{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T23:39:15Z","timestamp":1783381155947,"version":"3.54.6"},"reference-count":41,"publisher":"Codon Publications","issue":"6","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Allergologia et Immunopathologia"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.aller.2020.03.005","type":"journal-article","created":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T13:42:11Z","timestamp":1589204531000},"page":"711-719","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Evaluation of the frequency and diagnostic delay of primary immunodeficiency disorders among suspected patients based on the 10 warning sign criteria: A cross-sectional study in Iran"],"prefix":"10.15586","volume":"48","author":[{"given":"A.","family":"Bahrami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Sayyahfar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Soltani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Khodadost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7322-3369","authenticated-orcid":false,"given":"B.","family":"Moazzami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3836-1827","authenticated-orcid":false,"given":"N.","family":"Rezaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6228","reference":[{"key":"10.1016\/j.aller.2020.03.005_bib0210","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s10875-007-9103-1","article-title":"Population prevalence of diagnosed primary immunodeficiency diseases in the United States","volume":"27","author":"Boyle","year":"2007","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.aller.2020.03.005_bib0215","doi-asserted-by":"crossref","first-page":"S182","DOI":"10.1016\/j.jaci.2009.07.053","article-title":"Primary immunodeficiencies","volume":"125","author":"Notarangelo","year":"2010","journal-title":"J Allergy Clin Immunol"},{"issue":"Suppl. 1","key":"10.1016\/j.aller.2020.03.005_bib0220","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1365-2249.2009.04023.x","article-title":"Immunodeficiencies","volume":"158","author":"Ballow","year":"2009","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.aller.2020.03.005_bib0225","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1097\/ACI.0000000000000222","article-title":"Current screening approaches for antibody deficiency","volume":"15","author":"Holding","year":"2015","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.aller.2020.03.005_bib0230","first-page":"629","article-title":"Evaluating for immunodeficiency in children with recurrent infection","volume":"43","author":"Lee","year":"2014","journal-title":"Aust Fam Physician"},{"issue":"Suppl. 1","key":"10.1016\/j.aller.2020.03.005_bib0235","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1365-2249.2009.03954.x","article-title":"The European internet-based patient and research database for primary immunodeficiencies: results 2006\u20132008","volume":"157","author":"Gathmann","year":"2009","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.aller.2020.03.005_bib0240","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1023\/B:JOCI.0000018063.55963.0c","article-title":"Online registry of genetic and clinical immunodeficiency diagnostic laboratories, IDdiagnostics","volume":"24","author":"Samarghitean","year":"2004","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.aller.2020.03.005_bib0245","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1023\/A:1023255102170","article-title":"Primary immunodeficiency diseases in Latin America: first report from eight countries participating in the LAGID. Latin American Group for Primary Immunodeficiency Diseases","volume":"18","author":"Zelazko","year":"1998","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.aller.2020.03.005_bib0250","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s10875-006-9047-x","article-title":"Frequency and clinical manifestations of patients with primary immunodeficiency disorders in Iran: update from the Iranian Primary Immunodeficiency Registry","volume":"26","author":"Rezaei","year":"2006","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.aller.2020.03.005_bib0255","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1007\/s10875-014-0001-z","article-title":"Primary immunodeficiency disorders in Iran: update and new insights from the third report of the national registry","volume":"34","author":"Aghamohammadi","year":"2014","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.aller.2020.03.005_bib0260","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1007\/s10875-018-0556-1","article-title":"Fourth Update on the Iranian National Registry of Primary Immunodeficiencies: integration of molecular diagnosis","volume":"38","author":"Abolhassani","year":"2018","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.aller.2020.03.005_bib0265","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1007\/s10875-018-0556-1","article-title":"Fourth update on the Iranian National Registry of Primary Immunodeficiencies: integration of molecular diagnosis","volume":"38","author":"Abolhassani","year":"2018","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.aller.2020.03.005_bib0270","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1007\/s10875-012-9763-3","article-title":"The prevalences [correction] and patient characteristics of primary immunodeficiency diseases in Turkey \u2013 two centers study","volume":"33","author":"Kilic","year":"2013","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.aller.2020.03.005_bib0275","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s10875-007-9105-z","article-title":"Primary immunodeficiency diseases in Australia and New Zealand","volume":"27","author":"Kirkpatrick","year":"2007","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.aller.2020.03.005_bib0280","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10875-012-9751-7","article-title":"Primary immunodeficiency diseases worldwide: more common than generally thought","volume":"33","author":"Bousfiha","year":"2013","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.aller.2020.03.005_bib0285","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.3389\/fimmu.2018.01439","article-title":"Changing the lives of people with primary immunodeficiencies (PI) with early testing and diagnosis","volume":"9","author":"Condino-Neto","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.aller.2020.03.005_bib0290","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3389\/fped.2019.00381","article-title":"Long term outcome and immune function after hematopoietic stem cell transplantation for primary immunodeficiency","volume":"7","author":"Gennery","year":"2019","journal-title":"Front Pediatr"},{"key":"10.1016\/j.aller.2020.03.005_bib0295","doi-asserted-by":"crossref","first-page":"336","DOI":"10.5114\/ceji.2017.72825","article-title":"Evaluation of infectious and non-infectious complications in patients with primary immunodeficiency","volume":"42","author":"Bazregari","year":"2017","journal-title":"Cent Eur J Immunol"},{"key":"10.1016\/j.aller.2020.03.005_bib0300","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s12865-014-0031-6","article-title":"Primary immunodeficiency in infection-prone children in southern Sweden: occurrence, clinical characteristics and immunological findings","volume":"15","author":"Brodszki","year":"2014","journal-title":"BMC Immunol"},{"key":"10.1016\/j.aller.2020.03.005_bib0305","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1182\/blood.V99.3.872","article-title":"Hematopoietic stem cell transplantation for severe combined immunodeficiency in the neonatal period leads to superior thymic output and improved survival","volume":"99","author":"Myers","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.aller.2020.03.005_bib0310","doi-asserted-by":"crossref","first-page":"3243","DOI":"10.1182\/blood-2010-08-300384","article-title":"Neonatal diagnosis of severe combined immunodeficiency leads to significantly improved survival outcome: the case for newborn screening","volume":"117","author":"Brown","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.aller.2020.03.005_bib0315","first-page":"1","article-title":"National consensus on diagnosis and management guidelines for primary immunodeficiency","volume":"2","author":"Abolhassani","year":"2019","journal-title":"Immunol Genet J"},{"key":"10.1016\/j.aller.2020.03.005_bib0320","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2015.04.049","article-title":"Practice parameter for the diagnosis and management of primary immunodeficiency","volume":"136","author":"Bonilla","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.aller.2020.03.005_bib0325","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1749-6632.2011.06206.x","article-title":"Ten warning signs of primary immunodeficiency: a new paradigm is needed for the 21st century","volume":"1238","author":"Arkwright","year":"2011","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.aller.2020.03.005_bib0330","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1097\/MOP.0b013e3282f1ddd5","article-title":"Common variable immunodeficiency in children","volume":"19","author":"Glocker","year":"2007","journal-title":"Curr Opin Pediatr"},{"key":"10.1016\/j.aller.2020.03.005_bib0335","first-page":"CR217","article-title":"Screening for B- and T-cell defects in Egyptian infants and children with suspected primary immunodeficiency","volume":"15","author":"Hossny","year":"2009","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.aller.2020.03.005_bib0340","doi-asserted-by":"crossref","first-page":"1","DOI":"10.21608\/zumj.2014.4360","article-title":"Assessment of primary immunodeficiency disorders among children at Zagazig University Hospital","volume":"20","author":"Hussien","year":"2014","journal-title":"Zagazig Univ Med J"},{"key":"10.1016\/j.aller.2020.03.005_bib0345","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s12026-011-8241-y","article-title":"Global study of primary immunodeficiency diseases (PI) \u2013 diagnosis, treatment, and economic impact: an updated report from the Jeffrey Modell Foundation","volume":"51","author":"Modell","year":"2011","journal-title":"Immunol Res"},{"key":"10.1016\/j.aller.2020.03.005_bib0350","first-page":"208","article-title":"Pediatric patients with common variable immunodeficiency: long-term follow-up","volume":"22","author":"Mohammadinejad","year":"2012","journal-title":"J Investig Allergol Clin Immunol"},{"key":"10.1016\/j.aller.2020.03.005_bib0355","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s10875-008-9260-x","article-title":"Primary immunodeficiency diseases in Egyptian children: a single-center study","volume":"29","author":"Reda","year":"2009","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.aller.2020.03.005_bib0360","first-page":"187254","article-title":"Primary immunodeficiency diseases at reference and high-specialty hospitals in the state of Guanajuato, Mexico","author":"Guan\u00ed-Guerra","year":"2013","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.aller.2020.03.005_bib0365","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s12098-008-0022-9","article-title":"Spectrum of primary immune deficiency at a tertiary care hospital","volume":"75","author":"Verma","year":"2008","journal-title":"Indian J Pediatr"},{"key":"10.1016\/j.aller.2020.03.005_bib0370","doi-asserted-by":"crossref","first-page":"S435","DOI":"10.1016\/j.jaci.2005.09.051","article-title":"2. Update on primary immunodeficiency diseases","volume":"117","author":"Bonilla","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.aller.2020.03.005_bib0375","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1007\/s10875-008-9229-9","article-title":"IgA deficiency: correlation between clinical and immunological phenotypes","volume":"29","author":"Aghamohammadi","year":"2009","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.aller.2020.03.005_bib0380","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1136\/adc.56.12.939","article-title":"Eczema and atopy in early childhood: low IgA plasma cell counts in the jejunal mucosa","volume":"56","author":"Sloper","year":"1981","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.aller.2020.03.005_bib0385","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1111\/j.1365-2249.2007.03432.x","article-title":"Recognition, clinical diagnosis and management of patients with primary antibody deficiencies: a systematic review","volume":"149","author":"Wood","year":"2007","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.aller.2020.03.005_bib0390","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1136\/bmj.308.6928.581","article-title":"Consensus on diagnosis and management of primary antibody deficiencies. Consensus Panel for the Diagnosis and Management of Primary Antibody Deficiencies","volume":"308","author":"Chapel","year":"1994","journal-title":"BMJ"},{"key":"10.1016\/j.aller.2020.03.005_bib0395","doi-asserted-by":"crossref","first-page":"16","DOI":"10.4065\/84.1.16","article-title":"Incidence and temporal trends of primary immunodeficiency: a population-based cohort study","volume":"84","author":"Joshi","year":"2009","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.aller.2020.03.005_bib0400","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jmii.2011.01.026","article-title":"Impact of delayed diagnosis in children with primary antibody deficiencies","volume":"44","author":"Aghamohammadi","year":"2011","journal-title":"J Microbiol Immunol Infect"},{"key":"10.1016\/j.aller.2020.03.005_bib0405","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1136\/qshc.4.4.263","article-title":"Management of primary antibody deficiency by consultant immunologists in the United Kingdom: a paradigm for other rare diseases","volume":"4","author":"Spickett","year":"1995","journal-title":"Qual Health Care"},{"key":"10.1016\/j.aller.2020.03.005_bib0410","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1136\/jcp.2004.016204","article-title":"Primary antibody deficiency and diagnostic delay","volume":"58","author":"Seymour","year":"2005","journal-title":"J Clin Pathol"}],"container-title":["Allergologia et Immunopathologia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301054620300641?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0301054620300641?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T22:52:38Z","timestamp":1609455158000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0301054620300641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["S0301054620300641"],"URL":"https:\/\/doi.org\/10.1016\/j.aller.2020.03.005","relation":{},"ISSN":["0301-0546"],"issn-type":[{"value":"0301-0546","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of the frequency and diagnostic delay of primary immunodeficiency disorders among suspected patients based on the 10 warning sign criteria: A cross-sectional study in Iran","name":"articletitle","label":"Article Title"},{"value":"Allergologia et Immunopathologia","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aller.2020.03.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 SEICAP. Published by Elsevier Espa\u00f1a, S.L.U. All rights reserved.","name":"copyright","label":"Copyright"}]}}