{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T05:37:53Z","timestamp":1781415473334,"version":"3.54.1"},"reference-count":40,"publisher":"Codon Publications","issue":"3","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Allergologia et Immunopathologia"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.aller.2016.08.011","type":"journal-article","created":{"date-parts":[[2016,11,17]],"date-time":"2016-11-17T05:16:26Z","timestamp":1479359786000},"page":"210-217","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"title":["Meta-analysis of prevalence of wheezing and recurrent wheezing in infants"],"prefix":"10.15586","volume":"46","author":[{"given":"I.","family":"Alvarez-Alvarez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Guillen-Grima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Aguinaga-Ontoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6228","reference":[{"key":"10.1016\/j.aller.2016.08.011_bib0205","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1002\/ppul.20486","article-title":"Health-related quality of life of pre-school children with wheezing illness","volume":"41","author":"Oostenbrink","year":"2006","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.aller.2016.08.011_bib0210","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1056\/NEJM199501193320301","article-title":"Asthma and wheezing in the first six years of life","volume":"332","author":"Martinez","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/j.aller.2016.08.011_bib0215","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.jaci.2005.06.024","article-title":"Rhinovirus illnesses during infancy predict subsequent childhood wheezing","volume":"116","author":"Lemanske","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.aller.2016.08.011_bib0220","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1164\/ajrccm.163.2.2006009","article-title":"Effects of maternal smoking during pregnancy and environmental tobacco smoke on asthma and wheezing in children","volume":"163","author":"Gilliland","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.aller.2016.08.011_bib0225","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1542\/peds.2006-3742","article-title":"Family history of asthma and atopy: in-depth analyses of the impact on asthma and wheeze in 7- to 8-year-old children","volume":"120","author":"Bjerg","year":"2007","journal-title":"Pediatrics"},{"key":"10.1016\/j.aller.2016.08.011_bib0230","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1136\/thx.2007.085480","article-title":"Ambient air pollution triggers wheezing symptoms in infants","volume":"63","author":"Andersen","year":"2008","journal-title":"Thorax"},{"key":"10.1016\/j.aller.2016.08.011_bib0235","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1183\/09031936.98.12020315","article-title":"Worldwide variations in the prevalence of asthma symptoms: the International Study of Asthma and Allergies in Childhood (ISAAC)","volume":"12","author":"Asher","year":"1998","journal-title":"Eur Respir J"},{"key":"10.1016\/j.aller.2016.08.011_bib0240","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1136\/thx.2006.070169","article-title":"Worldwide trends in the prevalence of asthma symptoms: phase III of the International Study of Asthma and Allergies in Childhood (ISAAC)","volume":"62","author":"Pearce","year":"2007","journal-title":"Thorax"},{"key":"10.1016\/j.aller.2016.08.011_bib0245","series-title":"Estudio Internacional de Sibilancias en Lactantes (EISL) [Internet]","author":"Mallol","year":"2016"},{"key":"10.1016\/j.aller.2016.08.011_bib0250","doi-asserted-by":"crossref","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS Med"},{"key":"10.1016\/j.aller.2016.08.011_bib0255","series-title":"National Heart, Lung and Blood Institute Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies [Internet]","year":"2016"},{"key":"10.1016\/j.aller.2016.08.011_bib0260","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"10.1016\/j.aller.2016.08.011_bib0265","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1159\/000102613","article-title":"The International Study of Wheezing in Infants: questionnaire validation","volume":"144","author":"Mallol","year":"2007","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.aller.2016.08.011_bib0270","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1136\/thorax.56.4.290","article-title":"Prenatal risk factors of wheezing at the age of four years in Tanzania","volume":"56","author":"Sunyer","year":"2001","journal-title":"Thorax"},{"key":"10.1016\/j.aller.2016.08.011_bib0275","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1590\/S0021-75572007000500012","article-title":"Prevalence of recurrent wheezing in infants","volume":"83","author":"Chong Neto","year":"2007","journal-title":"J Pediatr (Rio J)"},{"key":"10.1016\/j.aller.2016.08.011_bib0280","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1111\/j.1365-2222.2010.03479.x","article-title":"Prevalence and risk factors of wheeze and eczema in 1-year-old children: the Butajira birth cohort, Ethiopia","volume":"40","author":"Belyhun","year":"2010","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.aller.2016.08.011_bib0285","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.aller.2010.01.003","article-title":"Poverty-associated risk factors for wheezing in the first year of life in Honduras and El Salvador","volume":"38","author":"Bueso","year":"2010","journal-title":"Allergol Immunopathol (Madr)"},{"key":"10.1016\/j.aller.2016.08.011_bib0290","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1590\/S1806-37132010000400003","article-title":"Prevalence and severity of wheezing in the first year of life","volume":"36","author":"Dela Bianca","year":"2010","journal-title":"J Bras Pneumol"},{"key":"10.1016\/j.aller.2016.08.011_bib0295","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/ppul.21161","article-title":"Prevalence and risk factors of wheeze in Dutch infants in their first year of life","volume":"45","author":"Visser","year":"2010","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.aller.2016.08.011_bib0300","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1590\/S0102-311X2011000800010","article-title":"Prevalence of wheezing and associated risk factors among infants in Recife, Pernambuco State, Brazil","volume":"27","author":"Medeiros","year":"2011","journal-title":"Cad Saude Publ"},{"key":"10.1016\/j.aller.2016.08.011_bib0305","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.aller.2011.03.014","article-title":"Study of wheezing and its risk factors in the first year of life in the Province of Salamanca, Spain. The EISL Study","volume":"40","author":"Pellegrini-Belinchon","year":"2012","journal-title":"Allergol Immunopathol (Madr)"},{"key":"10.1016\/j.aller.2016.08.011_bib0310","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jped.2013.08.007","article-title":"Prevalence and risk factors associated with wheezing in the first year of life","volume":"90","author":"Costa Bessa","year":"2014","journal-title":"J Pediatr (Rio J)"},{"key":"10.1016\/j.aller.2016.08.011_bib0315","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1590\/0103-0582201432303","article-title":"Prevalence and severity of wheezing in the first year of life in the city of Santo Andr\u00e9, Brazil","volume":"32","author":"Ferreira","year":"2014","journal-title":"Rev Paul Pediatr"},{"key":"10.1016\/j.aller.2016.08.011_bib0320","first-page":"313","article-title":"Prevalence and clinical characteristics of wheezing in children in the first year of life, living in Cuiab\u00e1, Mato Grosso, Brazil","volume":"32","author":"Moraes","year":"2014","journal-title":"Rev Paul Pediatr"},{"key":"10.1016\/j.aller.2016.08.011_bib0325","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.aller.2014.09.001","article-title":"Wheezing and risk factors in the first year of life in Cantabria, Spain. The EISL study","volume":"43","author":"Bercedo-Sanz","year":"2015","journal-title":"Allergol Immunopathol (Madr)"},{"key":"10.1016\/j.aller.2016.08.011_bib0330","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.aller.2015.08.002","article-title":"Prevalence and risk factors for wheezing in infants in the region of Pamplona, Spain","volume":"44","author":"Alvarez-Alvarez","year":"2016","journal-title":"Allergol Immunopathol (Madr)"},{"key":"10.1016\/j.aller.2016.08.011_bib0335","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1136\/thx.2008.106609","article-title":"Global variation in the prevalence and severity of asthma symptoms: Phase Three of the International Study of Asthma and Allergies in Childhood (ISAAC)","volume":"64","author":"Lai","year":"2009","journal-title":"Thorax"},{"key":"10.1016\/j.aller.2016.08.011_bib0340","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1183\/09031936.00066307","article-title":"Wheezing in childhood: incidence, longitudinal patterns and factors predicting persistence","volume":"32","author":"Matricardi","year":"2008","journal-title":"Eur Respir J"},{"key":"10.1016\/j.aller.2016.08.011_bib0345","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1002\/ppul.20644","article-title":"Prevalence of asthma-like symptoms in young children","volume":"42","author":"Bisgaard","year":"2007","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.aller.2016.08.011_bib0350","doi-asserted-by":"crossref","first-page":"22","DOI":"10.4168\/aair.2016.8.1.22","article-title":"Prevalence, severity, and treatment of recurrent wheezing during the first year of life: a cross-sectional study of 12,405 Latin American children","volume":"8","author":"Mallol","year":"2016","journal-title":"Allergy Asthma Immunol Res"},{"key":"10.1016\/j.aller.2016.08.011_bib0355","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1111\/j.1399-3038.2010.01035.x","article-title":"International study of wheezing in infants: risk factors in affluent and non-affluent countries during the first year of life","volume":"21","author":"Garcia-Marcos","year":"2010","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.aller.2016.08.011_bib0360","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1111\/j.1399-3038.2009.00971.x","article-title":"Wheeze in children: the impact of parental education on atopic and non-atopic symptoms","volume":"21","author":"de Meer","year":"2010","journal-title":"Pediatr Allergy Immunol"},{"key":"10.1016\/j.aller.2016.08.011_bib0365","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1186\/1465-9921-11-167","article-title":"Poverty, dirt, infections and non-atopic wheezing in children from a Brazilian urban center","volume":"11","author":"Barreto","year":"2010","journal-title":"Respir Res"},{"key":"10.1016\/j.aller.2016.08.011_bib0370","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1365-2222.2011.03873.x","article-title":"African ancestry early life exposures, and respiratory morbidity in early childhood","volume":"42","author":"Kumar","year":"2012","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.aller.2016.08.011_bib0375","series-title":"WHO Global Urban Ambient Air Pollution Database [Internet]","author":"World Health Organization","year":"2016"},{"key":"10.1016\/j.aller.2016.08.011_bib0380","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1056\/NEJMoa1414123","article-title":"Association of improved air quality with lung development in children","volume":"372","author":"Gauderman","year":"2015","journal-title":"N Eng J Med"},{"key":"10.1016\/j.aller.2016.08.011_bib0385","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1136\/thx.2007.078964","article-title":"Relationship between air pollution, lung function and asthma in adolescents","volume":"62","author":"Islam","year":"2007","journal-title":"Thorax"},{"key":"10.1016\/j.aller.2016.08.011_bib0390","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/1465-9921-11-114","article-title":"The presence of serum anti-Ascaris lumbricoides IgE antibodies and of Trichuris trichiura infection are risk factors for wheezing and\/or atopy in preschool-aged Brazilian children","volume":"11","author":"Alc\u00e2ntara-Neves","year":"2010","journal-title":"Respir Res"},{"key":"10.1016\/j.aller.2016.08.011_bib0395","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/S0140-6736(01)06579-5","article-title":"Independent effects of intestinal parasite infection and domestic allergen exposure on risk of wheeze in Ethiopia: a nested case-control study","volume":"358","author":"Scrivener","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.aller.2016.08.011_bib0400","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1164\/rccm.200210-1204OC","article-title":"Wheezing, allergy, and parasite infection in children in urban and rural Ethiopia","volume":"167","author":"Dagoye","year":"2003","journal-title":"Am J Respir Crit Care Med"}],"container-title":["Allergologia et Immunopathologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301054616301227?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301054616301227?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T22:51:25Z","timestamp":1609455085000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301054616301227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["S0301054616301227"],"URL":"https:\/\/doi.org\/10.1016\/j.aller.2016.08.011","relation":{},"ISSN":["0301-0546"],"issn-type":[{"value":"0301-0546","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Meta-analysis of prevalence of wheezing and recurrent wheezing in infants","name":"articletitle","label":"Article Title"},{"value":"Allergologia et Immunopathologia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aller.2016.08.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 SEICAP. Published by Elsevier Espa\u00f1a, S.L.U. All rights reserved.","name":"copyright","label":"Copyright"}]}}