{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T05:41:19Z","timestamp":1761025279546,"version":"build-2065373602"},"reference-count":38,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["airmedicaljournal.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Air Medical Journal"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.amj.2021.05.010","type":"journal-article","created":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T04:17:25Z","timestamp":1624594645000},"page":"359-362","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Use of Tranexamic Acid in Traumatic Resuscitation in a Prehospital Setting: A Case Report"],"prefix":"10.1016","volume":"40","author":[{"given":"Lilyan Paula de Sousa Teixeira","family":"Lima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo Regis Souza","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herberth Jessie","family":"Martins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel Augusto de Souza","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larissa Michetti","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f4nica Beatriz Ortolan","family":"Libardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan Almeida Milward","family":"Azevedo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.amj.2021.05.010_bib0001","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1097\/JTN.0000000000000383","article-title":"Resuscitative strategies in the trauma patient: the past, the present, and the future","volume":"25","author":"Eick","year":"2018","journal-title":"J Trauma Nurs"},{"key":"10.1016\/j.amj.2021.05.010_bib0002","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1056\/NEJMoa1802345","article-title":"Prehospital plasma during air medical transport in trauma patients at risk for hemorrhagic shock","volume":"379","author":"Sperry","year":"2018","journal-title":"N Engl J Med"},{"key":"10.1016\/j.amj.2021.05.010_bib0003","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1097\/SLA.0000000000003324","article-title":"Blood product and crystalloid resuscitation in the severely injured patient prehospital: The secondary analysis of the rrehospital air medical plasma trial","volume":"273","author":"Guyette","year":"2021","journal-title":"Ann Surg"},{"key":"10.1016\/j.amj.2021.05.010_bib0004","doi-asserted-by":"crossref","first-page":"728","DOI":"10.3357\/AMHP.4492.2016","article-title":"Army air ambulance blood product program in the combat zone and challenges to best practices","volume":"87","author":"Powell-Dunford","year":"2016","journal-title":"Aerosp Med Hum Perform"},{"key":"10.1016\/j.amj.2021.05.010_bib0005","doi-asserted-by":"crossref","DOI":"10.1001\/jamasurg.2019.5085","article-title":"Association of prehospital plasma transfusion with survival in trauma patients with hemorrhagic shock when transport times are longer than 20 minutes: the post hoc analysis of the PAMper and COMBAT clinical trials","volume":"155","author":"Pusateri","year":"2020","journal-title":"JAMA Surg"},{"key":"10.1016\/j.amj.2021.05.010_bib0006","unstructured":"JI News. Pioneering health project in Latin America begins this tuesday in Bragan\u00e7a Paulista: Bragan\u00e7a Paulista will be the first city in Latin America to perform blood transfusion in a pre-hospital environment (SECOM). Available at: https:\/\/www.ji.com.br\/artigo\/projeto-de-saude-pioneiro-na-america-latina-comeca-nesta-terca-em-braganca-paulista. Accessed March 9, 2021."},{"key":"10.1016\/j.amj.2021.05.010_bib0007","unstructured":"ANVISA National Health Surveillance Agency. Sanitary surveillance manual for the transport of blood and components in the context of hemotherapy. Available at: http:\/\/antigo.anvisa.gov.br\/documents\/4048533\/4048644\/manual_transporte_sangue_componentes.pdf\/62ea6ec8-50be-4b22-8209-18acb70be1c1. Accessed March 9, 2021."},{"key":"10.1016\/j.amj.2021.05.010_bib0008","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1590\/0102-6720201600040017","article-title":"Tranexamic acid use in trauma: a cost-effectiveness analysis for use in Brazil","volume":"29","author":"Pinto","year":"2016","journal-title":"Arq Bras Cir Dig"},{"key":"10.1016\/j.amj.2021.05.010_bib0009","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.ajem.2018.03.033","article-title":"Efficacy of prehospital administration of tranexamic acid in trauma patients: a meta-analysis of the randomized controlled trials","volume":"36","author":"El-Menyar","year":"2018","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.amj.2021.05.010_bib0010","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1213\/ANE.0000000000002708","article-title":"The impact of prehospital tranexamicacid on blood coagulation in trauma patients","volume":"126","author":"Stein","year":"2018","journal-title":"Anesth Analg"},{"key":"10.1016\/j.amj.2021.05.010_bib0011","doi-asserted-by":"crossref","first-page":"S70","DOI":"10.1097\/TA.0000000000000640","article-title":"Tranexamic acid as part of remote damage-control resuscitation in the prehospital setting: a critical appraisal of the medical literature and available alternatives","volume":"78","author":"Ausset","year":"2015","journal-title":"J Trauma Acute Care Surg"},{"key":"10.1016\/j.amj.2021.05.010_bib0012","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0140-6736(10)60835-5","article-title":"Effects of tranexamic acid on death, vascular occupational events, and blood transfer in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial","volume":"376","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.amj.2021.05.010_bib0013","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1016\/S0140-6736(17)30638-4","article-title":"Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double blind, placebo-controlled trial","volume":"389","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.amj.2021.05.010_bib0014","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1056\/NEJMoa1606424","article-title":"Tranexamic acid in patients undergoing coronary-artery surgery","volume":"376","author":"Myles","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.amj.2021.05.010_bib0015","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1016\/S0140-6736(19)32233-0","article-title":"Effects of tranexamic acid on death, disability, vascular occupational events and other morbidities in patients with acute traumatic brain injury (CRASH-3): a randomised, placebo-controlled trial","volume":"394","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.amj.2021.05.010_bib0016","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1111\/anae.12910","article-title":"The current place of tranexamic acid in the management of bleeding","volume":"70","author":"Hunt","year":"2015","journal-title":"Anaesthesia"},{"key":"10.1016\/j.amj.2021.05.010_bib0017","first-page":"612","article-title":"Effects of tranexamic acid on death, vascular occupational events, and blood transfer in trauma patients with significant haemorrhage (CRASH-2) A randomised, placebo-controlled trial","volume":"59","author":"Williams-Johnson","year":"2010","journal-title":"West Indian Med J"},{"key":"10.1016\/j.amj.2021.05.010_bib0018","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1097\/TA.0000000000002061","article-title":"Tranexamic acid administration is associated with an increased risk of posttraumatic venous thromboembolism","volume":"86","author":"Myers","year":"2019","journal-title":"J Trauma Acute Care Surg"},{"key":"10.1016\/j.amj.2021.05.010_bib0019","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1001\/jama.2020.8958","article-title":"Effect of out-of-hospital tranexamic acid vs placebo on 6-month functional neurologic outcomes in patients with moderate or severe traumatic brain injury","volume":"324","author":"Rowell","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.amj.2021.05.010_bib0020","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/1742-6723.12172","article-title":"Tranexamic acid for trauma: filling out the GAP in evidence","volume":"26","author":"Mitra","year":"2014","journal-title":"Emerg Med Australas"},{"key":"10.1016\/j.amj.2021.05.010_bib0021","first-page":"11","article-title":"Tranexamic acid during prehospital transport in patients at risk for hemorrhage after injury: A double-blind, placebo-controlled, randomized clinical trial","volume":"156","author":"Guyette","year":"2020","journal-title":"JAMA Surg"},{"key":"10.1016\/j.amj.2021.05.010_bib0022","first-page":"20","article-title":"Tranexamic acid prehospital: STAAMP of approval or return to sender?","volume":"156","author":"Dumas","year":"2021","journal-title":"JAMA Surg"},{"year":"2020","series-title":"Department of Health of the Federal District: UPA 24h","key":"10.1016\/j.amj.2021.05.010_bib0023"},{"year":"2013","series-title":"Instructive Manual of the Emergency and Emergency Care Network in the Unified Health System (SUS)","key":"10.1016\/j.amj.2021.05.010_bib0024"},{"key":"10.1016\/j.amj.2021.05.010_bib0025","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD004896.pub3","article-title":"Antifibrinolytic drugs for acute traumatic injury","volume":"12","author":"Roberts","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.amj.2021.05.010_bib0026","doi-asserted-by":"crossref","first-page":"e18987","DOI":"10.1371\/journal.pone.0018987","article-title":"Cost-effective analysis of administering tranexamic acid to bleeding trauma patients using evidence from the CRASH-2 trial","volume":"6","author":"Guerriero","year":"2011","journal-title":"PLoS One"},{"journal-title":"Official Gazette of the Union","first-page":"112","year":"2011","key":"10.1016\/j.amj.2021.05.010_bib0027"},{"year":"2018","series-title":"ATLS \u2014 Advanced Trauma Life Support for Doctors","key":"10.1016\/j.amj.2021.05.010_bib0028"},{"key":"10.1016\/j.amj.2021.05.010_bib0029","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.amj.2019.01.002","article-title":"Hemorrhage treatment adjuncts in the helicopter emergency medical service","volume":"38","author":"Schober","year":"2019","journal-title":"Air Med J"},{"key":"10.1016\/j.amj.2021.05.010_bib0030","doi-asserted-by":"crossref","first-page":"673","DOI":"10.5811\/westjem.2017.2.32044","article-title":"Efficacy and safety of tranexamic acid in prehospital traumatic hemorrhagic shock: outcomes of the Cal-Pat study","volume":"18","author":"Neeki","year":"2017","journal-title":"West J Emerg Med"},{"key":"10.1016\/j.amj.2021.05.010_bib0031","first-page":"182","article-title":"Tranexamic acid and thrombosis","volume":"22","year":"2013","journal-title":"Prescrire Int"},{"year":"2019","series-title":"PHTLS: Trauma Life Support Prehospital (Military Edition)","key":"10.1016\/j.amj.2021.05.010_bib0032"},{"year":"2018","series-title":"PHTLS: Pre-hospital Care to the Polytraumatized","author":"National Association of Emergency Medical Technicians","key":"10.1016\/j.amj.2021.05.010_bib0033"},{"year":"2019","series-title":"TECC: Tactical Emergency Casualty Care","key":"10.1016\/j.amj.2021.05.010_bib0034"},{"key":"10.1016\/j.amj.2021.05.010_bib0035","doi-asserted-by":"crossref","first-page":"557","DOI":"10.3109\/10903127.2016.1142628","article-title":"Guidance document for the prehospital use of tranexamic acid in injured patients","volume":"20","author":"Fischer","year":"2016","journal-title":"Prehosp Emerg Care"},{"key":"10.1016\/j.amj.2021.05.010_bib0036","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s13054-019-2347-3","article-title":"The European guideline on management of major bleeding and coagulopathy following trauma: fifth edition","volume":"23","author":"Spahn","year":"2019","journal-title":"Crit Care"},{"key":"10.1016\/j.amj.2021.05.010_bib0037","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.amj.2013.05.001","article-title":"Prehospital use of tranexamic acid for hemorrhagic shock in primary and secondary air medical evacuation","volume":"32","author":"Vu","year":"2013","journal-title":"Air Med J"},{"key":"10.1016\/j.amj.2021.05.010_bib0038","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.injury.2013.08.025","article-title":"Tranexamic acid in the prehospital setting: Israel Defense Forces' initial experience","volume":"45","author":"Lipsky","year":"2014","journal-title":"Injury"}],"container-title":["Air Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1067991X21001139?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1067991X21001139?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T05:22:55Z","timestamp":1761024175000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1067991X21001139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["S1067991X21001139"],"URL":"https:\/\/doi.org\/10.1016\/j.amj.2021.05.010","relation":{},"ISSN":["1067-991X"],"issn-type":[{"type":"print","value":"1067-991X"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Use of Tranexamic Acid in Traumatic Resuscitation in a Prehospital Setting: A Case Report","name":"articletitle","label":"Article Title"},{"value":"Air Medical Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.amj.2021.05.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Air Medical Journal Associates. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}