{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:40:45Z","timestamp":1790286045003,"version":"4.1.0"},"reference-count":35,"publisher":"Codon Publications","issue":"6","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Allergologia et Immunopathologia"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.aller.2019.12.008","type":"journal-article","created":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T11:37:52Z","timestamp":1586777872000},"page":"675-685","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Clinical and immunological features of 44 common variable immunodeficiency patients: the experience of a single center in Turkey"],"prefix":"10.15586","volume":"48","author":[{"given":"S.","family":"Nepesov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.D.","family":"Aygun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Firtina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Cokugras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Camcioglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6228","reference":[{"key":"10.1016\/j.aller.2019.12.008_bib0005","first-page":"201","article-title":"Orphanet","volume":"13","author":"Odnoletkova","year":"2018","journal-title":"J Rare Dis"},{"key":"10.1016\/j.aller.2019.12.008_bib0010","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1182\/blood-2011-09-377945","article-title":"Morbidity and mortality in common variable immune deficiency over 4 decades","volume":"119","author":"Resnick","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.aller.2019.12.008_bib0015","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jaip.2015.07.025","article-title":"International Consensus Document (ICON): common variable immunodeficiency disorders","volume":"4","author":"Bonilla","year":"2016","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.aller.2019.12.008_bib0020","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1006\/clim.1999.4799","article-title":"Diagnostic criteria for primary immunodeficiencies, Representing PAGID (Pan-American Group for Immunodeficiency) and ESID (European Society for Immunodeficiencies)","volume":"93","author":"Conley","year":"1999","journal-title":"Clin Immunol"},{"key":"10.1016\/j.aller.2019.12.008_bib0025","series-title":"New Clinical Diagnosis Criteria for the ESID Registry","author":"European Society for Immunodeficiencies","year":"2020"},{"key":"10.1016\/j.aller.2019.12.008_bib0030","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1006\/clim.1999.4725","article-title":"Common variable immunodeficiency: clinical and immunological features of 248 patients","volume":"92","author":"Cunningham-Rundles","year":"1999","journal-title":"Clin Immunol"},{"key":"10.1016\/j.aller.2019.12.008_bib0035","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jaci.2013.12.1077","article-title":"Clinical picture and treatment of 2212 patients with common variable immunodeficiency","volume":"134","author":"Gathmann","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.aller.2019.12.008_bib0040","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/j.jaci.2015.04.049","article-title":"Practice parameter for the diagnosis and management of primary immunodeficiency","volume":"136","author":"Bonilla","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.aller.2019.12.008_bib0045","first-page":"19","article-title":"Serum immunoglobulin (IgG, IgM, IgA) and IgG subclass concentrations in healthy children: a study using nephelometric technique","volume":"48","author":"Aksu","year":"2006","journal-title":"Turk J Pediatr"},{"key":"10.1016\/j.aller.2019.12.008_bib0050","first-page":"125","article-title":"Peripheral blood lymphocyte subsets in healthy Turkish children","volume":"46","author":"Ikincio\u011fullari","year":"2004","journal-title":"Turk J Pediatr"},{"key":"10.1016\/j.aller.2019.12.008_bib0055","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1007\/s10875-012-9763-3","article-title":"The prevalences [correction] and patient characteristics of primary immunodeficiency diseases in Turkey \u2013 two centers study","volume":"33","author":"Kilic","year":"2013","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.aller.2019.12.008_bib0060","doi-asserted-by":"crossref","DOI":"10.1177\/2058738418779458","article-title":"Familial inheritance and screening of first-degree relatives in common variable immunodeficiency and immunoglobulin A deficiency patients","volume":"32","author":"Karaca","year":"2018","journal-title":"Int J Immunopathol Pharmacol"},{"key":"10.1016\/j.aller.2019.12.008_bib0065","first-page":"3527480","article-title":"Evaluation of clinical and immunological characteristics of children with common variable immunodeficiency","author":"Alkan","year":"2018","journal-title":"Int J Pediatr"},{"key":"10.1016\/j.aller.2019.12.008_bib0070","doi-asserted-by":"crossref","first-page":"119","DOI":"10.5114\/ceji.2019.87060","article-title":"Characteristics of the patients followed with the diagnosis of common variable immunodeficiency and the complications","volume":"44","author":"Erdem","year":"2019","journal-title":"Cent Eur J Immunol"},{"key":"10.1016\/j.aller.2019.12.008_bib0075","doi-asserted-by":"crossref","first-page":"310","DOI":"10.4103\/0366-6999.150092","article-title":"Clinical and immunological features of common variable immunodeficiency in China","volume":"128","author":"Lin","year":"2015","journal-title":"Chin Med J"},{"key":"10.1016\/j.aller.2019.12.008_bib0080","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1128\/CDLI.12.7.825-832.2005","article-title":"Clinical and immunological features of 65 Iranian patients with common variable immunodeficiency","volume":"12","author":"Aghamohammadi","year":"2005","journal-title":"Clin Diagn Lab Immunol"},{"key":"10.1016\/j.aller.2019.12.008_bib0085","first-page":"346","article-title":"Alteration in humoral immunity is common among family members of patients with common variable immunodeficiency","volume":"24","author":"Karakoc-Aydiner","year":"2014","journal-title":"J Investig Allergol Clin Immunol"},{"key":"10.1016\/j.aller.2019.12.008_bib0090","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1007\/s10875-007-9075-1","article-title":"Long-term follow-up and outcome of a large cohort of patients with common variable immunodeficiency","volume":"27","author":"Quinti","year":"2007","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.aller.2019.12.008_bib0095","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.aller.2013.01.007","article-title":"Clinical and immunological features of common variable immunodeficiency in Mexican patients","volume":"42","author":"Ram\u00edrez-Vargas","year":"2014","journal-title":"Allergol Immunopathol (Madr)"},{"key":"10.1016\/j.aller.2019.12.008_bib0100","first-page":"208","article-title":"Pediatric patients with common variable immunodeficiency: long-term follow-up","volume":"22","author":"Mohammadinejad","year":"2012","journal-title":"J Investig Allergol Clin Immunol"},{"key":"10.1016\/j.aller.2019.12.008_bib0105","first-page":"260","article-title":"Clinical and immunologic features of pediatric patients with common variable immunodeficiency and respiratory complications","volume":"18","author":"Aydogan","year":"2008","journal-title":"J Investig Allergol Clin Immunol"},{"key":"10.1016\/j.aller.2019.12.008_bib0110","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/s10875-011-9604-9","article-title":"Parental consanguinity is associated with a severe phenotype in common variable immunodeficiency","volume":"32","author":"Rivoisy","year":"2012","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.aller.2019.12.008_bib0115","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1067\/j.cpradiol.2017.04.007","article-title":"Granulomatous-lymphocytic interstitial lung disease in a patient with common variable immunodeficiency","volume":"47","author":"Shah","year":"2018","journal-title":"Curr Probl Diagn Radiol"},{"key":"10.1016\/j.aller.2019.12.008_bib0120","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.jaci.2004.05.057","article-title":"Granulomatous-lymphocytic lung disease shortens survival in common variable immunodeficiency","volume":"114","author":"Bates","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.aller.2019.12.008_bib0125","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s11882-009-0051-0","article-title":"Autoimmunity in common variable immunodeficiency","volume":"9","author":"Agarwal","year":"2009","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.aller.2019.12.008_bib0130","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jaut.2005.04.006","article-title":"Treatment and outcome of autoimmune hematologic disease in common variable immunodeficiency (CVID)","volume":"25","author":"Wang","year":"2005","journal-title":"J Autoimmun"},{"key":"10.1016\/j.aller.2019.12.008_bib0135","doi-asserted-by":"crossref","first-page":"83","DOI":"10.5114\/ceji.2015.50838","article-title":"Thrombocytopenia in common variable immunodeficiency patients \u2013 clinical course, management, and effect of immunoglobulins","volume":"40","author":"Pituch-Noworolska","year":"2015","journal-title":"Cent Eur J Immunol"},{"key":"10.1016\/j.aller.2019.12.008_bib0140","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S1081-1206(10)61096-4","article-title":"Spectrum of illness in pediatric common variable immunodeficiency","volume":"97","author":"Ogershok","year":"2006","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.aller.2019.12.008_bib0145","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.leukres.2015.02.002","article-title":"Lymphoproliferative disease and cancer among patients with common variable immunodeficiency","volume":"39","author":"Gangemi","year":"2015","journal-title":"Leuk Res"},{"key":"10.1016\/j.aller.2019.12.008_bib0150","first-page":"222","article-title":"Clinical and immunological analysis of 23 adult patients with common variable immunodeficiency","volume":"20","author":"Ardeniz","year":"2010","journal-title":"J Investig Allergol Clin Immunol"},{"key":"10.1016\/j.aller.2019.12.008_bib0155","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1067\/mai.2002.124999","article-title":"Efficacy of intravenous immunoglobulin in the prevention of pneumonia in patients with common variable immunodeficiency","volume":"109","author":"Busse","year":"2002","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.aller.2019.12.008_bib0160","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/cei.12485","article-title":"Current treatment options with immunoglobulin G for the individualization of care in patients with primary immunodeficiency disease","volume":"179","author":"Jolles","year":"2015","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.aller.2019.12.008_bib0165","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1007\/s10875-012-9720-1","article-title":"Home-based subcutaneous immunoglobulin versus hospital-based intravenous immunoglobulin in treatment of primary antibody deficiencies: systematic review and meta analysis","volume":"32","author":"Abolhassani","year":"2012","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.aller.2019.12.008_bib0170","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1097\/MOH.0b013e328302c7b6","article-title":"Lymphoma in common variable immunodeficiency: interplay between immune dysregulation, infection and genetics","volume":"15","author":"Chua","year":"2008","journal-title":"Curr Opin Hematol"},{"key":"10.1016\/j.aller.2019.12.008_bib0175","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1007\/s00431-015-2508-6","article-title":"Non-Hodgkin lymphoma in pediatric patients with common variable immunodeficiency","volume":"174","author":"Piquer Gibert","year":"2015","journal-title":"Eur J Pediatr"}],"container-title":["Allergologia et Immunopathologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030105462030032X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030105462030032X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T22:52:37Z","timestamp":1609455157000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030105462030032X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["S030105462030032X"],"URL":"https:\/\/doi.org\/10.1016\/j.aller.2019.12.008","relation":{},"ISSN":["0301-0546"],"issn-type":[{"value":"0301-0546","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical and immunological features of 44 common variable immunodeficiency patients: the experience of a single center in Turkey","name":"articletitle","label":"Article Title"},{"value":"Allergologia et Immunopathologia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aller.2019.12.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 SEICAP. Published by Elsevier Espa\u00f1a, S.L.U. All rights reserved.","name":"copyright","label":"Copyright"}]}}