09.001_bib0275","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1183\/09031936.95.08030483","article-title":"International Study of Asthma and Allergies in Childhood (ISAAC): rationale and methods","volume":"8","author":"Asher","year":"1995","journal-title":"Eur Respir J"},{"key":"10.1016\/j.aller.2015.09.001_bib0280","unstructured":"Mallol J, Garc\u00eda-Marcos L. Observatorio del Estudio Internacional de Sibilancias en Lactantes (EISL). 2007; Volume, DOI: January 14, 2009. http:\/\/www.respirar.org\/eisl\/index.htm."},{"key":"10.1016\/j.aller.2015.09.001_bib0285","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1111\/j.1399-3038.2010.01035.x","article-title":"International study of wheezing in infants: risk factors in affluent and non-affluent countries during the first year of life","volume":"21","author":"Garcia-Marcos","year":"2010","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.aller.2015.09.001_bib0290","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.aller.2011.03.014","article-title":"Study of wheezing and its risk factors in the first year of life in the Province of Salamanca, Spain. The EISL Study","volume":"40","author":"Pellegrini","year":"2012","journal-title":"Allergol Immunopathol (Madr)"},{"key":"10.1016\/j.aller.2015.09.001_bib0295","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.aller.2014.09.001","article-title":"Wheezing and risk factors in the first year of life in Cantabria, Spain. The EISL Study","volume":"43","author":"Bercedo Sanz","year":"2015","journal-title":"Allergol Immunopathol (Madr)"},{"key":"10.1016\/j.aller.2015.09.001_bib0300","doi-asserted-by":"crossref","DOI":"10.1002\/ppul.23160","article-title":"Pneumonia and wheezing and in the first year: an international perspective","author":"Garc\u00eda-Marcos","year":"2015","journal-title":"Pediatric Pulmonol"},{"key":"10.1016\/j.aller.2015.09.001_bib0305","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1159\/000102613","article-title":"The International Study of Wheezing in Infants: questionnaire validation","volume":"144","author":"Mallol","year":"2007","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.aller.2015.09.001_bib0310","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1093\/ije\/25.3.609","article-title":"Validation of questionnaire and bronchial hyperresponsiveness against respiratory physician assessment in the diagnosis of asthma","volume":"25","author":"Jenkins","year":"1996","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.aller.2015.09.001_bib0315","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/ppul.21161","article-title":"Prevalence and risk factors of wheeze in Dutch infants in their first year of life","volume":"45","author":"Visser","year":"2010","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.aller.2015.09.001_bib0320","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1093\/tropej\/fms016","article-title":"Risk factors for wheezing disorders in infants in the first year of life living in S\u00e3o Paulo, Brazil","volume":"58","author":"Dela Bianca","year":"2012","journal-title":"J Trop Pediatr"},{"key":"10.1016\/j.aller.2015.09.001_bib0325","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.rmed.2013.01.015","article-title":"Latitude modifies the effect size of factors related to recurrent wheeze in the first year of life","volume":"107","author":"Garcia-Marcos","year":"2013","journal-title":"Respir Med"},{"key":"10.1016\/j.aller.2015.09.001_bib0330","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1183\/09031936.00100609","article-title":"Dairy food, calcium and vitamin D intake in pregnancy, and wheeze and eczema in infants","volume":"35","author":"Miyake","year":"2010","journal-title":"Eur Respir J"},{"key":"10.1016\/j.aller.2015.09.001_bib0335","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1002\/ppul.21205","article-title":"Olive oil during pregnancy is associated with reduced wheezing during the first year of life of the offspring","volume":"45","author":"Castro-Rodriguez","year":"2010","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.aller.2015.09.001_bib0340","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1136\/thx.2006.069419","article-title":"Protective effect of fruits, vegetables and the Mediterranean diet on asthma and allergies among children in Crete","volume":"62","author":"Chatzi","year":"2007","journal-title":"Thorax"},{"key":"10.1016\/j.aller.2015.09.001_bib0345","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1136\/thx.2006.060020","article-title":"Relationship of asthma and rhinoconjunctivitis with obesity, exercise and Mediterranean diet in Spanish schoolchildren","volume":"62","author":"Garcia-Marcos","year":"2007","journal-title":"Thorax"},{"key":"10.1016\/j.aller.2015.09.001_bib0350","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1093\/ije\/30.6.1473","article-title":"Avon Longitudinal Study of Parents and Children, Risk factor associations with wheezing patterns in children followed longitudinally from birth to 3(1\/2) years","volume":"30","author":"Sherriff","year":"2001","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.aller.2015.09.001_bib0355","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1136\/adc.88.3.224","article-title":"Breast feeding and respiratory morbidity in infancy: a birth cohort study","volume":"88","author":"Oddy","year":"2003","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.aller.2015.09.001_bib0360","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.jpeds.2007.03.022","article-title":"Breast-feeding duration and infant atopic manifestations, by maternal allergic status, in the first 2 years of life (KOALA study)","volume":"151","author":"Snijders","year":"2007","journal-title":"J Pediatr"},{"key":"10.1016\/j.aller.2015.09.001_bib0365","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.anpedi.2009.09.007","article-title":"Incidencia y factores de riesgo de bronquitis sibilantes en los primeros 6 meses de vida en una cohorte de Alzira (Valencia)","volume":"72","author":"P\u00e9rez Tarazona","year":"2010","journal-title":"An Pediatr (Barc)"},{"key":"10.1016\/j.aller.2015.09.001_bib0370","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1177\/0890334412453083","article-title":"Modes of infant feeding and the occurrence of coughing\/wheezing in the first year of life","volume":"29","author":"Soto-Ram\u00edrez","year":"2013","journal-title":"J Hum Lact"},{"key":"10.1016\/j.aller.2015.09.001_bib0375","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1136\/thx.2009.123232","article-title":"First trimester maternal tobacco smoking habits and fetal growth","volume":"65","author":"Prabhu","year":"2010","journal-title":"Thorax"},{"key":"10.1016\/j.aller.2015.09.001_bib0380","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1159\/000176304","article-title":"Is the effect of prenatal paracetamol exposure on wheezing in preschool children modified by asthma in the mother?","volume":"149","author":"Garcia-Marcos","year":"2009","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.aller.2015.09.001_bib0385","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1097\/AOG.0b013e3181c225c0","article-title":"Prenatal exposure to acetaminophen and asthma in children","volume":"114","author":"Kang","year":"2009","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.aller.2015.09.001_bib0390","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/ppul.23037","article-title":"Smoke exposure, wheezing, and asthma development: a systematic review and meta-analysis in unselected birth cohorts","volume":"50","author":"Silvestri","year":"2015","journal-title":"Pediatr Pulmonol"}],"container-title":["Allergologia et Immunopathologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301054615001457?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301054615001457?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T22:50:37Z","timestamp":1609455037000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301054615001457"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["S0301054615001457"],"URL":"https:\/\/doi.org\/10.1016\/j.aller.2015.09.001","relation":{},"ISSN":["0301-0546"],"issn-type":[{"value":"0301-0546","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Factors associated to recurrent wheezing in infants under one year of age in the province of Salamanca, Spain: Is intervention possible? A predictive model","name":"articletitle","label":"Article Title"},{"value":"Allergologia et Immunopathologia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aller.2015.09.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2015 SEICAP. Published by Elsevier Espa\u00f1a, S.L.U. All rights reserved.","name":"copyright","label":"Copyright"}]}}